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The map label for this gene is merR [H]

Identifier: 74317356

GI number: 74317356

Start: 1421275

End: 1421682

Strand: Reverse

Name: merR [H]

Synonym: Tbd_1338

Alternate gene names: 74317356

Gene position: 1421682-1421275 (Counterclockwise)

Preceding gene: 74317360

Following gene: 74317355

Centisome position: 48.86

GC content: 62.01

Gene sequence:

>408_bases
ATGGAGAGCAATCTAGGGAATCTGAGCATCGGCGCCTTCGCCAAGGCCGTCGGGGTCAATGTGGAAACAATAAGGTTCTA
TCAGCGAAGGGGCCTGTTGCCGGAGCCGGACAAGCCCTATGGCAGCATTCGCCGCTATACGACGTCCGATGTGTCGCGGA
TGCAGTTCATCAAGGCCGCGCAGCGCCTGGGCTTCAGTCTGGACGAGATCGCCGAGCTGCTCGAACTCGAGGACGGTTCG
CATTGCAGCGAAGCGCGCGCGCAGGCCGAACGCAAGCTCGTGGACGTGCGCGCCCGTCTCGCCGACCTGCGGCGTATCGA
ACGCGTACTGGCCGACCTGATCCAGCGCTGCTGCGCTATTAGCGGAGATGTTCGGTGTCCGCTCATTGCATCGCTGAAAG
GGAGCTGA

Upstream 100 bases:

>100_bases
CGCCGATGAGTGGCAAGCGTCCGGTTTTCCCTTGCGACATGGCGTCTCCTTTCGAAATACCGTAACCTTATTTCCGTAGT
TATGTACGGAGTCAAGTTGT

Downstream 100 bases:

>100_bases
CGACGGATCAAAGTCTCCTTGCTGTTCGCCATCACCGCGGCGGCGGAAATCGTCGGCTGCTACCTGCCGTGGCTGGTGCT
TAGGCAGGACAAGCTCGCGT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MESNLGNLSIGAFAKAVGVNVETIRFYQRRGLLPEPDKPYGSIRRYTTSDVSRMQFIKAAQRLGFSLDEIAELLELEDGS
HCSEARAQAERKLVDVRARLADLRRIERVLADLIQRCCAISGDVRCPLIASLKGS

Sequences:

>Translated_135_residues
MESNLGNLSIGAFAKAVGVNVETIRFYQRRGLLPEPDKPYGSIRRYTTSDVSRMQFIKAAQRLGFSLDEIAELLELEDGS
HCSEARAQAERKLVDVRARLADLRRIERVLADLIQRCCAISGDVRCPLIASLKGS
>Mature_135_residues
MESNLGNLSIGAFAKAVGVNVETIRFYQRRGLLPEPDKPYGSIRRYTTSDVSRMQFIKAAQRLGFSLDEIAELLELEDGS
HCSEARAQAERKLVDVRARLADLRRIERVLADLIQRCCAISGDVRCPLIASLKGS

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=35.9375, Blast_Score=84, Evalue=2e-18,
Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=26.7175572519084, Blast_Score=61, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15024; Mature: 15024

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNLGNLSIGAFAKAVGVNVETIRFYQRRGLLPEPDKPYGSIRRYTTSDVSRMQFIKAA
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QRLGFSLDEIAELLELEDGSHCSEARAQAERKLVDVRARLADLRRIERVLADLIQRCCAI
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGDVRCPLIASLKGS
CCCCCCCHHCCCCCC
>Mature Secondary Structure
MESNLGNLSIGAFAKAVGVNVETIRFYQRRGLLPEPDKPYGSIRRYTTSDVSRMQFIKAA
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QRLGFSLDEIAELLELEDGSHCSEARAQAERKLVDVRARLADLRRIERVLADLIQRCCAI
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGDVRCPLIASLKGS
CCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]