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The map label for this gene is pdxA [H]

Identifier: 74318357

GI number: 74318357

Start: 2414289

End: 2415275

Strand: Direct

Name: pdxA [H]

Synonym: Tbd_2339

Alternate gene names: 74318357

Gene position: 2414289-2415275 (Clockwise)

Preceding gene: 74318356

Following gene: 74318358

Centisome position: 82.97

GC content: 72.04

Gene sequence:

>987_bases
GTGAACCCGCCCGTTGTCGCGCTGACCGCCGGCGAGCCGGCAGGCGTCGGCCCCGACCTCTGCATCGCCCTCTCGCAGCG
GCCGCTGCCGTGTCGCATGACCGTCCTCGGCGACGTGCAAGTGCTCGAGGCGCGCGCCCGCCAGCTCGGCGTCGAGGTCG
AATTCCTCGCTGGGGAGTCCGTCCCCGAACATCGGCCGGGGGCGCTCCACGTCCGTCATATCCCGGCCGCGGCAGCCGTG
AATGCAGGCCAGCTCGACCGCCGCAACAGCGCGCACGTGCTGGCGCTGCTCGACGCCGCGCTCGCCGGCTGCATGGGCGG
CGCCTACCAGGCACTGGTGACCGCCCCGGTGCACAAGGGCGTGATCAACGATGCGGGCTTTCCCTTCACCGGCCACACCG
AATATCTCGCCGATCACAGCGGGACGCCGCGGGTCGTCATGATGCTGGCCGGCGGCGGGCTGCGCGTCGCGCTCGCGACG
ACGCACCTGCCACTGCGCGCGGTCGCCGACGCGATCACGCCGGCACTTCTCGACCAAGTCGTTCGCATCCTGGCTGCCGA
GCTGGCGCGCAGATTCGGCCTTGCGCGCCCCCGCATCGCCGTCGCCGGCCTCAACCCGCACGCCGGTGAATCGGGCCATC
TCGGGCGCGAGGAGATCGAGATCATCGAACCCGCGCTCGCGCGCCTGCGCGCCGAAGGTTTCGACCTCGTCGGCCCGCTG
CCCGCCGACACGCTGTTCTCGCGGATACGCCTCGACCCCTGCGACGCGGTGCTGGCGATGTACCACGATCAGGGGCTGCC
CGTGCTGAAATACGCGAGCTTCGGCAGCGCGGTCAACATCACGCTCGGCCTGCCCTTCATCCGCACCTCGGTCGACCACG
GCACGGCGCTCGACCTCGCCGGCAGCGGCCGCGCCGAAGTCGGCAGCCTCGTCGCCGCGATCGCAATGGCGACCGAGATG
GCCACCCGGGACGCGGTGGCTCCCTGA

Upstream 100 bases:

>100_bases
GCCGAAGAGGCCTTCCAGGACTGGGTCCGGCAGATACGCGACGCCGCCTACGTCGAACTGCGCCCGATCGATTGACGCCC
GCTACGGCCGTGCGCGCACC

Downstream 100 bases:

>100_bases
GCCGCCCCAACCCTCGGTCTCCGCCTCACCAGCCATGCACACACCGCGCAAACGCTTCGGCCAGAATTTCCTGATCGATG
ACGGCATCGTCCATGCGATC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNPPVVALTAGEPAGVGPDLCIALSQRPLPCRMTVLGDVQVLEARARQLGVEVEFLAGESVPEHRPGALHVRHIPAAAAV
NAGQLDRRNSAHVLALLDAALAGCMGGAYQALVTAPVHKGVINDAGFPFTGHTEYLADHSGTPRVVMMLAGGGLRVALAT
THLPLRAVADAITPALLDQVVRILAAELARRFGLARPRIAVAGLNPHAGESGHLGREEIEIIEPALARLRAEGFDLVGPL
PADTLFSRIRLDPCDAVLAMYHDQGLPVLKYASFGSAVNITLGLPFIRTSVDHGTALDLAGSGRAEVGSLVAAIAMATEM
ATRDAVAP

Sequences:

>Translated_328_residues
MNPPVVALTAGEPAGVGPDLCIALSQRPLPCRMTVLGDVQVLEARARQLGVEVEFLAGESVPEHRPGALHVRHIPAAAAV
NAGQLDRRNSAHVLALLDAALAGCMGGAYQALVTAPVHKGVINDAGFPFTGHTEYLADHSGTPRVVMMLAGGGLRVALAT
THLPLRAVADAITPALLDQVVRILAAELARRFGLARPRIAVAGLNPHAGESGHLGREEIEIIEPALARLRAEGFDLVGPL
PADTLFSRIRLDPCDAVLAMYHDQGLPVLKYASFGSAVNITLGLPFIRTSVDHGTALDLAGSGRAEVGSLVAAIAMATEM
ATRDAVAP
>Mature_328_residues
MNPPVVALTAGEPAGVGPDLCIALSQRPLPCRMTVLGDVQVLEARARQLGVEVEFLAGESVPEHRPGALHVRHIPAAAAV
NAGQLDRRNSAHVLALLDAALAGCMGGAYQALVTAPVHKGVINDAGFPFTGHTEYLADHSGTPRVVMMLAGGGLRVALAT
THLPLRAVADAITPALLDQVVRILAAELARRFGLARPRIAVAGLNPHAGESGHLGREEIEIIEPALARLRAEGFDLVGPL
PADTLFSRIRLDPCDAVLAMYHDQGLPVLKYASFGSAVNITLGLPFIRTSVDHGTALDLAGSGRAEVGSLVAAIAMATEM
ATRDAVAP

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=318, Percent_Identity=57.2327044025157, Blast_Score=344, Evalue=4e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34091; Mature: 34091

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPVVALTAGEPAGVGPDLCIALSQRPLPCRMTVLGDVQVLEARARQLGVEVEFLAGES
CCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
VPEHRPGALHVRHIPAAAAVNAGQLDRRNSAHVLALLDAALAGCMGGAYQALVTAPVHKG
CCCCCCCEEEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
VINDAGFPFTGHTEYLADHSGTPRVVMMLAGGGLRVALATTHLPLRAVADAITPALLDQV
CCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHH
VRILAAELARRFGLARPRIAVAGLNPHAGESGHLGREEIEIIEPALARLRAEGFDLVGPL
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PADTLFSRIRLDPCDAVLAMYHDQGLPVLKYASFGSAVNITLGLPFIRTSVDHGTALDLA
CHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCHHEECCCCCCEEEEC
GSGRAEVGSLVAAIAMATEMATRDAVAP
CCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNPPVVALTAGEPAGVGPDLCIALSQRPLPCRMTVLGDVQVLEARARQLGVEVEFLAGES
CCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
VPEHRPGALHVRHIPAAAAVNAGQLDRRNSAHVLALLDAALAGCMGGAYQALVTAPVHKG
CCCCCCCEEEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
VINDAGFPFTGHTEYLADHSGTPRVVMMLAGGGLRVALATTHLPLRAVADAITPALLDQV
CCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHH
VRILAAELARRFGLARPRIAVAGLNPHAGESGHLGREEIEIIEPALARLRAEGFDLVGPL
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PADTLFSRIRLDPCDAVLAMYHDQGLPVLKYASFGSAVNITLGLPFIRTSVDHGTALDLA
CHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCHHEECCCCCCEEEEC
GSGRAEVGSLVAAIAMATEMATRDAVAP
CCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA