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The map label for this gene is cvrA [H]

Identifier: 75674535

GI number: 75674535

Start: 378252

End: 380045

Strand: Direct

Name: cvrA [H]

Synonym: Nwi_0337

Alternate gene names: 75674535

Gene position: 378252-380045 (Clockwise)

Preceding gene: 75674532

Following gene: 75674547

Centisome position: 11.12

GC content: 64.38

Gene sequence:

>1794_bases
ATGGCATCCCTGGATTCGGTCAGTCTGGCCATCCTGCTTGGCGCGATTCTGGTCATGGCCGGAATTCTGTCGAGCCTGCT
GGCGTTGCGGTTTGGCGCTCCCTTGCTGCTCGTCTTTCTGTTCATAGGCATGTTGGCGGGTGATTCCGGGCCCGGCGGCC
TGTCATTCAGCGACGTCCAGAACACCTATCTCGTGGGGTCGGCCGCGCTGGCGCTGATCCTGTTCGACGGCGGTCTGAAG
ACCCGGTTCCAGAGCATCCGCACGGTGCTGGCGCCCTCGATGGTGCTCGCCACGCTGGGCGTGCTGCTGACCGCACTGGT
CACGGCGCCGGTCGCCAGATATGCGCTCGATCTCAACTGGACCGAGGCGCTGCTGATCGGCGCGGTCGTCGCCTCCACCG
ACGCGGCCGCGGTGTTCCTGCTGGTCCACGCGCAAGGGCTGCGGCTGCGTCCGCGGGTTGGCGCGACGCTGGAGGCGGAG
TCCGGCACCAACGACCCCTTCGCGGTGTTTCTCACGCTGATGCTGGTCGAGTTGATCTCGGTCGGCGACAGTTCGGTCTG
GCATGTGGTGATCGAGTTTCTCCGGGAGTCCATGCTGGGCGGCATTGTCGGTGTGATCGGCGGACGGCTCGTGGTCGTCG
CCCTGAATCGGGTGGCGCTTCCCCAGGGGTTGCATGCGCCGTTCGTCACGACCGCGGCGCTCGTGATTTTCGGGGTGGCG
CAGATATTTCATGCATCGGGATTTCTCGCGGTCTATCTCGCGGGAATCATCATCGGCAATCGTCCGACGCGCGCGCACAG
TTCGGTGGTGACGTTCCTCGACGCCGCGACCTGGCTGGCGCAGATCGTGATGTTCGTGTTGCTCGGCTTGCTGGTCTCGC
CGTACCGCCTGATGGACAGCGCGCTTCCGGCGGTGCTCGTCGCGTTCGTGCTGATGCTGGTGGCGCGGCCGCTCGCGGTC
TTTTTATGTCTCGCGCCGTTTCCCTTTAACTGGCGGGAAAAGCTGTTCATTGCCTGGACCGGGCTGCGGGGGGCGGTTGC
GATCTTTCTTGCCTCGATTCCGATGCTGGTCGGCCTGTCGAAGGCGTATCTGTATTTCGACGTCGCGTTCGTCGTGGTGA
TCATCTCGCTTTTGCTGCAGGGCTGGACGCTTGCTCCGGCCGCCCGGCGACTGCATGTGGCGTTGCCGCGGGCCGACCGG
GGGCCGCGCCGCGTCGAACTCGATTTGCCGGGACAGCTCGAACAACAGTTGGTCGGCTATGCGGTACGACCGACAAGCCT
GTTTCTTCGGCGCGGGCTGATTCCGTCGTGGTCGAAGCCGACGCTCGTGATTCGCAACGAGAAAATCCTGACGCCCGCTG
AGGCCGAACCGATCGAAGCGGGAGACTATCTCTATCTGCTGGCGCCGCCGGAAAAGGCCGAGGCCCTCGACCGCTTTTTT
GTCGATATGCAGCCGATGGCGTCGCCGGACCCGCATCTGCTGGGCGACTTCCTGGTCTCCGGCGAAACCAGCCTTGGCGA
CATCGCGCAGATCTACGGCGTTTCCGTCGATCCGGCCGCAGCGGAGCTGACGCTGGCGGATTATTTCGATGTCCATCTCG
ATCGCGCGCCGAAAGAGGGGGCGACCCTGCCGCTTGACGCCATCGTCCTCGTCGCGCGTAACATCAGCCAGGGCCGCGTC
AACGCAGTCGGACTCCGTTTGCCACAAGACGAGGAAAAACGGCCGGCGCCGTCCAGAATGGGTACATTGAAGCAGAAAGC
GGCGAAGGCCTGGTCGGCGGTTGCAGGGACCTGA

Upstream 100 bases:

>100_bases
CCTGGCGCACAAATAAGGCCGACCGGCAGAAAATCGATTGGCGCGCTGCGGCACCGGCGATAAGGATGAAAGCGCTCGTG
TTTACCGCTTCGGACCTCTG

Downstream 100 bases:

>100_bases
CCACGCACGGGCAGTTCGGGTTAAGCGGGCAGGACCTCGGGCCCGCCGAACGCCGCGACCCGGCCGCGCTTGAGCATCAC
GATGTGCGAAGCGAGCTGGC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MASLDSVSLAILLGAILVMAGILSSLLALRFGAPLLLVFLFIGMLAGDSGPGGLSFSDVQNTYLVGSAALALILFDGGLK
TRFQSIRTVLAPSMVLATLGVLLTALVTAPVARYALDLNWTEALLIGAVVASTDAAAVFLLVHAQGLRLRPRVGATLEAE
SGTNDPFAVFLTLMLVELISVGDSSVWHVVIEFLRESMLGGIVGVIGGRLVVVALNRVALPQGLHAPFVTTAALVIFGVA
QIFHASGFLAVYLAGIIIGNRPTRAHSSVVTFLDAATWLAQIVMFVLLGLLVSPYRLMDSALPAVLVAFVLMLVARPLAV
FLCLAPFPFNWREKLFIAWTGLRGAVAIFLASIPMLVGLSKAYLYFDVAFVVVIISLLLQGWTLAPAARRLHVALPRADR
GPRRVELDLPGQLEQQLVGYAVRPTSLFLRRGLIPSWSKPTLVIRNEKILTPAEAEPIEAGDYLYLLAPPEKAEALDRFF
VDMQPMASPDPHLLGDFLVSGETSLGDIAQIYGVSVDPAAAELTLADYFDVHLDRAPKEGATLPLDAIVLVARNISQGRV
NAVGLRLPQDEEKRPAPSRMGTLKQKAAKAWSAVAGT

Sequences:

>Translated_597_residues
MASLDSVSLAILLGAILVMAGILSSLLALRFGAPLLLVFLFIGMLAGDSGPGGLSFSDVQNTYLVGSAALALILFDGGLK
TRFQSIRTVLAPSMVLATLGVLLTALVTAPVARYALDLNWTEALLIGAVVASTDAAAVFLLVHAQGLRLRPRVGATLEAE
SGTNDPFAVFLTLMLVELISVGDSSVWHVVIEFLRESMLGGIVGVIGGRLVVVALNRVALPQGLHAPFVTTAALVIFGVA
QIFHASGFLAVYLAGIIIGNRPTRAHSSVVTFLDAATWLAQIVMFVLLGLLVSPYRLMDSALPAVLVAFVLMLVARPLAV
FLCLAPFPFNWREKLFIAWTGLRGAVAIFLASIPMLVGLSKAYLYFDVAFVVVIISLLLQGWTLAPAARRLHVALPRADR
GPRRVELDLPGQLEQQLVGYAVRPTSLFLRRGLIPSWSKPTLVIRNEKILTPAEAEPIEAGDYLYLLAPPEKAEALDRFF
VDMQPMASPDPHLLGDFLVSGETSLGDIAQIYGVSVDPAAAELTLADYFDVHLDRAPKEGATLPLDAIVLVARNISQGRV
NAVGLRLPQDEEKRPAPSRMGTLKQKAAKAWSAVAGT
>Mature_596_residues
ASLDSVSLAILLGAILVMAGILSSLLALRFGAPLLLVFLFIGMLAGDSGPGGLSFSDVQNTYLVGSAALALILFDGGLKT
RFQSIRTVLAPSMVLATLGVLLTALVTAPVARYALDLNWTEALLIGAVVASTDAAAVFLLVHAQGLRLRPRVGATLEAES
GTNDPFAVFLTLMLVELISVGDSSVWHVVIEFLRESMLGGIVGVIGGRLVVVALNRVALPQGLHAPFVTTAALVIFGVAQ
IFHASGFLAVYLAGIIIGNRPTRAHSSVVTFLDAATWLAQIVMFVLLGLLVSPYRLMDSALPAVLVAFVLMLVARPLAVF
LCLAPFPFNWREKLFIAWTGLRGAVAIFLASIPMLVGLSKAYLYFDVAFVVVIISLLLQGWTLAPAARRLHVALPRADRG
PRRVELDLPGQLEQQLVGYAVRPTSLFLRRGLIPSWSKPTLVIRNEKILTPAEAEPIEAGDYLYLLAPPEKAEALDRFFV
DMQPMASPDPHLLGDFLVSGETSLGDIAQIYGVSVDPAAAELTLADYFDVHLDRAPKEGATLPLDAIVLVARNISQGRVN
AVGLRLPQDEEKRPAPSRMGTLKQKAAKAWSAVAGT

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=571, Percent_Identity=39.5796847635727, Blast_Score=340, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 63693; Mature: 63562

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLDSVSLAILLGAILVMAGILSSLLALRFGAPLLLVFLFIGMLAGDSGPGGLSFSDVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
NTYLVGSAALALILFDGGLKTRFQSIRTVLAPSMVLATLGVLLTALVTAPVARYALDLNW
CHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TEALLIGAVVASTDAAAVFLLVHAQGLRLRPRVGATLEAESGTNDPFAVFLTLMLVELIS
HHHHHHHHHHHCCCHHHHHHEEECCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
VGDSSVWHVVIEFLRESMLGGIVGVIGGRLVVVALNRVALPQGLHAPFVTTAALVIFGVA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCCCCHHHHHHHHHHHHHH
QIFHASGFLAVYLAGIIIGNRPTRAHSSVVTFLDAATWLAQIVMFVLLGLLVSPYRLMDS
HHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ALPAVLVAFVLMLVARPLAVFLCLAPFPFNWREKLFIAWTGLRGAVAIFLASIPMLVGLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHH
KAYLYFDVAFVVVIISLLLQGWTLAPAARRLHVALPRADRGPRRVELDLPGQLEQQLVGY
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEECCCCCCCCCEEEECCCCHHHHHHHCE
AVRPTSLFLRRGLIPSWSKPTLVIRNEKILTPAEAEPIEAGDYLYLLAPPEKAEALDRFF
ECCHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHH
VDMQPMASPDPHLLGDFLVSGETSLGDIAQIYGVSVDPAAAELTLADYFDVHLDRAPKEG
HCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHHHHCCCCCCC
ATLPLDAIVLVARNISQGRVNAVGLRLPQDEEKRPAPSRMGTLKQKAAKAWSAVAGT
CCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASLDSVSLAILLGAILVMAGILSSLLALRFGAPLLLVFLFIGMLAGDSGPGGLSFSDVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
NTYLVGSAALALILFDGGLKTRFQSIRTVLAPSMVLATLGVLLTALVTAPVARYALDLNW
CHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TEALLIGAVVASTDAAAVFLLVHAQGLRLRPRVGATLEAESGTNDPFAVFLTLMLVELIS
HHHHHHHHHHHCCCHHHHHHEEECCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
VGDSSVWHVVIEFLRESMLGGIVGVIGGRLVVVALNRVALPQGLHAPFVTTAALVIFGVA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCCCCHHHHHHHHHHHHHH
QIFHASGFLAVYLAGIIIGNRPTRAHSSVVTFLDAATWLAQIVMFVLLGLLVSPYRLMDS
HHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ALPAVLVAFVLMLVARPLAVFLCLAPFPFNWREKLFIAWTGLRGAVAIFLASIPMLVGLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHH
KAYLYFDVAFVVVIISLLLQGWTLAPAARRLHVALPRADRGPRRVELDLPGQLEQQLVGY
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEECCCCCCCCCEEEECCCCHHHHHHHCE
AVRPTSLFLRRGLIPSWSKPTLVIRNEKILTPAEAEPIEAGDYLYLLAPPEKAEALDRFF
ECCHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHH
VDMQPMASPDPHLLGDFLVSGETSLGDIAQIYGVSVDPAAAELTLADYFDVHLDRAPKEG
HCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHHHHCCCCCCC
ATLPLDAIVLVARNISQGRVNAVGLRLPQDEEKRPAPSRMGTLKQKAAKAWSAVAGT
CCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA