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The map label for this gene is polX [H]

Identifier: 74317464

GI number: 74317464

Start: 1531277

End: 1533001

Strand: Direct

Name: polX [H]

Synonym: Tbd_1446

Alternate gene names: 74317464

Gene position: 1531277-1533001 (Clockwise)

Preceding gene: 74317462

Following gene: 74317467

Centisome position: 52.62

GC content: 68.99

Gene sequence:

>1725_bases
ATGCCCACGCACAACGCCGATATCGCCGCGGTCTTTTCCGAAATCGCCGACCGCCTTGAAATCCAGGGCGCCAACCCGTT
TCGCATCCGCGCCTACCGCAACGCGGCGTTGACGCTCGGCGAGCTCGCGCAGGACGCGCGCGGCATGCTCGCCAAAGGCG
AGGACTTGCGGCACATCCCCGGCATCGGCGACGACCTGGCGAGCAAGATCAGCGAAATCGTCGACACGGGCCGCTGCGAT
CTGCTCGAACGCCTGCGGCGCGACCTGCCGCCGGCCGTCACCGAGTTGCTGCGCATTCCCGGTCTCGGTCCGCGCCGGGT
CCGCGCGCTCTATCACGATCTGCAGGTACAGACCGTCGAGCAGCTCTACCGCGCGGCGCGCGACGGCCGCATCCGCGCGT
TGCCCGGTTTCGGCGAAAAAACCGAGCTTCACATCATCGAGGCGATCGAGGCACACGCGAGCAAGACGCAGCGCTTCAAG
CTCGCCGTCGCCGCCCAGTATGCCGACGCGCTCAGCGCATTCCTGCAGACCCAGCCCGGGGTAACAAAGGTCGCGGTCGC
CGGCAGCTTCCGGCGCATGCGCGAGACCGTCGGCGACCTCGACATCGTCGCGACGGCTGCCGCCGACAGCCCCGTGATCG
CGCGGCTGACCGGCTACGACGAGGTCGCGACCGTCCTCGGGGCAGGCAGCACCCGCGCAAGCGTCGTCCTCAAGAGCGGC
CTGCAGGTCGATCTGCGCGTCGTCGCCGAGCAGGCGTTCGGCGCGGCGCTGCACTATTTCACCGGATCCAAGGCCCACAA
CATCGCGCTCCGGCGGATCGCGCAAAGGCGCGGCCTCAAGATCAACGAGTACGGCGTGTTCCGCGACAGCGAGCGCATCG
CCGGCGAGGACGAGAGCTCGGTCTACCGCAGCGTCGACCTGCCCTGGATTCCGCCCGAACTGCGCGAGGACCGCGGCGAA
ATCGAGGCCGCGCGCGCCGGCCATCTGCCGCGGCTGGTCGAGCGCGCCGACCTGCGCGGCGACCTCCACGCGCACACCAC
GGCGACCGACGGCCACGACAGCCTGCGCGAGATGGCGCGCGCAGCCCAGGCGATCGGCCTCGAGTATCTCGCGATCACCG
AACACTCACGCCGTCTCGCGGTGGCACGCGGACTCGACCCGCTCCGACTCGCGCGGCAATGCGACGCGATCGACCGGCTC
AACGCCGAACTCGACAGCTTCACCTTGCTGAAGGGCATCGAGGTCGACATCCTCGAAAACGGCGATCTCGACCTCCCCGA
CGACGTGCTCGGCCGCCTCGACCTGGTCGTCGGCGCGGTGCACAGCCGATTCGACCTCTCGCGCGCACGGCAGACGCGCC
GCATCCTGCGCGCGATGGAACACCCGCACTTCACGCTGCTCGCGCATCCCACCGGGCGCCGGCTCGAGCACCGCGAGCCC
TACGACGTCGACATGCTGCGCATCATCCGCGAGGCGAAAAGCCGCGGCTGCTTTCTCGAACTCAACGCCCATCCCGAACG
CCTCGACCTGCTCGACACCCACTGCCACATGGCGAAGGAGGAAGGCGTGCTCGTGAGCGTCAACTCGGACGCGCACAGCC
GCTTCGACTTCGCGAACCTCAGTTACGGGATAGGGCAGGCGCGCCGCGGCTGGCTCGAGAAGGACGACGTCCTCAACACC
CGACCGCTCGCGGCGCTGAGACCGCTGCTGAAGCGCACGATGTAA

Upstream 100 bases:

>100_bases
CTGCTGGGACACCGCGCGTCGGCTCGCGTTCACCCGCGCGGTCCCCGCACCCCGCGCAGCGCCGTGTTCTATACCCATAG
GGCGCCCCCTGACGCCGCCT

Downstream 100 bases:

>100_bases
GCCGGCGCCTGCGCGGCTTTTCGGCCGCCACTGACGCAGAGCGGCGTCAGCCGGCTCGCAGCCCCGGCAGCGCGCGTGTC
ACTCCGCCTCGGGCCCGCCG

Product: DNA polymerase X

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MPTHNADIAAVFSEIADRLEIQGANPFRIRAYRNAALTLGELAQDARGMLAKGEDLRHIPGIGDDLASKISEIVDTGRCD
LLERLRRDLPPAVTELLRIPGLGPRRVRALYHDLQVQTVEQLYRAARDGRIRALPGFGEKTELHIIEAIEAHASKTQRFK
LAVAAQYADALSAFLQTQPGVTKVAVAGSFRRMRETVGDLDIVATAAADSPVIARLTGYDEVATVLGAGSTRASVVLKSG
LQVDLRVVAEQAFGAALHYFTGSKAHNIALRRIAQRRGLKINEYGVFRDSERIAGEDESSVYRSVDLPWIPPELREDRGE
IEAARAGHLPRLVERADLRGDLHAHTTATDGHDSLREMARAAQAIGLEYLAITEHSRRLAVARGLDPLRLARQCDAIDRL
NAELDSFTLLKGIEVDILENGDLDLPDDVLGRLDLVVGAVHSRFDLSRARQTRRILRAMEHPHFTLLAHPTGRRLEHREP
YDVDMLRIIREAKSRGCFLELNAHPERLDLLDTHCHMAKEEGVLVSVNSDAHSRFDFANLSYGIGQARRGWLEKDDVLNT
RPLAALRPLLKRTM

Sequences:

>Translated_574_residues
MPTHNADIAAVFSEIADRLEIQGANPFRIRAYRNAALTLGELAQDARGMLAKGEDLRHIPGIGDDLASKISEIVDTGRCD
LLERLRRDLPPAVTELLRIPGLGPRRVRALYHDLQVQTVEQLYRAARDGRIRALPGFGEKTELHIIEAIEAHASKTQRFK
LAVAAQYADALSAFLQTQPGVTKVAVAGSFRRMRETVGDLDIVATAAADSPVIARLTGYDEVATVLGAGSTRASVVLKSG
LQVDLRVVAEQAFGAALHYFTGSKAHNIALRRIAQRRGLKINEYGVFRDSERIAGEDESSVYRSVDLPWIPPELREDRGE
IEAARAGHLPRLVERADLRGDLHAHTTATDGHDSLREMARAAQAIGLEYLAITEHSRRLAVARGLDPLRLARQCDAIDRL
NAELDSFTLLKGIEVDILENGDLDLPDDVLGRLDLVVGAVHSRFDLSRARQTRRILRAMEHPHFTLLAHPTGRRLEHREP
YDVDMLRIIREAKSRGCFLELNAHPERLDLLDTHCHMAKEEGVLVSVNSDAHSRFDFANLSYGIGQARRGWLEKDDVLNT
RPLAALRPLLKRTM
>Mature_573_residues
PTHNADIAAVFSEIADRLEIQGANPFRIRAYRNAALTLGELAQDARGMLAKGEDLRHIPGIGDDLASKISEIVDTGRCDL
LERLRRDLPPAVTELLRIPGLGPRRVRALYHDLQVQTVEQLYRAARDGRIRALPGFGEKTELHIIEAIEAHASKTQRFKL
AVAAQYADALSAFLQTQPGVTKVAVAGSFRRMRETVGDLDIVATAAADSPVIARLTGYDEVATVLGAGSTRASVVLKSGL
QVDLRVVAEQAFGAALHYFTGSKAHNIALRRIAQRRGLKINEYGVFRDSERIAGEDESSVYRSVDLPWIPPELREDRGEI
EAARAGHLPRLVERADLRGDLHAHTTATDGHDSLREMARAAQAIGLEYLAITEHSRRLAVARGLDPLRLARQCDAIDRLN
AELDSFTLLKGIEVDILENGDLDLPDDVLGRLDLVVGAVHSRFDLSRARQTRRILRAMEHPHFTLLAHPTGRRLEHREPY
DVDMLRIIREAKSRGCFLELNAHPERLDLLDTHCHMAKEEGVLVSVNSDAHSRFDFANLSYGIGQARRGWLEKDDVLNTR
PLAALRPLLKRTM

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI4505931, Length=306, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63711; Mature: 63579

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTHNADIAAVFSEIADRLEIQGANPFRIRAYRNAALTLGELAQDARGMLAKGEDLRHIP
CCCCCHHHHHHHHHHHHHHEECCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCC
GIGDDLASKISEIVDTGRCDLLERLRRDLPPAVTELLRIPGLGPRRVRALYHDLQVQTVE
CCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QLYRAARDGRIRALPGFGEKTELHIIEAIEAHASKTQRFKLAVAAQYADALSAFLQTQPG
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VTKVAVAGSFRRMRETVGDLDIVATAAADSPVIARLTGYDEVATVLGAGSTRASVVLKSG
CEEEEHHHHHHHHHHHHCCHHEEEECCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHCC
LQVDLRVVAEQAFGAALHYFTGSKAHNIALRRIAQRRGLKINEYGVFRDSERIAGEDESS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHCCCCCHHH
VYRSVDLPWIPPELREDRGEIEAARAGHLPRLVERADLRGDLHAHTTATDGHDSLREMAR
HHHCCCCCCCCHHHHHCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
AAQAIGLEYLAITEHSRRLAVARGLDPLRLARQCDAIDRLNAELDSFTLLKGIEVDILEN
HHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECC
GDLDLPDDVLGRLDLVVGAVHSRFDLSRARQTRRILRAMEHPHFTLLAHPTGRRLEHREP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
YDVDMLRIIREAKSRGCFLELNAHPERLDLLDTHCHMAKEEGVLVSVNSDAHSRFDFANL
CCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
SYGIGQARRGWLEKDDVLNTRPLAALRPLLKRTM
CCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTHNADIAAVFSEIADRLEIQGANPFRIRAYRNAALTLGELAQDARGMLAKGEDLRHIP
CCCCHHHHHHHHHHHHHHEECCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCC
GIGDDLASKISEIVDTGRCDLLERLRRDLPPAVTELLRIPGLGPRRVRALYHDLQVQTVE
CCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QLYRAARDGRIRALPGFGEKTELHIIEAIEAHASKTQRFKLAVAAQYADALSAFLQTQPG
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VTKVAVAGSFRRMRETVGDLDIVATAAADSPVIARLTGYDEVATVLGAGSTRASVVLKSG
CEEEEHHHHHHHHHHHHCCHHEEEECCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHCC
LQVDLRVVAEQAFGAALHYFTGSKAHNIALRRIAQRRGLKINEYGVFRDSERIAGEDESS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHCCCCCHHH
VYRSVDLPWIPPELREDRGEIEAARAGHLPRLVERADLRGDLHAHTTATDGHDSLREMAR
HHHCCCCCCCCHHHHHCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
AAQAIGLEYLAITEHSRRLAVARGLDPLRLARQCDAIDRLNAELDSFTLLKGIEVDILEN
HHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECC
GDLDLPDDVLGRLDLVVGAVHSRFDLSRARQTRRILRAMEHPHFTLLAHPTGRRLEHREP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
YDVDMLRIIREAKSRGCFLELNAHPERLDLLDTHCHMAKEEGVLVSVNSDAHSRFDFANL
CCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
SYGIGQARRGWLEKDDVLNTRPLAALRPLLKRTM
CCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]