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The map label for this gene is fabI [H]

Identifier: 74317690

GI number: 74317690

Start: 1757864

End: 1758718

Strand: Direct

Name: fabI [H]

Synonym: Tbd_1672

Alternate gene names: 74317690

Gene position: 1757864-1758718 (Clockwise)

Preceding gene: 74317684

Following gene: 74317697

Centisome position: 60.41

GC content: 63.04

Gene sequence:

>855_bases
GTGTACCCAAGCGCGCCGTCAACGTCAGCCGTTATAATCTCGCCCTACTCAACTCTTCGCTTCGAGACCATCATGGGATT
TCTTGCAGGAAAACGCTTGCTGATCACCGGTGTGATATCCAACCGTTCGATCGCCTATGGCATCGCTGCCGCGTGCAAGC
GTGAGGGCGCCGAGCTGGCCTTCACCTACCAGGGGGAGCGTATCAAGGATCGCGTGACGGAGTTCGCCCAGGAGTTCGGT
TCCGACCTGGTGTTTCAATGCGACGTCGGCAGCGACGAGCAGATCGACGCGCTGTTCACGGAACTCGGCACGCGTTGGGA
CGGCCTCGACGGTCTCGTTCACTCGATCGCCTTCGCCCCCAAGGAGGCGCTCGCCGGCGATTTCCTCTCAGCGGTCACCC
GCGAAAACTTCCGCATCGCCCACGACATCAGTTCCTACAGTTTCGCCGCGCTGGCCAAGGCTGCGCTGCCGCTCATGGAA
GGCCGCCAGGCCGCGCTGCTGACGCTGTCGTATCTCGGCGCAGTGCGCTCGGTCCCCAACTACAACGTCATGGGCCTGGC
CAAGGCGAGCCTCGAATCCAGCGTCTACTACATGGCGCAAAGCCTCGGCCCCAAGGGAATCCGCGTCAACGCCGTGTCGG
CGGGCCCGATCAAGACGCTCGCCGCGAGCGGCATCGCCAACTTCGGCGAGAAGCTCGATCTCGTTGCGAAGAACGCGCCG
CTGCGCCGCAACGTCACGATCGACGAGGTCGGCAACGTCGTCGCCTTCATGCTCTCGGATCTCGCGTCGGGTATCACCGG
GGAAATCACCTACGTCGATGCCGGATTCAATTCGACGGCGGGCGCCGAATCGTGA

Upstream 100 bases:

>100_bases
GGCGGCTTGACTGTCCGGGTATGGGTTGTTCCACGTGTCGCCGCATCCGGCGAGCAAAGCGAGTCCGAGCAGTACCGAGC
CTGTACGCGTCATGGCGCCA

Downstream 100 bases:

>100_bases
GCCGCTAAAGCCCCAAAAAAACGCGCCCGAAGGCGCGTTTTTTTTAGTCTTCCCGGCCCTCGATCGCGTTCGGCTGGATC
TTGACCTTGTGGCCGGCGGT

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MYPSAPSTSAVIISPYSTLRFETIMGFLAGKRLLITGVISNRSIAYGIAAACKREGAELAFTYQGERIKDRVTEFAQEFG
SDLVFQCDVGSDEQIDALFTELGTRWDGLDGLVHSIAFAPKEALAGDFLSAVTRENFRIAHDISSYSFAALAKAALPLME
GRQAALLTLSYLGAVRSVPNYNVMGLAKASLESSVYYMAQSLGPKGIRVNAVSAGPIKTLAASGIANFGEKLDLVAKNAP
LRRNVTIDEVGNVVAFMLSDLASGITGEITYVDAGFNSTAGAES

Sequences:

>Translated_284_residues
MYPSAPSTSAVIISPYSTLRFETIMGFLAGKRLLITGVISNRSIAYGIAAACKREGAELAFTYQGERIKDRVTEFAQEFG
SDLVFQCDVGSDEQIDALFTELGTRWDGLDGLVHSIAFAPKEALAGDFLSAVTRENFRIAHDISSYSFAALAKAALPLME
GRQAALLTLSYLGAVRSVPNYNVMGLAKASLESSVYYMAQSLGPKGIRVNAVSAGPIKTLAASGIANFGEKLDLVAKNAP
LRRNVTIDEVGNVVAFMLSDLASGITGEITYVDAGFNSTAGAES
>Mature_284_residues
MYPSAPSTSAVIISPYSTLRFETIMGFLAGKRLLITGVISNRSIAYGIAAACKREGAELAFTYQGERIKDRVTEFAQEFG
SDLVFQCDVGSDEQIDALFTELGTRWDGLDGLVHSIAFAPKEALAGDFLSAVTRENFRIAHDISSYSFAALAKAALPLME
GRQAALLTLSYLGAVRSVPNYNVMGLAKASLESSVYYMAQSLGPKGIRVNAVSAGPIKTLAASGIANFGEKLDLVAKNAP
LRRNVTIDEVGNVVAFMLSDLASGITGEITYVDAGFNSTAGAES

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=27.6679841897233, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=28.6274509803922, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=27.1653543307087, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=61.3899613899614, Blast_Score=327, Evalue=6e-91,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=27.843137254902, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=28.4615384615385, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI2367365, Length=257, Percent_Identity=28.4046692607004, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=25.9842519685039, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 30118; Mature: 30118

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPSAPSTSAVIISPYSTLRFETIMGFLAGKRLLITGVISNRSIAYGIAAACKREGAELA
CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCCEEE
FTYQGERIKDRVTEFAQEFGSDLVFQCDVGSDEQIDALFTELGTRWDGLDGLVHSIAFAP
EEECCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCC
KEALAGDFLSAVTRENFRIAHDISSYSFAALAKAALPLMEGRQAALLTLSYLGAVRSVPN
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
YNVMGLAKASLESSVYYMAQSLGPKGIRVNAVSAGPIKTLAASGIANFGEKLDLVAKNAP
CCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
LRRNVTIDEVGNVVAFMLSDLASGITGEITYVDAGFNSTAGAES
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MYPSAPSTSAVIISPYSTLRFETIMGFLAGKRLLITGVISNRSIAYGIAAACKREGAELA
CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCCEEE
FTYQGERIKDRVTEFAQEFGSDLVFQCDVGSDEQIDALFTELGTRWDGLDGLVHSIAFAP
EEECCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCC
KEALAGDFLSAVTRENFRIAHDISSYSFAALAKAALPLMEGRQAALLTLSYLGAVRSVPN
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
YNVMGLAKASLESSVYYMAQSLGPKGIRVNAVSAGPIKTLAASGIANFGEKLDLVAKNAP
CCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
LRRNVTIDEVGNVVAFMLSDLASGITGEITYVDAGFNSTAGAES
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]