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The map label for this gene is era [H]

Identifier: 74318103

GI number: 74318103

Start: 2177914

End: 2178807

Strand: Reverse

Name: era [H]

Synonym: Tbd_2085

Alternate gene names: 74318103

Gene position: 2178807-2177914 (Counterclockwise)

Preceding gene: 74318104

Following gene: 74318102

Centisome position: 74.88

GC content: 64.77

Gene sequence:

>894_bases
ATGAACGTCTCTACCGAATACCGCTGCGGCCTCGTCGCCATCGTCGGCCGTCCCAACGTCGGCAAGTCGACGCTGCTCAA
TCGCCTGGTCGGGCAGAAGGTCAGCATCACCTCGCGCAAGGCGCAGACGACGCGTCACCGCGTCATGGGGATCCACACCA
CCGACAGGGCGCAGTTCGTGTTCGTCGACACGCCGGGCTTCCAGACACGGCACACGAGCACGATGAACCGTGCGATGAAC
AAGCGCGTGCGCGAAACCCTGTCCGACACCGACGTCGTCATGATGCTGGTCGAGGCAGGGCGGCTCACGCGCGAGGATCG
TCAGGTCATGGAACTGCTGCCGAAGGACCGGCCGCTGCTGCTCGTCGTGAACAAGGTCGACCAGGCGAAGGACCGCGCCG
CCTTGATGGCCTACCTGCAGCAGGTCGCGGCGGCGCACGCCTTCACCGAGATCGTGCCGGTCTCGGCCAAGCAGGGCAGC
AACCTCGACGAACTGCTGAAGACGCTCGAGAAGCATCTGCCGGAGAACCCGCCGCTCTTCGGCGAGGACCACGTGACCGA
CCAGACCGAGCGCCAGCTCGCGGCCGAGCTCATCCGCGAAAAGGTCTTCCGCCTGTGCGGCGAAGAGATTCCCTACGCCG
TCGCCGTCGTCATCGACAAGTTCGAGGAAGAGGGAAACCTGCGGCGCATCTTCGCGACCATCCTCGTCGACCGCGACAGC
CACAAGGCGATCGTGATCGGCAAGGGCGGGGAAAAGCTCAAGACCATTTCGACCCAGGCCCGGCTCGACATGGAGCATGC
CTTCGACGGCAGGGTCTATCTCGAAGTGTGGGTCAAGGTCAAGGGCGGCTGGGCCGACGACCTGCGCACGCTGAAATCGC
TCGGCCTGGATTGA

Upstream 100 bases:

>100_bases
GCCTGCTCGCCAAGCCGGTGTTGAGCACGCGCGGCACCGGCAAGAGCCGCCGTGCCGCGGAACAGGAGGCGGCGCGCCAG
GCCTGCGCCGAATTGCAGCG

Downstream 100 bases:

>100_bases
CTATTTTTCCCGGGCGCAGGCACGAAGGTGCACGGAAAGAGTCGAATCGCAATCGATGCCCGCCTCGCGGTCCCTAGGCA
TGTCGAGCGACGCCCGCGTT

Product: GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNVSTEYRCGLVAIVGRPNVGKSTLLNRLVGQKVSITSRKAQTTRHRVMGIHTTDRAQFVFVDTPGFQTRHTSTMNRAMN
KRVRETLSDTDVVMMLVEAGRLTREDRQVMELLPKDRPLLLVVNKVDQAKDRAALMAYLQQVAAAHAFTEIVPVSAKQGS
NLDELLKTLEKHLPENPPLFGEDHVTDQTERQLAAELIREKVFRLCGEEIPYAVAVVIDKFEEEGNLRRIFATILVDRDS
HKAIVIGKGGEKLKTISTQARLDMEHAFDGRVYLEVWVKVKGGWADDLRTLKSLGLD

Sequences:

>Translated_297_residues
MNVSTEYRCGLVAIVGRPNVGKSTLLNRLVGQKVSITSRKAQTTRHRVMGIHTTDRAQFVFVDTPGFQTRHTSTMNRAMN
KRVRETLSDTDVVMMLVEAGRLTREDRQVMELLPKDRPLLLVVNKVDQAKDRAALMAYLQQVAAAHAFTEIVPVSAKQGS
NLDELLKTLEKHLPENPPLFGEDHVTDQTERQLAAELIREKVFRLCGEEIPYAVAVVIDKFEEEGNLRRIFATILVDRDS
HKAIVIGKGGEKLKTISTQARLDMEHAFDGRVYLEVWVKVKGGWADDLRTLKSLGLD
>Mature_297_residues
MNVSTEYRCGLVAIVGRPNVGKSTLLNRLVGQKVSITSRKAQTTRHRVMGIHTTDRAQFVFVDTPGFQTRHTSTMNRAMN
KRVRETLSDTDVVMMLVEAGRLTREDRQVMELLPKDRPLLLVVNKVDQAKDRAALMAYLQQVAAAHAFTEIVPVSAKQGS
NLDELLKTLEKHLPENPPLFGEDHVTDQTERQLAAELIREKVFRLCGEEIPYAVAVVIDKFEEEGNLRRIFATILVDRDS
HKAIVIGKGGEKLKTISTQARLDMEHAFDGRVYLEVWVKVKGGWADDLRTLKSLGLD

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=321, Percent_Identity=26.791277258567, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1788919, Length=298, Percent_Identity=48.993288590604, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI87082120, Length=159, Percent_Identity=29.559748427673, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646434, Length=319, Percent_Identity=26.3322884012539, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550813, Length=184, Percent_Identity=31.5217391304348, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33425; Mature: 33425

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSTEYRCGLVAIVGRPNVGKSTLLNRLVGQKVSITSRKAQTTRHRVMGIHTTDRAQFV
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHEEEEEECCCEEEE
FVDTPGFQTRHTSTMNRAMNKRVRETLSDTDVVMMLVEAGRLTREDRQVMELLPKDRPLL
EEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEE
LVVNKVDQAKDRAALMAYLQQVAAAHAFTEIVPVSAKQGSNLDELLKTLEKHLPENPPLF
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCCCCC
GEDHVTDQTERQLAAELIREKVFRLCGEEIPYAVAVVIDKFEEEGNLRRIFATILVDRDS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECCC
HKAIVIGKGGEKLKTISTQARLDMEHAFDGRVYLEVWVKVKGGWADDLRTLKSLGLD
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MNVSTEYRCGLVAIVGRPNVGKSTLLNRLVGQKVSITSRKAQTTRHRVMGIHTTDRAQFV
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHEEEEEECCCEEEE
FVDTPGFQTRHTSTMNRAMNKRVRETLSDTDVVMMLVEAGRLTREDRQVMELLPKDRPLL
EEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEE
LVVNKVDQAKDRAALMAYLQQVAAAHAFTEIVPVSAKQGSNLDELLKTLEKHLPENPPLF
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCCCCC
GEDHVTDQTERQLAAELIREKVFRLCGEEIPYAVAVVIDKFEEEGNLRRIFATILVDRDS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECCC
HKAIVIGKGGEKLKTISTQARLDMEHAFDGRVYLEVWVKVKGGWADDLRTLKSLGLD
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]