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The map label for this gene is phoP [H]

Identifier: 75675380

GI number: 75675380

Start: 1292649

End: 1293320

Strand: Direct

Name: phoP [H]

Synonym: Nwi_1187

Alternate gene names: 75675380

Gene position: 1292649-1293320 (Clockwise)

Preceding gene: 75675379

Following gene: 75675381

Centisome position: 38.0

GC content: 63.39

Gene sequence:

>672_bases
TTGCGCCTTCTCGTCGTCGAGGATGATCCCGATCTCAATCGTCAGCTCACGACAGCGCTGACCGACGCCGGCTACGTCGT
CGATCGCGCGTTCGACGGCGAGGAGGCGCATTTCCTCGGTGACAGCGAACCTTATGACGCGGTGGTGCTGGACATCGGCC
TGCCGAAGATGGACGGCATTTCCGTGCTGGAAGCCTGGCGGCGGGGGGGCCGCACCATGCCGGTCCTGATTCTCACCGCG
CGGGATCGCTGGAGCGACAAGGTGCAGGGGTTCGACGCCGGCGCTGACGACTATGTTGCGAAACCCTTCCATCTGGAGGA
AATCCTGGCGCGGATGCGCGCGCTGCTGCGACGGAGCACGGGGCACGCGCACTCCGAACTGACCTGCGGGCCGGTGACGC
TGGATACCCGCACGGGCCGCGTCAGCGTCGGCGGCAATCCGGTCAAGATGACGTCGCATGAATACCGGCTGCTGGCCTAC
CTCATGCACCATATCGGCCGGGTCGTGTCGCGCACCGAACTGGTCGAACATCTTTACGATCAGGATTTCGATCGTGACTC
CAACACAATCGAAGTGTTTGTCGGCCGTATTCGCAAGAAGCTGGACGTCGATATCATCCAGACGGTACGCGGGCTCGGCT
ATCTGCTCACGCCGCCGGCAGATGCGCGTTAG

Upstream 100 bases:

>100_bases
TTGCGGCAAGGGTATGCGAACTTCGGAATCGGGACATTAGCGTTCATTTGCCATTCACGCGGTGACGGTTCATCCTGAAG
GGAGGAATCAGGAGCCCGCT

Downstream 100 bases:

>100_bases
GGAAATTCTAGGCTTTCGTTCCAATTCGCTGGCGTCGCGGCTGTTCCTGTCGGCGACCGCGTGGGTCGTGGTCGTGCTCC
TCGTGACCGGCGTGGTGCTG

Product: two component transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEAHFLGDSEPYDAVVLDIGLPKMDGISVLEAWRRGGRTMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHLEEILARMRALLRRSTGHAHSELTCGPVTLDTRTGRVSVGGNPVKMTSHEYRLLAY
LMHHIGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGLGYLLTPPADAR

Sequences:

>Translated_223_residues
MRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEAHFLGDSEPYDAVVLDIGLPKMDGISVLEAWRRGGRTMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHLEEILARMRALLRRSTGHAHSELTCGPVTLDTRTGRVSVGGNPVKMTSHEYRLLAY
LMHHIGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGLGYLLTPPADAR
>Mature_223_residues
MRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEAHFLGDSEPYDAVVLDIGLPKMDGISVLEAWRRGGRTMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHLEEILARMRALLRRSTGHAHSELTCGPVTLDTRTGRVSVGGNPVKMTSHEYRLLAY
LMHHIGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGLGYLLTPPADAR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=42.2727272727273, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=44.4444444444444, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=39.2857142857143, Blast_Score=167, Evalue=3e-43,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=43.5185185185185, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=37.8995433789954, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=34.8214285714286, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=31.8777292576419, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=32.8767123287671, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=31.8181818181818, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=31.9634703196347, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=29.7297297297297, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=28.755364806867, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788550, Length=133, Percent_Identity=36.0902255639098, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=25.1063829787234, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25041; Mature: 25041

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEAHFLGDSEPYDAVVLDIGLPKMDGI
CEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCCEEEEECCCCCCCCH
SVLEAWRRGGRTMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEILARMRALLRRST
HHHHHHHHCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GHAHSELTCGPVTLDTRTGRVSVGGNPVKMTSHEYRLLAYLMHHIGRVVSRTELVEHLYD
CCCCCCEECCCEEECCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGLGYLLTPPADAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCC
>Mature Secondary Structure
MRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEAHFLGDSEPYDAVVLDIGLPKMDGI
CEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCCEEEEECCCCCCCCH
SVLEAWRRGGRTMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEILARMRALLRRST
HHHHHHHHCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GHAHSELTCGPVTLDTRTGRVSVGGNPVKMTSHEYRLLAYLMHHIGRVVSRTELVEHLYD
CCCCCCEECCCEEECCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGLGYLLTPPADAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA