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The map label for this gene is proA [H]

Identifier: 74318460

GI number: 74318460

Start: 2510907

End: 2512187

Strand: Reverse

Name: proA [H]

Synonym: Tbd_2442

Alternate gene names: 74318460

Gene position: 2512187-2510907 (Counterclockwise)

Preceding gene: 74318461

Following gene: 74318459

Centisome position: 86.34

GC content: 68.7

Gene sequence:

>1281_bases
ATGATGGACGTGAAAAGCTACATGCAGACCCTCGGCAGGCAGGCGCGCGAGGCCTCGCGCGCGATCGCGCGCGCCGACAC
CGAGCAGAAGAACCGCGCCTTGCTCACGATGGCCGCGGCGATCCGGCGCGACGCCGCCAGGCTCCTGGCCGCCAACGCAC
AGGATATGGAACACGCCCGCGCCGCGGGTTACGACGCCGCGCTGCTCGACCGCCTGCAACTGAGCGAGAAGACGGTCGCC
GGCATGGCCGAGGGCCTCGAACAGATCGCGGCGCTGCCTGATCCGGTCGGCGAGATCGATGGCCTCAAATTCCGCCCGTC
GGGCATCCAGGTCGGCAAGATGCGGGTGCCGCTCGGCGTCATCGGCATCATCTACGAAGCCCGCCCCAACGTGACCGCCG
ATGCGGCCGCGCTGTGCCTGAAGTCCGGCAACGCGGCGATCCTGCGCGGCGGTTCCGAGGCGCTGCGCTGCAACCAGGCC
GTCGCGGCCTGTGTGCGCGAAGGCCTCGAGGCTGCCGGCCTGCCGGCCGCCGTGGTGCAAGTCGTCGAAACGACCGACCG
CGCCGCGGTCGGCGAACTCATCACGATGAAGGACTACGTCGACGTCATCGTGCCGCGCGGCGGCAAGGGTCTGATCGAGC
GCATCACCGGCGAGGCGCGCGTGCCGGTGATCAAGCATCTGCACGGCAACTGCCATGTCTACGTGGACGACCGCGCGGAC
CTCGCCAAAGCCGTGAAGATCGTCGAGAACGCCAAGACCCAGCGCTACGGCACCTGCAACACGACCGAGTCACTGCTCGT
CGCGCGCGCGGTTGCGGCCGCAGCGCTGCCGCAGATCGGCGCAATGCTGGCCGGCAAGGGCGTCGAGATGCGCGGCTGTC
CCGAGTCGCTGGCGATCCTGCAGGCGGCGGGCGTCCCGGCCGACAAGCTCAGGCCGGCCGTCGAGTCGGACTGGTACGAG
GAATACCTGGGGCCAATCATCGCGGTCAAGGTCGTCGACGACCTCGACGCCGCGATGATCCATATCAACACCCACGGCTC
CCAGCACACCGACGCGATCGTCACCGAAGACTACGGCCGCGCGCGCCGCTTCCTGCGCGAGGTCGATTCGGCCAGTGTCG
TCGTCAATGCATCGACGCGCTTTGCCGACGGTTTCGAGTACGGACTCGGCGCTGAGATCGGCATATCCACCGACAAGATC
CACGCTCGCGGGCCGGTCGGCCTCGAGGGGCTTACGAGCCAGAAATGGGTCGTGCTGGGGGATGGCCACGTGCGCGCCTA
G

Upstream 100 bases:

>100_bases
GCCAGGCGAAAGGCCTGGACCGCATAGGCGATCCGTGGGACAGCCTGCTGCGCGCTGCGATGACACTTGCCGGCGGTGAA
CGCCGCGAAAACAGGACACG

Downstream 100 bases:

>100_bases
CGATGCACGCTGTCGGCGTCTTCGGCGGTACCTTCGATCCGATTCATTTCGGCCATCTGCGGCTGGCCGAGGAAATGGCC
GAGGCGCTCGGCCTCGCACG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MMDVKSYMQTLGRQAREASRAIARADTEQKNRALLTMAAAIRRDAARLLAANAQDMEHARAAGYDAALLDRLQLSEKTVA
GMAEGLEQIAALPDPVGEIDGLKFRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAALCLKSGNAAILRGGSEALRCNQA
VAACVREGLEAAGLPAAVVQVVETTDRAAVGELITMKDYVDVIVPRGGKGLIERITGEARVPVIKHLHGNCHVYVDDRAD
LAKAVKIVENAKTQRYGTCNTTESLLVARAVAAAALPQIGAMLAGKGVEMRGCPESLAILQAAGVPADKLRPAVESDWYE
EYLGPIIAVKVVDDLDAAMIHINTHGSQHTDAIVTEDYGRARRFLREVDSASVVVNASTRFADGFEYGLGAEIGISTDKI
HARGPVGLEGLTSQKWVVLGDGHVRA

Sequences:

>Translated_426_residues
MMDVKSYMQTLGRQAREASRAIARADTEQKNRALLTMAAAIRRDAARLLAANAQDMEHARAAGYDAALLDRLQLSEKTVA
GMAEGLEQIAALPDPVGEIDGLKFRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAALCLKSGNAAILRGGSEALRCNQA
VAACVREGLEAAGLPAAVVQVVETTDRAAVGELITMKDYVDVIVPRGGKGLIERITGEARVPVIKHLHGNCHVYVDDRAD
LAKAVKIVENAKTQRYGTCNTTESLLVARAVAAAALPQIGAMLAGKGVEMRGCPESLAILQAAGVPADKLRPAVESDWYE
EYLGPIIAVKVVDDLDAAMIHINTHGSQHTDAIVTEDYGRARRFLREVDSASVVVNASTRFADGFEYGLGAEIGISTDKI
HARGPVGLEGLTSQKWVVLGDGHVRA
>Mature_426_residues
MMDVKSYMQTLGRQAREASRAIARADTEQKNRALLTMAAAIRRDAARLLAANAQDMEHARAAGYDAALLDRLQLSEKTVA
GMAEGLEQIAALPDPVGEIDGLKFRPSGIQVGKMRVPLGVIGIIYEARPNVTADAAALCLKSGNAAILRGGSEALRCNQA
VAACVREGLEAAGLPAAVVQVVETTDRAAVGELITMKDYVDVIVPRGGKGLIERITGEARVPVIKHLHGNCHVYVDDRAD
LAKAVKIVENAKTQRYGTCNTTESLLVARAVAAAALPQIGAMLAGKGVEMRGCPESLAILQAAGVPADKLRPAVESDWYE
EYLGPIIAVKVVDDLDAAMIHINTHGSQHTDAIVTEDYGRARRFLREVDSASVVVNASTRFADGFEYGLGAEIGISTDKI
HARGPVGLEGLTSQKWVVLGDGHVRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=38.2211538461538, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=38.2211538461538, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI1786438, Length=420, Percent_Identity=46.6666666666667, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17569967, Length=421, Percent_Identity=34.916864608076, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17569969, Length=421, Percent_Identity=34.916864608076, Blast_Score=261, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=440, Percent_Identity=37.0454545454545, Blast_Score=279, Evalue=7e-76,
Organism=Drosophila melanogaster, GI21357643, Length=422, Percent_Identity=37.6777251184834, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45195; Mature: 45195

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDVKSYMQTLGRQAREASRAIARADTEQKNRALLTMAAAIRRDAARLLAANAQDMEHAR
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AAGYDAALLDRLQLSEKTVAGMAEGLEQIAALPDPVGEIDGLKFRPSGIQVGKMRVPLGV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEECEEECCCEE
IGIIYEARPNVTADAAALCLKSGNAAILRGGSEALRCNQAVAACVREGLEAAGLPAAVVQ
EEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCHHHCCCHHHHHH
VVETTDRAAVGELITMKDYVDVIVPRGGKGLIERITGEARVPVIKHLHGNCHVYVDDRAD
HHHHCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCHHHCCCCCEEEEECCHHH
LAKAVKIVENAKTQRYGTCNTTESLLVARAVAAAALPQIGAMLAGKGVEMRGCPESLAIL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
QAAGVPADKLRPAVESDWYEEYLGPIIAVKVVDDLDAAMIHINTHGSQHTDAIVTEDYGR
HHCCCCHHHHCCCHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCHHH
ARRFLREVDSASVVVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWVVLG
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEEE
DGHVRA
CCCCCC
>Mature Secondary Structure
MMDVKSYMQTLGRQAREASRAIARADTEQKNRALLTMAAAIRRDAARLLAANAQDMEHAR
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AAGYDAALLDRLQLSEKTVAGMAEGLEQIAALPDPVGEIDGLKFRPSGIQVGKMRVPLGV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEECEEECCCEE
IGIIYEARPNVTADAAALCLKSGNAAILRGGSEALRCNQAVAACVREGLEAAGLPAAVVQ
EEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCHHHCCCHHHHHH
VVETTDRAAVGELITMKDYVDVIVPRGGKGLIERITGEARVPVIKHLHGNCHVYVDDRAD
HHHHCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCHHHCCCCCEEEEECCHHH
LAKAVKIVENAKTQRYGTCNTTESLLVARAVAAAALPQIGAMLAGKGVEMRGCPESLAIL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
QAAGVPADKLRPAVESDWYEEYLGPIIAVKVVDDLDAAMIHINTHGSQHTDAIVTEDYGR
HHCCCCHHHHCCCHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCHHH
ARRFLREVDSASVVVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWVVLG
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEEE
DGHVRA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA