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The map label for this gene is mucB [H]

Identifier: 74318111

GI number: 74318111

Start: 2184647

End: 2185603

Strand: Reverse

Name: mucB [H]

Synonym: Tbd_2093

Alternate gene names: 74318111

Gene position: 2185603-2184647 (Counterclockwise)

Preceding gene: 74318112

Following gene: 74318110

Centisome position: 75.11

GC content: 66.46

Gene sequence:

>957_bases
ATGCGGCGGTACAGGGTGGCGCGGCAAGCGGTGCTTGCCGCGGGCTTCGCCGGGCTCATGCTGCTGTCCGGCCTCGCGCG
GGCAAACAGCGCCCTCGAGTGGCTGCAGCGAGCCGCGAGCGCGGCCAAAGAGCAGAATTACAGCGGCATCTACGTCTACC
ATCACGGCGATGAGGTCGAGGTCTTGCGTGTCCTGCACCGCAACGACGGCAGGCGCGAGCAGGAAAAAACCGAGGTGATG
GACGGGACGCAGCGCCATTTCCTGCGTGTCAACAGCGACGTGTATTGCCATCTGGCGGACGGAAAGCAGGTGCGCCTCGA
GCGCAACGCGTCCCGGCGCTTCTTTCCCGCCTTTCTGCCCGCGCGCGCGGCCGGGCTCGCCGAGCTTTACGAGGTCAAGC
TCGGCGGCGTCGAACGCGTCGCGGGGCGGCCATGCCAGGTCGTGATGCTGGAGCCGCGCGACGGCTATCGGCACGCCTTC
CAACTGTGGCTCGACAGCCGCACCGGCCTGCCCCTCAAGTCGCGCATCGTCAACAGCGACGGCGAGGTCGTGTCGATGTT
CGTTTTTTCGGAAGTACAGATCGGAAGGCCTCCGGACGCCAGCCTTTTCCGCAATGAGCTCGCCGGCAAGCAGGTCCAGC
AGGTCAGCCTCGGGCAGCGTATCGACCTGCCGTGGAGCGTGACGCCGCCCCCCGGATTCGAGCGGGTCCAGGAGGCGGTA
CGGACCCTGCCCGGCAGGAACACCCCGGTCACCCACCTCGTATTCTCGGACGGCCTGAGCGTCCTGTCGATGTTCATCGA
GCCGGCCGATCCGGGCGTGCCAAGCCTGCAAGGGCTGTCGGCGGAAGGCGCGATCGGCGTCTACGCGCGCGCACTCGACG
GACACACGATCACGACGGTCGGAGAAGTGCCGAATCTCGCATTGATAGAAACCGGCAATTCGGTCAGAAGGAAGTAG

Upstream 100 bases:

>100_bases
AATTCGCGCCCTACGTCGTCGCGCATCAGGAGTTCGCGCCGAGCGCAGTGGCGACGCCGGTTTTTGAACCCGTCGTGGCA
GTAGGCATGGAGCCGCGCTG

Downstream 100 bases:

>100_bases
CGCACCACCCATGCTGGAACAGACAGCGGAGATCGTCAAAACCGCACCCGAGGGCGTCTGGGTGCGCGCCGTGGAGCCGT
CGGGCTGCGGCAGTTGCGGT

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRRYRVARQAVLAAGFAGLMLLSGLARANSALEWLQRAASAAKEQNYSGIYVYHHGDEVEVLRVLHRNDGRREQEKTEVM
DGTQRHFLRVNSDVYCHLADGKQVRLERNASRRFFPAFLPARAAGLAELYEVKLGGVERVAGRPCQVVMLEPRDGYRHAF
QLWLDSRTGLPLKSRIVNSDGEVVSMFVFSEVQIGRPPDASLFRNELAGKQVQQVSLGQRIDLPWSVTPPPGFERVQEAV
RTLPGRNTPVTHLVFSDGLSVLSMFIEPADPGVPSLQGLSAEGAIGVYARALDGHTITTVGEVPNLALIETGNSVRRK

Sequences:

>Translated_318_residues
MRRYRVARQAVLAAGFAGLMLLSGLARANSALEWLQRAASAAKEQNYSGIYVYHHGDEVEVLRVLHRNDGRREQEKTEVM
DGTQRHFLRVNSDVYCHLADGKQVRLERNASRRFFPAFLPARAAGLAELYEVKLGGVERVAGRPCQVVMLEPRDGYRHAF
QLWLDSRTGLPLKSRIVNSDGEVVSMFVFSEVQIGRPPDASLFRNELAGKQVQQVSLGQRIDLPWSVTPPPGFERVQEAV
RTLPGRNTPVTHLVFSDGLSVLSMFIEPADPGVPSLQGLSAEGAIGVYARALDGHTITTVGEVPNLALIETGNSVRRK
>Mature_318_residues
MRRYRVARQAVLAAGFAGLMLLSGLARANSALEWLQRAASAAKEQNYSGIYVYHHGDEVEVLRVLHRNDGRREQEKTEVM
DGTQRHFLRVNSDVYCHLADGKQVRLERNASRRFFPAFLPARAAGLAELYEVKLGGVERVAGRPCQVVMLEPRDGYRHAF
QLWLDSRTGLPLKSRIVNSDGEVVSMFVFSEVQIGRPPDASLFRNELAGKQVQQVSLGQRIDLPWSVTPPPGFERVQEAV
RTLPGRNTPVTHLVFSDGLSVLSMFIEPADPGVPSLQGLSAEGAIGVYARALDGHTITTVGEVPNLALIETGNSVRRK

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=294, Percent_Identity=26.1904761904762, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 35164; Mature: 35164

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRYRVARQAVLAAGFAGLMLLSGLARANSALEWLQRAASAAKEQNYSGIYVYHHGDEVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHH
VLRVLHRNDGRREQEKTEVMDGTQRHFLRVNSDVYCHLADGKQVRLERNASRRFFPAFLP
HHHHHHCCCCCCHHHHHHHHCCCCHHEEEECCCEEEEECCCCEEEEECCCCCCCCHHHHH
ARAAGLAELYEVKLGGVERVAGRPCQVVMLEPRDGYRHAFQLWLDSRTGLPLKSRIVNSD
HHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCCCHHHHHHHEECCCCCCCHHHHEECCC
GEVVSMFVFSEVQIGRPPDASLFRNELAGKQVQQVSLGQRIDLPWSVTPPPGFERVQEAV
CCEEEEEEEEHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RTLPGRNTPVTHLVFSDGLSVLSMFIEPADPGVPSLQGLSAEGAIGVYARALDGHTITTV
HHCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
GEVPNLALIETGNSVRRK
CCCCCEEEEECCCHHCCC
>Mature Secondary Structure
MRRYRVARQAVLAAGFAGLMLLSGLARANSALEWLQRAASAAKEQNYSGIYVYHHGDEVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHH
VLRVLHRNDGRREQEKTEVMDGTQRHFLRVNSDVYCHLADGKQVRLERNASRRFFPAFLP
HHHHHHCCCCCCHHHHHHHHCCCCHHEEEECCCEEEEECCCCEEEEECCCCCCCCHHHHH
ARAAGLAELYEVKLGGVERVAGRPCQVVMLEPRDGYRHAFQLWLDSRTGLPLKSRIVNSD
HHHHHHHHHHHHHCCCHHHHCCCCEEEEEECCCCCHHHHHHHEECCCCCCCHHHHEECCC
GEVVSMFVFSEVQIGRPPDASLFRNELAGKQVQQVSLGQRIDLPWSVTPPPGFERVQEAV
CCEEEEEEEEHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RTLPGRNTPVTHLVFSDGLSVLSMFIEPADPGVPSLQGLSAEGAIGVYARALDGHTITTV
HHCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
GEVPNLALIETGNSVRRK
CCCCCEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]