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The map label for this gene is murA

Identifier: 74317909

GI number: 74317909

Start: 1990106

End: 1991359

Strand: Reverse

Name: murA

Synonym: Tbd_1891

Alternate gene names: 74317909

Gene position: 1991359-1990106 (Counterclockwise)

Preceding gene: 74317910

Following gene: 74317908

Centisome position: 68.44

GC content: 68.5

Gene sequence:

>1254_bases
ATGGACGCACTGCTGATCCAGGGCGGCAATCCGCTCGCGGGCGAGGTGCGGATTTCCGGGGCGAAGAACGCCGCGCTGCC
GATCCTGACCGCGAGCCTGCTTACGGCCGAGCCGCTCAGGCTCGGCAACGTGCCGCACCTCAAGGACATCAGCACCATGC
TCGCGCTGCTCGGGCACATGGGCGTGCGCGTCACGCTCGACGACAAGAATCACGTCACGCTTTCGGGCGATTCGATCCCG
CACAAGGAAGCGCCCTACGAAATGGTCAAGACCATGCGCGCGGCGATCCTCGTGCTCGGGCCGACGCTCGCGCGCTTCGG
CGAGGCGCGCGTCTCGCTGCCCGGCGGTTGCGCGATCGGCTCGCGCCCGGTCGACCTGCACATCAAAGGCCTGCAGGCCA
TGGGCGCCGACATCTCGATCGAACACGGCTACATCCACGCGCGCTGCAAGCGCCTGCAAGGGGCGCGGATCGTCATGGAC
ATGGTGACCGTGACGGGGACCGAGAATCTGATGATGGCGGCGGCACTCGCCGAGGGGACGACCGTGCTCGAGAACGCGGC
ACGCGAACCCGAGGTCGTCGATCTCGCACGCTGCCTCATCGCGATGGGCGCGAAGATCGAGGGCGCCGGCACTGACGTCA
TCACCGTGCACGGCGTCGAGGCGCTCCACGGCGCCGAGTACTCGGTCATGGCCGATCGCATCGAGACCGGCACCTTTCTC
GTCGCGGCCGCGATGACCGGCGGCCGCGTGCGCGCGACGCACACCTCGCCCGACACGCTCGAAGCCGTGATTTCGAAGCT
GCGCGAGGCCGGTGCCAAGGTGAGCGTCGGCGACGACTGGATCGAAGTCGAATCGACCGGCAAGCTCGACTCGGTCGACG
TGCGCACTGCGCCGCATCCGGCGTTTCCGACCGACATGCAGGCCCAGTTCATGGCGATGAACACGATCGCCGTGGGCGCC
GCGAGCGTGACGGAAACAATTTTCGAGAACCGCTTCATGCACGTGCAGGAGCTGCGCCGCCTCGGCGCCAACATCGAGGT
CTCGGGCCATACCGCGCTCGTCCGGGGCGTGGCGCGTCTCGACGGCGCGACCGTGATGGCGACCGACCTGCGCGCCTCGG
CCTGCCTGGTGCTGGCGGGCCTCGTCGCCGCGGGCGAGACCACGATCGAGCGCATCTACCACCTCGACCGCGGCTACGAG
CGCATCGAGGAAAAGCTGACCCAGCTGGGCGGGCGCATCAAGCGCGTGCACTGA

Upstream 100 bases:

>100_bases
CACCGCCTGGTCTACGACGCGCTCGGCACCCGCATGCACGCGCAGATCCACGCCCTGTCCATGAAGACCTACACGCCGGA
AGACTGGGCCGCGCGCTGAC

Downstream 100 bases:

>100_bases
AGACGGACGAGCCATGAGCAATACCGGCATCACACTGGCCCTGTCGAAGGGCCGCATATTCGACGAGACGCTGCCGCTTC
TGGCCGCCGCGGGCATCACG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDALLIQGGNPLAGEVRISGAKNAALPILTASLLTAEPLRLGNVPHLKDISTMLALLGHMGVRVTLDDKNHVTLSGDSIP
HKEAPYEMVKTMRAAILVLGPTLARFGEARVSLPGGCAIGSRPVDLHIKGLQAMGADISIEHGYIHARCKRLQGARIVMD
MVTVTGTENLMMAAALAEGTTVLENAAREPEVVDLARCLIAMGAKIEGAGTDVITVHGVEALHGAEYSVMADRIETGTFL
VAAAMTGGRVRATHTSPDTLEAVISKLREAGAKVSVGDDWIEVESTGKLDSVDVRTAPHPAFPTDMQAQFMAMNTIAVGA
ASVTETIFENRFMHVQELRRLGANIEVSGHTALVRGVARLDGATVMATDLRASACLVLAGLVAAGETTIERIYHLDRGYE
RIEEKLTQLGGRIKRVH

Sequences:

>Translated_417_residues
MDALLIQGGNPLAGEVRISGAKNAALPILTASLLTAEPLRLGNVPHLKDISTMLALLGHMGVRVTLDDKNHVTLSGDSIP
HKEAPYEMVKTMRAAILVLGPTLARFGEARVSLPGGCAIGSRPVDLHIKGLQAMGADISIEHGYIHARCKRLQGARIVMD
MVTVTGTENLMMAAALAEGTTVLENAAREPEVVDLARCLIAMGAKIEGAGTDVITVHGVEALHGAEYSVMADRIETGTFL
VAAAMTGGRVRATHTSPDTLEAVISKLREAGAKVSVGDDWIEVESTGKLDSVDVRTAPHPAFPTDMQAQFMAMNTIAVGA
ASVTETIFENRFMHVQELRRLGANIEVSGHTALVRGVARLDGATVMATDLRASACLVLAGLVAAGETTIERIYHLDRGYE
RIEEKLTQLGGRIKRVH
>Mature_417_residues
MDALLIQGGNPLAGEVRISGAKNAALPILTASLLTAEPLRLGNVPHLKDISTMLALLGHMGVRVTLDDKNHVTLSGDSIP
HKEAPYEMVKTMRAAILVLGPTLARFGEARVSLPGGCAIGSRPVDLHIKGLQAMGADISIEHGYIHARCKRLQGARIVMD
MVTVTGTENLMMAAALAEGTTVLENAAREPEVVDLARCLIAMGAKIEGAGTDVITVHGVEALHGAEYSVMADRIETGTFL
VAAAMTGGRVRATHTSPDTLEAVISKLREAGAKVSVGDDWIEVESTGKLDSVDVRTAPHPAFPTDMQAQFMAMNTIAVGA
ASVTETIFENRFMHVQELRRLGANIEVSGHTALVRGVARLDGATVMATDLRASACLVLAGLVAAGETTIERIYHLDRGYE
RIEEKLTQLGGRIKRVH

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=57.8947368421053, Blast_Score=480, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_THIDA (Q3SHP2)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315649.1
- ProteinModelPortal:   Q3SHP2
- SMR:   Q3SHP2
- STRING:   Q3SHP2
- GeneID:   3674001
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1891
- NMPDR:   fig|292415.3.peg.1988
- eggNOG:   COG0766
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- PhylomeDB:   Q3SHP2
- BioCyc:   TDEN292415:TBD_1891-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 44245; Mature: 44245

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALLIQGGNPLAGEVRISGAKNAALPILTASLLTAEPLRLGNVPHLKDISTMLALLGHM
CCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHCC
GVRVTLDDKNHVTLSGDSIPHKEAPYEMVKTMRAAILVLGPTLARFGEARVSLPGGCAIG
CEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCEEECCCCCCCC
SRPVDLHIKGLQAMGADISIEHGYIHARCKRLQGARIVMDMVTVTGTENLMMAAALAEGT
CCCEEEEEECHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCH
TVLENAAREPEVVDLARCLIAMGAKIEGAGTDVITVHGVEALHGAEYSVMADRIETGTFL
HHHHHCCCCCHHHHHHHHHHHHCCEECCCCCCEEEEECCHHHCCCCHHHHHHHHCCCEEE
VAAAMTGGRVRATHTSPDTLEAVISKLREAGAKVSVGDDWIEVESTGKLDSVDVRTAPHP
EEEECCCCEEEEECCCHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCEEEECCCCC
AFPTDMQAQFMAMNTIAVGAASVTETIFENRFMHVQELRRLGANIEVSGHTALVRGVARL
CCCCCCCHHHEEHHHHHHCHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCHHHHHHHHHH
DGATVMATDLRASACLVLAGLVAAGETTIERIYHLDRGYERIEEKLTQLGGRIKRVH
CCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure
MDALLIQGGNPLAGEVRISGAKNAALPILTASLLTAEPLRLGNVPHLKDISTMLALLGHM
CCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHCC
GVRVTLDDKNHVTLSGDSIPHKEAPYEMVKTMRAAILVLGPTLARFGEARVSLPGGCAIG
CEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCEEECCCCCCCC
SRPVDLHIKGLQAMGADISIEHGYIHARCKRLQGARIVMDMVTVTGTENLMMAAALAEGT
CCCEEEEEECHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCH
TVLENAAREPEVVDLARCLIAMGAKIEGAGTDVITVHGVEALHGAEYSVMADRIETGTFL
HHHHHCCCCCHHHHHHHHHHHHCCEECCCCCCEEEEECCHHHCCCCHHHHHHHHCCCEEE
VAAAMTGGRVRATHTSPDTLEAVISKLREAGAKVSVGDDWIEVESTGKLDSVDVRTAPHP
EEEECCCCEEEEECCCHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCEEEECCCCC
AFPTDMQAQFMAMNTIAVGAASVTETIFENRFMHVQELRRLGANIEVSGHTALVRGVARL
CCCCCCCHHHEEHHHHHHCHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCHHHHHHHHHH
DGATVMATDLRASACLVLAGLVAAGETTIERIYHLDRGYERIEEKLTQLGGRIKRVH
CCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA