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The map label for this gene is rfbC [H]

Identifier: 75674744

GI number: 75674744

Start: 612357

End: 612953

Strand: Direct

Name: rfbC [H]

Synonym: Nwi_0546

Alternate gene names: 75674744

Gene position: 612357-612953 (Clockwise)

Preceding gene: 75674739

Following gene: 75674745

Centisome position: 18.0

GC content: 58.79

Gene sequence:

>597_bases
ATGAGAAGGCGTCATGAGTTAACAAATGCAAAGAAACTGAAAATGAATGTTATTCAAACCGAAGTTCCCGAGGTCGTCAT
CTTCGAACCCCGGCTGTTCGGAGACCAGCGCGGCTTTTTTCTCGAGACGTATCAGTTTCCCCGTTACGCCGAGCACGGCG
TCACGCGACCGTTCGTTCAGGACAACCTCTCCCGCTCCGCGCGGGGCGTGCTGCGCGGGTTGCACCTGCAAAACCCATCT
CCGCAAGGGAAGCTGGTCACGGTGCTGCGCGGTAAGGTTCTGGATGTCGCGGTCGACGTGCGCGCCGGCAGTCCGAATTT
CGGCCGTCACGTCGCTGTTGAGTTGAGCGAAGAGAATAGGCGGCAGCTCTGGGTCCCCCGCGGCTTCGCGCACGGCTTTG
TCGTTCTCTCCGAGACGGCCGATTTCTTCTACAAATGCGACGACCTCTACAGTCCGAAGAACGAACTCTCGATTCGCTGG
AATGACCCTACGATCGGTATCGACTGGGGCGTGGAGACGCCGTCCTTGTCCGCCAAGGACGCGGACGCTCCGCTGCTGGC
GGACGTAAAGAACTTTCCAATCCATGGGCAGGTGTGA

Upstream 100 bases:

>100_bases
CGGGAACCCGTCCCCCCCGCAAGAATGATGCCCTTCATGGCCCCTCTCATCTATCGCAGACAACATAACATATAGTGTTA
AGCGTGCAAGTTTGTTATCA

Downstream 100 bases:

>100_bases
TGGCAAGTCTGATGCGGATACTGTTGACGGGTAGTAGCGGTCAGGTCGGCGGAGCGCTGCGTCCGCTGCTGAAGGAAGGC
GGCATGGTCATCGCGCCGTC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase related

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MRRRHELTNAKKLKMNVIQTEVPEVVIFEPRLFGDQRGFFLETYQFPRYAEHGVTRPFVQDNLSRSARGVLRGLHLQNPS
PQGKLVTVLRGKVLDVAVDVRAGSPNFGRHVAVELSEENRRQLWVPRGFAHGFVVLSETADFFYKCDDLYSPKNELSIRW
NDPTIGIDWGVETPSLSAKDADAPLLADVKNFPIHGQV

Sequences:

>Translated_198_residues
MRRRHELTNAKKLKMNVIQTEVPEVVIFEPRLFGDQRGFFLETYQFPRYAEHGVTRPFVQDNLSRSARGVLRGLHLQNPS
PQGKLVTVLRGKVLDVAVDVRAGSPNFGRHVAVELSEENRRQLWVPRGFAHGFVVLSETADFFYKCDDLYSPKNELSIRW
NDPTIGIDWGVETPSLSAKDADAPLLADVKNFPIHGQV
>Mature_198_residues
MRRRHELTNAKKLKMNVIQTEVPEVVIFEPRLFGDQRGFFLETYQFPRYAEHGVTRPFVQDNLSRSARGVLRGLHLQNPS
PQGKLVTVLRGKVLDVAVDVRAGSPNFGRHVAVELSEENRRQLWVPRGFAHGFVVLSETADFFYKCDDLYSPKNELSIRW
NDPTIGIDWGVETPSLSAKDADAPLLADVKNFPIHGQV

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=158, Percent_Identity=53.1645569620253, Blast_Score=167, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17550412, Length=162, Percent_Identity=45.0617283950617, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 22480; Mature: 22480

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRHELTNAKKLKMNVIQTEVPEVVIFEPRLFGDQRGFFLETYQFPRYAEHGVTRPFVQ
CCCCHHCCCCHHEEEEEECCCCCEEEEECCEECCCCCCCEEEECCCCCHHHCCCCCCHHH
DNLSRSARGVLRGLHLQNPSPQGKLVTVLRGKVLDVAVDVRAGSPNFGRHVAVELSEENR
HHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCCEEEEEECCCCC
RQLWVPRGFAHGFVVLSETADFFYKCDDLYSPKNELSIRWNDPTIGIDWGVETPSLSAKD
EEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCC
ADAPLLADVKNFPIHGQV
CCCCEEEHHCCCCCCCCC
>Mature Secondary Structure
MRRRHELTNAKKLKMNVIQTEVPEVVIFEPRLFGDQRGFFLETYQFPRYAEHGVTRPFVQ
CCCCHHCCCCHHEEEEEECCCCCEEEEECCEECCCCCCCEEEECCCCCHHHCCCCCCHHH
DNLSRSARGVLRGLHLQNPSPQGKLVTVLRGKVLDVAVDVRAGSPNFGRHVAVELSEENR
HHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCCEEEEEECCCCC
RQLWVPRGFAHGFVVLSETADFFYKCDDLYSPKNELSIRWNDPTIGIDWGVETPSLSAKD
EEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCC
ADAPLLADVKNFPIHGQV
CCCCEEEHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]