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The map label for this gene is aqpZ [H]

Identifier: 75675193

GI number: 75675193

Start: 1096310

End: 1097026

Strand: Direct

Name: aqpZ [H]

Synonym: Nwi_1000

Alternate gene names: 75675193

Gene position: 1096310-1097026 (Clockwise)

Preceding gene: 75675191

Following gene: 75675197

Centisome position: 32.22

GC content: 64.16

Gene sequence:

>717_bases
ATGGACCTCAGGAAATACGCGGCCGAACTGATTGGCACTTTTTGGCTGACTTTTATGGGATGCGGCAGCGCCGTCATCGC
GGCGGCGTTTCCCGAGGTCGGCATCGGGCTGCTGGGCGTTGCTCTCACCTTCGGCTTGAGCGTCGTCACCATGGCCTACG
CGATCGGCCATATTTCGGGCTGTCATCTCAATCCGGCGGTCACCCTGGGTCTGACCGCGGGCGGGCGGTTTCCGGCGGCG
CAGGTGGTTCCCTACATCATTGCGCAGGTGATCGGGGCGATTGCCGCCGCCGCGCTGCTCTATGTGATCGCCAGCGGAGC
GGCGGGCTTCGATGTCGCCAAGGGTTTCGCATCGAACGGCTACGGTGAGCACTCGCCGGGGCACTACAACCTCACGGTGT
CCTTCATCACCGAGGTGACGATGACGGCCATGTTCCTGTTCGTCATCATGGGATCGACCCACGGCAAGGCCCCGGCGGGT
TTCGCGCCGCTGGCGATCGGGCTCGCGCTGGTGATGATTCATCTTGTCAGCATTCCCGTCACCAACACGTCGGTGAATCC
GGCGCGCAGCACCGGTCCGGCGCTTTTCGTCGGCGGCTGGGCTCTGGAGCAGCTCTGGCTGTTCTGGGTAGCGCCGCTGA
TCGGCGGTGTTATCGGCGGCGTGGTCTATCGCGGACTCAGCAGTGAGCCGGAAGGCGTCGTCGCGGGGAAAAAGTAG

Upstream 100 bases:

>100_bases
ATTCCCCCAAAGATGCGTGATTGGGGTTCAGCAAGGCCTCACATCGGGGTTTTATAGGCTTGCTCGGGGTGATTGATTCT
TCAACAAAGGAAGGCGTGTC

Downstream 100 bases:

>100_bases
CGTCACAGGCGAGCGATTGCCGGGCTTGATCCGGCAATCCTTTTTCTGTGAGAAATCTTTCTCTGGCCAGACGCGCTTTC
GGCGTCGGTGCCATTATCAG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MDLRKYAAELIGTFWLTFMGCGSAVIAAAFPEVGIGLLGVALTFGLSVVTMAYAIGHISGCHLNPAVTLGLTAGGRFPAA
QVVPYIIAQVIGAIAAAALLYVIASGAAGFDVAKGFASNGYGEHSPGHYNLTVSFITEVTMTAMFLFVIMGSTHGKAPAG
FAPLAIGLALVMIHLVSIPVTNTSVNPARSTGPALFVGGWALEQLWLFWVAPLIGGVIGGVVYRGLSSEPEGVVAGKK

Sequences:

>Translated_238_residues
MDLRKYAAELIGTFWLTFMGCGSAVIAAAFPEVGIGLLGVALTFGLSVVTMAYAIGHISGCHLNPAVTLGLTAGGRFPAA
QVVPYIIAQVIGAIAAAALLYVIASGAAGFDVAKGFASNGYGEHSPGHYNLTVSFITEVTMTAMFLFVIMGSTHGKAPAG
FAPLAIGLALVMIHLVSIPVTNTSVNPARSTGPALFVGGWALEQLWLFWVAPLIGGVIGGVVYRGLSSEPEGVVAGKK
>Mature_238_residues
MDLRKYAAELIGTFWLTFMGCGSAVIAAAFPEVGIGLLGVALTFGLSVVTMAYAIGHISGCHLNPAVTLGLTAGGRFPAA
QVVPYIIAQVIGAIAAAALLYVIASGAAGFDVAKGFASNGYGEHSPGHYNLTVSFITEVTMTAMFLFVIMGSTHGKAPAG
FAPLAIGLALVMIHLVSIPVTNTSVNPARSTGPALFVGGWALEQLWLFWVAPLIGGVIGGVVYRGLSSEPEGVVAGKK

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502179, Length=224, Percent_Identity=34.375, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI37694062, Length=228, Percent_Identity=35.5263157894737, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4755125, Length=196, Percent_Identity=36.2244897959184, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI4502181, Length=196, Percent_Identity=36.2244897959184, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=34.5291479820628, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912506, Length=246, Percent_Identity=32.9268292682927, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI86792455, Length=225, Percent_Identity=30.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI157266307, Length=241, Percent_Identity=30.2904564315353, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502187, Length=240, Percent_Identity=30, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22538420, Length=250, Percent_Identity=29.6, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4826645, Length=246, Percent_Identity=28.0487804878049, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45446752, Length=202, Percent_Identity=31.1881188118812, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI310133356, Length=205, Percent_Identity=30.7317073170732, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310114181, Length=205, Percent_Identity=30.7317073170732, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787101, Length=230, Percent_Identity=67.8260869565217, Blast_Score=289, Evalue=1e-79,
Organism=Escherichia coli, GI1790362, Length=248, Percent_Identity=30.241935483871, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71993722, Length=239, Percent_Identity=29.2887029288703, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=242, Percent_Identity=28.5123966942149, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=241, Percent_Identity=29.4605809128631, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531431, Length=238, Percent_Identity=29.8319327731092, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531429, Length=238, Percent_Identity=29.8319327731092, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=239, Percent_Identity=28.4518828451883, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992961, Length=239, Percent_Identity=28.8702928870293, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652747, Length=223, Percent_Identity=39.9103139013453, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45551084, Length=223, Percent_Identity=39.9103139013453, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24652751, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19922038, Length=234, Percent_Identity=32.0512820512821, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136672, Length=232, Percent_Identity=31.8965517241379, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45550503, Length=221, Percent_Identity=28.0542986425339, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24762342, Length=191, Percent_Identity=30.3664921465969, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24762344, Length=226, Percent_Identity=30.0884955752212, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24762346, Length=230, Percent_Identity=29.5652173913043, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24762348, Length=230, Percent_Identity=29.5652173913043, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130305, Length=230, Percent_Identity=29.5652173913043, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24322; Mature: 24322

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRKYAAELIGTFWLTFMGCGSAVIAAAFPEVGIGLLGVALTFGLSVVTMAYAIGHISG
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CHLNPAVTLGLTAGGRFPAAQVVPYIIAQVIGAIAAAALLYVIASGAAGFDVAKGFASNG
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
YGEHSPGHYNLTVSFITEVTMTAMFLFVIMGSTHGKAPAGFAPLAIGLALVMIHLVSIPV
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGPALFVGGWALEQLWLFWVAPLIGGVIGGVVYRGLSSEPEGVVAGKK
CCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLRKYAAELIGTFWLTFMGCGSAVIAAAFPEVGIGLLGVALTFGLSVVTMAYAIGHISG
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CHLNPAVTLGLTAGGRFPAAQVVPYIIAQVIGAIAAAALLYVIASGAAGFDVAKGFASNG
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
YGEHSPGHYNLTVSFITEVTMTAMFLFVIMGSTHGKAPAGFAPLAIGLALVMIHLVSIPV
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGPALFVGGWALEQLWLFWVAPLIGGVIGGVVYRGLSSEPEGVVAGKK
CCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]