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The map label for this gene is mdtA [H]

Identifier: 74317379

GI number: 74317379

Start: 1440704

End: 1441855

Strand: Reverse

Name: mdtA [H]

Synonym: Tbd_1361

Alternate gene names: 74317379

Gene position: 1441855-1440704 (Counterclockwise)

Preceding gene: 74317380

Following gene: 74317378

Centisome position: 49.55

GC content: 70.57

Gene sequence:

>1152_bases
ATGAAACGGCTCCCTGTGCAACGGCGCACGCTCATGCTCGTCGCCGTGATCCTTCCGCTGCTCGCGCTCTTCGTCTACGT
CGGGCTGCGCTCGGGGCCGCTAGCACCGGTGCCCGTCGCGACCACCACAGTCGAATCGCGGCCGGTCACGCCGGCGCTCT
TCGGCATCGGCACGGTCGAGGCGCGCTACACGTACAAGATCGGTCCGACCGTCGCCGGGCGCGTCAAGCGGCTGGACGTG
CACGCGGGAGATACGGTCCGCGCAGGGCAGGTACTCGGCGAGATGGACCCGGTCGATCTCGACGATCGCGTCCGCGCCCA
GGAAGCGGCTGCCAAGCGCGCACAGGCCAATCTGCGCGAGGCCGAAGCGCGGAAGTCCTATGCCGAGGCCCAGGCGAGCC
GCTATCAGCAACTCTTCACCGTGCGTTCGACCAGCGAGGAAATCCTCACCGCCAAGCAGCAGGAGCTGCAGATCGCGGAA
GCCGCGCTGGCGGCGGCGCGGGAAGACATCGCGCGGGCCCGGTCGGACCGCGAAGCGCTACTGACACAGCGGCGGAACCT
GCGCCTGGTGACGCCGGTCGGCGGCGTCGTCGCCGTGCGCGACGCCGACCCCGGCACGACCGTCGTCGCCGGGCAGGCCG
TGATCGAGGTGATCGACCCCGAGAGCCTGTGGGTCAACGTGCGCTTCGACCAGATGCGCGCCGCGGGGCTGGCGCGCGGG
CTGCCAGCGCGGATCGTTCTGCGCTCGCGCGACGGCCACACCCTGAAAGGGCGCGTGCTGCGCATCGAACCGATGGCCGA
CGCCGTGACCGAGGAGACGCTCGCTAAGGTGACGTTCGACACGCGGCCTGCGCCGCTGCCGCCGGTCGGCGAACTGGCCG
AAGTCACGGTGGAACTGCCGGCTCTTGCGGCGGCGCCGAGCGTGCCCAACGCCGCGATCCGCCGCGAGGGCGGGCAGGTC
GGCGTGTGGCGGGTCGTGGACGGCGACCTTCGGTTCACGCCGGTCAAGCTCGGCGCCTCCGATCTCGACGGCCATGTGCA
GGTGCGTGAAGGACTCGAACCGGGCGACCGCGTCGTGACCTATAGCGAAAAGGCCTTGACCGAGCGCAGCCGCGTCAAGG
TCGTCGAGCGCATCGCGGGAACGTCGAAATGA

Upstream 100 bases:

>100_bases
GTCTGGTCATGCAGTCCCTGCTTGCCGGTGATGTCGCGGGCATCCGCCGCGACGCGCCGCGGGTGTTCGCCATCTACCGG
CGCGGCATCGGGAGAACGCT

Downstream 100 bases:

>100_bases
TCAGCCTGGCCGGTCGCGACATTCTTCATGCCTGGGGCAAGTTCGTCTTCACCGGCGTCGGGCTGGGCCTGCTGATCGGC
GTGACGCTGGTCATGGCCGG

Product: RND efflux membrane protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKRLPVQRRTLMLVAVILPLLALFVYVGLRSGPLAPVPVATTTVESRPVTPALFGIGTVEARYTYKIGPTVAGRVKRLDV
HAGDTVRAGQVLGEMDPVDLDDRVRAQEAAAKRAQANLREAEARKSYAEAQASRYQQLFTVRSTSEEILTAKQQELQIAE
AALAAAREDIARARSDREALLTQRRNLRLVTPVGGVVAVRDADPGTTVVAGQAVIEVIDPESLWVNVRFDQMRAAGLARG
LPARIVLRSRDGHTLKGRVLRIEPMADAVTEETLAKVTFDTRPAPLPPVGELAEVTVELPALAAAPSVPNAAIRREGGQV
GVWRVVDGDLRFTPVKLGASDLDGHVQVREGLEPGDRVVTYSEKALTERSRVKVVERIAGTSK

Sequences:

>Translated_383_residues
MKRLPVQRRTLMLVAVILPLLALFVYVGLRSGPLAPVPVATTTVESRPVTPALFGIGTVEARYTYKIGPTVAGRVKRLDV
HAGDTVRAGQVLGEMDPVDLDDRVRAQEAAAKRAQANLREAEARKSYAEAQASRYQQLFTVRSTSEEILTAKQQELQIAE
AALAAAREDIARARSDREALLTQRRNLRLVTPVGGVVAVRDADPGTTVVAGQAVIEVIDPESLWVNVRFDQMRAAGLARG
LPARIVLRSRDGHTLKGRVLRIEPMADAVTEETLAKVTFDTRPAPLPPVGELAEVTVELPALAAAPSVPNAAIRREGGQV
GVWRVVDGDLRFTPVKLGASDLDGHVQVREGLEPGDRVVTYSEKALTERSRVKVVERIAGTSK
>Mature_383_residues
MKRLPVQRRTLMLVAVILPLLALFVYVGLRSGPLAPVPVATTTVESRPVTPALFGIGTVEARYTYKIGPTVAGRVKRLDV
HAGDTVRAGQVLGEMDPVDLDDRVRAQEAAAKRAQANLREAEARKSYAEAQASRYQQLFTVRSTSEEILTAKQQELQIAE
AALAAAREDIARARSDREALLTQRRNLRLVTPVGGVVAVRDADPGTTVVAGQAVIEVIDPESLWVNVRFDQMRAAGLARG
LPARIVLRSRDGHTLKGRVLRIEPMADAVTEETLAKVTFDTRPAPLPPVGELAEVTVELPALAAAPSVPNAAIRREGGQV
GVWRVVDGDLRFTPVKLGASDLDGHVQVREGLEPGDRVVTYSEKALTERSRVKVVERIAGTSK

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=370, Percent_Identity=25.6756756756757, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082036, Length=367, Percent_Identity=27.2479564032698, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41418; Mature: 41418

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS50096 IQ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLPVQRRTLMLVAVILPLLALFVYVGLRSGPLAPVPVATTTVESRPVTPALFGIGTVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCEE
ARYTYKIGPTVAGRVKRLDVHAGDTVRAGQVLGEMDPVDLDDRVRAQEAAAKRAQANLRE
EEEEEEECCCCCCCEEEEEECCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AEARKSYAEAQASRYQQLFTVRSTSEEILTAKQQELQIAEAALAAAREDIARARSDREAL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQRRNLRLVTPVGGVVAVRDADPGTTVVAGQAVIEVIDPESLWVNVRFDQMRAAGLARG
HHHCCCCEEEECCCCEEEEECCCCCCEEEECCEEEEEECCCEEEEEEEHHHHHHHHHHCC
LPARIVLRSRDGHTLKGRVLRIEPMADAVTEETLAKVTFDTRPAPLPPVGELAEVTVELP
CCEEEEEECCCCCEEECEEEEEECHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHEEECC
ALAAAPSVPNAAIRREGGQVGVWRVVDGDLRFTPVKLGASDLDGHVQVREGLEPGDRVVT
HHHCCCCCCCHHHHCCCCCEEEEEEECCCEEEEEEECCCCCCCCCEEEECCCCCCCEEEE
YSEKALTERSRVKVVERIAGTSK
ECHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRLPVQRRTLMLVAVILPLLALFVYVGLRSGPLAPVPVATTTVESRPVTPALFGIGTVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCEE
ARYTYKIGPTVAGRVKRLDVHAGDTVRAGQVLGEMDPVDLDDRVRAQEAAAKRAQANLRE
EEEEEEECCCCCCCEEEEEECCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AEARKSYAEAQASRYQQLFTVRSTSEEILTAKQQELQIAEAALAAAREDIARARSDREAL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQRRNLRLVTPVGGVVAVRDADPGTTVVAGQAVIEVIDPESLWVNVRFDQMRAAGLARG
HHHCCCCEEEECCCCEEEEECCCCCCEEEECCEEEEEECCCEEEEEEEHHHHHHHHHHCC
LPARIVLRSRDGHTLKGRVLRIEPMADAVTEETLAKVTFDTRPAPLPPVGELAEVTVELP
CCEEEEEECCCCCEEECEEEEEECHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHEEECC
ALAAAPSVPNAAIRREGGQVGVWRVVDGDLRFTPVKLGASDLDGHVQVREGLEPGDRVVT
HHHCCCCCCCHHHHCCCCCEEEEEEECCCEEEEEEECCCCCCCCCEEEECCCCCCCEEEE
YSEKALTERSRVKVVERIAGTSK
ECHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]