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The map label for this gene is rnc

Identifier: 74318104

GI number: 74318104

Start: 2178804

End: 2179484

Strand: Reverse

Name: rnc

Synonym: Tbd_2086

Alternate gene names: 74318104

Gene position: 2179484-2178804 (Counterclockwise)

Preceding gene: 74318105

Following gene: 74318103

Centisome position: 74.9

GC content: 69.16

Gene sequence:

>681_bases
TTGAATAACGCCTTGCTCGACGCGCGCCTGCAGCAGGCGCTCGGCTACACCTTCTCGCGTTCGGGCCTCCTGCAGCAGGC
ACTGACGCATCGCAGCTACGGTGCGCTCAACAACGAGCGGCTCGAGTTTCTCGGCGACTCGGTGCTCAACTGCAGCGTCG
CGCGCGCGCTTTACGACGCCTTCCCGGACCTGCCTGAAGGCAGCCTGTCGCGGCTGCGCGCGAACCTCGTGCGCCAGGAA
ACGCTTGCCGAGATCGCGGGCGCGCTGCGGCTCGGCGACTCGCTCCGGCTCGGCGAGGGCGAACTCAAGAGCGGCGGCTT
CCGCCGCCCGTCCATCCTCGCCGACGCGCTCGAATCGCTGTTCGGCGCGGTGTTCCTCGATGCCGGTTTCGACGAGGCGC
AGCGCGTCGTGCGGCGGCTGTTCGATCCGCTCGTCGCGCAGATCGACCCCAAGGCCTCGGGCAAGGACCCGAAGACGCGG
CTGCAGGAAATTCTCCAGTCCCGCCGGCTGCCGCTGCCCGAATACCGCCTCGTCGGTACCGAAGGCGAGGCGCACGACCA
GAGCTTCATCGTCGAATGCCTGCTCGCCAAGCCGGTGTTGAGCACGCGCGGCACCGGCAAGAGCCGCCGTGCCGCGGAAC
AGGAGGCGGCGCGCCAGGCCTGCGCCGAATTGCAGCGATGA

Upstream 100 bases:

>100_bases
GTCATCTCGGCCGAGTATGAGTTCCGCACCCAGCTCGTCGGCAACGTGAGCCTCGTGGTCGACTTCGCCGCGAGCACCGA
TCCCGCCGCCGTCCGCGACA

Downstream 100 bases:

>100_bases
ACGTCTCTACCGAATACCGCTGCGGCCTCGTCGCCATCGTCGGCCGTCCCAACGTCGGCAAGTCGACGCTGCTCAATCGC
CTGGTCGGGCAGAAGGTCAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNNALLDARLQQALGYTFSRSGLLQQALTHRSYGALNNERLEFLGDSVLNCSVARALYDAFPDLPEGSLSRLRANLVRQE
TLAEIAGALRLGDSLRLGEGELKSGGFRRPSILADALESLFGAVFLDAGFDEAQRVVRRLFDPLVAQIDPKASGKDPKTR
LQEILQSRRLPLPEYRLVGTEGEAHDQSFIVECLLAKPVLSTRGTGKSRRAAEQEAARQACAELQR

Sequences:

>Translated_226_residues
MNNALLDARLQQALGYTFSRSGLLQQALTHRSYGALNNERLEFLGDSVLNCSVARALYDAFPDLPEGSLSRLRANLVRQE
TLAEIAGALRLGDSLRLGEGELKSGGFRRPSILADALESLFGAVFLDAGFDEAQRVVRRLFDPLVAQIDPKASGKDPKTR
LQEILQSRRLPLPEYRLVGTEGEAHDQSFIVECLLAKPVLSTRGTGKSRRAAEQEAARQACAELQR
>Mature_226_residues
MNNALLDARLQQALGYTFSRSGLLQQALTHRSYGALNNERLEFLGDSVLNCSVARALYDAFPDLPEGSLSRLRANLVRQE
TLAEIAGALRLGDSLRLGEGELKSGGFRRPSILADALESLFGAVFLDAGFDEAQRVVRRLFDPLVAQIDPKASGKDPKTR
LQEILQSRRLPLPEYRLVGTEGEAHDQSFIVECLLAKPVLSTRGTGKSRRAAEQEAARQACAELQR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=28.7610619469027, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=28.7610619469027, Blast_Score=85, Evalue=6e-17,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=54.5023696682464, Blast_Score=221, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=29.8701298701299, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=29.8701298701299, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323895, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=226, Percent_Identity=29.2035398230088, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_THIDA (Q3SH50)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315844.1
- ProteinModelPortal:   Q3SH50
- SMR:   Q3SH50
- STRING:   Q3SH50
- GeneID:   3672258
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2086
- NMPDR:   fig|292415.3.peg.2241
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q3SH50
- ProtClustDB:   PRK00102
- BioCyc:   TDEN292415:TBD_2086-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 24820; Mature: 24820

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNALLDARLQQALGYTFSRSGLLQQALTHRSYGALNNERLEFLGDSVLNCSVARALYDA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
FPDLPEGSLSRLRANLVRQETLAEIAGALRLGDSLRLGEGELKSGGFRRPSILADALESL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FGAVFLDAGFDEAQRVVRRLFDPLVAQIDPKASGKDPKTRLQEILQSRRLPLPEYRLVGT
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECC
EGEAHDQSFIVECLLAKPVLSTRGTGKSRRAAEQEAARQACAELQR
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNALLDARLQQALGYTFSRSGLLQQALTHRSYGALNNERLEFLGDSVLNCSVARALYDA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
FPDLPEGSLSRLRANLVRQETLAEIAGALRLGDSLRLGEGELKSGGFRRPSILADALESL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FGAVFLDAGFDEAQRVVRRLFDPLVAQIDPKASGKDPKTRLQEILQSRRLPLPEYRLVGT
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECC
EGEAHDQSFIVECLLAKPVLSTRGTGKSRRAAEQEAARQACAELQR
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA