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The map label for this gene is czcC [H]

Identifier: 75675647

GI number: 75675647

Start: 1585422

End: 1586693

Strand: Direct

Name: czcC [H]

Synonym: Nwi_1455

Alternate gene names: 75675647

Gene position: 1585422-1586693 (Clockwise)

Preceding gene: 75675646

Following gene: 75675648

Centisome position: 46.6

GC content: 63.68

Gene sequence:

>1272_bases
ATGTTGTTAAAGTCCGCCGCGCATCTTGCGTGGGCGATGGCGCTGCTGATCAGCCCCTGGCTGATGACGCCGTCGTATTC
GCAAGCGCTGACCTTGAGGGCCGCGCTTCAACGCGCGCTCGCCGCCAACCCGCGTCTGACCGCCGCCGGGCGCGATGTCG
GCATCGCAACCGGCAGGGGTATCCAGGCCGGGATGCTGATAAATCCCGAAGCATCGTATCAGCAGGATAACTCGCTCGGT
TCCGGAAATTATCGCGGAACGCGGTCGGCGGAGACAACGCTCCAGATCAGCCAGTTGTTCGAGCTTTTCGGCAAGCGAGA
CGCGCGAATTGCCGTCGGCCGGGCCGGCGTGGAGACCGCGGTGATACAGCGCAAGGCCGTTCGCCTTGAAGTCTTGTCCG
AGACGGCTGTCGCTTTTCTGAGCGTTCTCGGCGCCCAGCGCAGGATCCAGATTCTGGACGAGCAGATCGCCGCGATCGAT
GCGTTGACGCCGTTGCTGCAGCGGCGGGTGGAGGCCGGCGCGTCGTCATCCGCCGAGATCGGCCGGGCGGACGTCGCATC
CGCATTGATGAAAGCGGACCGCGAGCGGATCCGGGCGAGGCTTGCCAGCGCCAGGCGCGAGCTGGCCGCGCTGATGGGAG
ACACTTCCGCCAAGTTCAAGTCCGTCGCGGGACGGCTGGACGACCTGGGCCGGCCTCCGTCTTTTCAGGCCGTGGTTGCC
GCGATCGATGCGAATCCGCAGTTGATGCGCTGGACGGCCATCTATGCTCAACGCAACGCCGAACTTCTGGTGGCGCGGCT
GAAGCCCTATCCCGACGTTCGCGTCAGCGCGGGCTGGCGTCATTTCAACACGACCAACGACGACGCCGTCATACTCTCGC
TTTCGGTTCCCATCCCGGTATACGACCAGAATCAGGGCAACATCCTTTCCGCGCAGGAAAACCTCGCAAAAACCAGAGCC
GAACGGGAATCCAATCGCAACACGCTGATCGTGCTCGCAGGGCGTGCCTATGACTCGCTGCAAGGTTCTTTACGCGAACT
GAAGGTGCTGCGTGAGATTGCGATTCCGAAGTCGCGCAGCGCCGCCGATGCGATCTTCGAAGGATACGGGCAGGGGCGCT
TTTCGTTGCTCGAAGTGCTCGATGCCCTGGCGAATGTCGCACAGGCGCGCCTGCGTGAGCAGGAGGCGCAGCAGAACTTT
CACGTAGGCGTCGCGACGATCGAGGGTCTGGTCGGCAATCCGTTCGCGTTGGCGCGAGGGGGCGTCCGATGA

Upstream 100 bases:

>100_bases
ATCTTGTCCCCGGTATCGATACGCCTCCGCCGAAACTCCTGGGCTGAACGTATTCACGGGCGCATCGACGTCCTGATTCC
GTTATTCGCCAGGATCTTCC

Downstream 100 bases:

>100_bases
TCAAGAGATTCACGATAATCATATTCGCCGTCGTGGTGCTTGCGGTCGCAGGGATCGGCTATCGCATGTTGGATCTGACA
GACCCCGGTGTTCCCGCATT

Product: Outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLLKSAAHLAWAMALLISPWLMTPSYSQALTLRAALQRALAANPRLTAAGRDVGIATGRGIQAGMLINPEASYQQDNSLG
SGNYRGTRSAETTLQISQLFELFGKRDARIAVGRAGVETAVIQRKAVRLEVLSETAVAFLSVLGAQRRIQILDEQIAAID
ALTPLLQRRVEAGASSSAEIGRADVASALMKADRERIRARLASARRELAALMGDTSAKFKSVAGRLDDLGRPPSFQAVVA
AIDANPQLMRWTAIYAQRNAELLVARLKPYPDVRVSAGWRHFNTTNDDAVILSLSVPIPVYDQNQGNILSAQENLAKTRA
ERESNRNTLIVLAGRAYDSLQGSLRELKVLREIAIPKSRSAADAIFEGYGQGRFSLLEVLDALANVAQARLREQEAQQNF
HVGVATIEGLVGNPFALARGGVR

Sequences:

>Translated_423_residues
MLLKSAAHLAWAMALLISPWLMTPSYSQALTLRAALQRALAANPRLTAAGRDVGIATGRGIQAGMLINPEASYQQDNSLG
SGNYRGTRSAETTLQISQLFELFGKRDARIAVGRAGVETAVIQRKAVRLEVLSETAVAFLSVLGAQRRIQILDEQIAAID
ALTPLLQRRVEAGASSSAEIGRADVASALMKADRERIRARLASARRELAALMGDTSAKFKSVAGRLDDLGRPPSFQAVVA
AIDANPQLMRWTAIYAQRNAELLVARLKPYPDVRVSAGWRHFNTTNDDAVILSLSVPIPVYDQNQGNILSAQENLAKTRA
ERESNRNTLIVLAGRAYDSLQGSLRELKVLREIAIPKSRSAADAIFEGYGQGRFSLLEVLDALANVAQARLREQEAQQNF
HVGVATIEGLVGNPFALARGGVR
>Mature_423_residues
MLLKSAAHLAWAMALLISPWLMTPSYSQALTLRAALQRALAANPRLTAAGRDVGIATGRGIQAGMLINPEASYQQDNSLG
SGNYRGTRSAETTLQISQLFELFGKRDARIAVGRAGVETAVIQRKAVRLEVLSETAVAFLSVLGAQRRIQILDEQIAAID
ALTPLLQRRVEAGASSSAEIGRADVASALMKADRERIRARLASARRELAALMGDTSAKFKSVAGRLDDLGRPPSFQAVVA
AIDANPQLMRWTAIYAQRNAELLVARLKPYPDVRVSAGWRHFNTTNDDAVILSLSVPIPVYDQNQGNILSAQENLAKTRA
ERESNRNTLIVLAGRAYDSLQGSLRELKVLREIAIPKSRSAADAIFEGYGQGRFSLLEVLDALANVAQARLREQEAQQNF
HVGVATIEGLVGNPFALARGGVR

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 45738; Mature: 45738

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKSAAHLAWAMALLISPWLMTPSYSQALTLRAALQRALAANPRLTAAGRDVGIATGRG
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCC
IQAGMLINPEASYQQDNSLGSGNYRGTRSAETTLQISQLFELFGKRDARIAVGRAGVETA
CEECEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
VIQRKAVRLEVLSETAVAFLSVLGAQRRIQILDEQIAAIDALTPLLQRRVEAGASSSAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRADVASALMKADRERIRARLASARRELAALMGDTSAKFKSVAGRLDDLGRPPSFQAVVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHEEE
AIDANPQLMRWTAIYAQRNAELLVARLKPYPDVRVSAGWRHFNTTNDDAVILSLSVPIPV
EECCCCCCEEHHHHHHHCCCCEEEEECCCCCCCEEECCCEECCCCCCCEEEEEEECCCCE
YDQNQGNILSAQENLAKTRAERESNRNTLIVLAGRAYDSLQGSLRELKVLREIAIPKSRS
EECCCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
AADAIFEGYGQGRFSLLEVLDALANVAQARLREQEAQQNFHVGVATIEGLVGNPFALARG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHCCCCCCHHHCCC
GVR
CCC
>Mature Secondary Structure
MLLKSAAHLAWAMALLISPWLMTPSYSQALTLRAALQRALAANPRLTAAGRDVGIATGRG
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCC
IQAGMLINPEASYQQDNSLGSGNYRGTRSAETTLQISQLFELFGKRDARIAVGRAGVETA
CEECEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
VIQRKAVRLEVLSETAVAFLSVLGAQRRIQILDEQIAAIDALTPLLQRRVEAGASSSAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRADVASALMKADRERIRARLASARRELAALMGDTSAKFKSVAGRLDDLGRPPSFQAVVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHEEE
AIDANPQLMRWTAIYAQRNAELLVARLKPYPDVRVSAGWRHFNTTNDDAVILSLSVPIPV
EECCCCCCEEHHHHHHHCCCCEEEEECCCCCCCEEECCCEECCCCCCCEEEEEEECCCCE
YDQNQGNILSAQENLAKTRAERESNRNTLIVLAGRAYDSLQGSLRELKVLREIAIPKSRS
EECCCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
AADAIFEGYGQGRFSLLEVLDALANVAQARLREQEAQQNFHVGVATIEGLVGNPFALARG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHCCCCCCHHHCCC
GVR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]