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The map label for this gene is cya [H]

Identifier: 75674731

GI number: 75674731

Start: 593906

End: 594985

Strand: Direct

Name: cya [H]

Synonym: Nwi_0533

Alternate gene names: 75674731

Gene position: 593906-594985 (Clockwise)

Preceding gene: 75674729

Following gene: 75674732

Centisome position: 17.46

GC content: 61.94

Gene sequence:

>1080_bases
ATGGCCGTTTCCTACCTGACGAAGACCGAGCTAGGCGAGTTTTTTCATAGTAACGGAAACATCGAGGCGGGCGTGCGATC
GGCGTTGATCGATTCGCTCGAGCAAAGCGGTGTGTTCAACGATGACGACAATAGCGCGAGGGGGTGGCTCCAGTCCGGGC
CGTTTCCGGGCGGAGAGGTTCCGCCTGTCGTCCAGATCCTGGGCGTATCCAACTCGACGAATGTCGAGACGAATCCCAAC
CTGAAAGCGATCGTGCTGGATGATCACAGCGCCAGGCTGGACGTGACCGGAGGGGATAACGACGTCTTTGTCGCCGCAGG
CAAAGGGCATGACACGATCAACCTGAATGATAGCGGCAACGATACGGTTTACGGCGGTAGCGGCAACGATGTGATCCGGG
CGAGCGAAGGCGACAACCTGCTGTTCGGCGGGGCCGGCAATGACAGCATTTACGGCGGCGCCGGCAACGATACGCTGGAC
GGGGGTGCTGGCAATGACCTCCTGGTGTCCGGTGGTGCGCGGGCCGCGGGCGTTGGCGGCGACGCGCGCATCGCCAGTGC
GGACGACAGCGCCTTCGGCGCCGCTGGCCGCGGGCATCATCATGGCGGTGGTCATGGAGATGATCGTGGATGGGGTCGCG
GGGATGATCACGGTGGCGGTCGGGGCGGTGACCATGGTGGCGGCGTCGGCGAGATAGAGGGACACAGCACGCTTATAGGC
GGCGCTGGCAATGACACGCTGGTAGGCATGCAGGGCGATGTACTGCAGGGCGGTGCGGGCAACGATCAGTTTACGTTGCT
GTCAGGTGATGGGAGCGCCAACTCCACGCTGTACGGTGGTGGCGGCGATGACACCTTCCGGATCGAGGCGCGTAGCGGCA
GCGACACCATCTTCGGCGGCAACGGTAACGACACGGCCGAATTTGTGGGCCGGTCGTTCTTCGATGTCGCCAAGATCGAT
GTCGATGCGAGCACGTCGACCTACACACTGCACTTCAGCGATCAACAAACCGTCGCGGTTAATGGCGTTGAGGAACTGCA
TTTCAGCGATCAGATCGTCACCCTGCCGAAGCTCTCATAG

Upstream 100 bases:

>100_bases
AATTGCAGCATGCGGTGTCGATTGGCGTCGACCGGTCATATCTGCTTTCGCATGACTCTTGAAGAATTCAGTCTCTTAAA
GAATCCAGCTAGAGGGCGCC

Downstream 100 bases:

>100_bases
TCCGGGTAGAAGGACAGGATCGTTAAAGCCCCGCTTCGGCGGGGCTTTTGCTTCTGTGATGCCGCTTCGCTTTTGTGATG
TGACGACATGCCTCTATAGT

Product: hemolysin-type calcium-binding region

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAVSYLTKTELGEFFHSNGNIEAGVRSALIDSLEQSGVFNDDDNSARGWLQSGPFPGGEVPPVVQILGVSNSTNVETNPN
LKAIVLDDHSARLDVTGGDNDVFVAAGKGHDTINLNDSGNDTVYGGSGNDVIRASEGDNLLFGGAGNDSIYGGAGNDTLD
GGAGNDLLVSGGARAAGVGGDARIASADDSAFGAAGRGHHHGGGHGDDRGWGRGDDHGGGRGGDHGGGVGEIEGHSTLIG
GAGNDTLVGMQGDVLQGGAGNDQFTLLSGDGSANSTLYGGGGDDTFRIEARSGSDTIFGGNGNDTAEFVGRSFFDVAKID
VDASTSTYTLHFSDQQTVAVNGVEELHFSDQIVTLPKLS

Sequences:

>Translated_359_residues
MAVSYLTKTELGEFFHSNGNIEAGVRSALIDSLEQSGVFNDDDNSARGWLQSGPFPGGEVPPVVQILGVSNSTNVETNPN
LKAIVLDDHSARLDVTGGDNDVFVAAGKGHDTINLNDSGNDTVYGGSGNDVIRASEGDNLLFGGAGNDSIYGGAGNDTLD
GGAGNDLLVSGGARAAGVGGDARIASADDSAFGAAGRGHHHGGGHGDDRGWGRGDDHGGGRGGDHGGGVGEIEGHSTLIG
GAGNDTLVGMQGDVLQGGAGNDQFTLLSGDGSANSTLYGGGGDDTFRIEARSGSDTIFGGNGNDTAEFVGRSFFDVAKID
VDASTSTYTLHFSDQQTVAVNGVEELHFSDQIVTLPKLS
>Mature_358_residues
AVSYLTKTELGEFFHSNGNIEAGVRSALIDSLEQSGVFNDDDNSARGWLQSGPFPGGEVPPVVQILGVSNSTNVETNPNL
KAIVLDDHSARLDVTGGDNDVFVAAGKGHDTINLNDSGNDTVYGGSGNDVIRASEGDNLLFGGAGNDSIYGGAGNDTLDG
GAGNDLLVSGGARAAGVGGDARIASADDSAFGAAGRGHHHGGGHGDDRGWGRGDDHGGGRGGDHGGGVGEIEGHSTLIGG
AGNDTLVGMQGDVLQGGAGNDQFTLLSGDGSANSTLYGGGGDDTFRIEARSGSDTIFGGNGNDTAEFVGRSFFDVAKIDV
DASTSTYTLHFSDQQTVAVNGVEELHFSDQIVTLPKLS

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 36228; Mature: 36097

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSYLTKTELGEFFHSNGNIEAGVRSALIDSLEQSGVFNDDDNSARGWLQSGPFPGGEV
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCC
PPVVQILGVSNSTNVETNPNLKAIVLDDHSARLDVTGGDNDVFVAAGKGHDTINLNDSGN
CCEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEECCCCCEEEECCCCC
DTVYGGSGNDVIRASEGDNLLFGGAGNDSIYGGAGNDTLDGGAGNDLLVSGGARAAGVGG
CEEECCCCCCEEEECCCCEEEEECCCCCCEECCCCCCCCCCCCCCCEEEECCCCEECCCC
DARIASADDSAFGAAGRGHHHGGGHGDDRGWGRGDDHGGGRGGDHGGGVGEIEGHSTLIG
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEE
GAGNDTLVGMQGDVLQGGAGNDQFTLLSGDGSANSTLYGGGGDDTFRIEARSGSDTIFGG
CCCCCEEEECCCCEEECCCCCCEEEEEECCCCCCCEEECCCCCCEEEEEECCCCCEEECC
NGNDTAEFVGRSFFDVAKIDVDASTSTYTLHFSDQQTVAVNGVEELHFSDQIVTLPKLS
CCCCHHHHHCCHHEEEEEEEECCCCEEEEEEECCCCEEEECCHHHHCCCCEEEECCCCC
>Mature Secondary Structure 
AVSYLTKTELGEFFHSNGNIEAGVRSALIDSLEQSGVFNDDDNSARGWLQSGPFPGGEV
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCC
PPVVQILGVSNSTNVETNPNLKAIVLDDHSARLDVTGGDNDVFVAAGKGHDTINLNDSGN
CCEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEECCCCCEEEECCCCC
DTVYGGSGNDVIRASEGDNLLFGGAGNDSIYGGAGNDTLDGGAGNDLLVSGGARAAGVGG
CEEECCCCCCEEEECCCCEEEEECCCCCCEECCCCCCCCCCCCCCCEEEECCCCEECCCC
DARIASADDSAFGAAGRGHHHGGGHGDDRGWGRGDDHGGGRGGDHGGGVGEIEGHSTLIG
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEE
GAGNDTLVGMQGDVLQGGAGNDQFTLLSGDGSANSTLYGGGGDDTFRIEARSGSDTIFGG
CCCCCEEEECCCCEEECCCCCCEEEEEECCCCCCCEEECCCCCCEEEEEECCCCCEEECC
NGNDTAEFVGRSFFDVAKIDVDASTSTYTLHFSDQQTVAVNGVEELHFSDQIVTLPKLS
CCCCHHHHHCCHHEEEEEEEECCCCEEEEEEECCCCEEEECCHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]