Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 75675593

GI number: 75675593

Start: 1526114

End: 1527646

Strand: Direct

Name: pccB [H]

Synonym: Nwi_1401

Alternate gene names: 75675593

Gene position: 1526114-1527646 (Clockwise)

Preceding gene: 75675592

Following gene: 75675594

Centisome position: 44.86

GC content: 61.19

Gene sequence:

>1533_bases
ATGAAGAACATTCGCGAAGCGCTCGATGCCCGGCGGGCGGCCGCGAAGCTTGGCGGCGGCGAGAAGCGCATCGAGGCGCA
GCACAGGCGCGGCAAGCTGACCGCTCGCGAACGCATCGAGATCCTGCTCGACAAAGGTTCGTTCGAGGAGTTCGACATGT
TCGTCGAGCATCGCTCGGTCGAATTCGGCATGGAAAAATCGAAGGTGCCGGGCGACGGCGTGGTGACCGGATGGGGCACC
GTCAACGGTCGCACGATTTTCGTCTTCGCGAAGGACTTCACCGTGTTCGGCGGTTCGCTGTCGGAAACGCATGCGTTGAA
GATCACGAAAATCCAGGACCTGGCGCTGAAGGCGAGGGCGCCGATCATCGGTCTCTATGATGCCGGCGGCGCGCGCATTC
AGGAAGGCGTGGCGGCGCTGGCCGGTTACTCCTATGTCTTCCGCCGCAACGTGCAGGCCTCGGGCGTGATCCCGCAGATC
AGCGTCATCATGGGGCCGTGCGCCGGCGGCGATGTCTATTCGCCCGCGATGACCGATTTCATCTTCATGGTGAAGAACAC
GAGCTACATGTTCGTCACCGGGCCCGACGTGGTGAAAACCGTCACAGGCGAGGCGGTGACTTCGGAAGAACTCGGCGGCG
CCAGCGTGCACACGACGAAATCGTCGATTGCCGACGGCGCGTTCGAAAACGATGTCGAGGCGCTCTTGCAGATGCGTCGC
CTGATCGACTTCCTGCCGGGCAACAACACAGATGGCGTGCCGGAATGGCCGAGCTTCGATGAGGTCGAGCGGACCGATGA
CTCGCTCGACACGCTGGTGCCGGACAATCCCAACAAGCCCTACGATATTAAGGAACTGATCCTGAAGGTCGTGGACGAAG
GCGATTTCTTCGAGATCGCGGAAACGTTCGCTAAGAACATCGTCACCGGCTTCGGCCGCATCGCCGGACGCACCGTCGGT
TTCGTCGCCAACCAGCCGATGGTGCTGGCCGGCGTGCTCGACTCCGATGCGTCACGCAAGGCAGCGCGCTTCGTTCGCTT
TTGCGACGCCTTCAACATTCCGATTGTCACCTTCGTGGACGTGCCGGGCTTCTTGCCGGGCACAGCGCAGGAATATGGCG
GGCTGATCAAGCATGGCGCGAAGCTCCTGTTCGCGTATTCGCAATGCACGGTGCCGCTTGTGACCGTCATCACGCGCAAG
GCCTATGGCGGCGCGTTCGACGTGATGGCGTCCAAGGAGATTGGCGCGGATATCAATTACGCCTGGCCGACGGCGCAGAT
CGCGGTGATGGGCGCGAAGGGCGCGGTGGAGATCATCTTTCGCAACGATATCGGCGACGAGGAGAAGATCGCCGCGCGCA
CCAGGGAATACGAGGATCGTTTCCTGTCACCGTTCGTCGCCGCCGAACGCGGCTACATCGACGACGTTATTTTGCCGTCC
TCGACGCGTCGGCGCATTGCGAGAGCACTTGCGATGTTGAGGGACAAGCATGTAGAGGTGTTAGCAAAAAAACACGACAA
TTTGCCGTTGTGA

Upstream 100 bases:

>100_bases
CAGGTGACGGCGCCGCCTCCGCGCCGCGCCTGTTGGTGACAGCCTCAAAAACGGCGGTTAGGGTCTAATCCAAGTTCATT
GAACCAGACCAGGCACGGCC

Downstream 100 bases:

>100_bases
GATATGCCAGTATGTCGAGGGATTTAGCTCAAACTCCGGGACGAAAATCCGCAGCATTTCGTGCATATAGGGAGTATCCG
CATCGTACAATCGCGATAAT

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKNIREALDARRAAAKLGGGEKRIEAQHRRGKLTARERIEILLDKGSFEEFDMFVEHRSVEFGMEKSKVPGDGVVTGWGT
VNGRTIFVFAKDFTVFGGSLSETHALKITKIQDLALKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRNVQASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKNTSYMFVTGPDVVKTVTGEAVTSEELGGASVHTTKSSIADGAFENDVEALLQMRR
LIDFLPGNNTDGVPEWPSFDEVERTDDSLDTLVPDNPNKPYDIKELILKVVDEGDFFEIAETFAKNIVTGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRK
AYGGAFDVMASKEIGADINYAWPTAQIAVMGAKGAVEIIFRNDIGDEEKIAARTREYEDRFLSPFVAAERGYIDDVILPS
STRRRIARALAMLRDKHVEVLAKKHDNLPL

Sequences:

>Translated_510_residues
MKNIREALDARRAAAKLGGGEKRIEAQHRRGKLTARERIEILLDKGSFEEFDMFVEHRSVEFGMEKSKVPGDGVVTGWGT
VNGRTIFVFAKDFTVFGGSLSETHALKITKIQDLALKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRNVQASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKNTSYMFVTGPDVVKTVTGEAVTSEELGGASVHTTKSSIADGAFENDVEALLQMRR
LIDFLPGNNTDGVPEWPSFDEVERTDDSLDTLVPDNPNKPYDIKELILKVVDEGDFFEIAETFAKNIVTGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRK
AYGGAFDVMASKEIGADINYAWPTAQIAVMGAKGAVEIIFRNDIGDEEKIAARTREYEDRFLSPFVAAERGYIDDVILPS
STRRRIARALAMLRDKHVEVLAKKHDNLPL
>Mature_510_residues
MKNIREALDARRAAAKLGGGEKRIEAQHRRGKLTARERIEILLDKGSFEEFDMFVEHRSVEFGMEKSKVPGDGVVTGWGT
VNGRTIFVFAKDFTVFGGSLSETHALKITKIQDLALKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRNVQASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKNTSYMFVTGPDVVKTVTGEAVTSEELGGASVHTTKSSIADGAFENDVEALLQMRR
LIDFLPGNNTDGVPEWPSFDEVERTDDSLDTLVPDNPNKPYDIKELILKVVDEGDFFEIAETFAKNIVTGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRK
AYGGAFDVMASKEIGADINYAWPTAQIAVMGAKGAVEIIFRNDIGDEEKIAARTREYEDRFLSPFVAAERGYIDDVILPS
STRRRIARALAMLRDKHVEVLAKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=510, Percent_Identity=61.7647058823529, Blast_Score=644, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=59.622641509434, Blast_Score=630, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=32.7345309381238, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679960, Length=358, Percent_Identity=24.8603351955307, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38679977, Length=358, Percent_Identity=24.8603351955307, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38679967, Length=358, Percent_Identity=24.8603351955307, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38679974, Length=358, Percent_Identity=24.8603351955307, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI38679971, Length=358, Percent_Identity=24.8603351955307, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI134142062, Length=358, Percent_Identity=24.5810055865922, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=60.3550295857988, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=60.3550295857988, Blast_Score=644, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=508, Percent_Identity=33.0708661417323, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71997163, Length=328, Percent_Identity=24.390243902439, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24586065, Length=506, Percent_Identity=34.1897233201581, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55681; Mature: 55681

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIREALDARRAAAKLGGGEKRIEAQHRRGKLTARERIEILLDKGSFEEFDMFVEHRSV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHEEEEECCCCCHHHHHHHHHHHH
EFGMEKSKVPGDGVVTGWGTVNGRTIFVFAKDFTVFGGSLSETHALKITKIQDLALKARA
HCCCHHCCCCCCCEEEECCCCCCEEEEEEEECEEEECCCCCCCCEEEEEEHHHHHHHHCC
PIIGLYDAGGARIQEGVAALAGYSYVFRRNVQASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHE
IFMVKNTSYMFVTGPDVVKTVTGEAVTSEELGGASVHTTKSSIADGAFENDVEALLQMRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCEEECCHHHHHCCCCHHHHHHHHHHHH
LIDFLPGNNTDGVPEWPSFDEVERTDDSLDTLVPDNPNKPYDIKELILKVVDEGDFFEIA
HHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
ETFAKNIVTGFGRIAGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVD
HHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRKAYGGAFDVMASKEIGADINY
CCCCCCCCHHHHCHHHHCCHHEEEEHHHCCHHHHHHHHHHHCCCEEEEEECHHCCCCCCC
AWPTAQIAVMGAKGAVEIIFRNDIGDEEKIAARTREYEDRFLSPFVAAERGYIDDVILPS
CCCCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCC
STRRRIARALAMLRDKHVEVLAKKHDNLPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNIREALDARRAAAKLGGGEKRIEAQHRRGKLTARERIEILLDKGSFEEFDMFVEHRSV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHEEEEECCCCCHHHHHHHHHHHH
EFGMEKSKVPGDGVVTGWGTVNGRTIFVFAKDFTVFGGSLSETHALKITKIQDLALKARA
HCCCHHCCCCCCCEEEECCCCCCEEEEEEEECEEEECCCCCCCCEEEEEEHHHHHHHHCC
PIIGLYDAGGARIQEGVAALAGYSYVFRRNVQASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHE
IFMVKNTSYMFVTGPDVVKTVTGEAVTSEELGGASVHTTKSSIADGAFENDVEALLQMRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCEEECCHHHHHCCCCHHHHHHHHHHHH
LIDFLPGNNTDGVPEWPSFDEVERTDDSLDTLVPDNPNKPYDIKELILKVVDEGDFFEIA
HHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
ETFAKNIVTGFGRIAGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVD
HHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRKAYGGAFDVMASKEIGADINY
CCCCCCCCHHHHCHHHHCCHHEEEEHHHCCHHHHHHHHHHHCCCEEEEEECHHCCCCCCC
AWPTAQIAVMGAKGAVEIIFRNDIGDEEKIAARTREYEDRFLSPFVAAERGYIDDVILPS
CCCCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCC
STRRRIARALAMLRDKHVEVLAKKHDNLPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]