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The map label for this gene is pgi2 [H]

Identifier: 74318081

GI number: 74318081

Start: 2154354

End: 2156036

Strand: Reverse

Name: pgi2 [H]

Synonym: Tbd_2063

Alternate gene names: 74318081

Gene position: 2156036-2154354 (Counterclockwise)

Preceding gene: 74318083

Following gene: 74318080

Centisome position: 74.1

GC content: 64.53

Gene sequence:

>1683_bases
ATGGTTTCATCAGTACTTGTGCGCACCGGCGACACGAGGACGTCGGGGCTTTCGACGCGCCCCGTCCATCGGCTGCTGCA
GGCGCATCATTCGCGCATGGCCGACGTGCATATGCGCGAACTCTTCGATACCGACCCGCAGCGTTTCGAGCGTTTTTCGC
TGCAGGTCGGCGATCTCCTGCTCGACTACTCGAAGAACCGGATCACCGACGAGACGATGGATCTTCTCGTGCGGATGGCC
GAGGAGTCGGACGTCGCCGGCTGGCGCGAGCGCATGTTTCGCGGCGACAAGATCAACACGACCGAGAATCGGGCCGTGCT
GCACGTCGCGCTGCGCAACCGCAGCAACCGTCCGGTGAACGTCGACGGCGAGGACGTCATGCCCAAGGTCAACGCGGTCA
TCGAGCGCATGGGCGCCTTCGCCGAGCAGGTCAGAGGCGGAGTCTGGCGCGGCTACAGCGGCGCGCTGATCACCGACGTC
GTGAACATCGGCATCGGCGGCTCCGACCTCGGCCCGCAGATGGTCGTGCAGGCGCTCAAGCCCTACCGCCATCCCCGTTT
GAAGCTGCACTTCATTTCCAACGTCGACGGCGCCCACGTCAAGGAGACGCTCGAGGCGCTCGACCCCGAGACGACGCTCT
TCATCGTCTCGTCGAAGACCTTCACCACCCAGGAGACGATGACCAACGCGCATTACGCGCGCGACTGGTTTCTCGCCCGC
GCCGGCGACGTCGCGCATGTCGCACGGCACTTTGTCGCGGTGTCGACCAATCGCGACGCGGTCACGGCCTTCGGCATCGA
CGCCGCCAACATGTTCGAATTCTGGGACTGGGTCGGTGGGCGCTATTCGCTGTGGTCGGCGATCGGCCTGTCGATCGTCC
TCGCCGTCGGCGCCGAGCGCTTCCTCGAACTGCTCGAAGGCGCGCACGAGATGGATGAGCATTTCCGCCACGCGCCGCTG
CGGCAGAACATGCCCGTGATCCTGGCGCTGCTGGGCATCTGGTACAACAATTTCTTCGGCGCCGAGTCTCACGCGATCCT
GCCTTACGACCATTATTTGCGCAGCCTGCCCGCCTATCTCGAGCAGGCCGACATGGAATCGAACGGGAAGTCGGTCGACC
GCGACGGACGCGTCGTCGACTACCCGACCGGGCAGATCATCTGGGGCGCGACCGGCATCAACGGGCAGCATGCCTTCTAC
CAGTTGCTGCACCAGGGCACGAAGATGATTCCGGCCGACTTCATCGTGTCGATCACGCCGCATACCGAACTGCAGGAGCA
CCACGACATCCTGATCGCCAATTTCCTCGCGCAGACCGAGGCGCTCATGCGCGGGCGCACGCGCGAGGAGACGCTGGAGG
AAATGGGTCGCAGCCCCGGCGACCCGTCGGTCCAGCACCGCGTGTTCGAGGGCAATCATCCGAGCAACGCGATCCTGCTG
AAGAAGCTGACGCCGCACACGTTGGGCATGTTGATCGCGCTGTACGAACACAAGATCTTCGTCGAGGGCGTAATCTGGAA
CCTCAACTCCTACGACCAGTGGGGGGTGGAACTCGGCAAGCAGCTCGCAGGGCGGATCCTGCCGGAGCTGCACGCCGACG
CGCCCGTCGCGGGACACGACGCCTCGACCAACGCGCTGATCAACCACTACCGTCGCATGACGCAGCCGCATCCCGGGCTC
TGA

Upstream 100 bases:

>100_bases
GATGCGGGAACGGCGTTTGCTGGCAAGGGTCGAAGGCCTGCGGGCGGCAATCCGGGAGGGATCGGGCCCGCAGGCCGGTG
ATTTGAGAAAGGGAAAACGC

Downstream 100 bases:

>100_bases
GCGGCATGGAGTGGATCGCAGGCGACATCGGAGGAACGAAGAGCTGGCTCGTGTGGATCGGGCCGCCTGGCGACGGCCTG
CACCCGCGCTTCGAGCGCGT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI 2; Phosphoglucose isomerase 2; PGI 2; Phosphohexose isomerase 2; PHI 2 [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MVSSVLVRTGDTRTSGLSTRPVHRLLQAHHSRMADVHMRELFDTDPQRFERFSLQVGDLLLDYSKNRITDETMDLLVRMA
EESDVAGWRERMFRGDKINTTENRAVLHVALRNRSNRPVNVDGEDVMPKVNAVIERMGAFAEQVRGGVWRGYSGALITDV
VNIGIGGSDLGPQMVVQALKPYRHPRLKLHFISNVDGAHVKETLEALDPETTLFIVSSKTFTTQETMTNAHYARDWFLAR
AGDVAHVARHFVAVSTNRDAVTAFGIDAANMFEFWDWVGGRYSLWSAIGLSIVLAVGAERFLELLEGAHEMDEHFRHAPL
RQNMPVILALLGIWYNNFFGAESHAILPYDHYLRSLPAYLEQADMESNGKSVDRDGRVVDYPTGQIIWGATGINGQHAFY
QLLHQGTKMIPADFIVSITPHTELQEHHDILIANFLAQTEALMRGRTREETLEEMGRSPGDPSVQHRVFEGNHPSNAILL
KKLTPHTLGMLIALYEHKIFVEGVIWNLNSYDQWGVELGKQLAGRILPELHADAPVAGHDASTNALINHYRRMTQPHPGL

Sequences:

>Translated_560_residues
MVSSVLVRTGDTRTSGLSTRPVHRLLQAHHSRMADVHMRELFDTDPQRFERFSLQVGDLLLDYSKNRITDETMDLLVRMA
EESDVAGWRERMFRGDKINTTENRAVLHVALRNRSNRPVNVDGEDVMPKVNAVIERMGAFAEQVRGGVWRGYSGALITDV
VNIGIGGSDLGPQMVVQALKPYRHPRLKLHFISNVDGAHVKETLEALDPETTLFIVSSKTFTTQETMTNAHYARDWFLAR
AGDVAHVARHFVAVSTNRDAVTAFGIDAANMFEFWDWVGGRYSLWSAIGLSIVLAVGAERFLELLEGAHEMDEHFRHAPL
RQNMPVILALLGIWYNNFFGAESHAILPYDHYLRSLPAYLEQADMESNGKSVDRDGRVVDYPTGQIIWGATGINGQHAFY
QLLHQGTKMIPADFIVSITPHTELQEHHDILIANFLAQTEALMRGRTREETLEEMGRSPGDPSVQHRVFEGNHPSNAILL
KKLTPHTLGMLIALYEHKIFVEGVIWNLNSYDQWGVELGKQLAGRILPELHADAPVAGHDASTNALINHYRRMTQPHPGL
>Mature_560_residues
MVSSVLVRTGDTRTSGLSTRPVHRLLQAHHSRMADVHMRELFDTDPQRFERFSLQVGDLLLDYSKNRITDETMDLLVRMA
EESDVAGWRERMFRGDKINTTENRAVLHVALRNRSNRPVNVDGEDVMPKVNAVIERMGAFAEQVRGGVWRGYSGALITDV
VNIGIGGSDLGPQMVVQALKPYRHPRLKLHFISNVDGAHVKETLEALDPETTLFIVSSKTFTTQETMTNAHYARDWFLAR
AGDVAHVARHFVAVSTNRDAVTAFGIDAANMFEFWDWVGGRYSLWSAIGLSIVLAVGAERFLELLEGAHEMDEHFRHAPL
RQNMPVILALLGIWYNNFFGAESHAILPYDHYLRSLPAYLEQADMESNGKSVDRDGRVVDYPTGQIIWGATGINGQHAFY
QLLHQGTKMIPADFIVSITPHTELQEHHDILIANFLAQTEALMRGRTREETLEEMGRSPGDPSVQHRVFEGNHPSNAILL
KKLTPHTLGMLIALYEHKIFVEGVIWNLNSYDQWGVELGKQLAGRILPELHADAPVAGHDASTNALINHYRRMTQPHPGL

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=541, Percent_Identity=58.2255083179298, Blast_Score=664, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=541, Percent_Identity=54.5286506469501, Blast_Score=605, Evalue=1e-173,
Organism=Escherichia coli, GI1790457, Length=532, Percent_Identity=62.9699248120301, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=560, Percent_Identity=56.0714285714286, Blast_Score=636, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=525, Percent_Identity=59.0476190476191, Blast_Score=635, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=537, Percent_Identity=51.7690875232775, Blast_Score=588, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24651916, Length=541, Percent_Identity=56.9316081330869, Blast_Score=631, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=541, Percent_Identity=56.9316081330869, Blast_Score=631, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=541, Percent_Identity=56.9316081330869, Blast_Score=631, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 62973; Mature: 62973

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSVLVRTGDTRTSGLSTRPVHRLLQAHHSRMADVHMRELFDTDPQRFERFSLQVGDLL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LDYSKNRITDETMDLLVRMAEESDVAGWRERMFRGDKINTTENRAVLHVALRNRSNRPVN
HHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCC
VDGEDVMPKVNAVIERMGAFAEQVRGGVWRGYSGALITDVVNIGIGGSDLGPQMVVQALK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
PYRHPRLKLHFISNVDGAHVKETLEALDPETTLFIVSSKTFTTQETMTNAHYARDWFLAR
HCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHC
AGDVAHVARHFVAVSTNRDAVTAFGIDAANMFEFWDWVGGRYSLWSAIGLSIVLAVGAER
CCCHHHHHHHHEEEECCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FLELLEGAHEMDEHFRHAPLRQNMPVILALLGIWYNNFFGAESHAILPYDHYLRSLPAYL
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHH
EQADMESNGKSVDRDGRVVDYPTGQIIWGATGINGQHAFYQLLHQGTKMIPADFIVSITP
HHHCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECC
HTELQEHHDILIANFLAQTEALMRGRTREETLEEMGRSPGDPSVQHRVFEGNHPSNAILL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHEEEECCCCCCCEEEE
KKLTPHTLGMLIALYEHKIFVEGVIWNLNSYDQWGVELGKQLAGRILPELHADAPVAGHD
ECCCHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ASTNALINHYRRMTQPHPGL
CCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVSSVLVRTGDTRTSGLSTRPVHRLLQAHHSRMADVHMRELFDTDPQRFERFSLQVGDLL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LDYSKNRITDETMDLLVRMAEESDVAGWRERMFRGDKINTTENRAVLHVALRNRSNRPVN
HHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCC
VDGEDVMPKVNAVIERMGAFAEQVRGGVWRGYSGALITDVVNIGIGGSDLGPQMVVQALK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
PYRHPRLKLHFISNVDGAHVKETLEALDPETTLFIVSSKTFTTQETMTNAHYARDWFLAR
HCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHC
AGDVAHVARHFVAVSTNRDAVTAFGIDAANMFEFWDWVGGRYSLWSAIGLSIVLAVGAER
CCCHHHHHHHHEEEECCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FLELLEGAHEMDEHFRHAPLRQNMPVILALLGIWYNNFFGAESHAILPYDHYLRSLPAYL
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHH
EQADMESNGKSVDRDGRVVDYPTGQIIWGATGINGQHAFYQLLHQGTKMIPADFIVSITP
HHHCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECC
HTELQEHHDILIANFLAQTEALMRGRTREETLEEMGRSPGDPSVQHRVFEGNHPSNAILL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHEEEECCCCCCCEEEE
KKLTPHTLGMLIALYEHKIFVEGVIWNLNSYDQWGVELGKQLAGRILPELHADAPVAGHD
ECCCHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ASTNALINHYRRMTQPHPGL
CCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA