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The map label for this gene is yegE [H]

Identifier: 74317678

GI number: 74317678

Start: 1743752

End: 1745848

Strand: Reverse

Name: yegE [H]

Synonym: Tbd_1660

Alternate gene names: 74317678

Gene position: 1745848-1743752 (Counterclockwise)

Preceding gene: 74317679

Following gene: 74317673

Centisome position: 60.0

GC content: 65.81

Gene sequence:

>2097_bases
ATGGCGCTCGCACTCGGGATACGCGGGCGCGTGATCGGCCTGACGCTCGTGCCGGTGGCGATCATCGGCGTTCTTCTGCT
GTTCCAGCTCATCAGCGGAAAAATCGACGACCTCGATCAGTCGCTGCGCACGCGTGCGGTCGCCATCGCCCGGCAGCTTG
CGCCGGCGGCCGAATACGGCGTGGCGTCGGGCAACATCGACGTGCTGCAGACGCTGCTCGAAAAAGCTGCGGTCGAACCC
GACGTGCGGGGGGTCGCGGTGTTCGCCGATGACGGCCAGTGGCTGGCACAGGTCGGGCTGGGCAACTGGGATGACCCGTC
GCGCCGCCACTTGTCCACGGACCATATCCAGCAGATCGAATACCCGGATCGCCTCGTCTACTACGCGCCGATCACGCGGA
CCGAGGTTGCGGTCGACGACTTCAGTTCGGTCGGCGGACGGGCGGGCGCTGCGACCCGTCCGACGCGGCTGCTCGGCTGG
GTCGGTCTCGAGGTATCGCGGAGCGCGACGGTCAAGAGTCAACGCGATGCGATCGTACGCAGTCTGCTGATCCTGCTCGC
CGGCCTCAGCGTCAGCTTCTATCTCGCGTGGCGCATCGGACGGCAGATCACGCGGCCGATCCTCGCGCTCACGCACACCG
TGAGCCGGATCGGCGAGGGGCACCTCGACGAGCGCGTCGTCCAGAGCGGGCAGGCCGAACTCGGCGTCCTGCAACGCGGC
GTCAACAACATGGCGGCCCACCTGCAGGCGATGCACGGCCAGATGCAGGCCAAGATCGATCAGGCCACCGCGCGCCTGGT
CTATCAGGCGAGCCACGACGCGCTGACCGGCTTGATCAATCGCCGCGAGTTCGAGCAGCGGCTCGAACGCGCGCGCATGT
CGGCGCTGGAACAGGGACGGGAACACGCACTGTGCTACATGGACCTCGACCAGTTCAAGGTGATCAACGACTCGTGCGGC
CACGCCGCCGGCGACGAACTGTTGCGCCAACTCGCCCTGCTGCTCAAGGGCAAGCTGCGGGAGCGTGACACGCTCGCGCG
TCTCGGCGGCGACGAATTCGCGCTCCTGCTGGAAAACTGCAGCATCGACGACGCGCTCGAAGTCGCCGACGCATTCCGCT
CTGAGGTGCAGCGCTTCCGCTTCAAATGGGGCGACCGCATCTTTGCGGTCGGCATGAGCGTCGGCATGGTCGCGATCGAC
GCCGACAGTGGCACTGCCGCCGGCCTCATGTCGGCGGCCGACGCCGCGTGCTACGTGGCGAAGGATCGCGGGCGCAATCA
GATCCACCTTTACGAGAGCCGCGACTCAGACCTGGTCCGCCATCGCGGCGAGATGCAGTGGGTCACGCGCATCCAGCGCG
CGCTCGAGGAAAATCGCCTGAGCCTCTCCTGGCAGGAAATCCGCCGCACCGACGCAGCACCCGAGCCGGGCACGCGCCAC
GTCGAGCTGTTGTTGCGAATGATCGACGACGACGGCGGCGAGATCCTGCCGATGGCCTTCATTCCTGCGGCGGAACGCTA
CTCGATCATGCCGGCGCTCGACGCCTGGGTGGTCGAGGAGACGCTACGGCTGTGCAAGCGCTACCTCAAATCGACCTGCG
AGGTGCATTGCCTGTTTGCGGTGAACCTGTCGGGCGCATCGCTGAAGGACCCCACCTTCCGCAAGACACTGCTCGCGCAA
CTGCAGCAGAATCCGGAACTGGGCCCGCACCTGTGCTTCGAAATCACCGAAACCGCTGCGATCGGCAACCTCGGCGTCGT
CAATGGTTTCATCGACGCGATGCGTGGCTTCGGCTGCAGCTTCGCGCTCGACGACTTCGGCAGCGGCCTGTCGTCGTTCA
CCTACCTTAAAAACCTGCGCGTCGACTACCTCAAGATCGATGGTGCCTTCGTGCGTGACATCGCGACCAACGCGATCGAC
CGCTCGATGGTCGAAGCGATCCACCGCATCGGCCACCAGATGGGGCTGCAGACGGTCGCAGAATACGTCGAGTCGGAGGA
GATTCTGAGTCTGTTGCGCGAGATCGGCGTCGATTACGCACAGGGCAGCGCCGTGCGCCGCCCTGAGCCGATCGACACCT
TGTGCGCGCGGGATTGA

Upstream 100 bases:

>100_bases
CTTATTTCAGCGTTTCGATCAACCGCCAAGTCGCCCGTTCGCTCGGTTTCGTCCTGCCGCAGGAAAACGAGCTGGAAAAG
CGTCTGGGAGAGGAAATCTG

Downstream 100 bases:

>100_bases
GTGGGACCGCGCCTCACTCGCCGACGCTGAAACCGGCGTCGACGACCGCCTGGGCCATGGCAGCGCGATCCACTTTGGCG
GCGTCGTAGACGACGCGCGC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 698; Mature: 697

Protein sequence:

>698_residues
MALALGIRGRVIGLTLVPVAIIGVLLLFQLISGKIDDLDQSLRTRAVAIARQLAPAAEYGVASGNIDVLQTLLEKAAVEP
DVRGVAVFADDGQWLAQVGLGNWDDPSRRHLSTDHIQQIEYPDRLVYYAPITRTEVAVDDFSSVGGRAGAATRPTRLLGW
VGLEVSRSATVKSQRDAIVRSLLILLAGLSVSFYLAWRIGRQITRPILALTHTVSRIGEGHLDERVVQSGQAELGVLQRG
VNNMAAHLQAMHGQMQAKIDQATARLVYQASHDALTGLINRREFEQRLERARMSALEQGREHALCYMDLDQFKVINDSCG
HAAGDELLRQLALLLKGKLRERDTLARLGGDEFALLLENCSIDDALEVADAFRSEVQRFRFKWGDRIFAVGMSVGMVAID
ADSGTAAGLMSAADAACYVAKDRGRNQIHLYESRDSDLVRHRGEMQWVTRIQRALEENRLSLSWQEIRRTDAAPEPGTRH
VELLLRMIDDDGGEILPMAFIPAAERYSIMPALDAWVVEETLRLCKRYLKSTCEVHCLFAVNLSGASLKDPTFRKTLLAQ
LQQNPELGPHLCFEITETAAIGNLGVVNGFIDAMRGFGCSFALDDFGSGLSSFTYLKNLRVDYLKIDGAFVRDIATNAID
RSMVEAIHRIGHQMGLQTVAEYVESEEILSLLREIGVDYAQGSAVRRPEPIDTLCARD

Sequences:

>Translated_698_residues
MALALGIRGRVIGLTLVPVAIIGVLLLFQLISGKIDDLDQSLRTRAVAIARQLAPAAEYGVASGNIDVLQTLLEKAAVEP
DVRGVAVFADDGQWLAQVGLGNWDDPSRRHLSTDHIQQIEYPDRLVYYAPITRTEVAVDDFSSVGGRAGAATRPTRLLGW
VGLEVSRSATVKSQRDAIVRSLLILLAGLSVSFYLAWRIGRQITRPILALTHTVSRIGEGHLDERVVQSGQAELGVLQRG
VNNMAAHLQAMHGQMQAKIDQATARLVYQASHDALTGLINRREFEQRLERARMSALEQGREHALCYMDLDQFKVINDSCG
HAAGDELLRQLALLLKGKLRERDTLARLGGDEFALLLENCSIDDALEVADAFRSEVQRFRFKWGDRIFAVGMSVGMVAID
ADSGTAAGLMSAADAACYVAKDRGRNQIHLYESRDSDLVRHRGEMQWVTRIQRALEENRLSLSWQEIRRTDAAPEPGTRH
VELLLRMIDDDGGEILPMAFIPAAERYSIMPALDAWVVEETLRLCKRYLKSTCEVHCLFAVNLSGASLKDPTFRKTLLAQ
LQQNPELGPHLCFEITETAAIGNLGVVNGFIDAMRGFGCSFALDDFGSGLSSFTYLKNLRVDYLKIDGAFVRDIATNAID
RSMVEAIHRIGHQMGLQTVAEYVESEEILSLLREIGVDYAQGSAVRRPEPIDTLCARD
>Mature_697_residues
ALALGIRGRVIGLTLVPVAIIGVLLLFQLISGKIDDLDQSLRTRAVAIARQLAPAAEYGVASGNIDVLQTLLEKAAVEPD
VRGVAVFADDGQWLAQVGLGNWDDPSRRHLSTDHIQQIEYPDRLVYYAPITRTEVAVDDFSSVGGRAGAATRPTRLLGWV
GLEVSRSATVKSQRDAIVRSLLILLAGLSVSFYLAWRIGRQITRPILALTHTVSRIGEGHLDERVVQSGQAELGVLQRGV
NNMAAHLQAMHGQMQAKIDQATARLVYQASHDALTGLINRREFEQRLERARMSALEQGREHALCYMDLDQFKVINDSCGH
AAGDELLRQLALLLKGKLRERDTLARLGGDEFALLLENCSIDDALEVADAFRSEVQRFRFKWGDRIFAVGMSVGMVAIDA
DSGTAAGLMSAADAACYVAKDRGRNQIHLYESRDSDLVRHRGEMQWVTRIQRALEENRLSLSWQEIRRTDAAPEPGTRHV
ELLLRMIDDDGGEILPMAFIPAAERYSIMPALDAWVVEETLRLCKRYLKSTCEVHCLFAVNLSGASLKDPTFRKTLLAQL
QQNPELGPHLCFEITETAAIGNLGVVNGFIDAMRGFGCSFALDDFGSGLSSFTYLKNLRVDYLKIDGAFVRDIATNAIDR
SMVEAIHRIGHQMGLQTVAEYVESEEILSLLREIGVDYAQGSAVRRPEPIDTLCARD

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=437, Percent_Identity=34.324942791762, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1787541, Length=433, Percent_Identity=31.6397228637413, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI1788849, Length=414, Percent_Identity=28.743961352657, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081921, Length=471, Percent_Identity=25.4777070063694, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87082096, Length=520, Percent_Identity=25.5769230769231, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1790496, Length=245, Percent_Identity=33.0612244897959, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI226510982, Length=525, Percent_Identity=25.5238095238095, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1789149, Length=269, Percent_Identity=28.996282527881, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081881, Length=247, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1788502, Length=242, Percent_Identity=30.1652892561983, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI145693134, Length=167, Percent_Identity=32.9341317365269, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081980, Length=215, Percent_Identity=31.6279069767442, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786584, Length=174, Percent_Identity=29.8850574712644, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI87082007, Length=178, Percent_Identity=35.3932584269663, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1787262, Length=164, Percent_Identity=32.9268292682927, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786507, Length=212, Percent_Identity=28.7735849056604, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787055, Length=252, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI87081845, Length=211, Percent_Identity=27.9620853080569, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI87081743, Length=236, Percent_Identity=27.9661016949153, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081977, Length=182, Percent_Identity=32.4175824175824, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787802, Length=175, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1789650, Length=428, Percent_Identity=23.1308411214953, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788085, Length=166, Percent_Identity=31.3253012048193, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788956, Length=251, Percent_Identity=26.6932270916335, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081974, Length=153, Percent_Identity=32.0261437908497, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787056, Length=158, Percent_Identity=30.379746835443, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1787816, Length=179, Percent_Identity=27.3743016759777, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 77066; Mature: 76935

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALALGIRGRVIGLTLVPVAIIGVLLLFQLISGKIDDLDQSLRTRAVAIARQLAPAAEYG
CEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHCC
VASGNIDVLQTLLEKAAVEPDVRGVAVFADDGQWLAQVGLGNWDDPSRRHLSTDHIQQIE
CCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHCCCCCCCCCHHHCCCHHHHHHCC
YPDRLVYYAPITRTEVAVDDFSSVGGRAGAATRPTRLLGWVGLEVSRSATVKSQRDAIVR
CCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEECCCHHHHHHHHHHHH
SLLILLAGLSVSFYLAWRIGRQITRPILALTHTVSRIGEGHLDERVVQSGQAELGVLQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
VNNMAAHLQAMHGQMQAKIDQATARLVYQASHDALTGLINRREFEQRLERARMSALEQGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EHALCYMDLDQFKVINDSCGHAAGDELLRQLALLLKGKLRERDTLARLGGDEFALLLENC
HCEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
SIDDALEVADAFRSEVQRFRFKWGDRIFAVGMSVGMVAIDADSGTAAGLMSAADAACYVA
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHEEEE
KDRGRNQIHLYESRDSDLVRHRGEMQWVTRIQRALEENRLSLSWQEIRRTDAAPEPGTRH
CCCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHH
VELLLRMIDDDGGEILPMAFIPAAERYSIMPALDAWVVEETLRLCKRYLKSTCEVHCLFA
HHHHHHHHCCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VNLSGASLKDPTFRKTLLAQLQQNPELGPHLCFEITETAAIGNLGVVNGFIDAMRGFGCS
EECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHEEHHHHHCCCCHHHHHHHHHHHCCCCC
FALDDFGSGLSSFTYLKNLRVDYLKIDGAFVRDIATNAIDRSMVEAIHRIGHQMGLQTVA
EEHHHHCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYVESEEILSLLREIGVDYAQGSAVRRPEPIDTLCARD
HHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
ALALGIRGRVIGLTLVPVAIIGVLLLFQLISGKIDDLDQSLRTRAVAIARQLAPAAEYG
EEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHCC
VASGNIDVLQTLLEKAAVEPDVRGVAVFADDGQWLAQVGLGNWDDPSRRHLSTDHIQQIE
CCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHCCCCCCCCCHHHCCCHHHHHHCC
YPDRLVYYAPITRTEVAVDDFSSVGGRAGAATRPTRLLGWVGLEVSRSATVKSQRDAIVR
CCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEECCCHHHHHHHHHHHH
SLLILLAGLSVSFYLAWRIGRQITRPILALTHTVSRIGEGHLDERVVQSGQAELGVLQRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
VNNMAAHLQAMHGQMQAKIDQATARLVYQASHDALTGLINRREFEQRLERARMSALEQGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EHALCYMDLDQFKVINDSCGHAAGDELLRQLALLLKGKLRERDTLARLGGDEFALLLENC
HCEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
SIDDALEVADAFRSEVQRFRFKWGDRIFAVGMSVGMVAIDADSGTAAGLMSAADAACYVA
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHEEEE
KDRGRNQIHLYESRDSDLVRHRGEMQWVTRIQRALEENRLSLSWQEIRRTDAAPEPGTRH
CCCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHH
VELLLRMIDDDGGEILPMAFIPAAERYSIMPALDAWVVEETLRLCKRYLKSTCEVHCLFA
HHHHHHHHCCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VNLSGASLKDPTFRKTLLAQLQQNPELGPHLCFEITETAAIGNLGVVNGFIDAMRGFGCS
EECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHEEHHHHHCCCCHHHHHHHHHHHCCCCC
FALDDFGSGLSSFTYLKNLRVDYLKIDGAFVRDIATNAIDRSMVEAIHRIGHQMGLQTVA
EEHHHHCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYVESEEILSLLREIGVDYAQGSAVRRPEPIDTLCARD
HHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]