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The map label for this gene is fabD [H]

Identifier: 74317568

GI number: 74317568

Start: 1634088

End: 1635020

Strand: Reverse

Name: fabD [H]

Synonym: Tbd_1550

Alternate gene names: 74317568

Gene position: 1635020-1634088 (Counterclockwise)

Preceding gene: 74317569

Following gene: 74317567

Centisome position: 56.19

GC content: 68.06

Gene sequence:

>933_bases
ATGGATACAACAATGAAGCTTGCATTCGTGTTTCCCGGACAGGGCTCGCAGTCGGTCGGCATGATGCAGGGCTGGGGCGC
GCGCGCCGACATACGTGCCACCTTCGCCGAGGCCTCCGACGCGTTGGGCCAGGACCTTTGGGCACTCGTGACCGAGGGGC
CGGCCGAGCTTCTGAACCAGACCGTGAACACCCAGCCCGCGATGTTGGCAGCGGACGTCGCCGCCTGGCGGGCGTGGCAG
ACCCAGGGCGGGGCGAAGCCGGTGGTGCTCGCAGGGCACAGTCTCGGCGAATACGCGGCGCTGGTCGCTGCCGACGCCTT
GAGTTTCGTCGACGCGATCAAGCTCGTGCGCTTTCGTGCCGAGGCCATGCAGTCCGCCGTGCCCGAAGGCGTCGGCGCGA
TGGCCGCGATTCTCGGTCTGGACGATGATGCCGTGCGTGCGGTGTGCGCCGATGCGGCGGCGGGGGAAGTGGTCGAGGCG
GTGAATCTCAATTCGCCCGGACAGGTCGTCATCGCCGGCAACAAGGGCGCGGTCGAGCGTGCAATGGCGCTCGCCAAGGA
GCGGGGCGCGAAGCGGGCCTTGCCGCTGCCGGTCAGCGTGCCGTCGCACTCTTCCCTGATGCGCCCGGCAGCCGAGAAGC
TGCTGGCCTACCTTGAGAACGTGGCGATTTCCGCGCCGCGTATTCCGGTGCTTCACAATACCGACGTGCAATCCCATGAC
GAGGCGGCGGCGATCCGCGCCGCCCTCGCCAAGCAACTGCATACGCCGGTCCGGTGGGTCGAAACCGTGCGGGCGCTCAA
GGCGGCGGGTGTCGAGCGCGTCATTGAATGCGGCCCCGGCAAGGTGCTGGCCGGGCTCAACAAACGTATCGACGACAGCC
TCGCCGCGCTCGCGCTCGTCGACGAAGCGAGCCTGCAGGCCGCACTCAACTAA

Upstream 100 bases:

>100_bases
GTGACTCCGCCGCGCTAGAGGGTCGCACAGTGAAACCCGCTTGTGTTTTACGCGCCGGCATGGCATCCGCCGTGCGGGTA
TCCACCTTCACTGAATACTC

Downstream 100 bases:

>100_bases
GGAGAAAAGGATGGAGGAGGGACGCTTCGCACAGCGTGCGAATCTGCAAGGCCGGGTCGCGCTGGTCACCGGCGCGAGCC
GGGGCATCGGTCAGGCGATC

Product: [Acyl-carrier-protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDTTMKLAFVFPGQGSQSVGMMQGWGARADIRATFAEASDALGQDLWALVTEGPAELLNQTVNTQPAMLAADVAAWRAWQ
TQGGAKPVVLAGHSLGEYAALVAADALSFVDAIKLVRFRAEAMQSAVPEGVGAMAAILGLDDDAVRAVCADAAAGEVVEA
VNLNSPGQVVIAGNKGAVERAMALAKERGAKRALPLPVSVPSHSSLMRPAAEKLLAYLENVAISAPRIPVLHNTDVQSHD
EAAAIRAALAKQLHTPVRWVETVRALKAAGVERVIECGPGKVLAGLNKRIDDSLAALALVDEASLQAALN

Sequences:

>Translated_310_residues
MDTTMKLAFVFPGQGSQSVGMMQGWGARADIRATFAEASDALGQDLWALVTEGPAELLNQTVNTQPAMLAADVAAWRAWQ
TQGGAKPVVLAGHSLGEYAALVAADALSFVDAIKLVRFRAEAMQSAVPEGVGAMAAILGLDDDAVRAVCADAAAGEVVEA
VNLNSPGQVVIAGNKGAVERAMALAKERGAKRALPLPVSVPSHSSLMRPAAEKLLAYLENVAISAPRIPVLHNTDVQSHD
EAAAIRAALAKQLHTPVRWVETVRALKAAGVERVIECGPGKVLAGLNKRIDDSLAALALVDEASLQAALN
>Mature_310_residues
MDTTMKLAFVFPGQGSQSVGMMQGWGARADIRATFAEASDALGQDLWALVTEGPAELLNQTVNTQPAMLAADVAAWRAWQ
TQGGAKPVVLAGHSLGEYAALVAADALSFVDAIKLVRFRAEAMQSAVPEGVGAMAAILGLDDDAVRAVCADAAAGEVVEA
VNLNSPGQVVIAGNKGAVERAMALAKERGAKRALPLPVSVPSHSSLMRPAAEKLLAYLENVAISAPRIPVLHNTDVQSHD
EAAAIRAALAKQLHTPVRWVETVRALKAAGVERVIECGPGKVLAGLNKRIDDSLAALALVDEASLQAALN

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=301, Percent_Identity=34.8837209302326, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI27477045, Length=106, Percent_Identity=42.4528301886792, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1787334, Length=305, Percent_Identity=58.0327868852459, Blast_Score=330, Evalue=6e-92,
Organism=Caenorhabditis elegans, GI71984332, Length=296, Percent_Identity=32.7702702702703, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=294, Percent_Identity=29.5918367346939, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24665753, Length=297, Percent_Identity=35.6902356902357, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32185; Mature: 32185

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTMKLAFVFPGQGSQSVGMMQGWGARADIRATFAEASDALGQDLWALVTEGPAELLNQ
CCCCEEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TVNTQPAMLAADVAAWRAWQTQGGAKPVVLAGHSLGEYAALVAADALSFVDAIKLVRFRA
HCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EAMQSAVPEGVGAMAAILGLDDDAVRAVCADAAAGEVVEAVNLNSPGQVVIAGNKGAVER
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHH
AMALAKERGAKRALPLPVSVPSHSSLMRPAAEKLLAYLENVAISAPRIPVLHNTDVQSHD
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCH
EAAAIRAALAKQLHTPVRWVETVRALKAAGVERVIECGPGKVLAGLNKRIDDSLAALALV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DEASLQAALN
HHHHHHHHCC
>Mature Secondary Structure
MDTTMKLAFVFPGQGSQSVGMMQGWGARADIRATFAEASDALGQDLWALVTEGPAELLNQ
CCCCEEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TVNTQPAMLAADVAAWRAWQTQGGAKPVVLAGHSLGEYAALVAADALSFVDAIKLVRFRA
HCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EAMQSAVPEGVGAMAAILGLDDDAVRAVCADAAAGEVVEAVNLNSPGQVVIAGNKGAVER
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHH
AMALAKERGAKRALPLPVSVPSHSSLMRPAAEKLLAYLENVAISAPRIPVLHNTDVQSHD
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCH
EAAAIRAALAKQLHTPVRWVETVRALKAAGVERVIECGPGKVLAGLNKRIDDSLAALALV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DEASLQAALN
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]