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The map label for this gene is lepB [H]

Identifier: 74318106

GI number: 74318106

Start: 2179897

End: 2180706

Strand: Reverse

Name: lepB [H]

Synonym: Tbd_2088

Alternate gene names: 74318106

Gene position: 2180706-2179897 (Counterclockwise)

Preceding gene: 74318107

Following gene: 74318105

Centisome position: 74.94

GC content: 61.11

Gene sequence:

>810_bases
ATGAACTTCGCCCTCATTCTGTTCGTCGCGCTCGTCGTCACCGGCGGCATCTGGCTGCTCGATGCGCTGTTGTTGAAGCG
CGGCCGCGACAAGGACGCGCGCGAGCCGCTCCTGGTCGAATATGCGAAAAGCTTTTTCCCGGTCATCCTGATCGTGTTCG
GCCTGCGCTCCTTCCTGGTCGAGCCGTTCAAGATCCCGTCGGGATCGATGATGCCGACGCTGCTGATCGGCGACTTCATC
CTGGTCAACAAATACACCTACGGCATCCGTCTGCCGGTCATCAACAAGAAGATCGTCCAGCTCAACAACCCGGAGCGCGG
CGACGTGATGGTGTTCCGTTATCCGGCCGATCCCGGCCTCGACTACATCAAGCGCGTGGTCGGCGTGCCGGGCGACGTCG
TCGAGTACCGCGAAAAGAAGCTCAGCGTCAACGGCCGCGCCGTGCCCGTGCGCAACACCGGCACCTACAGCTACGTCGGC
AACGGTCTCAATTACATCACGGCGATGGTGTACGACGAACGGCTGAACGGCACCGGCCACACAATGATGGTCGAACCGGG
CAAGCCCTCGGTCGCGTCGGCGCAGGTGATGGATTTTCCTCAGCGCGAGAACTGCTCCTACAATGCCGACGGAGAAGGCT
TCGTCTGCAAGGTGCCGCCCGGCCAGTACTTCATGATGGGCGACAACCGCGACGCCAGCAACGACAGCCGCTACTGGGGC
TTCGTGCCGGACAGGAACATCGTCGGCAAGGCCTTTTTCATCTGGATGAACTTCGACGACTTCGGTCGAATCGGCACCAC
GATCCGATAA

Upstream 100 bases:

>100_bases
TGCTCGAAAAACAGAAGGCCGGCAAGCGCCGCATGAAGCAGGTCGGCAACGTCGAAATCCCGCAGGAAGCCTTTCTTGCG
ATCCTCCAGGTCTCGGATAA

Downstream 100 bases:

>100_bases
TCAACAAACAATCAAGGAGAACTCATGGATTGCGCCTCCCTCCGCGCCGGGCAACGCGGCCTGAGCCTGTTCGGTTTCCT
GTTCGTCATCGCCATGCTTG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNFALILFVALVVTGGIWLLDALLLKRGRDKDAREPLLVEYAKSFFPVILIVFGLRSFLVEPFKIPSGSMMPTLLIGDFI
LVNKYTYGIRLPVINKKIVQLNNPERGDVMVFRYPADPGLDYIKRVVGVPGDVVEYREKKLSVNGRAVPVRNTGTYSYVG
NGLNYITAMVYDERLNGTGHTMMVEPGKPSVASAQVMDFPQRENCSYNADGEGFVCKVPPGQYFMMGDNRDASNDSRYWG
FVPDRNIVGKAFFIWMNFDDFGRIGTTIR

Sequences:

>Translated_269_residues
MNFALILFVALVVTGGIWLLDALLLKRGRDKDAREPLLVEYAKSFFPVILIVFGLRSFLVEPFKIPSGSMMPTLLIGDFI
LVNKYTYGIRLPVINKKIVQLNNPERGDVMVFRYPADPGLDYIKRVVGVPGDVVEYREKKLSVNGRAVPVRNTGTYSYVG
NGLNYITAMVYDERLNGTGHTMMVEPGKPSVASAQVMDFPQRENCSYNADGEGFVCKVPPGQYFMMGDNRDASNDSRYWG
FVPDRNIVGKAFFIWMNFDDFGRIGTTIR
>Mature_269_residues
MNFALILFVALVVTGGIWLLDALLLKRGRDKDAREPLLVEYAKSFFPVILIVFGLRSFLVEPFKIPSGSMMPTLLIGDFI
LVNKYTYGIRLPVINKKIVQLNNPERGDVMVFRYPADPGLDYIKRVVGVPGDVVEYREKKLSVNGRAVPVRNTGTYSYVG
NGLNYITAMVYDERLNGTGHTMMVEPGKPSVASAQVMDFPQRENCSYNADGEGFVCKVPPGQYFMMGDNRDASNDSRYWG
FVPDRNIVGKAFFIWMNFDDFGRIGTTIR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=312, Percent_Identity=41.3461538461538, Blast_Score=202, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 30253; Mature: 30253

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVALVVTGGIWLLDALLLKRGRDKDAREPLLVEYAKSFFPVILIVFGLRSFLV
CCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
EPFKIPSGSMMPTLLIGDFILVNKYTYGIRLPVINKKIVQLNNPERGDVMVFRYPADPGL
CCEECCCCCCCHHHHHCCEEEEEEEEEEEEEEECCCEEEEECCCCCCCEEEEEECCCCCH
DYIKRVVGVPGDVVEYREKKLSVNGRAVPVRNTGTYSYVGNGLNYITAMVYDERLNGTGH
HHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHCCCHHHEEEEEEHHHCCCCCC
TMMVEPGKPSVASAQVMDFPQRENCSYNADGEGFVCKVPPGQYFMMGDNRDASNDSRYWG
EEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCEEE
FVPDRNIVGKAFFIWMNFDDFGRIGTTIR
CCCCCCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNFALILFVALVVTGGIWLLDALLLKRGRDKDAREPLLVEYAKSFFPVILIVFGLRSFLV
CCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
EPFKIPSGSMMPTLLIGDFILVNKYTYGIRLPVINKKIVQLNNPERGDVMVFRYPADPGL
CCEECCCCCCCHHHHHCCEEEEEEEEEEEEEEECCCEEEEECCCCCCCEEEEEECCCCCH
DYIKRVVGVPGDVVEYREKKLSVNGRAVPVRNTGTYSYVGNGLNYITAMVYDERLNGTGH
HHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHCCCHHHEEEEEEHHHCCCCCC
TMMVEPGKPSVASAQVMDFPQRENCSYNADGEGFVCKVPPGQYFMMGDNRDASNDSRYWG
EEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCEEE
FVPDRNIVGKAFFIWMNFDDFGRIGTTIR
CCCCCCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]