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The map label for this gene is ffh [H]

Identifier: 74318391

GI number: 74318391

Start: 2448001

End: 2449344

Strand: Direct

Name: ffh [H]

Synonym: Tbd_2373

Alternate gene names: 74318391

Gene position: 2448001-2449344 (Clockwise)

Preceding gene: 74318382

Following gene: 74318392

Centisome position: 84.13

GC content: 64.73

Gene sequence:

>1344_bases
ATGTTCGAAAACCTCAGTGGACGCCTCGCCGGCGTCGTCAAGAACCTGCGCGGACAGGCTCGCATCACCGAAGCCAATAT
TCAGGATACCTTGCGGCAGGTGCGGCTCGCGCTGCTCGAGGCAGACGTCGCGCTGCCCGTCGTCAAGAGCTTCATCGACG
CGGTGAAGGCGCGAGCGCTGGGCCAGGAGGTACTCACCAGCCTGTCGCCCGGACAAGCCCTGATCGGCATCGTCCACGAA
GAGCTCACCCGGCTCATGGGCGGCGAGAACGCCGACCTGAATCTCGCGGCGACGCCGCCCGCCGTTATCCTGATGGCCGG
CCTGCAGGGCTCGGGCAAGACGACCACGAGTGGCAAACTCGCGCTGCTCCTGAAAAACCGCAAGAAGAAAGTACTGCTCG
CCTCGGCCGACGTCTACCGGCCCGCCGCGATCGACCAGCTGCGACAGCTCGCGAAACAGCTCGACGTCAGCTTCTTCGAC
GCCGATAGCGAGCGCGACCCGCTGAAAATCGCGCGCGCCGCGCAGGATCACGCGCGCAAGCAGTTCTACGACGTGCTGAT
CGTCGATACCGCAGGCCGTCTCGCGATCGACGAGGCCATGATGAACGAGATCAAGGCGCTGCACGCCGCCATCACGCCCG
TCGAAACGCTGTTCGTGGTCGATGCGATGCAGGGCCAGGACGCCGTCAACGTGGCGCGCGCCTTCAACGAAGCGCTGCCG
CTCACCGGCGTCGTCCTGACCAAGCTCGACGGCGACGCGCGCGGCGGCGCGGCGCTTTCGGTCCGACAGATCACCGGCAA
GCCGCTGAAGTTCATCGGCGTCGGCGAAAAACCCAACGGCCTCGAGCCCTTCCATCCCGAAAGGATGGCGCAACGCATTC
TCGGCATGGGGGACGTGCTGTCGCTGATCGAGCAGGCGCAAAGTTCGGTCGACCTGGCCGAGGCAAAGAAAATCGCCGAC
AAGGTCAAGAAAGGCAAGGACTTCGACCTCGAGGACTTCAAGGCGCAGATCCAGCAGATGCGCAAGATGGGCGGGCTGTC
AGCGCTGATGGACAAGCTTCCGGGCGCCGGCCAGATGGCGGTCCCGGCCGGCGCCGACGACAAGGCCGTGAATCGCATCG
AAGGCATCATCAACAGCATGACGCCGCTCGAGCGTCGCAAACCCGACATCATCAAGGCGAGCCGCAAGCGCCGCATCGCC
GCCGGGGCCGGCGTGCAGGTGCAGGAGGTCAACAAACTGCTGAACCAGTTCGGCCAGGCGCAGAAGATGATGAAAATGAT
GGGCAAGGGCGGCATCGGCAAGATGATGCGCGGCATGAAAGGCATGCTCCCCGGGATGCGCTGA

Upstream 100 bases:

>100_bases
GCTCACGCACAGGGCGGCCAGCGAAAACGGAGACATTCGTTAAAATAGGAAGGCGTTCCAGCCTATTATCCATGCCGCCC
GAGGCGGCAACAAGGAAGCC

Downstream 100 bases:

>100_bases
GCCGGCACTGGCGGACCGATCCGATTCGGGTATAATTCGCGGTTTTCTCCGTTTACCCGGTGGGTTGAATCATGGTCGTT
ATTCGTCTTTCGCGCGGCGG

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFENLSGRLAGVVKNLRGQARITEANIQDTLRQVRLALLEADVALPVVKSFIDAVKARALGQEVLTSLSPGQALIGIVHE
ELTRLMGGENADLNLAATPPAVILMAGLQGSGKTTTSGKLALLLKNRKKKVLLASADVYRPAAIDQLRQLAKQLDVSFFD
ADSERDPLKIARAAQDHARKQFYDVLIVDTAGRLAIDEAMMNEIKALHAAITPVETLFVVDAMQGQDAVNVARAFNEALP
LTGVVLTKLDGDARGGAALSVRQITGKPLKFIGVGEKPNGLEPFHPERMAQRILGMGDVLSLIEQAQSSVDLAEAKKIAD
KVKKGKDFDLEDFKAQIQQMRKMGGLSALMDKLPGAGQMAVPAGADDKAVNRIEGIINSMTPLERRKPDIIKASRKRRIA
AGAGVQVQEVNKLLNQFGQAQKMMKMMGKGGIGKMMRGMKGMLPGMR

Sequences:

>Translated_447_residues
MFENLSGRLAGVVKNLRGQARITEANIQDTLRQVRLALLEADVALPVVKSFIDAVKARALGQEVLTSLSPGQALIGIVHE
ELTRLMGGENADLNLAATPPAVILMAGLQGSGKTTTSGKLALLLKNRKKKVLLASADVYRPAAIDQLRQLAKQLDVSFFD
ADSERDPLKIARAAQDHARKQFYDVLIVDTAGRLAIDEAMMNEIKALHAAITPVETLFVVDAMQGQDAVNVARAFNEALP
LTGVVLTKLDGDARGGAALSVRQITGKPLKFIGVGEKPNGLEPFHPERMAQRILGMGDVLSLIEQAQSSVDLAEAKKIAD
KVKKGKDFDLEDFKAQIQQMRKMGGLSALMDKLPGAGQMAVPAGADDKAVNRIEGIINSMTPLERRKPDIIKASRKRRIA
AGAGVQVQEVNKLLNQFGQAQKMMKMMGKGGIGKMMRGMKGMLPGMR
>Mature_447_residues
MFENLSGRLAGVVKNLRGQARITEANIQDTLRQVRLALLEADVALPVVKSFIDAVKARALGQEVLTSLSPGQALIGIVHE
ELTRLMGGENADLNLAATPPAVILMAGLQGSGKTTTSGKLALLLKNRKKKVLLASADVYRPAAIDQLRQLAKQLDVSFFD
ADSERDPLKIARAAQDHARKQFYDVLIVDTAGRLAIDEAMMNEIKALHAAITPVETLFVVDAMQGQDAVNVARAFNEALP
LTGVVLTKLDGDARGGAALSVRQITGKPLKFIGVGEKPNGLEPFHPERMAQRILGMGDVLSLIEQAQSSVDLAEAKKIAD
KVKKGKDFDLEDFKAQIQQMRKMGGLSALMDKLPGAGQMAVPAGADDKAVNRIEGIINSMTPLERRKPDIIKASRKRRIA
AGAGVQVQEVNKLLNQFGQAQKMMKMMGKGGIGKMMRGMKGMLPGMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=455, Percent_Identity=32.3076923076923, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI226371618, Length=397, Percent_Identity=32.7455919395466, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI295424842, Length=305, Percent_Identity=29.1803278688525, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI23308697, Length=305, Percent_Identity=29.1803278688525, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=34.3558282208589, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1788963, Length=447, Percent_Identity=64.6532438478747, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1789874, Length=250, Percent_Identity=35.6, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=415, Percent_Identity=33.0120481927711, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=31.0810810810811, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=439, Percent_Identity=35.3075170842825, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=310, Percent_Identity=25.8064516129032, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17647949, Length=433, Percent_Identity=31.6397228637413, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24641198, Length=301, Percent_Identity=28.9036544850498, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48120; Mature: 48120

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSGRLAGVVKNLRGQARITEANIQDTLRQVRLALLEADVALPVVKSFIDAVKARAL
CCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLTSLSPGQALIGIVHEELTRLMGGENADLNLAATPPAVILMAGLQGSGKTTTSGKL
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCE
ALLLKNRKKKVLLASADVYRPAAIDQLRQLAKQLDVSFFDADSERDPLKIARAAQDHARK
EEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHH
QFYDVLIVDTAGRLAIDEAMMNEIKALHAAITPVETLFVVDAMQGQDAVNVARAFNEALP
HHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
LTGVVLTKLDGDARGGAALSVRQITGKPLKFIGVGEKPNGLEPFHPERMAQRILGMGDVL
CCCEEEEECCCCCCCCCEEEEHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHHH
SLIEQAQSSVDLAEAKKIADKVKKGKDFDLEDFKAQIQQMRKMGGLSALMDKLPGAGQMA
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEE
VPAGADDKAVNRIEGIINSMTPLERRKPDIIKASRKRRIAAGAGVQVQEVNKLLNQFGQA
CCCCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QKMMKMMGKGGIGKMMRGMKGMLPGMR
HHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFENLSGRLAGVVKNLRGQARITEANIQDTLRQVRLALLEADVALPVVKSFIDAVKARAL
CCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLTSLSPGQALIGIVHEELTRLMGGENADLNLAATPPAVILMAGLQGSGKTTTSGKL
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCE
ALLLKNRKKKVLLASADVYRPAAIDQLRQLAKQLDVSFFDADSERDPLKIARAAQDHARK
EEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHH
QFYDVLIVDTAGRLAIDEAMMNEIKALHAAITPVETLFVVDAMQGQDAVNVARAFNEALP
HHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
LTGVVLTKLDGDARGGAALSVRQITGKPLKFIGVGEKPNGLEPFHPERMAQRILGMGDVL
CCCEEEEECCCCCCCCCEEEEHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHHH
SLIEQAQSSVDLAEAKKIADKVKKGKDFDLEDFKAQIQQMRKMGGLSALMDKLPGAGQMA
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEE
VPAGADDKAVNRIEGIINSMTPLERRKPDIIKASRKRRIAAGAGVQVQEVNKLLNQFGQA
CCCCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QKMMKMMGKGGIGKMMRGMKGMLPGMR
HHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]