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The map label for this gene is dapA

Identifier: 74317116

GI number: 74317116

Start: 1157283

End: 1158173

Strand: Direct

Name: dapA

Synonym: Tbd_1098

Alternate gene names: 74317116

Gene position: 1157283-1158173 (Clockwise)

Preceding gene: 74317115

Following gene: 74317117

Centisome position: 39.77

GC content: 65.99

Gene sequence:

>891_bases
ATGGCAGAAATAAGCACGGCCAGAGGAAGCCTGGTCGCGATCGTGACCCCGATGTCGGATGACGGCGCGCTCGATCTGGG
CGCGTTGCGCCGTCTGATCGACTGGCACATCGAACAGGGAACTGACGGCATCGTCATCGTCGGCACGACCGGCGAGTCGC
CGACGGTCAACTTCGACGAGCACTGTCTGCTGATCCGCACCGCGGTCGAACAGGCGGGTGGACGCGTGCCGGTCATCGCA
GGTACCGGTGCCAATTCGACCAGCGAGGCGATCGCGCTCACCGAATGCGCGCGCGCGGCCGGTGCCCAGGCGGGCCTCTC
GGTCGTGCCCTACTACAACAAGCCGACGCAGGAAGGGCTCTACCAGCACTACCGCAAGATCGCCGAAGCGGTCGACCTGC
CGCTCATCCTTTACAACGTGCCCGGGCGGACGGTGGCCGATCTCGCCAACGACACGGCGGTGCGCCTCGCGGAAGTGCCC
GGCATCGTCGGCCTCAAGGACGCGACTGGCAACATGGAACGCGCGGCCGATCTGGTGCGTCGGGTGCCGAAGGGTTTTGC
TCTCTACAGCGGCGACGACGCGTCGGCGTTGCCGTTCATGTTGCTCGGCGGACACGGCGTGATCTCGGTCACGGCGAACG
TCGCGCCTCGGTTGATGCACGAAATGTGCGTCGCGGCCTTCGAAGGGAATCTCGCGCGTGCGCGCGAATGCAACGACGCG
CTGTTGCCGCTGCATAGCAAGCTTTTCGTCGAAGCCAATCCGATTCCGGTCAAGTGGGCGTGCGCCGAACTTGGCCTGAT
TCCCCCGGGCCTGCGCCTGCCGCTGACGCCGCTGTCTGGCGGACAGCACGAAGTCGTGCGCGCCGCAATGCGCCACGCCG
AATTGATCTAG

Upstream 100 bases:

>100_bases
TCGCGTCACGCCCCGCGGCCAGATGGATTAGAATGTGGCGATTTATCACGGCTGTCGCCCCAAGGCGGCGCGGCAGTCCC
ATAACAGCGGCGGAAACAGC

Downstream 100 bases:

>100_bases
CGTGACGCGGCCGCGTTGCGTGCTCCAGATGTAAAACCCGCGATTTAGGACACCCTTTCATGCGTTTATTGCCCCTGTTC
TTGATGGTCACCCTTGCTGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAEISTARGSLVAIVTPMSDDGALDLGALRRLIDWHIEQGTDGIVIVGTTGESPTVNFDEHCLLIRTAVEQAGGRVPVIA
GTGANSTSEAIALTECARAAGAQAGLSVVPYYNKPTQEGLYQHYRKIAEAVDLPLILYNVPGRTVADLANDTAVRLAEVP
GIVGLKDATGNMERAADLVRRVPKGFALYSGDDASALPFMLLGGHGVISVTANVAPRLMHEMCVAAFEGNLARARECNDA
LLPLHSKLFVEANPIPVKWACAELGLIPPGLRLPLTPLSGGQHEVVRAAMRHAELI

Sequences:

>Translated_296_residues
MAEISTARGSLVAIVTPMSDDGALDLGALRRLIDWHIEQGTDGIVIVGTTGESPTVNFDEHCLLIRTAVEQAGGRVPVIA
GTGANSTSEAIALTECARAAGAQAGLSVVPYYNKPTQEGLYQHYRKIAEAVDLPLILYNVPGRTVADLANDTAVRLAEVP
GIVGLKDATGNMERAADLVRRVPKGFALYSGDDASALPFMLLGGHGVISVTANVAPRLMHEMCVAAFEGNLARARECNDA
LLPLHSKLFVEANPIPVKWACAELGLIPPGLRLPLTPLSGGQHEVVRAAMRHAELI
>Mature_295_residues
AEISTARGSLVAIVTPMSDDGALDLGALRRLIDWHIEQGTDGIVIVGTTGESPTVNFDEHCLLIRTAVEQAGGRVPVIAG
TGANSTSEAIALTECARAAGAQAGLSVVPYYNKPTQEGLYQHYRKIAEAVDLPLILYNVPGRTVADLANDTAVRLAEVPG
IVGLKDATGNMERAADLVRRVPKGFALYSGDDASALPFMLLGGHGVISVTANVAPRLMHEMCVAAFEGNLARARECNDAL
LPLHSKLFVEANPIPVKWACAELGLIPPGLRLPLTPLSGGQHEVVRAAMRHAELI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=204, Percent_Identity=28.4313725490196, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI13540533, Length=228, Percent_Identity=25.8771929824561, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=57.7854671280277, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI87082415, Length=239, Percent_Identity=39.7489539748954, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789620, Length=242, Percent_Identity=31.404958677686, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1786463, Length=249, Percent_Identity=31.3253012048193, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_THIDA (Q3SJU8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314856.1
- HSSP:   P0A6L2
- ProteinModelPortal:   Q3SJU8
- SMR:   Q3SJU8
- STRING:   Q3SJU8
- GeneID:   3673169
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1098
- NMPDR:   fig|292415.3.peg.1097
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q3SJU8
- ProtClustDB:   PRK03170
- BioCyc:   TDEN292415:TBD_1098-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31220; Mature: 31089

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 111-111

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEISTARGSLVAIVTPMSDDGALDLGALRRLIDWHIEQGTDGIVIVGTTGESPTVNFDE
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
HCLLIRTAVEQAGGRVPVIAGTGANSTSEAIALTECARAAGAQAGLSVVPYYNKPTQEGL
CCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
YQHYRKIAEAVDLPLILYNVPGRTVADLANDTAVRLAEVPGIVGLKDATGNMERAADLVR
HHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEHHHCCCCEEECCCCCCHHHHHHHHH
RVPKGFALYSGDDASALPFMLLGGHGVISVTANVAPRLMHEMCVAAFEGNLARARECNDA
HCCCCCEEECCCCCCCCCEEEECCCEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHCCCC
LLPLHSKLFVEANPIPVKWACAELGLIPPGLRLPLTPLSGGQHEVVRAAMRHAELI
CCCCCCEEEEECCCCCEEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEISTARGSLVAIVTPMSDDGALDLGALRRLIDWHIEQGTDGIVIVGTTGESPTVNFDE
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
HCLLIRTAVEQAGGRVPVIAGTGANSTSEAIALTECARAAGAQAGLSVVPYYNKPTQEGL
CCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
YQHYRKIAEAVDLPLILYNVPGRTVADLANDTAVRLAEVPGIVGLKDATGNMERAADLVR
HHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEHHHCCCCEEECCCCCCHHHHHHHHH
RVPKGFALYSGDDASALPFMLLGGHGVISVTANVAPRLMHEMCVAAFEGNLARARECNDA
HCCCCCEEECCCCCCCCCEEEECCCEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHCCCC
LLPLHSKLFVEANPIPVKWACAELGLIPPGLRLPLTPLSGGQHEVVRAAMRHAELI
CCCCCCEEEEECCCCCEEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA