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The map label for this gene is phoQ [H]

Identifier: 75675381

GI number: 75675381

Start: 1293310

End: 1294707

Strand: Direct

Name: phoQ [H]

Synonym: Nwi_1188

Alternate gene names: 75675381

Gene position: 1293310-1294707 (Clockwise)

Preceding gene: 75675380

Following gene: 75675382

Centisome position: 38.02

GC content: 63.66

Gene sequence:

>1398_bases
ATGCGCGTTAGGGAAATTCTAGGCTTTCGTTCCAATTCGCTGGCGTCGCGGCTGTTCCTGTCGGCGACCGCGTGGGTCGT
GGTCGTGCTCCTCGTGACCGGCGTGGTGCTGTCTTCAGTCTATCGCTCGGCGTCCGAGCGTGCCTTCGACCGCCGCCTCA
ATCTCTATCTCCGCACCCTGATCGCCGAAGTGACGGCGCCCGACGAGCCGGATGACCGTCAGTTCCAGTCGCTCGGTGAG
CCGCTGTTCGATCTGCCCTTGTCGGGCTGGTACTGGGAGGTCGACCGTACCGATCCGGGCAAAGCGGAAACCCGCGCATC
GCGCTCGCTATGGGACAAGAAGCTCCCGAAGCTCGTGGATCAGGGCATTGCGCTTTCCTCGTCCGGAGTCCGCGCCGGAT
ATGTCGACGGGCCCGAAGGTCAAATCCTCCGCATGGCGGAGCGGCCGGTCGATCTCGGCGCCGACGGCAAGTTCCGTGTC
GCCGTGGCCGGAGACGCCTCGGAAATTTTCGATGAAACGAGGGCTTTCGACTATTACCTCGGCGGCACCTTCGCCGCGCT
CACGATCGGATTGCTTCTCACCACGATCTTTCAGGTGCGATTCGGTCTTGCGCCGCTGAAACGGATCTCGGACGCGATCG
CCGACATCCGGTCGGGCCGCGCGGAGCGACTGGAAGGTGAATTCCCCGTGGAGATCGCGCCCCTTGCCTGGGAGACCAAC
GCGCTGATCGATGCCAACCGGGAGATCGTCGAGCGTGCCCGCACCCACGTCGGCAACCTCGCGCACGCGGTCAAGACGCC
GCTTTCGGTTATCATCAACGAGGCCAGCGCGCATGAGGGCGATTCCTTCGCCGCCAAAATGCTCGAACAGGCCGGGATGA
TGCGCAACCAGGTCGCCCATCATCTGGAGCGCGCCCGCCTGGCTGCGCGGCTCACCGTCATTGGAACGGTGACGGATGTC
GCGCCCGTCGTCGAGGCGCTGCGCAGGACCATGGAGAAAATTCATCGCGATCGCGATATCACGATTGAGGTCGACGTCAG
TCCGGGGACGAAATTTCGCGGCGAACGCCAGGATCTTGAGGAGATGGTCGGCAATCTTGTAGACAATGCCTGCAAGTGGG
CGCATTCGCGGGTGTTCATCACCACGTCCGTCCGTCCGCCTTCCGGAGTTGAGCCTGCGATGCTGCACATTACCGTCGAC
GATAACGGTCAGGGATTGTCGGATGCCGAGCGGATGCAGGCCTCGCAGCGCGGCCGCCGCATCGACGAGACCAAGCCGGG
ATCCGGACTGGGGTTGTCGATCGTCACCGATCTTGCAGCCCTCTATGGCGGTCGCCTGACGCTGGATACCGCGCCGATCG
GCGGATTGCGCGCCGAACTGTTGCTGCCGTCAGCTTGA

Upstream 100 bases:

>100_bases
AACACAATCGAAGTGTTTGTCGGCCGTATTCGCAAGAAGCTGGACGTCGATATCATCCAGACGGTACGCGGGCTCGGCTA
TCTGCTCACGCCGCCGGCAG

Downstream 100 bases:

>100_bases
GCCCCGGTTTGCTGGTCGTCCCATGTCGAAGTCCCGCCCGCATCACCCGTTCCCGTGCAATCGAATGCGGAATCCGTCCG
GCGAAAAGCGCCGGGGGAGC

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRVREILGFRSNSLASRLFLSATAWVVVVLLVTGVVLSSVYRSASERAFDRRLNLYLRTLIAEVTAPDEPDDRQFQSLGE
PLFDLPLSGWYWEVDRTDPGKAETRASRSLWDKKLPKLVDQGIALSSSGVRAGYVDGPEGQILRMAERPVDLGADGKFRV
AVAGDASEIFDETRAFDYYLGGTFAALTIGLLLTTIFQVRFGLAPLKRISDAIADIRSGRAERLEGEFPVEIAPLAWETN
ALIDANREIVERARTHVGNLAHAVKTPLSVIINEASAHEGDSFAAKMLEQAGMMRNQVAHHLERARLAARLTVIGTVTDV
APVVEALRRTMEKIHRDRDITIEVDVSPGTKFRGERQDLEEMVGNLVDNACKWAHSRVFITTSVRPPSGVEPAMLHITVD
DNGQGLSDAERMQASQRGRRIDETKPGSGLGLSIVTDLAALYGGRLTLDTAPIGGLRAELLLPSA

Sequences:

>Translated_465_residues
MRVREILGFRSNSLASRLFLSATAWVVVVLLVTGVVLSSVYRSASERAFDRRLNLYLRTLIAEVTAPDEPDDRQFQSLGE
PLFDLPLSGWYWEVDRTDPGKAETRASRSLWDKKLPKLVDQGIALSSSGVRAGYVDGPEGQILRMAERPVDLGADGKFRV
AVAGDASEIFDETRAFDYYLGGTFAALTIGLLLTTIFQVRFGLAPLKRISDAIADIRSGRAERLEGEFPVEIAPLAWETN
ALIDANREIVERARTHVGNLAHAVKTPLSVIINEASAHEGDSFAAKMLEQAGMMRNQVAHHLERARLAARLTVIGTVTDV
APVVEALRRTMEKIHRDRDITIEVDVSPGTKFRGERQDLEEMVGNLVDNACKWAHSRVFITTSVRPPSGVEPAMLHITVD
DNGQGLSDAERMQASQRGRRIDETKPGSGLGLSIVTDLAALYGGRLTLDTAPIGGLRAELLLPSA
>Mature_465_residues
MRVREILGFRSNSLASRLFLSATAWVVVVLLVTGVVLSSVYRSASERAFDRRLNLYLRTLIAEVTAPDEPDDRQFQSLGE
PLFDLPLSGWYWEVDRTDPGKAETRASRSLWDKKLPKLVDQGIALSSSGVRAGYVDGPEGQILRMAERPVDLGADGKFRV
AVAGDASEIFDETRAFDYYLGGTFAALTIGLLLTTIFQVRFGLAPLKRISDAIADIRSGRAERLEGEFPVEIAPLAWETN
ALIDANREIVERARTHVGNLAHAVKTPLSVIINEASAHEGDSFAAKMLEQAGMMRNQVAHHLERARLAARLTVIGTVTDV
APVVEALRRTMEKIHRDRDITIEVDVSPGTKFRGERQDLEEMVGNLVDNACKWAHSRVFITTSVRPPSGVEPAMLHITVD
DNGQGLSDAERMQASQRGRRIDETKPGSGLGLSIVTDLAALYGGRLTLDTAPIGGLRAELLLPSA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=292, Percent_Identity=27.3972602739726, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=22.6277372262774, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=29.1666666666667, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=26.2222222222222, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50915; Mature: 50915

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVREILGFRSNSLASRLFLSATAWVVVVLLVTGVVLSSVYRSASERAFDRRLNLYLRTL
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAEVTAPDEPDDRQFQSLGEPLFDLPLSGWYWEVDRTDPGKAETRASRSLWDKKLPKLVD
HHHHCCCCCCCHHHHHHHCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QGIALSSSGVRAGYVDGPEGQILRMAERPVDLGADGKFRVAVAGDASEIFDETRAFDYYL
CCCEECCCCCEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
GGTFAALTIGLLLTTIFQVRFGLAPLKRISDAIADIRSGRAERLEGEFPVEIAPLAWETN
CHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECCEECCC
ALIDANREIVERARTHVGNLAHAVKTPLSVIINEASAHEGDSFAAKMLEQAGMMRNQVAH
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
HLERARLAARLTVIGTVTDVAPVVEALRRTMEKIHRDRDITIEVDVSPGTKFRGERQDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
EMVGNLVDNACKWAHSRVFITTSVRPPSGVEPAMLHITVDDNGQGLSDAERMQASQRGRR
HHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCC
IDETKPGSGLGLSIVTDLAALYGGRLTLDTAPIGGLRAELLLPSA
CCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCEECCCC
>Mature Secondary Structure
MRVREILGFRSNSLASRLFLSATAWVVVVLLVTGVVLSSVYRSASERAFDRRLNLYLRTL
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAEVTAPDEPDDRQFQSLGEPLFDLPLSGWYWEVDRTDPGKAETRASRSLWDKKLPKLVD
HHHHCCCCCCCHHHHHHHCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QGIALSSSGVRAGYVDGPEGQILRMAERPVDLGADGKFRVAVAGDASEIFDETRAFDYYL
CCCEECCCCCEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
GGTFAALTIGLLLTTIFQVRFGLAPLKRISDAIADIRSGRAERLEGEFPVEIAPLAWETN
CHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECCEECCC
ALIDANREIVERARTHVGNLAHAVKTPLSVIINEASAHEGDSFAAKMLEQAGMMRNQVAH
CHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
HLERARLAARLTVIGTVTDVAPVVEALRRTMEKIHRDRDITIEVDVSPGTKFRGERQDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
EMVGNLVDNACKWAHSRVFITTSVRPPSGVEPAMLHITVDDNGQGLSDAERMQASQRGRR
HHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCC
IDETKPGSGLGLSIVTDLAALYGGRLTLDTAPIGGLRAELLLPSA
CCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA