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The map label for this gene is tadA [H]

Identifier: 74317234

GI number: 74317234

Start: 1271722

End: 1272177

Strand: Direct

Name: tadA [H]

Synonym: Tbd_1216

Alternate gene names: 74317234

Gene position: 1271722-1272177 (Clockwise)

Preceding gene: 74317233

Following gene: 74317235

Centisome position: 43.7

GC content: 68.64

Gene sequence:

>456_bases
ATGCGCGCGGCGCTCGAACTCGCGGCCGAGGGCGCAGCGGCAGGCGAGGTGCCGGTCGGCGCGCTTGTCGTGTGCGGCGG
CGAGATCGTCGGACGCGGCTACAACCGGCCGATTTCGAGCTTCGATCCGACGGCGCACGCCGAGGTGATGGCGCTGCGCG
ACGCCGCAGCGCGGCTGGGCAACTATCGACTAGTCGGCTGCACGCTCTACGTCACGATGGAACCCTGCGTCATGTGCGCC
GGCGCGATCCTGCATGCGCGCATCGCGCGCGTCGTCTACGGCGCGCGCGAATACAAGACCGGCGCGCACGGCAGCATCGT
CGACGTCTTCGCCGAGCCGCGGCTCAACTTCCATTGCGAGGTCGAGGGCGGGGTGCTGGCCGACGAATGCGCGGCGACGA
TCTCGGGTTTTTTCGAGGCGCGGCGATTGGAGAAGAAAAAGGAGACGACGCAGTGA

Upstream 100 bases:

>100_bases
ACAAGGACGTTTCGACGACGATGATTTACACCCACGTATTGAACAAGGGCGGGCGCGGCGTGACGAGCCCGCTCGACATG
TGATGGGCGACGAGGATTAC

Downstream 100 bases:

>100_bases
ACGAACGTGTGATCGACGTCGACATCGCCCGGCAGCGACTCTATCTGTGGGAGCGCTTCCCCGATGGCGACATGCTGATC
CGCGAGTATCCGGTGTCGAC

Product: tRNA-adenosine deaminase

Products: uridine; NH3

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MRAALELAAEGAAAGEVPVGALVVCGGEIVGRGYNRPISSFDPTAHAEVMALRDAAARLGNYRLVGCTLYVTMEPCVMCA
GAILHARIARVVYGAREYKTGAHGSIVDVFAEPRLNFHCEVEGGVLADECAATISGFFEARRLEKKKETTQ

Sequences:

>Translated_151_residues
MRAALELAAEGAAAGEVPVGALVVCGGEIVGRGYNRPISSFDPTAHAEVMALRDAAARLGNYRLVGCTLYVTMEPCVMCA
GAILHARIARVVYGAREYKTGAHGSIVDVFAEPRLNFHCEVEGGVLADECAATISGFFEARRLEKKKETTQ
>Mature_151_residues
MRAALELAAEGAAAGEVPVGALVVCGGEIVGRGYNRPISSFDPTAHAEVMALRDAAARLGNYRLVGCTLYVTMEPCVMCA
GAILHARIARVVYGAREYKTGAHGSIVDVFAEPRLNFHCEVEGGVLADECAATISGFFEARRLEKKKETTQ

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=149, Percent_Identity=31.5436241610738, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI19923945, Length=125, Percent_Identity=40, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI145693172, Length=148, Percent_Identity=56.0810810810811, Blast_Score=176, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17554608, Length=96, Percent_Identity=42.7083333333333, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17541138, Length=142, Percent_Identity=33.8028169014084, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555996, Length=79, Percent_Identity=43.0379746835443, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322425, Length=115, Percent_Identity=35.6521739130435, Blast_Score=67, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355527, Length=145, Percent_Identity=33.7931034482759, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.5

Molecular weight: Translated: 16030; Mature: 16030

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAALELAAEGAAAGEVPVGALVVCGGEIVGRGYNRPISSFDPTAHAEVMALRDAAARLG
CCCHHHHHHCCCCCCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
NYRLVGCTLYVTMEPCVMCAGAILHARIARVVYGAREYKTGAHGSIVDVFAEPRLNFHCE
CEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEE
VEGGVLADECAATISGFFEARRLEKKKETTQ
ECCCEEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRAALELAAEGAAAGEVPVGALVVCGGEIVGRGYNRPISSFDPTAHAEVMALRDAAARLG
CCCHHHHHHCCCCCCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
NYRLVGCTLYVTMEPCVMCAGAILHARIARVVYGAREYKTGAHGSIVDVFAEPRLNFHCE
CEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEE
VEGGVLADECAATISGFFEARRLEKKKETTQ
ECCCEEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytidine; H2O

Specific reaction: cytidine + H2O = uridine + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]