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The map label for this gene is msrA

Identifier: 75675164

GI number: 75675164

Start: 1068251

End: 1068790

Strand: Direct

Name: msrA

Synonym: Nwi_0971

Alternate gene names: 75675164

Gene position: 1068251-1068790 (Clockwise)

Preceding gene: 75675162

Following gene: 75675165

Centisome position: 31.4

GC content: 62.78

Gene sequence:

>540_bases
ATGACGGTTTCTACGGAACGTGCGGTTCTTGCCGGCGGTTGCTTCTGGGGTATGCAGGCTCTGTTGCGCCGGTATCCCGG
CGTGATCTCCACCCGGGTCGGCTACACCGGCGGCGACGTGCCGGACGCCACGTACCGCAATCACGGCGATCATGCCGAGG
CCATCGAAGTCAATTTCGATCCGACGGTGACCAGCTATCGGCAGCTGCTGGAGTTCTTTTTCCAGATTCATGATCCGACC
ACGGAGGACCGTCAGGGTTACGATCAGGGCCTAAGCTACCGGTCGGCGATCTTCTACACGAACGAGGAGCAGAAGCGGAT
CGCGGAGGAAACCATCGCCGAGATCGACGCGTCCGGTCTTTGGCCCGGCTATGTCGTCACCGATGTCGAGCCGGCCGGAC
CATTCTGGGAGGCCGAGCCCGAGCATCAGGATTACCTGGAGCGGGTTCCGAACGGTTACACCTGCCATTTCGTCCGGCCG
AACTGGAAGCTGCCACGCAAGCAGGACGCCGGTCAGACGGCGGCCGGCGGGGATCGCTGA

Upstream 100 bases:

>100_bases
GGATGGATGCCCCGGTTGGCGTGAAGAAACGCGTCAGAACAACAATCTGGAGCTTCGCTCCTAATTCTGTCAGAAGCGAA
GCTCCAGGAGAGAGGTGGGT

Downstream 100 bases:

>100_bases
AGGCGTTGGAACCGCCGATTTGCGGGCCTAGGCCGGATCGACATTCAGGATTCCCAGGCGGTCTGATCGCTGATTCATAG
GGTTCCGTGATTCTGACACG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MTVSTERAVLAGGCFWGMQALLRRYPGVISTRVGYTGGDVPDATYRNHGDHAEAIEVNFDPTVTSYRQLLEFFFQIHDPT
TEDRQGYDQGLSYRSAIFYTNEEQKRIAEETIAEIDASGLWPGYVVTDVEPAGPFWEAEPEHQDYLERVPNGYTCHFVRP
NWKLPRKQDAGQTAAGGDR

Sequences:

>Translated_179_residues
MTVSTERAVLAGGCFWGMQALLRRYPGVISTRVGYTGGDVPDATYRNHGDHAEAIEVNFDPTVTSYRQLLEFFFQIHDPT
TEDRQGYDQGLSYRSAIFYTNEEQKRIAEETIAEIDASGLWPGYVVTDVEPAGPFWEAEPEHQDYLERVPNGYTCHFVRP
NWKLPRKQDAGQTAAGGDR
>Mature_178_residues
TVSTERAVLAGGCFWGMQALLRRYPGVISTRVGYTGGDVPDATYRNHGDHAEAIEVNFDPTVTSYRQLLEFFFQIHDPTT
EDRQGYDQGLSYRSAIFYTNEEQKRIAEETIAEIDASGLWPGYVVTDVEPAGPFWEAEPEHQDYLERVPNGYTCHFVRPN
WKLPRKQDAGQTAAGGDR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=37.9746835443038, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=38.2165605095541, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=39.2523364485981, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=44.078947368421, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=40.5594405594406, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=37.3493975903614, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24664627, Length=148, Percent_Identity=36.4864864864865, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.2352941176471, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664631, Length=150, Percent_Identity=35.3333333333333, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_NITWN (Q3SU08)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_317585.1
- ProteinModelPortal:   Q3SU08
- SMR:   Q3SU08
- STRING:   Q3SU08
- GeneID:   3675007
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_0971
- NMPDR:   fig|323098.3.peg.539
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   VPNATYR
- PhylomeDB:   Q3SU08
- ProtClustDB:   PRK14054
- BioCyc:   NWIN323098:NWI_0971-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 20225; Mature: 20094

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSTERAVLAGGCFWGMQALLRRYPGVISTRVGYTGGDVPDATYRNHGDHAEAIEVNFD
CCCCCCCHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
PTVTSYRQLLEFFFQIHDPTTEDRQGYDQGLSYRSAIFYTNEEQKRIAEETIAEIDASGL
CCHHHHHHHHHHHHHHCCCCCCHHCCHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCC
WPGYVVTDVEPAGPFWEAEPEHQDYLERVPNGYTCHFVRPNWKLPRKQDAGQTAAGGDR
CCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVSTERAVLAGGCFWGMQALLRRYPGVISTRVGYTGGDVPDATYRNHGDHAEAIEVNFD
CCCCCCHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
PTVTSYRQLLEFFFQIHDPTTEDRQGYDQGLSYRSAIFYTNEEQKRIAEETIAEIDASGL
CCHHHHHHHHHHHHHHCCCCCCHHCCHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCC
WPGYVVTDVEPAGPFWEAEPEHQDYLERVPNGYTCHFVRPNWKLPRKQDAGQTAAGGDR
CCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA