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The map label for this gene is coaE

Identifier: 74318385

GI number: 74318385

Start: 2441333

End: 2441941

Strand: Reverse

Name: coaE

Synonym: Tbd_2367

Alternate gene names: 74318385

Gene position: 2441941-2441333 (Counterclockwise)

Preceding gene: 74318386

Following gene: 74318384

Centisome position: 83.92

GC content: 69.13

Gene sequence:

>609_bases
ATGTTCACGATCGGGCTGACCGGCGGCATCGGTTCCGGCAAGTCCGCAGCCGCAGAACGGTTTGCCGAGCTCGGCGTGCC
GGTCATCGATACCGACGTGATCGCGCACGAGCTGACGCGACCCGGCAGCCGCGCGCTGGACGTGATCCGCGCATCGTTCG
GGGAGGCGGTCATCGCCGCGGACGGCTCGCTCGACCGCCCCGTGCTGCGTCGCCGCGTGTTCGTCGACCCGGCTGCGCGG
CGGCAGCTCGAAGCGATTCTCCACCCCCTCATTCTTCACGAGGTGAAGGCACGGCTTGCGTCGCTTTCGGGGCCGTACGC
GGTGGCGGTCATCCCCCTGCTCGTCGAGACCGGCGCCTATGATGCGCCGGTCGACCGGATCGCGGTCGTCGACTGCCCGG
AAGAACTCCAGATCGCGCGCACCATTGCGCGCAGCGGACTCACCCCCGATGAGGTCGGCGCCATCCTCGCAGCGCAGGCG
GCGCGGCCTGCGCGCCTCGCGGTAGCCGACGACGTCATCGTCAATACCGGCTCTTTGGCGGCGCTTCGCGACCAAGTCGA
CGCGCTGCATCAGCGCTATCTCACGCTCGCTGCAAACCGTCTGCCTTGA

Upstream 100 bases:

>100_bases
GCCGTGTGCCGATCCCGTTCGGCCCCTACCTCGCGGGCGGGGGACTCGTTGCCCTGTTCTTCGGTGCGGACCTGACGCAG
GCCTATCTCGCGCAGTTCTG

Downstream 100 bases:

>100_bases
TTTTCAGGACGGATCGGCGACAATCGGGTGAACCCAACCGACGCGTTGCCGCGTGATTCACTACGAATATCCCCTGAGCG
AACGGATCCGCACCCTGTTG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFTIGLTGGIGSGKSAAAERFAELGVPVIDTDVIAHELTRPGSRALDVIRASFGEAVIAADGSLDRPVLRRRVFVDPAAR
RQLEAILHPLILHEVKARLASLSGPYAVAVIPLLVETGAYDAPVDRIAVVDCPEELQIARTIARSGLTPDEVGAILAAQA
ARPARLAVADDVIVNTGSLAALRDQVDALHQRYLTLAANRLP

Sequences:

>Translated_202_residues
MFTIGLTGGIGSGKSAAAERFAELGVPVIDTDVIAHELTRPGSRALDVIRASFGEAVIAADGSLDRPVLRRRVFVDPAAR
RQLEAILHPLILHEVKARLASLSGPYAVAVIPLLVETGAYDAPVDRIAVVDCPEELQIARTIARSGLTPDEVGAILAAQA
ARPARLAVADDVIVNTGSLAALRDQVDALHQRYLTLAANRLP
>Mature_202_residues
MFTIGLTGGIGSGKSAAAERFAELGVPVIDTDVIAHELTRPGSRALDVIRASFGEAVIAADGSLDRPVLRRRVFVDPAAR
RQLEAILHPLILHEVKARLASLSGPYAVAVIPLLVETGAYDAPVDRIAVVDCPEELQIARTIARSGLTPDEVGAILAAQA
ARPARLAVADDVIVNTGSLAALRDQVDALHQRYLTLAANRLP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=193, Percent_Identity=36.2694300518135, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI191252795, Length=193, Percent_Identity=36.2694300518135, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI110227607, Length=169, Percent_Identity=33.1360946745562, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI110227605, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227603, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227601, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI205277394, Length=156, Percent_Identity=34.6153846153846, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786292, Length=197, Percent_Identity=48.2233502538071, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17554944, Length=191, Percent_Identity=31.413612565445, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320402, Length=201, Percent_Identity=30.3482587064677, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=33.5164835164835, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658602, Length=162, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_THIDA (Q3SGD0)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316125.1
- ProteinModelPortal:   Q3SGD0
- SMR:   Q3SGD0
- STRING:   Q3SGD0
- GeneID:   3671860
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2367
- NMPDR:   fig|292415.3.peg.2440
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   Q3SGD0
- BioCyc:   TDEN292415:TBD_2367-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21303; Mature: 21303

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTIGLTGGIGSGKSAAAERFAELGVPVIDTDVIAHELTRPGSRALDVIRASFGEAVIAA
CEEEEECCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCCCHHHHHHHHHHHCCEEEEC
DGSLDRPVLRRRVFVDPAARRQLEAILHPLILHEVKARLASLSGPYAVAVIPLLVETGAY
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
DAPVDRIAVVDCPEELQIARTIARSGLTPDEVGAILAAQAARPARLAVADDVIVNTGSLA
CCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHHEECCCCHH
ALRDQVDALHQRYLTLAANRLP
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTIGLTGGIGSGKSAAAERFAELGVPVIDTDVIAHELTRPGSRALDVIRASFGEAVIAA
CEEEEECCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCCCHHHHHHHHHHHCCEEEEC
DGSLDRPVLRRRVFVDPAARRQLEAILHPLILHEVKARLASLSGPYAVAVIPLLVETGAY
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
DAPVDRIAVVDCPEELQIARTIARSGLTPDEVGAILAAQAARPARLAVADDVIVNTGSLA
CCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHHEECCCCHH
ALRDQVDALHQRYLTLAANRLP
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA