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The map label for this gene is gor [H]

Identifier: 75675416

GI number: 75675416

Start: 1344048

End: 1345430

Strand: Direct

Name: gor [H]

Synonym: Nwi_1223

Alternate gene names: 75675416

Gene position: 1344048-1345430 (Clockwise)

Preceding gene: 75675415

Following gene: 75675417

Centisome position: 39.51

GC content: 62.33

Gene sequence:

>1383_bases
ATGGCTGATTTCGATGTCGACCTGTTCGTCATAGGCGGCGGTTCCGGCGGTGTGCGCGCAGCGCGCATCGCCGCCGGATA
CGGCGCGCGTGTCATGGTCGCCGAAGAATACCGGATGGGCGGTACCTGCGTGATCCGGGGGTGCGTGCCGAAGAAGCTGT
TAGTCTACGGCTCTCATATCCGCCACGACATCGAAGATGCCGCCGGTTTTGGCTGGTCGATTCCGTCCGCGACGTTCGAC
TGGCCGGCGCTGATCGCCAACAAGGACAGGGAGATCGCCCGCCTCGAGGCGGCCTATACAGCTACCCTCGAGAAGGCCGG
CGTTCAAACCGTCAAGTCGCGGGCGGTATTCGAGGATGCGCACACGCTCCGGCTCACGACCGGCGAGACCATCCGTTCGA
AGCATGTGCTGATCGCGACGGGCGGCCGGCCCAATCAAGGACCTGCCATTCCCGGCATCGAGCACGTGATCTCTTCCAAT
GAGGCATTTCATCTTGATGAGTTGCCGAAGCGAATTGCGATTCAGGGCGGCGGATACATCGCGCTCGAATTCGCCTGCAT
CTTTGCCGGGTTCGGAAGTGATGTGACCCTGATCTATCGCGGGGACAACATCCTGCGCGGCTTCGATGATGACGTCCGCG
CCCATGTTCGCGCGGAAATGGAGAAGAGCGGCATCACGATCCTGACGGACTGCACTGTCGAGAGGGTCGATCGGCACGGC
GATGATTTCACGTCTCATCTATCGAACGGGTCGAGCGTTGCTTCCGATCAGGTGCTGTTTGCGATCGGCCGGCATCCGAA
CGTTGCCAATCTGGGACTTGAGAAGGCGGGCGTCGCCATCAACCCGGAGAACGGCGGCATAGCCGTCGACGGCTTTTCGC
GGACGAACGTGCCGCATATCTATGCGGTCGGCGATGTCACGCATCGCTTCAACCTGACGCCGGTCGCGATCCGAGAGGGG
CATGCGTTCGCGGACTCGGTGTTCGGAAACAAGCCGACGCGCGTGGATCATGCGGACATTCCGACCGCCGTGTTTTCGCA
GCCTGAAGTCGGAACGGTCGGCCTGACAGAAGCGCAGGCGAGGGCTGAGTACGCCGTCGATATCTACAAGGCGACGTTCC
GCCCGTTGAAGGCGACGTTATCGGGCCGCGATACCCGTATGCTGATGAAGCTGGTGGTGGACGCCACGACGGATCGCGTG
CTCGGTTGCCATATCGTCGGCGACGGCGCGGCCGAGATGACGCAGGTAGTCGGCATCGCGATCAGGATGAAGGCCACCAA
GGCCGATTTCGATGCGACCATGGCGCTGCATCCGACCGCGGCTGAAGAACTTGTGACGATGCGGACGCGAACCGCTCACC
ATGCGCGTGGGGCGGCCGAGTGA

Upstream 100 bases:

>100_bases
GAACCAGTGGGCGCAGCAGTTCGCGAGCGTCGTCAATGGCGAGTTTCGCGCGGAGATGCGCAAGCGCGGCAAGGAAATCT
GATCTCGATCGAGTTGGGGC

Downstream 100 bases:

>100_bases
AACGGCCCTGAAATAGAGGGTGGCCGGTTTCGGCGGGTGATCTCCGGAATAAATCAGGGTTCTAGAGCATCGGACCCGAA
AGTGGGAACCGGTTTCGGGA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MADFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLLVYGSHIRHDIEDAAGFGWSIPSATFD
WPALIANKDREIARLEAAYTATLEKAGVQTVKSRAVFEDAHTLRLTTGETIRSKHVLIATGGRPNQGPAIPGIEHVISSN
EAFHLDELPKRIAIQGGGYIALEFACIFAGFGSDVTLIYRGDNILRGFDDDVRAHVRAEMEKSGITILTDCTVERVDRHG
DDFTSHLSNGSSVASDQVLFAIGRHPNVANLGLEKAGVAINPENGGIAVDGFSRTNVPHIYAVGDVTHRFNLTPVAIREG
HAFADSVFGNKPTRVDHADIPTAVFSQPEVGTVGLTEAQARAEYAVDIYKATFRPLKATLSGRDTRMLMKLVVDATTDRV
LGCHIVGDGAAEMTQVVGIAIRMKATKADFDATMALHPTAAEELVTMRTRTAHHARGAAE

Sequences:

>Translated_460_residues
MADFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLLVYGSHIRHDIEDAAGFGWSIPSATFD
WPALIANKDREIARLEAAYTATLEKAGVQTVKSRAVFEDAHTLRLTTGETIRSKHVLIATGGRPNQGPAIPGIEHVISSN
EAFHLDELPKRIAIQGGGYIALEFACIFAGFGSDVTLIYRGDNILRGFDDDVRAHVRAEMEKSGITILTDCTVERVDRHG
DDFTSHLSNGSSVASDQVLFAIGRHPNVANLGLEKAGVAINPENGGIAVDGFSRTNVPHIYAVGDVTHRFNLTPVAIREG
HAFADSVFGNKPTRVDHADIPTAVFSQPEVGTVGLTEAQARAEYAVDIYKATFRPLKATLSGRDTRMLMKLVVDATTDRV
LGCHIVGDGAAEMTQVVGIAIRMKATKADFDATMALHPTAAEELVTMRTRTAHHARGAAE
>Mature_459_residues
ADFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLLVYGSHIRHDIEDAAGFGWSIPSATFDW
PALIANKDREIARLEAAYTATLEKAGVQTVKSRAVFEDAHTLRLTTGETIRSKHVLIATGGRPNQGPAIPGIEHVISSNE
AFHLDELPKRIAIQGGGYIALEFACIFAGFGSDVTLIYRGDNILRGFDDDVRAHVRAEMEKSGITILTDCTVERVDRHGD
DFTSHLSNGSSVASDQVLFAIGRHPNVANLGLEKAGVAINPENGGIAVDGFSRTNVPHIYAVGDVTHRFNLTPVAIREGH
AFADSVFGNKPTRVDHADIPTAVFSQPEVGTVGLTEAQARAEYAVDIYKATFRPLKATLSGRDTRMLMKLVVDATTDRVL
GCHIVGDGAAEMTQVVGIAIRMKATKADFDATMALHPTAAEELVTMRTRTAHHARGAAE

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=39.1304347826087, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=34.8684210526316, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148277065, Length=454, Percent_Identity=32.8193832599119, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI33519430, Length=454, Percent_Identity=32.8193832599119, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI33519428, Length=454, Percent_Identity=32.8193832599119, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI33519426, Length=454, Percent_Identity=32.8193832599119, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI148277071, Length=454, Percent_Identity=32.8193832599119, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI291045266, Length=473, Percent_Identity=33.615221987315, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI291045268, Length=470, Percent_Identity=31.2765957446809, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=28.8840262582057, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=41.7633410672854, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=30.9210526315789, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87081717, Length=447, Percent_Identity=31.3199105145414, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=29.1028446389497, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71983419, Length=435, Percent_Identity=38.8505747126437, Blast_Score=264, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI71983429, Length=435, Percent_Identity=38.8505747126437, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=467, Percent_Identity=31.9057815845824, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=32.9896907216495, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=30.242825607064, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=36.8763557483731, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=30.8855291576674, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=27.6008492569002, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=33.3333333333333, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=33.7579617834395, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=33.7579617834395, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=33.7579617834395, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=31.2227074235808, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49267; Mature: 49136

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS00310 LAMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLLVYGSHI
CCCCEEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCHHEECHHH
RHDIEDAAGFGWSIPSATFDWPALIANKDREIARLEAAYTATLEKAGVQTVKSRAVFEDA
HHHHHHHCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HTLRLTTGETIRSKHVLIATGGRPNQGPAIPGIEHVISSNEAFHLDELPKRIAIQGGGYI
CEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCEEHHHCCCEEEECCCCEE
ALEFACIFAGFGSDVTLIYRGDNILRGFDDDVRAHVRAEMEKSGITILTDCTVERVDRHG
EEEEEEEEECCCCCEEEEECCCCEECCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHCCC
DDFTSHLSNGSSVASDQVLFAIGRHPNVANLGLEKAGVAINPENGGIAVDGFSRTNVPHI
CHHHHHHCCCCCCCCCCEEEEECCCCCHHHCCCCCCCCEECCCCCCEEEECCCCCCCCEE
YAVGDVTHRFNLTPVAIREGHAFADSVFGNKPTRVDHADIPTAVFSQPEVGTVGLTEAQA
EEECCEEEEECCCEEEEECCCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCEEECCHHHH
RAEYAVDIYKATFRPLKATLSGRDTRMLMKLVVDATTDRVLGCHIVGDGAAEMTQVVGIA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHEEE
IRMKATKADFDATMALHPTAAEELVTMRTRTAHHARGAAE
EEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLLVYGSHI
CCCEEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCHHEECHHH
RHDIEDAAGFGWSIPSATFDWPALIANKDREIARLEAAYTATLEKAGVQTVKSRAVFEDA
HHHHHHHCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HTLRLTTGETIRSKHVLIATGGRPNQGPAIPGIEHVISSNEAFHLDELPKRIAIQGGGYI
CEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCEEHHHCCCEEEECCCCEE
ALEFACIFAGFGSDVTLIYRGDNILRGFDDDVRAHVRAEMEKSGITILTDCTVERVDRHG
EEEEEEEEECCCCCEEEEECCCCEECCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHCCC
DDFTSHLSNGSSVASDQVLFAIGRHPNVANLGLEKAGVAINPENGGIAVDGFSRTNVPHI
CHHHHHHCCCCCCCCCCEEEEECCCCCHHHCCCCCCCCEECCCCCCEEEECCCCCCCCEE
YAVGDVTHRFNLTPVAIREGHAFADSVFGNKPTRVDHADIPTAVFSQPEVGTVGLTEAQA
EEECCEEEEECCCEEEEECCCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCEEECCHHHH
RAEYAVDIYKATFRPLKATLSGRDTRMLMKLVVDATTDRVLGCHIVGDGAAEMTQVVGIA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHEEE
IRMKATKADFDATMALHPTAAEELVTMRTRTAHHARGAAE
EEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]