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The map label for this gene is prs [H]

Identifier: 74317483

GI number: 74317483

Start: 1549634

End: 1550617

Strand: Direct

Name: prs [H]

Synonym: Tbd_1465

Alternate gene names: 74317483

Gene position: 1549634-1550617 (Clockwise)

Preceding gene: 74317481

Following gene: 74317485

Centisome position: 53.26

GC content: 69.82

Gene sequence:

>984_bases
ATGGGACGCGAAGAACTCTGCCTGTTCAGCCTCAACGCGAGCCGCGGCCTCGGCGAGCGCATTGCCGCCCGGCTCGGCCA
GCCGCTGGCCGAGCACGAGGAGCGTGAGTTCGAGGACGGCGAACACAAGGCACGCCCGCTCGAGAGCGTGCGCGGCCGCG
ACGTCTACGTCGTGCAGTCGCTCCATGGCGAACCGGGTTCTAGCGCCAACGACAAGCTGATTCGGCTGCTGTTCTTCATC
GCGACGCTCAAGGACGCCTCGGCCGCACGCGTCACGGCGGTCGTCCCCTACCTCGCCTACGCGCGCAAGGACCGTCGCAG
CAAACCGCGTGATCCGGTCGGCAGCCGCTACGTCGCGCAGCTGTTCGAGAGCCTCGGAACCGACCGCATCGTGAGTCTCG
ACGTCCACAATCTCGCCGCCTACCAGAACGCGTTCCGCATCCCGGTCGAACATCTCGAAGCGCGGCCGCTCTTCGTCGCG
CATTTCGCCCCGGCGTTCGCAAACGACGACGTCGTGGTGGTCTCGCCCGACGTCGGCGGCGCCAAGCGCGCCGAGGCCCT
GCGCGCCTCCCTTTCACGCCGCATCGGGCGTCCCGCAGGCATGGCGTTCATCGAAAAATACCGCAGCGGCGGCATCGTCT
CGGGGGAAGCCGTCGTCGGCGACGTCGACGGCAAGCACGTCCTCATCGTCGACGACCTCGTCAGCAGCGGCACCACGCTC
GCCCGCGCGGCCGCCGCCTGCCGTAGCCGCGGCGCCACACGCGTCCTCGCCGTCGCGACGCACGGCGTGTTCGGCGGCGA
TGCCGTGCGCACCCTCGGTGACAGTGCGCTCGACGCGCTCGTCGTCACCGACAGCATCCCCACCTCGCACCTGCCGCCGC
CACTGGGCGAGCGCGTCGAAATCCTCGACATCGCGCCGCTCTTCGCCGAGGCGATCCGGCGGCTGCACGAAGCACGCTCG
CTCGGCGATCTGCTCGGCGATTAG

Upstream 100 bases:

>100_bases
TCCGAGCCCTGCGCTTTCGGTCCACGACCCCTCCCCTCGCGCGCCCGCTCTCAGCTTGGCATACGATGAAAGTACCGCCA
GTCTCCCGTCGGAAAAAGCC

Downstream 100 bases:

>100_bases
CGCAGCGTCGCCCTGGCGATGTGGCGCTCGGCCAGTTCGAGATAGTCGTGCGCGAGGGCCGGCCATCTCGCGGGCGGATG
GCGGCCGTCATCGTCCTTGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MGREELCLFSLNASRGLGERIAARLGQPLAEHEEREFEDGEHKARPLESVRGRDVYVVQSLHGEPGSSANDKLIRLLFFI
ATLKDASAARVTAVVPYLAYARKDRRSKPRDPVGSRYVAQLFESLGTDRIVSLDVHNLAAYQNAFRIPVEHLEARPLFVA
HFAPAFANDDVVVVSPDVGGAKRAEALRASLSRRIGRPAGMAFIEKYRSGGIVSGEAVVGDVDGKHVLIVDDLVSSGTTL
ARAAAACRSRGATRVLAVATHGVFGGDAVRTLGDSALDALVVTDSIPTSHLPPPLGERVEILDIAPLFAEAIRRLHEARS
LGDLLGD

Sequences:

>Translated_327_residues
MGREELCLFSLNASRGLGERIAARLGQPLAEHEEREFEDGEHKARPLESVRGRDVYVVQSLHGEPGSSANDKLIRLLFFI
ATLKDASAARVTAVVPYLAYARKDRRSKPRDPVGSRYVAQLFESLGTDRIVSLDVHNLAAYQNAFRIPVEHLEARPLFVA
HFAPAFANDDVVVVSPDVGGAKRAEALRASLSRRIGRPAGMAFIEKYRSGGIVSGEAVVGDVDGKHVLIVDDLVSSGTTL
ARAAAACRSRGATRVLAVATHGVFGGDAVRTLGDSALDALVVTDSIPTSHLPPPLGERVEILDIAPLFAEAIRRLHEARS
LGDLLGD
>Mature_326_residues
GREELCLFSLNASRGLGERIAARLGQPLAEHEEREFEDGEHKARPLESVRGRDVYVVQSLHGEPGSSANDKLIRLLFFIA
TLKDASAARVTAVVPYLAYARKDRRSKPRDPVGSRYVAQLFESLGTDRIVSLDVHNLAAYQNAFRIPVEHLEARPLFVAH
FAPAFANDDVVVVSPDVGGAKRAEALRASLSRRIGRPAGMAFIEKYRSGGIVSGEAVVGDVDGKHVLIVDDLVSSGTTLA
RAAAACRSRGATRVLAVATHGVFGGDAVRTLGDSALDALVVTDSIPTSHLPPPLGERVEILDIAPLFAEAIRRLHEARSL
GDLLGD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=323, Percent_Identity=36.8421052631579, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4506129, Length=324, Percent_Identity=36.1111111111111, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4506127, Length=321, Percent_Identity=36.4485981308411, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI84875539, Length=327, Percent_Identity=35.7798165137615, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI4506133, Length=354, Percent_Identity=28.8135593220339, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI194018537, Length=367, Percent_Identity=27.2479564032698, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1787458, Length=323, Percent_Identity=37.1517027863777, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25149168, Length=320, Percent_Identity=35, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17554704, Length=320, Percent_Identity=35, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17554702, Length=320, Percent_Identity=35, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71989924, Length=320, Percent_Identity=35, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17570245, Length=346, Percent_Identity=27.4566473988439, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320946, Length=326, Percent_Identity=35.8895705521472, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319403, Length=331, Percent_Identity=35.9516616314199, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321776, Length=329, Percent_Identity=34.3465045592705, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322667, Length=185, Percent_Identity=34.0540540540541, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=40.3508771929825, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21355239, Length=325, Percent_Identity=36.3076923076923, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI45551540, Length=348, Percent_Identity=33.9080459770115, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24651458, Length=322, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24651456, Length=322, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281362873, Length=322, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24651454, Length=322, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24651462, Length=109, Percent_Identity=36.697247706422, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651464, Length=109, Percent_Identity=36.697247706422, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45552010, Length=109, Percent_Identity=36.697247706422, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35119; Mature: 34988

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGREELCLFSLNASRGLGERIAARLGQPLAEHEEREFEDGEHKARPLESVRGRDVYVVQS
CCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCHHHHCCCCEEEEEE
LHGEPGSSANDKLIRLLFFIATLKDASAARVTAVVPYLAYARKDRRSKPRDPVGSRYVAQ
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
LFESLGTDRIVSLDVHNLAAYQNAFRIPVEHLEARPLFVAHFAPAFANDDVVVVSPDVGG
HHHHCCCCEEEEEEHHHHHHHHHHHCCCHHHHCCCCEEEEECCHHCCCCCEEEECCCCCC
AKRAEALRASLSRRIGRPAGMAFIEKYRSGGIVSGEAVVGDVDGKHVLIVDDLVSSGTTL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCEEEECCCCCEEEEEECHHHCCHHH
ARAAAACRSRGATRVLAVATHGVFGGDAVRTLGDSALDALVVTDSIPTSHLPPPLGERVE
HHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEE
ILDIAPLFAEAIRRLHEARSLGDLLGD
EEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GREELCLFSLNASRGLGERIAARLGQPLAEHEEREFEDGEHKARPLESVRGRDVYVVQS
CCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCHHHHCCCCEEEEEE
LHGEPGSSANDKLIRLLFFIATLKDASAARVTAVVPYLAYARKDRRSKPRDPVGSRYVAQ
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
LFESLGTDRIVSLDVHNLAAYQNAFRIPVEHLEARPLFVAHFAPAFANDDVVVVSPDVGG
HHHHCCCCEEEEEEHHHHHHHHHHHCCCHHHHCCCCEEEEECCHHCCCCCEEEECCCCCC
AKRAEALRASLSRRIGRPAGMAFIEKYRSGGIVSGEAVVGDVDGKHVLIVDDLVSSGTTL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCEEEECCCCCEEEEEECHHHCCHHH
ARAAAACRSRGATRVLAVATHGVFGGDAVRTLGDSALDALVVTDSIPTSHLPPPLGERVE
HHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEE
ILDIAPLFAEAIRRLHEARSLGDLLGD
EEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]