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The map label for this gene is fabH

Identifier: 74317569

GI number: 74317569

Start: 1635189

End: 1636148

Strand: Reverse

Name: fabH

Synonym: Tbd_1551

Alternate gene names: 74317569

Gene position: 1636148-1635189 (Counterclockwise)

Preceding gene: 74317570

Following gene: 74317568

Centisome position: 56.23

GC content: 65.94

Gene sequence:

>960_bases
TTGACCTATTCCCGCATTCTCGGCACCGGCGGTTACCTGCCGGCGCGCATCTTGACCAACGCCGACCTTGAGAAGCTCGT
CGACACCAACGACCAGTGGATCGTCGACCGCACCGGCATCCGCGAACGGCACATCGCGGCCGACGGCGAATTCACGAGCG
ACCTCGCGACTGCGGCAGCCCGCGCGGCACTCGAGGCGGCGAATCTCGCGGCCGACGACATCGACCTCCTGCTGGTCGCG
ACGACGACGCCGGATCTGGTCTTTCCAAGCACGGCCTGCATCGTGCAGTCCAAGCTCGGCATGACCAACGGCAAGCCGGC
CTTCGATCTACAGGCCGTCTGCAGCGGCTTCGTCTACGCGCTCTCGGTGGCCGACCAGTTCATCAAGGGCGGCGCGGCGA
AGCATGTGCTCGTGGTCGGCGCGGAGACCTTGTCGCGCATCACCGACTGGAACGACCGCAGCAACTGTATTCTGTGGGGG
GACGGCGCAGGCGCCGTCGTCGTCGGAGCATCGTCCGAGCCGGGGATCATCGCGACGCATATCCACGCCGATGGCCGGCA
CAAGGAATTGCTGCGCACGACGACCGGCCCTTCGAGCGGCTCGAAAACACCCGCGCTCATGCGCATGGAGGGCAACGCGG
TGTTCAAGATGGCTGTCAACACGCTCGATCGCATTGTTGACGAGACGCTCGAGGCGAACGGCCTCGCCAAGACCGACATC
GATTGGCTGGTGCCGCATCAGGCCAACATCCGCATCATCTCGGCGACCGCGAAGAAGCTCGGCATGAGCATGGACAACGT
CGTGACGACGGTCGCCGGACACGGCAACACCTCGGCCGCGTCGGTGCCGCTCGCGTTCGACGCCGCCGTGCGGGACGGCC
GTATCAAGCGCGGCCAGATCGTGCTCATGGAGGCGTTCGGCGGGGGGTTCACCTGGGGCTCGGCGCTGCTTAGGTATTGA

Upstream 100 bases:

>100_bases
ACGCCTTCGAGCATGCGATCGAAACCGCCGGCGACGAGGTCCGCAACAACGTGCTGAAACGCATCACGGATCAGATCCAA
CTCCTGCAACGGGTGGCCGC

Downstream 100 bases:

>100_bases
TGGCACGGCCACCGAACGCAGCGTGTCGACGTCATGTTCCGAATTCCCGCTGGTGCCGGGGCGCTGCAGTGACTCCGCCG
CGCTAGAGGGTCGCACAGTG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTYSRILGTGGYLPARILTNADLEKLVDTNDQWIVDRTGIRERHIAADGEFTSDLATAAARAALEAANLAADDIDLLLVA
TTTPDLVFPSTACIVQSKLGMTNGKPAFDLQAVCSGFVYALSVADQFIKGGAAKHVLVVGAETLSRITDWNDRSNCILWG
DGAGAVVVGASSEPGIIATHIHADGRHKELLRTTTGPSSGSKTPALMRMEGNAVFKMAVNTLDRIVDETLEANGLAKTDI
DWLVPHQANIRIISATAKKLGMSMDNVVTTVAGHGNTSAASVPLAFDAAVRDGRIKRGQIVLMEAFGGGFTWGSALLRY

Sequences:

>Translated_319_residues
MTYSRILGTGGYLPARILTNADLEKLVDTNDQWIVDRTGIRERHIAADGEFTSDLATAAARAALEAANLAADDIDLLLVA
TTTPDLVFPSTACIVQSKLGMTNGKPAFDLQAVCSGFVYALSVADQFIKGGAAKHVLVVGAETLSRITDWNDRSNCILWG
DGAGAVVVGASSEPGIIATHIHADGRHKELLRTTTGPSSGSKTPALMRMEGNAVFKMAVNTLDRIVDETLEANGLAKTDI
DWLVPHQANIRIISATAKKLGMSMDNVVTTVAGHGNTSAASVPLAFDAAVRDGRIKRGQIVLMEAFGGGFTWGSALLRY
>Mature_318_residues
TYSRILGTGGYLPARILTNADLEKLVDTNDQWIVDRTGIRERHIAADGEFTSDLATAAARAALEAANLAADDIDLLLVAT
TTPDLVFPSTACIVQSKLGMTNGKPAFDLQAVCSGFVYALSVADQFIKGGAAKHVLVVGAETLSRITDWNDRSNCILWGD
GAGAVVVGASSEPGIIATHIHADGRHKELLRTTTGPSSGSKTPALMRMEGNAVFKMAVNTLDRIVDETLEANGLAKTDID
WLVPHQANIRIISATAKKLGMSMDNVVTTVAGHGNTSAASVPLAFDAAVRDGRIKRGQIVLMEAFGGGFTWGSALLRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=61.198738170347, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_THIDA (Q3SIM4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315309.1
- ProteinModelPortal:   Q3SIM4
- SMR:   Q3SIM4
- STRING:   Q3SIM4
- GeneID:   3672031
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1551
- NMPDR:   fig|292415.3.peg.1550
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q3SIM4
- ProtClustDB:   PRK09352
- BioCyc:   TDEN292415:TBD_1551-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33692; Mature: 33561

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 246-246 ACT_SITE 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSRILGTGGYLPARILTNADLEKLVDTNDQWIVDRTGIRERHIAADGEFTSDLATAAA
CCCHHEECCCCCCHHHHHCCCCHHHHHCCCCCEEEECCCCCHHEEECCCCHHHHHHHHHH
RAALEAANLAADDIDLLLVATTTPDLVFPSTACIVQSKLGMTNGKPAFDLQAVCSGFVYA
HHHHHHHHCCCCCEEEEEEEECCCCEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LSVADQFIKGGAAKHVLVVGAETLSRITDWNDRSNCILWGDGAGAVVVGASSEPGIIATH
HHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEE
IHADGRHKELLRTTTGPSSGSKTPALMRMEGNAVFKMAVNTLDRIVDETLEANGLAKTDI
EECCCCHHHHHHCCCCCCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCCC
DWLVPHQANIRIISATAKKLGMSMDNVVTTVAGHGNTSAASVPLAFDAAVRDGRIKRGQI
CEECCCCCCEEEEEEEHHHHCCCHHHHEEEEECCCCCCCCCCCEEEEHHHCCCCCCCCEE
VLMEAFGGGFTWGSALLRY
EEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
TYSRILGTGGYLPARILTNADLEKLVDTNDQWIVDRTGIRERHIAADGEFTSDLATAAA
CCHHEECCCCCCHHHHHCCCCHHHHHCCCCCEEEECCCCCHHEEECCCCHHHHHHHHHH
RAALEAANLAADDIDLLLVATTTPDLVFPSTACIVQSKLGMTNGKPAFDLQAVCSGFVYA
HHHHHHHHCCCCCEEEEEEEECCCCEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LSVADQFIKGGAAKHVLVVGAETLSRITDWNDRSNCILWGDGAGAVVVGASSEPGIIATH
HHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEE
IHADGRHKELLRTTTGPSSGSKTPALMRMEGNAVFKMAVNTLDRIVDETLEANGLAKTDI
EECCCCHHHHHHCCCCCCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCCC
DWLVPHQANIRIISATAKKLGMSMDNVVTTVAGHGNTSAASVPLAFDAAVRDGRIKRGQI
CEECCCCCCEEEEEEEHHHHCCCHHHHEEEEECCCCCCCCCCCEEEEHHHCCCCCCCCEE
VLMEAFGGGFTWGSALLRY
EEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA