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The map label for this gene is tolC [H]

Identifier: 74318715

GI number: 74318715

Start: 2778336

End: 2779649

Strand: Direct

Name: tolC [H]

Synonym: Tbd_2697

Alternate gene names: 74318715

Gene position: 2778336-2779649 (Clockwise)

Preceding gene: 74318714

Following gene: 74318717

Centisome position: 95.48

GC content: 67.73

Gene sequence:

>1314_bases
ATGCCACTCAAGCCCCTGTTTCTTGCCCTGAGCCTCACGCTGGCGACCAGCGCCGGCGCCGCGAACCTGACCGAGGTCTA
CCGCAGCGCACAGGCCTACGACGCGACCTTCGCGTCGGCGCGGGCCGCCTATCGGGCCGGGCAGGAGGCGGTCGCGCAGG
GCCGCGCGGGACTGCTTCCCAACGTCGCGCTCGACGGCAACCTGCGCTACAACAGCCTTGATTCGAGCCTGCCCGGCGGC
GACGCCGACTACGACTCCAATGGTGCCTCGGTCAACGCCGCCCAGCCGCTTTTCCGCAAGCAGAATTGGGTGCAGTACGC
GCAGGCGAAAGAGCAGGTGAAGATCGCCGCGAGGCAGTTCGAGGTCGCCGAGCAGGATCTGATCCTGCGTGTCGCGCAGG
CCTACTTCGACGTGCTGCTGTCGCAGGACACGATCGCGTTCATCAACGCGCAGAAGGCCGCGATCACCGAACAGCTCGCG
GCGGCCAAGCGCAACTTCGAGGTCGGCACCGCGACCATCACCGACACCCACGAAGCGCAGGCGCGCTACGACCTTGCACT
CGCCCAGGAGATCGCCGAACAGAACACGCTCGATATCCGCCTGCGCGCGCTCGAAAAAATCATCGGCGCCCCGCCCGGCG
CACTCGACCGCCTGGCCGAACCGGTGCGCCTTGCTCCGCTCGCGGGCACTATCGAGGAATGGGCCGATCGCGCCGCCGAA
GGCAACCTGCAGGCGGAGATCCAGCGCATCGCGAAGACCATCGCCGACCAGGAAGTCGAGCGCAATCGCGCCGCGCGCTA
TCCCACGGTCGACGCGGTCGCCGGCTACAGCGTCAACAACAACCAGGCTTTCGGCAACCTGCAGGTCGATACGCGCGCCG
CGAGCGTCGGACTCGAACTCAACATGCCGATCTACCAGGGCGGGCTGATCAGTTCGCGCGTGCGCGAGGCGGTCGCCAAT
CAGGAAAAGGCACGTCACGATCTCGAGGCCGCGATTCGTGACGCGAGCCTGCAGGCGCGCGAGGCCTATCTCAACGTCAG
CAGCGGCGTCGCCCGTGTGCGCGCGCTCGAGCAAGCCTTGACCTCGACGCAGGCCCAGCTCGACTCGACCAAACTCGGCC
TCGATGTCGGCGTGCGCACGAACCTCGACGTGCTCAACGCCGAACAGCAGGTGCTCTCGGCGCGGCGCGACCTCGCCGCC
GCGCGCTACGAATACCTGCTTTCGGGTCTCGCACTGAAGGCCGCGGTCGGCACGCTCGGCCCCGCCGAACTCCTAGAGAT
CGATCAGCACCTCCATCCGGTCGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
TCAGCAACGTCGTCAACCTGTCCGGTGGCGTCGCAGCCTGGGCGGACGAGGTCGACCCGGCCATGGCGCGTTACTGAGTC
TTCCCCGGAACCGAGTCCAC

Downstream 100 bases:

>100_bases
GGCGCCTTCAGACCGGCACCAGGCCGGTGACGCGCGCGGCGGCGCCGCGATGCTGCGCGGCGAACGCCCGCCCCGCCTCG
CCCATGCGTTCGCGCGTCGC

Product: type I secretion outer membrane protein TolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPLKPLFLALSLTLATSAGAANLTEVYRSAQAYDATFASARAAYRAGQEAVAQGRAGLLPNVALDGNLRYNSLDSSLPGG
DADYDSNGASVNAAQPLFRKQNWVQYAQAKEQVKIAARQFEVAEQDLILRVAQAYFDVLLSQDTIAFINAQKAAITEQLA
AAKRNFEVGTATITDTHEAQARYDLALAQEIAEQNTLDIRLRALEKIIGAPPGALDRLAEPVRLAPLAGTIEEWADRAAE
GNLQAEIQRIAKTIADQEVERNRAARYPTVDAVAGYSVNNNQAFGNLQVDTRAASVGLELNMPIYQGGLISSRVREAVAN
QEKARHDLEAAIRDASLQAREAYLNVSSGVARVRALEQALTSTQAQLDSTKLGLDVGVRTNLDVLNAEQQVLSARRDLAA
ARYEYLLSGLALKAAVGTLGPAELLEIDQHLHPVAAR

Sequences:

>Translated_437_residues
MPLKPLFLALSLTLATSAGAANLTEVYRSAQAYDATFASARAAYRAGQEAVAQGRAGLLPNVALDGNLRYNSLDSSLPGG
DADYDSNGASVNAAQPLFRKQNWVQYAQAKEQVKIAARQFEVAEQDLILRVAQAYFDVLLSQDTIAFINAQKAAITEQLA
AAKRNFEVGTATITDTHEAQARYDLALAQEIAEQNTLDIRLRALEKIIGAPPGALDRLAEPVRLAPLAGTIEEWADRAAE
GNLQAEIQRIAKTIADQEVERNRAARYPTVDAVAGYSVNNNQAFGNLQVDTRAASVGLELNMPIYQGGLISSRVREAVAN
QEKARHDLEAAIRDASLQAREAYLNVSSGVARVRALEQALTSTQAQLDSTKLGLDVGVRTNLDVLNAEQQVLSARRDLAA
ARYEYLLSGLALKAAVGTLGPAELLEIDQHLHPVAAR
>Mature_436_residues
PLKPLFLALSLTLATSAGAANLTEVYRSAQAYDATFASARAAYRAGQEAVAQGRAGLLPNVALDGNLRYNSLDSSLPGGD
ADYDSNGASVNAAQPLFRKQNWVQYAQAKEQVKIAARQFEVAEQDLILRVAQAYFDVLLSQDTIAFINAQKAAITEQLAA
AKRNFEVGTATITDTHEAQARYDLALAQEIAEQNTLDIRLRALEKIIGAPPGALDRLAEPVRLAPLAGTIEEWADRAAEG
NLQAEIQRIAKTIADQEVERNRAARYPTVDAVAGYSVNNNQAFGNLQVDTRAASVGLELNMPIYQGGLISSRVREAVANQ
EKARHDLEAAIRDASLQAREAYLNVSSGVARVRALEQALTSTQAQLDSTKLGLDVGVRTNLDVLNAEQQVLSARRDLAAA
RYEYLLSGLALKAAVGTLGPAELLEIDQHLHPVAAR

Specific function: May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=434, Percent_Identity=30.4147465437788, Blast_Score=181, Evalue=6e-47,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47009; Mature: 46878

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKPLFLALSLTLATSAGAANLTEVYRSAQAYDATFASARAAYRAGQEAVAQGRAGLLP
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCC
NVALDGNLRYNSLDSSLPGGDADYDSNGASVNAAQPLFRKQNWVQYAQAKEQVKIAARQF
CEEECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVAEQDLILRVAQAYFDVLLSQDTIAFINAQKAAITEQLAAAKRNFEVGTATITDTHEAQ
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCEEEECCCHHHH
ARYDLALAQEIAEQNTLDIRLRALEKIIGAPPGALDRLAEPVRLAPLAGTIEEWADRAAE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCCEECCCHHHHHHHHHHHHC
GNLQAEIQRIAKTIADQEVERNRAARYPTVDAVAGYSVNNNQAFGNLQVDTRAASVGLEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEEECHHHHCCEEE
NMPIYQGGLISSRVREAVANQEKARHDLEAAIRDASLQAREAYLNVSSGVARVRALEQAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSTQAQLDSTKLGLDVGVRTNLDVLNAEQQVLSARRDLAAARYEYLLSGLALKAAVGTLG
HHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAELLEIDQHLHPVAAR
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PLKPLFLALSLTLATSAGAANLTEVYRSAQAYDATFASARAAYRAGQEAVAQGRAGLLP
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCC
NVALDGNLRYNSLDSSLPGGDADYDSNGASVNAAQPLFRKQNWVQYAQAKEQVKIAARQF
CEEECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVAEQDLILRVAQAYFDVLLSQDTIAFINAQKAAITEQLAAAKRNFEVGTATITDTHEAQ
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCEEEECCCHHHH
ARYDLALAQEIAEQNTLDIRLRALEKIIGAPPGALDRLAEPVRLAPLAGTIEEWADRAAE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCCEECCCHHHHHHHHHHHHC
GNLQAEIQRIAKTIADQEVERNRAARYPTVDAVAGYSVNNNQAFGNLQVDTRAASVGLEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEEECHHHHCCEEE
NMPIYQGGLISSRVREAVANQEKARHDLEAAIRDASLQAREAYLNVSSGVARVRALEQAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSTQAQLDSTKLGLDVGVRTNLDVLNAEQQVLSARRDLAAARYEYLLSGLALKAAVGTLG
HHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAELLEIDQHLHPVAAR
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]