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The map label for this gene is hisG

Identifier: 74317908

GI number: 74317908

Start: 1989442

End: 1990092

Strand: Reverse

Name: hisG

Synonym: Tbd_1890

Alternate gene names: 74317908

Gene position: 1990092-1989442 (Counterclockwise)

Preceding gene: 74317909

Following gene: 74317906

Centisome position: 68.39

GC content: 66.67

Gene sequence:

>651_bases
ATGAGCAATACCGGCATCACACTGGCCCTGTCGAAGGGCCGCATATTCGACGAGACGCTGCCGCTTCTGGCCGCCGCGGG
CATCACGCCGGCAGAGAGCCCGGAGTCGTCGCGCAAGCTCATCATCGGCACGAACCGCGACGACGTCCGTCTCATCATCG
TGCGCGCGAGCGACGTGCCGACCTACGTGCAATACGGCGCCGCCGACCTCGGCATTGCCGGCAAGGACGTGTTGAACGAG
CACGGCGGCCGCGGCCTCTACCAGCCGCTCGACCTGCAGATCGCCAAGTGCCGGATGATGGTCGCCGTGCGCGAGGGCTA
CGACTACGCCGGCACCGTCAAGCAGGGCGCGCGCATCCGCGTGGCGACCAAGTACGTCAACGCGGCGCGCGACCATTTTG
CGTCGAAAGGCGTGCACATCGACCTGATCAAGCTCTACGGCTCGATGGAGCTCGCCCCGCTGGTCGGCCTGTCCGACGTC
ATCGTCGACCTCGTGTCGACCGGCGGCACGCTCAAGGCGAATGGCCTCGCGGCGGTCGAACACATCTGCGACATCAGTTC
GCGACTGGTCGTGAACCAGGCCGCGCTCAAGCTCAAGCGCAGCGTAATCCAGCCTGTGGTGGATGCGTTTGCGGCGGCGG
TGGCGCGCTGA

Upstream 100 bases:

>100_bases
GAGCGCATCTACCACCTCGACCGCGGCTACGAGCGCATCGAGGAAAAGCTGACCCAGCTGGGCGGGCGCATCAAGCGCGT
GCACTGAAGACGGACGAGCC

Downstream 100 bases:

>100_bases
GAAGGTACGTGCAGGCAGCCGGGGTGTCGTTCGGGTCTCGGTGAGAAACCCCGCGCGTGTCGGTCGGGCAAAATAAGCAG
CGCCGAGCAGTCGAACGACT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSNTGITLALSKGRIFDETLPLLAAAGITPAESPESSRKLIIGTNRDDVRLIIVRASDVPTYVQYGAADLGIAGKDVLNE
HGGRGLYQPLDLQIAKCRMMVAVREGYDYAGTVKQGARIRVATKYVNAARDHFASKGVHIDLIKLYGSMELAPLVGLSDV
IVDLVSTGGTLKANGLAAVEHICDISSRLVVNQAALKLKRSVIQPVVDAFAAAVAR

Sequences:

>Translated_216_residues
MSNTGITLALSKGRIFDETLPLLAAAGITPAESPESSRKLIIGTNRDDVRLIIVRASDVPTYVQYGAADLGIAGKDVLNE
HGGRGLYQPLDLQIAKCRMMVAVREGYDYAGTVKQGARIRVATKYVNAARDHFASKGVHIDLIKLYGSMELAPLVGLSDV
IVDLVSTGGTLKANGLAAVEHICDISSRLVVNQAALKLKRSVIQPVVDAFAAAVAR
>Mature_215_residues
SNTGITLALSKGRIFDETLPLLAAAGITPAESPESSRKLIIGTNRDDVRLIIVRASDVPTYVQYGAADLGIAGKDVLNEH
GGRGLYQPLDLQIAKCRMMVAVREGYDYAGTVKQGARIRVATKYVNAARDHFASKGVHIDLIKLYGSMELAPLVGLSDVI
VDLVSTGGTLKANGLAAVEHICDISSRLVVNQAALKLKRSVIQPVVDAFAAAVAR

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=189, Percent_Identity=35.4497354497354, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=30.2702702702703, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_THIDA (Q3SHP3)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315648.1
- ProteinModelPortal:   Q3SHP3
- SMR:   Q3SHP3
- STRING:   Q3SHP3
- GeneID:   3674000
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1890
- NMPDR:   fig|292415.3.peg.1987
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q3SHP3
- ProtClustDB:   PRK01686
- BioCyc:   TDEN292415:TBD_1890-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22938; Mature: 22807

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTGITLALSKGRIFDETLPLLAAAGITPAESPESSRKLIIGTNRDDVRLIIVRASDVP
CCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCC
TYVQYGAADLGIAGKDVLNEHGGRGLYQPLDLQIAKCRMMVAVREGYDYAGTVKQGARIR
HHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VATKYVNAARDHFASKGVHIDLIKLYGSMELAPLVGLSDVIVDLVSTGGTLKANGLAAVE
EHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHCCCEEEECCHHHHH
HICDISSRLVVNQAALKLKRSVIQPVVDAFAAAVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTGITLALSKGRIFDETLPLLAAAGITPAESPESSRKLIIGTNRDDVRLIIVRASDVP
CCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCC
TYVQYGAADLGIAGKDVLNEHGGRGLYQPLDLQIAKCRMMVAVREGYDYAGTVKQGARIR
HHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VATKYVNAARDHFASKGVHIDLIKLYGSMELAPLVGLSDVIVDLVSTGGTLKANGLAAVE
EHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHCCCEEEECCHHHHH
HICDISSRLVVNQAALKLKRSVIQPVVDAFAAAVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA