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The map label for this gene is hppA [H]

Identifier: 74317518

GI number: 74317518

Start: 1589811

End: 1591850

Strand: Reverse

Name: hppA [H]

Synonym: Tbd_1500

Alternate gene names: 74317518

Gene position: 1591850-1589811 (Counterclockwise)

Preceding gene: 74317519

Following gene: 74317517

Centisome position: 54.71

GC content: 66.27

Gene sequence:

>2040_bases
ATGAATGAAGGCTTGCTGTTCGCTCTCGTGGCGGCAGGGCTTGCCCTGCTCTACGGGATCATATCGATCAAATGGATCCT
GGCGCTCCCGAGCGGCAACGACAGGATGCGTGAGATCGCGGCGGCGGTGCAGGAGGGTGCCTCCGCCTATCTGAATCGGC
AATACACGACGATCGGGATCGTCGGCGTGATCCTGCTGATCGCCATCTTCCTGTCGCTCGGCTGGCAGACCGCGGTCGGC
TTCGCGCTCGGCGCCGTGCTCTCGGGCCTGACCGGCTACATCGGCATGAACGTCTCGGTGCGTGCCAACGTGCGCACCGC
GCAGGCCGCCACCAACGGCCTCAACGCCGCGCTCAACGTCGCGTTCAAGGGCGGCGCCATCACCGGCCTGCTGGTCGTCG
GCCTCGGCCTCTTGGGCGTCGCCGGCTACTACGCCGTGCTGACGCTGGTGCTCGGCGAAAGCACCGAGGCTGCGACGCAC
GCGCTCGTCGGCCTCGCGTTCGGCGGTTCGCTGATCTCGATCTTCGCGCGTCTCGGCGGCGGCATCTTCACCAAGGGCGC
CGACGTCGGCGCGGACCTCGTCGGCAAGGTCGAAGCGGGCATCCCCGAAGACGACCCGCGCAACCCGGCCGTGATCGCTG
ACAACGTCGGCGACAACGTCGGCGACTGCGCCGGCATGGCGGCCGACCTGTTCGAGACCTACGCCGTGACGATCATCGCG
ACGATGCTGCTCGGCGGCCTGTTGATCACCGGCTCGCCCGAAGCCGTGATCTATCCGCTCGTGCTCGGCGGCTTCTCGAT
CATCGCTTCGGTCATCGGCACCTTCTTCGTCAAGGCGCGTGAAGGCGGCAAGATCATGAACGCCCTGTATCGCGGCCTGA
TCGTCTCCGGCGTGCTCGCCGCGATCGCCTTCTATCCGATCACGACCTGGATGATGGGCGAGGGCGTGACGATCGGCGGC
GAACTCGTGACCTCGCTGAACCTCTACTTCGCCTCGCTGATCGGCCTCGCGCTGACCGCGGCGATGGTGTGGATCACCGA
GTACTACACGGCGACCGAATTCAGCCCGGTCCGCCACATCGCGCAGGCCTCGACGACCGGCCACGGCACCAACGTGATCG
CCGGCCTCGGCGTGTCGATGAAGTCGACCGCAGCGCCGGTGCTCGCCGTCTGCGCCGCGATCTGGGGCGCCTATGAACTC
GCGGGCCTCTACGGGATTGCGATCGCTGCGACCTCGATGCTGTCGATGGCCGGCATCATCGTCGCCCTCGACGCCTACGG
CCCGATCACCGACAACGCCGGCGGCATCGCCGAAATGGCAGGCCTGCCCGACAGCATCCGCGACATCACCGACCCGCTCG
ACGCCGTCGGCAACACGACCAAGGCGGTGACCAAGGGCTACGCGATCGGCTCGGCCGGCCTTGCCGCGCTCGTGCTCTTC
GCCGACTACACCCACGCCCTGTCCACCCACGGCGGCCCGGCGCTGAGCTTCGACCTGTCGAACCACATGGTCATCATCGG
CCTCTTCATCGGCGGCATGGTTCCTTATCTCTTCGGCGCCATGGGCATGGAAGCGGTCGGTCGTGCGGCCGGTTCGGTCG
TCGTCGAGGTGCGTCGCCAGTTCAAGAGCATCCCCGGCATCATGGAAGGCACGGGCAAGCCGGAATACGGCACTTGCGTC
GACATGCTGACCAAAGCCGCGATCAAGGAAATGATCGTCCCGTCGCTGCTGCCGGTCGCGGTGCCTATCATCGTCGGCCT
CGCCCTCGGCCCGCAGGCCCTGGGCGGCGTGCTCGTGGGCACGATCATCACCGGCATCTTCGTCGCGATTTCGATGACCA
CCGGCGGCGGCGCCTGGGACAACGCCAAGAAGTACATCGAGGAGGGCAACCACGGCGGCAAGGGTTCAGAAGCGCATAAA
GCTGCCGTTACTGGGGATACCGTCGGCGATCCGTACAAGGACACCGCCGGTCCGGCCGTCAACCCGCTGATCAAGATCAT
CAACATCGTAGCGCTCTTGATCGTGCCGCTGATCATGTAA

Upstream 100 bases:

>100_bases
CCGGGCACGCGTTTCGAAGGCGGGCTCGCGATGGGCAGGGATCAGTAACCGACGGTAGCGAAAGCTGCCGTTTTTTTTTG
TTTTTTGAGGAGAACGGATA

Downstream 100 bases:

>100_bases
CACAGCCAGCTGAGTACGGCCATCTCACGCCCGGGGCCAGCGCGCCCCGGAACGACAACAATATATTGAAGAGAGGAATT
GACGATGGCTAAAAACATGG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MNEGLLFALVAAGLALLYGIISIKWILALPSGNDRMREIAAAVQEGASAYLNRQYTTIGIVGVILLIAIFLSLGWQTAVG
FALGAVLSGLTGYIGMNVSVRANVRTAQAATNGLNAALNVAFKGGAITGLLVVGLGLLGVAGYYAVLTLVLGESTEAATH
ALVGLAFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTIIA
TMLLGGLLITGSPEAVIYPLVLGGFSIIASVIGTFFVKAREGGKIMNALYRGLIVSGVLAAIAFYPITTWMMGEGVTIGG
ELVTSLNLYFASLIGLALTAAMVWITEYYTATEFSPVRHIAQASTTGHGTNVIAGLGVSMKSTAAPVLAVCAAIWGAYEL
AGLYGIAIAATSMLSMAGIIVALDAYGPITDNAGGIAEMAGLPDSIRDITDPLDAVGNTTKAVTKGYAIGSAGLAALVLF
ADYTHALSTHGGPALSFDLSNHMVIIGLFIGGMVPYLFGAMGMEAVGRAAGSVVVEVRRQFKSIPGIMEGTGKPEYGTCV
DMLTKAAIKEMIVPSLLPVAVPIIVGLALGPQALGGVLVGTIITGIFVAISMTTGGGAWDNAKKYIEEGNHGGKGSEAHK
AAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLIM

Sequences:

>Translated_679_residues
MNEGLLFALVAAGLALLYGIISIKWILALPSGNDRMREIAAAVQEGASAYLNRQYTTIGIVGVILLIAIFLSLGWQTAVG
FALGAVLSGLTGYIGMNVSVRANVRTAQAATNGLNAALNVAFKGGAITGLLVVGLGLLGVAGYYAVLTLVLGESTEAATH
ALVGLAFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTIIA
TMLLGGLLITGSPEAVIYPLVLGGFSIIASVIGTFFVKAREGGKIMNALYRGLIVSGVLAAIAFYPITTWMMGEGVTIGG
ELVTSLNLYFASLIGLALTAAMVWITEYYTATEFSPVRHIAQASTTGHGTNVIAGLGVSMKSTAAPVLAVCAAIWGAYEL
AGLYGIAIAATSMLSMAGIIVALDAYGPITDNAGGIAEMAGLPDSIRDITDPLDAVGNTTKAVTKGYAIGSAGLAALVLF
ADYTHALSTHGGPALSFDLSNHMVIIGLFIGGMVPYLFGAMGMEAVGRAAGSVVVEVRRQFKSIPGIMEGTGKPEYGTCV
DMLTKAAIKEMIVPSLLPVAVPIIVGLALGPQALGGVLVGTIITGIFVAISMTTGGGAWDNAKKYIEEGNHGGKGSEAHK
AAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLIM
>Mature_679_residues
MNEGLLFALVAAGLALLYGIISIKWILALPSGNDRMREIAAAVQEGASAYLNRQYTTIGIVGVILLIAIFLSLGWQTAVG
FALGAVLSGLTGYIGMNVSVRANVRTAQAATNGLNAALNVAFKGGAITGLLVVGLGLLGVAGYYAVLTLVLGESTEAATH
ALVGLAFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTIIA
TMLLGGLLITGSPEAVIYPLVLGGFSIIASVIGTFFVKAREGGKIMNALYRGLIVSGVLAAIAFYPITTWMMGEGVTIGG
ELVTSLNLYFASLIGLALTAAMVWITEYYTATEFSPVRHIAQASTTGHGTNVIAGLGVSMKSTAAPVLAVCAAIWGAYEL
AGLYGIAIAATSMLSMAGIIVALDAYGPITDNAGGIAEMAGLPDSIRDITDPLDAVGNTTKAVTKGYAIGSAGLAALVLF
ADYTHALSTHGGPALSFDLSNHMVIIGLFIGGMVPYLFGAMGMEAVGRAAGSVVVEVRRQFKSIPGIMEGTGKPEYGTCV
DMLTKAAIKEMIVPSLLPVAVPIIVGLALGPQALGGVLVGTIITGIFVAISMTTGGGAWDNAKKYIEEGNHGGKGSEAHK
AAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLIM

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 69054; Mature: 69054

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEGLLFALVAAGLALLYGIISIKWILALPSGNDRMREIAAAVQEGASAYLNRQYTTIGI
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
VGVILLIAIFLSLGWQTAVGFALGAVLSGLTGYIGMNVSVRANVRTAQAATNGLNAALNV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCHHEEE
AFKGGAITGLLVVGLGLLGVAGYYAVLTLVLGESTEAATHALVGLAFGGSLISIFARLGG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTIIA
CEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
TMLLGGLLITGSPEAVIYPLVLGGFSIIASVIGTFFVKAREGGKIMNALYRGLIVSGVLA
HHHHCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AIAFYPITTWMMGEGVTIGGELVTSLNLYFASLIGLALTAAMVWITEYYTATEFSPVRHI
HHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AQASTTGHGTNVIAGLGVSMKSTAAPVLAVCAAIWGAYELAGLYGIAIAATSMLSMAGII
HHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VALDAYGPITDNAGGIAEMAGLPDSIRDITDPLDAVGNTTKAVTKGYAIGSAGLAALVLF
EEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHH
ADYTHALSTHGGPALSFDLSNHMVIIGLFIGGMVPYLFGAMGMEAVGRAAGSVVVEVRRQ
HHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSIPGIMEGTGKPEYGTCVDMLTKAAIKEMIVPSLLPVAVPIIVGLALGPQALGGVLVG
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TIITGIFVAISMTTGGGAWDNAKKYIEEGNHGGKGSEAHKAAVTGDTVGDPYKDTAGPAV
HHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCHH
NPLIKIINIVALLIVPLIM
HHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNEGLLFALVAAGLALLYGIISIKWILALPSGNDRMREIAAAVQEGASAYLNRQYTTIGI
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
VGVILLIAIFLSLGWQTAVGFALGAVLSGLTGYIGMNVSVRANVRTAQAATNGLNAALNV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCHHEEE
AFKGGAITGLLVVGLGLLGVAGYYAVLTLVLGESTEAATHALVGLAFGGSLISIFARLGG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTIIA
CEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
TMLLGGLLITGSPEAVIYPLVLGGFSIIASVIGTFFVKAREGGKIMNALYRGLIVSGVLA
HHHHCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AIAFYPITTWMMGEGVTIGGELVTSLNLYFASLIGLALTAAMVWITEYYTATEFSPVRHI
HHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AQASTTGHGTNVIAGLGVSMKSTAAPVLAVCAAIWGAYELAGLYGIAIAATSMLSMAGII
HHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VALDAYGPITDNAGGIAEMAGLPDSIRDITDPLDAVGNTTKAVTKGYAIGSAGLAALVLF
EEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHH
ADYTHALSTHGGPALSFDLSNHMVIIGLFIGGMVPYLFGAMGMEAVGRAAGSVVVEVRRQ
HHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSIPGIMEGTGKPEYGTCVDMLTKAAIKEMIVPSLLPVAVPIIVGLALGPQALGGVLVG
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TIITGIFVAISMTTGGGAWDNAKKYIEEGNHGGKGSEAHKAAVTGDTVGDPYKDTAGPAV
HHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCHH
NPLIKIINIVALLIVPLIM
HHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]