Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 74318245

GI number: 74318245

Start: 2306178

End: 2307470

Strand: Direct

Name: atoC [H]

Synonym: Tbd_2227

Alternate gene names: 74318245

Gene position: 2306178-2307470 (Clockwise)

Preceding gene: 74318239

Following gene: 74318249

Centisome position: 79.26

GC content: 69.76

Gene sequence:

>1293_bases
ATGCCATCCATCGAACTGCAGGACATCATCGACGCGAACGACCAGCCTTTCGTCGTGATCGACAGCGCATACCGCATCGT
CGCGGCCAACCGGCGCTACGCGGAAACCTATGGCGCGACGCCCGAGGCGATCGTCGGCGAGCACTGCTACGCCGTGTCTC
ACCACTCGCCGCGGCCCTGCCACGAAAACGGCGAGCAATGCCCGCACCGCGCCCTGTTCGAGAACGGCGAGGCGGTCGAG
GTCGTGCACACGCACTTTCATGCCAACGATCAGCCCGAGCGCACTCGCATCCGCGGCCACGCGCTGCGCGGCCCGGACGG
CGAGCGCTACCTGGGCGAGCAGCTCTACCCGCTCGAAGCCGACATCGGCCTGGATTGCGACGCCATGCAGATGGTCGGGC
AGTCCCCGGCGTTTCTCGCGTGCGTCGACAATCTCGCGCGCGTCGCCGAAAGCGAAGCGTCGATCCTGCTGTATGGCGAA
AGCGGCGTCGGCAAGGAACTCGCCGCGCGCTTCATCCATGCTCGCTCGCAGCGCAGGGGCGGCGCCTTCATCGTGATCAA
CTGCGCCGCGGTGCCCGAAACCCTGTTCGAAAGCGAGCTGTTCGGCCACGAACGCGGCGCGTTCTCGGGCAGCAGCGGCC
TCAAGAAAGGCCTGTTCGAACTCGCCGACGGTGGCACGCTATTCCTCGACGAGGTCGCGGAGATCCCGCTGGCGCTGCAG
GCCAAGCTGCTGCGCGTACTGGAGACCGGGGAATTCCGCCGTGTCGGCGGCACCCACACGCTGACCGCGGACGTGCGGCT
GGTGTCGGCGACCAACCGCCGCCTGCTGGACGAAGTCGACGAAAAGCGCTTCCGGCTCGACCTCTACTACCGGCTGGCCG
GCATCGACGTCGTGCTGCCGCCGCTGCGCGAGCGCCGCGCCGACCTGCCCGCGCTGGCCGCCTTCCTGCTCAAGCGACTG
GCCGGCGGCCGCCGAGCCTGCCGGCTCGACGCGAGCGGACTGGCGGCGCTGCAGGCCTACGATTTTCCGGGGAACGTGCG
CGAACTGCGCAACCTGCTGCAGCGCGCGGTGCTGACCTGCCGCGACGGCGTGATCGGCGCCGCCGATCTGAACCTGCCCG
TCGCCGCCGTGACGCCGGTCCAGCCGGCGACGCAGGGGCTCGCCGACATCGAGCGCGCGCACATTCGCGCGCTGCTCGCC
AGCCGCGGCGGCCACCGCGGACGGGTCGCCCAGGCACTCGGCGTCACCGAGCGCACGCTGTACCGCAAGCTCAAACGCTA
CGGCCTGAGTTAG

Upstream 100 bases:

>100_bases
GGCCGTAATTACGCGGGGCGCGGCGGTGGTCCAACGCTGACATGGCTTTGATGTCATGGCACTGTTAGCATGTGTCATGA
CGATCAGCGGGGACCACGCC

Downstream 100 bases:

>100_bases
CGCCCGCGCGTTTCGGCGGGCCGGGCAAACGCCTTATTCGACGACGTCGCCGAAGCGCGCGTAGGCGAGCTCGGCCGCAC
GCACGACCGCCCGCGCCTTG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPSIELQDIIDANDQPFVVIDSAYRIVAANRRYAETYGATPEAIVGEHCYAVSHHSPRPCHENGEQCPHRALFENGEAVE
VVHTHFHANDQPERTRIRGHALRGPDGERYLGEQLYPLEADIGLDCDAMQMVGQSPAFLACVDNLARVAESEASILLYGE
SGVGKELAARFIHARSQRRGGAFIVINCAAVPETLFESELFGHERGAFSGSSGLKKGLFELADGGTLFLDEVAEIPLALQ
AKLLRVLETGEFRRVGGTHTLTADVRLVSATNRRLLDEVDEKRFRLDLYYRLAGIDVVLPPLRERRADLPALAAFLLKRL
AGGRRACRLDASGLAALQAYDFPGNVRELRNLLQRAVLTCRDGVIGAADLNLPVAAVTPVQPATQGLADIERAHIRALLA
SRGGHRGRVAQALGVTERTLYRKLKRYGLS

Sequences:

>Translated_430_residues
MPSIELQDIIDANDQPFVVIDSAYRIVAANRRYAETYGATPEAIVGEHCYAVSHHSPRPCHENGEQCPHRALFENGEAVE
VVHTHFHANDQPERTRIRGHALRGPDGERYLGEQLYPLEADIGLDCDAMQMVGQSPAFLACVDNLARVAESEASILLYGE
SGVGKELAARFIHARSQRRGGAFIVINCAAVPETLFESELFGHERGAFSGSSGLKKGLFELADGGTLFLDEVAEIPLALQ
AKLLRVLETGEFRRVGGTHTLTADVRLVSATNRRLLDEVDEKRFRLDLYYRLAGIDVVLPPLRERRADLPALAAFLLKRL
AGGRRACRLDASGLAALQAYDFPGNVRELRNLLQRAVLTCRDGVIGAADLNLPVAAVTPVQPATQGLADIERAHIRALLA
SRGGHRGRVAQALGVTERTLYRKLKRYGLS
>Mature_429_residues
PSIELQDIIDANDQPFVVIDSAYRIVAANRRYAETYGATPEAIVGEHCYAVSHHSPRPCHENGEQCPHRALFENGEAVEV
VHTHFHANDQPERTRIRGHALRGPDGERYLGEQLYPLEADIGLDCDAMQMVGQSPAFLACVDNLARVAESEASILLYGES
GVGKELAARFIHARSQRRGGAFIVINCAAVPETLFESELFGHERGAFSGSSGLKKGLFELADGGTLFLDEVAEIPLALQA
KLLRVLETGEFRRVGGTHTLTADVRLVSATNRRLLDEVDEKRFRLDLYYRLAGIDVVLPPLRERRADLPALAAFLLKRLA
GGRRACRLDASGLAALQAYDFPGNVRELRNLLQRAVLTCRDGVIGAADLNLPVAAVTPVQPATQGLADIERAHIRALLAS
RGGHRGRVAQALGVTERTLYRKLKRYGLS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=312, Percent_Identity=44.5512820512821, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=44.7019867549669, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1789087, Length=331, Percent_Identity=42.5981873111783, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=40.1869158878505, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082152, Length=318, Percent_Identity=42.7672955974843, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789233, Length=453, Percent_Identity=34.2163355408389, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1790299, Length=346, Percent_Identity=38.4393063583815, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786524, Length=317, Percent_Identity=41.3249211356467, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788905, Length=304, Percent_Identity=38.8157894736842, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081872, Length=233, Percent_Identity=45.0643776824034, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=39.1025641025641, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=32.1917808219178, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=33.7254901960784, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 47077; Mature: 46946

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50112 PAS ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIELQDIIDANDQPFVVIDSAYRIVAANRRYAETYGATPEAIVGEHCYAVSHHSPRPC
CCCCCHHHHHCCCCCCEEEECCCEEEEECCCHHHHHCCCCCHHHHCCCEEEECCCCCCCC
HENGEQCPHRALFENGEAVEVVHTHFHANDQPERTRIRGHALRGPDGERYLGEQLYPLEA
CCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCHHHCCCCCCCCC
DIGLDCDAMQMVGQSPAFLACVDNLARVAESEASILLYGESGVGKELAARFIHARSQRRG
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCC
GAFIVINCAAVPETLFESELFGHERGAFSGSSGLKKGLFELADGGTLFLDEVAEIPLALQ
CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHCCHHHH
AKLLRVLETGEFRRVGGTHTLTADVRLVSATNRRLLDEVDEKRFRLDLYYRLAGIDVVLP
HHHHHHHHCCCCEECCCCEEEEEEEEEEEHHHHHHHHHHHHHHHEEEEEEEEECCEEECC
PLRERRADLPALAAFLLKRLAGGRRACRLDASGLAALQAYDFPGNVRELRNLLQRAVLTC
CHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
RDGVIGAADLNLPVAAVTPVQPATQGLADIERAHIRALLASRGGHRGRVAQALGVTERTL
CCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHH
YRKLKRYGLS
HHHHHHHCCC
>Mature Secondary Structure 
PSIELQDIIDANDQPFVVIDSAYRIVAANRRYAETYGATPEAIVGEHCYAVSHHSPRPC
CCCCHHHHHCCCCCCEEEECCCEEEEECCCHHHHHCCCCCHHHHCCCEEEECCCCCCCC
HENGEQCPHRALFENGEAVEVVHTHFHANDQPERTRIRGHALRGPDGERYLGEQLYPLEA
CCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCHHHCCCCCCCCC
DIGLDCDAMQMVGQSPAFLACVDNLARVAESEASILLYGESGVGKELAARFIHARSQRRG
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCC
GAFIVINCAAVPETLFESELFGHERGAFSGSSGLKKGLFELADGGTLFLDEVAEIPLALQ
CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHCCHHHH
AKLLRVLETGEFRRVGGTHTLTADVRLVSATNRRLLDEVDEKRFRLDLYYRLAGIDVVLP
HHHHHHHHCCCCEECCCCEEEEEEEEEEEHHHHHHHHHHHHHHHEEEEEEEEECCEEECC
PLRERRADLPALAAFLLKRLAGGRRACRLDASGLAALQAYDFPGNVRELRNLLQRAVLTC
CHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
RDGVIGAADLNLPVAAVTPVQPATQGLADIERAHIRALLASRGGHRGRVAQALGVTERTL
CCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHHH
YRKLKRYGLS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]