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The map label for this gene is alr

Identifier: 74318118

GI number: 74318118

Start: 2190267

End: 2191370

Strand: Reverse

Name: alr

Synonym: Tbd_2100

Alternate gene names: 74318118

Gene position: 2191370-2190267 (Counterclockwise)

Preceding gene: 74318119

Following gene: 74318115

Centisome position: 75.31

GC content: 68.84

Gene sequence:

>1104_bases
ATGCGTCCGATCAAAGCGTCGATCTCGGCGGACGCGATGGCCCACAACCTTCGCGTCGCACGGCGTCACGCCGGCGCCGC
GCGGGTGTTCGCCGTAGTGAAGGCGAACGCCTACGGTCACGGTCTGTCGCGCGCGTTGCGCGCCTTCGGGGCGGCCGACG
GCTTCGCGGTGCTGACGCTCGAGGAAGCGGCGAGCCTGCGGCAGATGGGTGTCGACAAGCCGATCCTGCTGCTCGAGGGC
ATCTTCGACGCCGGCGAGATTGCGGCTTGCGCCGAACTCGATCTCTGGCCGGTATTGCATCATGCCCGGCAGCTCGACTG
GCTCGAGCAACAGCGACCGGCGCGCGCGCTCGAGGTGTTTCTCAAATTCGACAGCGGGATGCATCGCCTTGGTTTTCCGC
TTGCCGAACACGCTGAGGTCGTCGCGCGGGTTCGAGCCCTGGCGGGCGTTGCGCGTGTCACGCTGATGACGCACTTTGCG
CAGGCCGACGACAGCGCCGGTGTCGCCTGGCAGTTGCAGCCGTTTCGGGAAGCGCTCGACGGCCATGGCCTGCCGTGGAG
CAGCGCGAATTCGGCGGCGCTCATGCGCTATCCAGAGACGGTCGGCGACTGGGTGCGTCCGGGCATCATGCTGTACGGCG
CCTCGCCGTTTACCGACGTCCCCGCCAGCGGGCTCGGCCTCGAGCCCGCGATGACGCTGCGCTCCGAAATCATCGCGGTG
CAGACGCTCGCGGCCGGCGAAGGCATCGGCTACGGCCAGACTTTTCGTGCCGACAAGCCGATGCGCGCCGGCGTCGTCGC
CTGCGGCTACGCCGACGGCTATCCGCGTCATGCGCCGACCGGCACACCGGTCGTCGTCGACGGCCGACGCACCCGGACGC
TCGGCCGCGTGTCGATGGATATGCTCTGCGTCGACCTCAGCGAATGTCCGGCCGCGGGGGTCGGAAGCGCGGTGGTGTTG
TGGGGCGACGGATTGCCGGTCGACGACGTCGCCGCGGCCGCCGGCACGAGCAGCTACGAATTGCTGTGCGCGCTCGCGCC
GAGAGTGCCGATCGAGGAAGTCGGCAGAAATCAGGAAGCGGGCAGGGGCTTCGGCAACGAGTGA

Upstream 100 bases:

>100_bases
AGCAGCGTAACGGCCCGATCGGCACGGTGCGGCTGGCTTTCCTCGGCGAGTACACGCGCTTCGAAACGCTGGCGCAGCCG
GGCTCGTACTAACCCTTCCG

Downstream 100 bases:

>100_bases
GGCAGCGCGTGCCGGGGCCTCACGCGACGAAGCACTCGAGGTGCCGCTCGCCGTCGACGAAACCGGCGATCGACAGCCGT
TTCACCTCGGCAGCGAGCGC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MRPIKASISADAMAHNLRVARRHAGAARVFAVVKANAYGHGLSRALRAFGAADGFAVLTLEEAASLRQMGVDKPILLLEG
IFDAGEIAACAELDLWPVLHHARQLDWLEQQRPARALEVFLKFDSGMHRLGFPLAEHAEVVARVRALAGVARVTLMTHFA
QADDSAGVAWQLQPFREALDGHGLPWSSANSAALMRYPETVGDWVRPGIMLYGASPFTDVPASGLGLEPAMTLRSEIIAV
QTLAAGEGIGYGQTFRADKPMRAGVVACGYADGYPRHAPTGTPVVVDGRRTRTLGRVSMDMLCVDLSECPAAGVGSAVVL
WGDGLPVDDVAAAAGTSSYELLCALAPRVPIEEVGRNQEAGRGFGNE

Sequences:

>Translated_367_residues
MRPIKASISADAMAHNLRVARRHAGAARVFAVVKANAYGHGLSRALRAFGAADGFAVLTLEEAASLRQMGVDKPILLLEG
IFDAGEIAACAELDLWPVLHHARQLDWLEQQRPARALEVFLKFDSGMHRLGFPLAEHAEVVARVRALAGVARVTLMTHFA
QADDSAGVAWQLQPFREALDGHGLPWSSANSAALMRYPETVGDWVRPGIMLYGASPFTDVPASGLGLEPAMTLRSEIIAV
QTLAAGEGIGYGQTFRADKPMRAGVVACGYADGYPRHAPTGTPVVVDGRRTRTLGRVSMDMLCVDLSECPAAGVGSAVVL
WGDGLPVDDVAAAAGTSSYELLCALAPRVPIEEVGRNQEAGRGFGNE
>Mature_367_residues
MRPIKASISADAMAHNLRVARRHAGAARVFAVVKANAYGHGLSRALRAFGAADGFAVLTLEEAASLRQMGVDKPILLLEG
IFDAGEIAACAELDLWPVLHHARQLDWLEQQRPARALEVFLKFDSGMHRLGFPLAEHAEVVARVRALAGVARVTLMTHFA
QADDSAGVAWQLQPFREALDGHGLPWSSANSAALMRYPETVGDWVRPGIMLYGASPFTDVPASGLGLEPAMTLRSEIIAV
QTLAAGEGIGYGQTFRADKPMRAGVVACGYADGYPRHAPTGTPVVVDGRRTRTLGRVSMDMLCVDLSECPAAGVGSAVVL
WGDGLPVDDVAAAAGTSSYELLCALAPRVPIEEVGRNQEAGRGFGNE

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=356, Percent_Identity=51.9662921348315, Blast_Score=344, Evalue=4e-96,
Organism=Escherichia coli, GI1790487, Length=358, Percent_Identity=41.8994413407821, Blast_Score=264, Evalue=8e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_THIDA (Q3SH36)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315858.1
- HSSP:   P10724
- ProteinModelPortal:   Q3SH36
- SMR:   Q3SH36
- STRING:   Q3SH36
- GeneID:   3672872
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2100
- NMPDR:   fig|292415.3.peg.2276
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   GTHADWV
- PhylomeDB:   Q3SH36
- BioCyc:   TDEN292415:TBD_2100-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38941; Mature: 38941

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 34-34 ACT_SITE 251-251

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPIKASISADAMAHNLRVARRHAGAARVFAVVKANAYGHGLSRALRAFGAADGFAVLTL
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEH
EEAASLRQMGVDKPILLLEGIFDAGEIAACAELDLWPVLHHARQLDWLEQQRPARALEVF
HHHHHHHHHCCCCCEEHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LKFDSGMHRLGFPLAEHAEVVARVRALAGVARVTLMTHFAQADDSAGVAWQLQPFREALD
HHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHC
GHGLPWSSANSAALMRYPETVGDWVRPGIMLYGASPFTDVPASGLGLEPAMTLRSEIIAV
CCCCCCCCCCCCEEEECCHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
QTLAAGEGIGYGQTFRADKPMRAGVVACGYADGYPRHAPTGTPVVVDGRRTRTLGRVSMD
HHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHH
MLCVDLSECPAAGVGSAVVLWGDGLPVDDVAAAAGTSSYELLCALAPRVPIEEVGRNQEA
HHEEEHHHCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCC
GRGFGNE
CCCCCCC
>Mature Secondary Structure
MRPIKASISADAMAHNLRVARRHAGAARVFAVVKANAYGHGLSRALRAFGAADGFAVLTL
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEH
EEAASLRQMGVDKPILLLEGIFDAGEIAACAELDLWPVLHHARQLDWLEQQRPARALEVF
HHHHHHHHHCCCCCEEHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LKFDSGMHRLGFPLAEHAEVVARVRALAGVARVTLMTHFAQADDSAGVAWQLQPFREALD
HHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHC
GHGLPWSSANSAALMRYPETVGDWVRPGIMLYGASPFTDVPASGLGLEPAMTLRSEIIAV
CCCCCCCCCCCCEEEECCHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
QTLAAGEGIGYGQTFRADKPMRAGVVACGYADGYPRHAPTGTPVVVDGRRTRTLGRVSMD
HHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHH
MLCVDLSECPAAGVGSAVVLWGDGLPVDDVAAAAGTSSYELLCALAPRVPIEEVGRNQEA
HHEEEHHHCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCC
GRGFGNE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA