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The map label for this gene is kefC [H]

Identifier: 75674804

GI number: 75674804

Start: 684948

End: 686672

Strand: Direct

Name: kefC [H]

Synonym: Nwi_0606

Alternate gene names: 75674804

Gene position: 684948-686672 (Clockwise)

Preceding gene: 75674803

Following gene: 75674805

Centisome position: 20.13

GC content: 63.25

Gene sequence:

>1725_bases
ATGCACCAACTCATCGGCGACATCACGCTTTGCATCCTGTTTGCCTGGGGTCTCGGGCTGGCCGCGCATTTTTCCCGGCA
GCCGCTGATCCTGGCCTATCTGCTGGCCGGGTTCTTCATCGGCCCGTTCGGAATGGGATTGGTCAAATCGCAGGAATCGA
TCCGGACCATTTCCGAACTCGGCCTGATCTTCATGCTGTTCATGATCGGCCTGGAAATCGACCTGAAGAAGATCATGCGC
GCGGGGCCGGTGATCCTGATCGCCGGCGGCGGCCAGTTGCTCGGGGGCTGCATTCTCGGCGCGCTGTTCTTCGTGATGAT
CGGTCTGCCGTCCGGCGGGTTCGACGCGCTCTATCTCTGCGTCGCGTGTGCGCTCTCGAGTACGGTCATCATCGTCAAGG
TGCTTTACGAAAAGCATGAACTCGATACGCTGCCGGGCCGCGTCACGCTCGGCGTGCTGGTGCTGCAGGACGTCTTCGCG
ATCCTGTTCCTGGCGGTCCAGCCCAGTCTCGACGATCTTCACATGTCCATTGTCCTGCTCTCGATCGCGCGGGTCGCCAC
GCTGGTCGCGACCGCGCTGATCGTCAGCCGCTATGTCCTGCCTTTCCTGTTTCATCAGATCGCGCGCCGGCCCGAACTGG
TGCTGCTGGGCGCGCTGGCGTGGTGCTTCCTGATCGGCGAAATCGCTGAACGGTTGCATCTGTCCCGCGAGATGGGCTCG
CTGGTGGCCGGGGTCTCGCTCTCGACCTTCCCCTACGCGCTCGATGTCACAGCCAAGGTGACGACGCTGCGCGACTTCTT
CATCACGCTGTTCTTCGTCGCGCTGGGCATGACCATTCCGATTCCGAACGGATCGGTGATCGGGCTCGCGCTGATGATCG
CGGCCTTCACCGTGGCGAGCCGTCTCGCCACCACCTTCCTGCCCCTGTACCTGATGAGACAGGGACTGCGCGCCAGCCTG
CTGCCGGCCATCAATCTGGCGCAGATCAGCGAGTTCTCGCTCGTCGTGATTCAAACCGGACTGATTGCAGGTCACATCCA
GAGCGAGACGGCGAGCGCGGCGTCGTTCGCGTTCGTGGTGCTGGCGGTGCTGAGCACGTTCGCCATCGGCCGGAGCGATC
AGCTCTCGCGGCAGGCCATCAGGTTTCTGAAGCGGCTCGGCTTTCGGGATCTCGATCGCCTCCAGGCAGGCGAGGGGGGG
CATGGCGCAGGGGCTCATGGCGAGCCGCGACGCATTGTCATTCTTGGATTCTTCCGGGCCGCCAGCGCGCTGCTGAACGA
GATCGAACGCCGGGACGAGGCGATGCTGGACCAGATCGGGGTGGTCGACTTCAATCCGCTGGTGTTCAAGACCCTCTCCG
CCCGCGGCCTGCAAGTCACTTACGGCGACATCAGCAATGTGGATACGCTGGTCCATGCCGGGGTCGGCAGAGCCGAGATC
ATCATTCTGAGCGTGCCGGATTCGCTGCTCAAGGGCGCCAATAATGAAAAGCTCGTCCGTCACGTCCGCGCGCTGAACCC
GACCGCGAAGATCATCTCGAGGGCGGACCGGTTATCGGACGTCGAGGATCAATATGCCGCCGGCGCGGATTACGTGACGC
TCACCCGCCTGACCGATGCGCAGGAATTGTTCGCGGCGATCGAGGCTGCGGAAAACGGACTGCTGGCCGACAAGCGCGCA
GAGACCGACGCTCTCCTGGAAGGGCGGCGGGAGGTGCTGCCTTAG

Upstream 100 bases:

>100_bases
GCTACCATTCCTTCTCACATGTAGTGTTGCAGGCCCGGCGAAGTCGGCTGTGACGACGCAGCTTGCCTGAGCGTTCGAGA
TATGCGAGCGGCTGAGAGGA

Downstream 100 bases:

>100_bases
CTGATCCAGGCGCGGGGTTCACCCTGCCGGATCATATATATGATGGCATGGTGGTGCGACCGCTTTTGCGGAGCGCCTCG
GTTGCGCCGCCGCCCGCTCT

Product: TrkA-N, Sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MHQLIGDITLCILFAWGLGLAAHFSRQPLILAYLLAGFFIGPFGMGLVKSQESIRTISELGLIFMLFMIGLEIDLKKIMR
AGPVILIAGGGQLLGGCILGALFFVMIGLPSGGFDALYLCVACALSSTVIIVKVLYEKHELDTLPGRVTLGVLVLQDVFA
ILFLAVQPSLDDLHMSIVLLSIARVATLVATALIVSRYVLPFLFHQIARRPELVLLGALAWCFLIGEIAERLHLSREMGS
LVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALMIAAFTVASRLATTFLPLYLMRQGLRASL
LPAINLAQISEFSLVVIQTGLIAGHIQSETASAASFAFVVLAVLSTFAIGRSDQLSRQAIRFLKRLGFRDLDRLQAGEGG
HGAGAHGEPRRIVILGFFRAASALLNEIERRDEAMLDQIGVVDFNPLVFKTLSARGLQVTYGDISNVDTLVHAGVGRAEI
IILSVPDSLLKGANNEKLVRHVRALNPTAKIISRADRLSDVEDQYAAGADYVTLTRLTDAQELFAAIEAAENGLLADKRA
ETDALLEGRREVLP

Sequences:

>Translated_574_residues
MHQLIGDITLCILFAWGLGLAAHFSRQPLILAYLLAGFFIGPFGMGLVKSQESIRTISELGLIFMLFMIGLEIDLKKIMR
AGPVILIAGGGQLLGGCILGALFFVMIGLPSGGFDALYLCVACALSSTVIIVKVLYEKHELDTLPGRVTLGVLVLQDVFA
ILFLAVQPSLDDLHMSIVLLSIARVATLVATALIVSRYVLPFLFHQIARRPELVLLGALAWCFLIGEIAERLHLSREMGS
LVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALMIAAFTVASRLATTFLPLYLMRQGLRASL
LPAINLAQISEFSLVVIQTGLIAGHIQSETASAASFAFVVLAVLSTFAIGRSDQLSRQAIRFLKRLGFRDLDRLQAGEGG
HGAGAHGEPRRIVILGFFRAASALLNEIERRDEAMLDQIGVVDFNPLVFKTLSARGLQVTYGDISNVDTLVHAGVGRAEI
IILSVPDSLLKGANNEKLVRHVRALNPTAKIISRADRLSDVEDQYAAGADYVTLTRLTDAQELFAAIEAAENGLLADKRA
ETDALLEGRREVLP
>Mature_574_residues
MHQLIGDITLCILFAWGLGLAAHFSRQPLILAYLLAGFFIGPFGMGLVKSQESIRTISELGLIFMLFMIGLEIDLKKIMR
AGPVILIAGGGQLLGGCILGALFFVMIGLPSGGFDALYLCVACALSSTVIIVKVLYEKHELDTLPGRVTLGVLVLQDVFA
ILFLAVQPSLDDLHMSIVLLSIARVATLVATALIVSRYVLPFLFHQIARRPELVLLGALAWCFLIGEIAERLHLSREMGS
LVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALMIAAFTVASRLATTFLPLYLMRQGLRASL
LPAINLAQISEFSLVVIQTGLIAGHIQSETASAASFAFVVLAVLSTFAIGRSDQLSRQAIRFLKRLGFRDLDRLQAGEGG
HGAGAHGEPRRIVILGFFRAASALLNEIERRDEAMLDQIGVVDFNPLVFKTLSARGLQVTYGDISNVDTLVHAGVGRAEI
IILSVPDSLLKGANNEKLVRHVRALNPTAKIISRADRLSDVEDQYAAGADYVTLTRLTDAQELFAAIEAAENGLLADKRA
ETDALLEGRREVLP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=384, Percent_Identity=25.78125, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1786232, Length=512, Percent_Identity=29.1015625, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786685, Length=583, Percent_Identity=24.0137221269297, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789749, Length=532, Percent_Identity=25.5639097744361, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 61914; Mature: 61914

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQLIGDITLCILFAWGLGLAAHFSRQPLILAYLLAGFFIGPFGMGLVKSQESIRTISEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GLIFMLFMIGLEIDLKKIMRAGPVILIAGGGQLLGGCILGALFFVMIGLPSGGFDALYLC
HHHHHHHHHCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VACALSSTVIIVKVLYEKHELDTLPGRVTLGVLVLQDVFAILFLAVQPSLDDLHMSIVLL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SIARVATLVATALIVSRYVLPFLFHQIARRPELVLLGALAWCFLIGEIAERLHLSREMGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALMIAAFTVAS
HHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHH
RLATTFLPLYLMRQGLRASLLPAINLAQISEFSLVVIQTGLIAGHIQSETASAASFAFVV
HHHHHHHHHHHHHHCCHHHHCCCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
LAVLSTFAIGRSDQLSRQAIRFLKRLGFRDLDRLQAGEGGHGAGAHGEPRRIVILGFFRA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHH
ASALLNEIERRDEAMLDQIGVVDFNPLVFKTLSARGLQVTYGDISNVDTLVHAGVGRAEI
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCEEE
IILSVPDSLLKGANNEKLVRHVRALNPTAKIISRADRLSDVEDQYAAGADYVTLTRLTDA
EEEECCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCH
QELFAAIEAAENGLLADKRAETDALLEGRREVLP
HHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHCCC
>Mature Secondary Structure
MHQLIGDITLCILFAWGLGLAAHFSRQPLILAYLLAGFFIGPFGMGLVKSQESIRTISEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GLIFMLFMIGLEIDLKKIMRAGPVILIAGGGQLLGGCILGALFFVMIGLPSGGFDALYLC
HHHHHHHHHCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VACALSSTVIIVKVLYEKHELDTLPGRVTLGVLVLQDVFAILFLAVQPSLDDLHMSIVLL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SIARVATLVATALIVSRYVLPFLFHQIARRPELVLLGALAWCFLIGEIAERLHLSREMGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPNGSVIGLALMIAAFTVAS
HHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHH
RLATTFLPLYLMRQGLRASLLPAINLAQISEFSLVVIQTGLIAGHIQSETASAASFAFVV
HHHHHHHHHHHHHHCCHHHHCCCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
LAVLSTFAIGRSDQLSRQAIRFLKRLGFRDLDRLQAGEGGHGAGAHGEPRRIVILGFFRA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHH
ASALLNEIERRDEAMLDQIGVVDFNPLVFKTLSARGLQVTYGDISNVDTLVHAGVGRAEI
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCEEE
IILSVPDSLLKGANNEKLVRHVRALNPTAKIISRADRLSDVEDQYAAGADYVTLTRLTDA
EEEECCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCEEEEEECCCH
QELFAAIEAAENGLLADKRAETDALLEGRREVLP
HHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA