Click here to switch to the map view.

The map label for this gene is adk

Identifier: 74317522

GI number: 74317522

Start: 1593889

End: 1594542

Strand: Reverse

Name: adk

Synonym: Tbd_1504

Alternate gene names: 74317522

Gene position: 1594542-1593889 (Counterclockwise)

Preceding gene: 74317523

Following gene: 74317521

Centisome position: 54.8

GC content: 64.37

Gene sequence:

>654_bases
ATGCGTCTGATTCTGTTGGGCGGCCCTGGCGCCGGCAAAGGCACCCAGGCCAATTACATCAAGGAAAAATACGGCATTCC
GCAAATCTCCACCGGCGACATGCTGCGTGCGCAGATCAAGGCGGGCACCGAACTCGGCATGAAGGCCAAGGCGATCATGG
ACGCCGGCGGCCTCGTCTCCGACGACATCATCATCGGCATGGTCAAGGCGCGCCTGCAGGAGGCCGACTGCAAGAACGGT
TACCTGTTCGACGGCTTCCCGCGCACGATCCCGCAAGCCGAGGCGATGAAGGCTGCCGGCGTGCCGATCGACTACGTCGT
CGAGATCGACGTCGCCGACGAGGAAATCATCAAGCGCATGTCGGGCCGCCGCGTCCACGTCGCGTCCGGCCGCACCTACC
ACGTCGTGTTCAACCCGCCCAAGGTCGCCGGCAAGGACGACGTGACCGGCGAGGACCTGATCCAGCGCGACGACGACCAG
GAAGAGACCGTCAAGAAACGCCTCGACGTCTACCACGCACAGACCGAGCCGCTCGTGAAGTACTACGGCGACTGGGCAGC
ACGCGGCGAAGCCGGCGCGCCCAAGTACGTCAAGATTTCGGGCGTCGGCAAGGTCGAGCAGATCCGCGATTCGATCTTCG
CCGCCCTCGGCTGA

Upstream 100 bases:

>100_bases
CTTGAATCCGGCAATAAAATTTTTTAAGTGTTGCTCCCCGCGCGCTTGCCTTAGGCTAGCGCGCTTTGGGACATTCATAT
CAATTTAGGGGAGACTCGCG

Downstream 100 bases:

>100_bases
GCCCGCGCGGAATCGAAGACGGGCCGCAACGACGATGCCGCACGCGATCGCCCCGATGACCGAGACCGAGCGCTGGATCG
TGTCCAGCGCGGTCAAGGAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRLILLGGPGAGKGTQANYIKEKYGIPQISTGDMLRAQIKAGTELGMKAKAIMDAGGLVSDDIIIGMVKARLQEADCKNG
YLFDGFPRTIPQAEAMKAAGVPIDYVVEIDVADEEIIKRMSGRRVHVASGRTYHVVFNPPKVAGKDDVTGEDLIQRDDDQ
EETVKKRLDVYHAQTEPLVKYYGDWAARGEAGAPKYVKISGVGKVEQIRDSIFAALG

Sequences:

>Translated_217_residues
MRLILLGGPGAGKGTQANYIKEKYGIPQISTGDMLRAQIKAGTELGMKAKAIMDAGGLVSDDIIIGMVKARLQEADCKNG
YLFDGFPRTIPQAEAMKAAGVPIDYVVEIDVADEEIIKRMSGRRVHVASGRTYHVVFNPPKVAGKDDVTGEDLIQRDDDQ
EETVKKRLDVYHAQTEPLVKYYGDWAARGEAGAPKYVKISGVGKVEQIRDSIFAALG
>Mature_217_residues
MRLILLGGPGAGKGTQANYIKEKYGIPQISTGDMLRAQIKAGTELGMKAKAIMDAGGLVSDDIIIGMVKARLQEADCKNG
YLFDGFPRTIPQAEAMKAAGVPIDYVVEIDVADEEIIKRMSGRRVHVASGRTYHVVFNPPKVAGKDDVTGEDLIQRDDDQ
EETVKKRLDVYHAQTEPLVKYYGDWAARGEAGAPKYVKISGVGKVEQIRDSIFAALG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=50.5376344086022, Blast_Score=203, Evalue=8e-53,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=50.5376344086022, Blast_Score=203, Evalue=9e-53,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=45.6043956043956, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=40.1098901098901, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=40.1098901098901, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=40.1098901098901, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=40.1098901098901, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=32.967032967033, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI22749187, Length=183, Percent_Identity=27.3224043715847, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=29.1208791208791, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=29.1208791208791, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706497, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=63.1336405529954, Blast_Score=282, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=49.4623655913978, Blast_Score=201, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17537943, Length=184, Percent_Identity=36.9565217391304, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=216, Percent_Identity=32.4074074074074, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320432, Length=205, Percent_Identity=52.6829268292683, Blast_Score=224, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=43.5483870967742, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=52.7173913043478, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=46.1538461538462, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=46.1538461538462, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=30.1675977653631, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=30.1675977653631, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=26.6304347826087, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=26.6304347826087, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_THIDA (Q3SIR8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315262.1
- HSSP:   P69441
- ProteinModelPortal:   Q3SIR8
- SMR:   Q3SIR8
- STRING:   Q3SIR8
- GeneID:   3672917
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1504
- NMPDR:   fig|292415.3.peg.1504
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q3SIR8
- BioCyc:   TDEN292415:TBD_1504-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23567; Mature: 23567

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGGPGAGKGTQANYIKEKYGIPQISTGDMLRAQIKAGTELGMKAKAIMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DDIIIGMVKARLQEADCKNGYLFDGFPRTIPQAEAMKAAGVPIDYVVEIDVADEEIIKRM
CHHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCCEEEEEEEECCHHHHHHHH
SGRRVHVASGRTYHVVFNPPKVAGKDDVTGEDLIQRDDDQEETVKKRLDVYHAQTEPLVK
CCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
YYGDWAARGEAGAPKYVKISGVGKVEQIRDSIFAALG
HHCCHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGGPGAGKGTQANYIKEKYGIPQISTGDMLRAQIKAGTELGMKAKAIMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DDIIIGMVKARLQEADCKNGYLFDGFPRTIPQAEAMKAAGVPIDYVVEIDVADEEIIKRM
CHHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCCEEEEEEEECCHHHHHHHH
SGRRVHVASGRTYHVVFNPPKVAGKDDVTGEDLIQRDDDQEETVKKRLDVYHAQTEPLVK
CCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
YYGDWAARGEAGAPKYVKISGVGKVEQIRDSIFAALG
HHCCHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA