Click here to switch to the map view.

The map label for this gene is czcC [H]

Identifier: 74317347

GI number: 74317347

Start: 1411877

End: 1413154

Strand: Reverse

Name: czcC [H]

Synonym: Tbd_1329

Alternate gene names: 74317347

Gene position: 1413154-1411877 (Counterclockwise)

Preceding gene: 74317348

Following gene: 74317346

Centisome position: 48.57

GC content: 68.47

Gene sequence:

>1278_bases
ATGCGAATCACGCTATCCGTATTGCTGCTCGCCCTGCCGTTGGCGGCGTGGGCGCAAACACCGCAAACCCGGCTGAATGC
AGGCACGCTGCGCGCCAGCGAACCAACGGCCCCGCTTACCCTGAACGCGGCACTGAATCTGGCGCTTGGCGCCAACCCCG
AGCTGTCGGCGGCGGGCCGCGAACTGGAGGCGCTCGATGCCACCATCACTCAGGCACACGTCCGACCCAACCCGGAATTT
TCGGCCTTGATCGAGGACACGCGCCGGGCGACACGGACCACGACGCTGCAGTTGAACCAGCCGATCGAGCTGGGCGGCAA
GCGTGGCGCCAGGATCGAAGCCGCCGAGCGCGGCCGTGATGCCGCGTCCCTGGAACTGGACGCCAAGCGTGCCGAGATTC
GCGCGGCGGTGACCGCGGCGTTTTTCGACGTGCTGGTCGCCCAGGAGCGCTCGCGGCTTGCCCAGGCGTCGGTCGAACTC
GCGCAACGCGCGACGGCCGCAGCCGCACGGCGGGTCACGGCCGGCAAGGTGTCCCCGGTCGAAGAAACCCGGGCGCGCGT
GGCCGAGGCCGGCGCCCGCGTCGAACTCGCGACGGCCACCAGCGAATTGACGACCGCGCGCCGTCGGCTGGCAGCCACCT
GGGCCAATCCGTCGCCGCGCTTCGAACGCGCCGAGGGCGATCCGGAAGCTTTGCCGCCGCTCCCTGCGCTGGCCCATCTG
AACGCGCGCCTCGCCGCTTCGCCCAGCCTGCTCCGCGCCAAGATCGAGGTCGAGCGCCGGCAAGCGCTGGCGAAGGTCGA
ACGCAGCCGTCGCGTTCCGGACCTGACGCTCAGCCTCGGGGCCAAACGCGACGAAGAGCGCGGCCTCAATCAGGCGATTT
TCGGCGTTTCGATACCGATCCCGGTGTTCGACCGCAATCAGGGAAACCTGCTGGAAGCGTTGCGCCGTACCGACAAGGCG
CAGGACCAGCTGTCCGCCGACGGGATCCGCCTGTTCAACGAACTGGCTGTTGCATACGAGCGGCTGAGTACCGCACGCCA
GGAGACAGCATCGCTGCGGCAGGACGTTCTTCCGGGCGCGCAAAGCGCTCTGGATGCCGCAACCCGAGGCTTCGAACTCG
GCAAATTCAGCTTTCTCGACGTACTCGATGCGCAGCGCACGCTGTTTCAGGCCCGCGCGCAAAGCCTGCGCGCATTGGCC
GAAGCGCACCGGTCGGCGGCCGAAATCGAGCGCATTCTTGGCGATACACGTCCGGCACCCGCTGCCGTCCAACCGTAG

Upstream 100 bases:

>100_bases
GCCTGAACCGGCGAGCGTTTGCTCCAACGCGACTTCCTGTCGCGAGCGTGTTTCGCACGCCGGTGTTCTTCGTTCCATTG
AGTTATCACGAGGAAAAACC

Downstream 100 bases:

>100_bases
GAACTCAACATGAAATTCAATCCGAACAAGAAACAGGCGCTGGTTATTGCCGGGGTTCTGGCAGTCGGCGTCCTCCTCGC
GGCGCTGGTCCTCGGTACCG

Product: cobalt-zinc-cadmium outer membrane resistance protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRITLSVLLLALPLAAWAQTPQTRLNAGTLRASEPTAPLTLNAALNLALGANPELSAAGRELEALDATITQAHVRPNPEF
SALIEDTRRATRTTTLQLNQPIELGGKRGARIEAAERGRDAASLELDAKRAEIRAAVTAAFFDVLVAQERSRLAQASVEL
AQRATAAAARRVTAGKVSPVEETRARVAEAGARVELATATSELTTARRRLAATWANPSPRFERAEGDPEALPPLPALAHL
NARLAASPSLLRAKIEVERRQALAKVERSRRVPDLTLSLGAKRDEERGLNQAIFGVSIPIPVFDRNQGNLLEALRRTDKA
QDQLSADGIRLFNELAVAYERLSTARQETASLRQDVLPGAQSALDAATRGFELGKFSFLDVLDAQRTLFQARAQSLRALA
EAHRSAAEIERILGDTRPAPAAVQP

Sequences:

>Translated_425_residues
MRITLSVLLLALPLAAWAQTPQTRLNAGTLRASEPTAPLTLNAALNLALGANPELSAAGRELEALDATITQAHVRPNPEF
SALIEDTRRATRTTTLQLNQPIELGGKRGARIEAAERGRDAASLELDAKRAEIRAAVTAAFFDVLVAQERSRLAQASVEL
AQRATAAAARRVTAGKVSPVEETRARVAEAGARVELATATSELTTARRRLAATWANPSPRFERAEGDPEALPPLPALAHL
NARLAASPSLLRAKIEVERRQALAKVERSRRVPDLTLSLGAKRDEERGLNQAIFGVSIPIPVFDRNQGNLLEALRRTDKA
QDQLSADGIRLFNELAVAYERLSTARQETASLRQDVLPGAQSALDAATRGFELGKFSFLDVLDAQRTLFQARAQSLRALA
EAHRSAAEIERILGDTRPAPAAVQP
>Mature_425_residues
MRITLSVLLLALPLAAWAQTPQTRLNAGTLRASEPTAPLTLNAALNLALGANPELSAAGRELEALDATITQAHVRPNPEF
SALIEDTRRATRTTTLQLNQPIELGGKRGARIEAAERGRDAASLELDAKRAEIRAAVTAAFFDVLVAQERSRLAQASVEL
AQRATAAAARRVTAGKVSPVEETRARVAEAGARVELATATSELTTARRRLAATWANPSPRFERAEGDPEALPPLPALAHL
NARLAASPSLLRAKIEVERRQALAKVERSRRVPDLTLSLGAKRDEERGLNQAIFGVSIPIPVFDRNQGNLLEALRRTDKA
QDQLSADGIRLFNELAVAYERLSTARQETASLRQDVLPGAQSALDAATRGFELGKFSFLDVLDAQRTLFQARAQSLRALA
EAHRSAAEIERILGDTRPAPAAVQP

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 45797; Mature: 45797

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITLSVLLLALPLAAWAQTPQTRLNAGTLRASEPTAPLTLNAALNLALGANPELSAAGR
CEEHHHHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCCEEECCEEEEEECCCCCHHHCCC
ELEALDATITQAHVRPNPEFSALIEDTRRATRTTTLQLNQPIELGGKRGARIEAAERGRD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCEEEHHHCCCC
AASLELDAKRAEIRAAVTAAFFDVLVAQERSRLAQASVELAQRATAAAARRVTAGKVSPV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EETRARVAEAGARVELATATSELTTARRRLAATWANPSPRFERAEGDPEALPPLPALAHL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHC
NARLAASPSLLRAKIEVERRQALAKVERSRRVPDLTLSLGAKRDEERGLNQAIFGVSIPI
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHCCCHHHHHEEECCC
PVFDRNQGNLLEALRRTDKAQDQLSADGIRLFNELAVAYERLSTARQETASLRQDVLPGA
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QSALDAATRGFELGKFSFLDVLDAQRTLFQARAQSLRALAEAHRSAAEIERILGDTRPAP
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AAVQP
CCCCC
>Mature Secondary Structure
MRITLSVLLLALPLAAWAQTPQTRLNAGTLRASEPTAPLTLNAALNLALGANPELSAAGR
CEEHHHHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCCEEECCEEEEEECCCCCHHHCCC
ELEALDATITQAHVRPNPEFSALIEDTRRATRTTTLQLNQPIELGGKRGARIEAAERGRD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEECCCHHCCCCCCCEEEHHHCCCC
AASLELDAKRAEIRAAVTAAFFDVLVAQERSRLAQASVELAQRATAAAARRVTAGKVSPV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EETRARVAEAGARVELATATSELTTARRRLAATWANPSPRFERAEGDPEALPPLPALAHL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHC
NARLAASPSLLRAKIEVERRQALAKVERSRRVPDLTLSLGAKRDEERGLNQAIFGVSIPI
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHCCCHHHHHEEECCC
PVFDRNQGNLLEALRRTDKAQDQLSADGIRLFNELAVAYERLSTARQETASLRQDVLPGA
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QSALDAATRGFELGKFSFLDVLDAQRTLFQARAQSLRALAEAHRSAAEIERILGDTRPAP
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AAVQP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]