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The map label for this gene is cotA [H]

Identifier: 74317090

GI number: 74317090

Start: 1130477

End: 1132597

Strand: Reverse

Name: cotA [H]

Synonym: Tbd_1072

Alternate gene names: 74317090

Gene position: 1132597-1130477 (Counterclockwise)

Preceding gene: 74317091

Following gene: 74317089

Centisome position: 38.92

GC content: 66.43

Gene sequence:

>2121_bases
ATGCTCGGGGGCGTCGCAGCGGAAGGCTTCGCGCGGTTCATCCGATCGGCAAAGGGGGGCAAGCGTATGGTCACACGTCG
CGCATTCCTGAAATACACCGCAAGCACCGTATTGACCTGGTTCGCGTTCGACCGATTCGGGATCCGCAAGGCGATCGCTG
ACATCCCCGGGGGATCGCTCGACCCGCGCGGGGTTCCAAAATTCGAAACGCCGCTGCTGATCCCGCCCGTGATGCCGCGA
GCAGCGAAGATCGCTCGCGCCGGCAAGAACGTCGACTATTACGAGATCTCGATGAAGCCCCTCCATCAGCAGATCCTCCC
CGTAGGCCTGCCCGCCACGCCGGTCTGGGGCTACGGCGCGGTGACGTCCGCGAGCAAGAAAGGATTGCTGCTGCACAATG
CGCCGTCGCTGACGATCGAGGCCAAGTGGGATACGCCGGTGCGCGTGAAGTGGATCAACGATCTCAAGGACGCGGCGGGC
AACTTCGTGCCCCATCTGCTGCCCGTCGACCCGACGCTGCACTGGGCGAACCCGCCCGGCGGCGCAACAGGACGCGACAC
GCGACCGACTTTCACGGAGACGCCCGGCCCCTATGACGGGCCGGTGCCCATCGTCACGCACGTGCATGGTGCGGCGGGCG
TGGGTGACGAGAGCGACGGCTACGCCGAAGCCTGGTATCTGCCCGCCGCGGGCGGCATCCCGCCGGGTTTTGCGACCGAG
GGTAGCTGGTACGGCTTCTTCGCCGACAAGGCCGCCGCCAAGTTCGGGGTCACCTGGGGTCCGGGCTACGCGGTCTTCCA
GTATCCGAACAAGAATCGCGCCTCGACCATCTGGTACCACGACCACACCCTGGGCATGACCCGCCTCAACGTATACGCCG
GCCCGGCCGGTTTCTACATCATCCGCGGCGGCCCCGCGGGCGATGACACCGTGATCGACAGCCGAACCGGGACGCCCGCC
ATACTGCCGGGACCGGCCCCGCGGGAGCACGACAAATTCCCGCCCAACAAGAGCTATCGCGAGATCCCGATGGCGATCCA
GGATCGTTCGTTCAACGCCGACGGCTCGCTGTTCTATCCGGACACGCGCACGTTTTTCGACGGGGTCGCGGGCCCCTTCG
TTCCGGAGTCCGACCTCTCGCCGATCTGGAACCCCGAGTTCTTCGGCAACATGATGACGGTCAACGGCAACACCTGGCCT
TTCCAGACCGTCGAGCAGGCGCGCTACCGCTTCCGCTTCCTGAACGGTTGCCAGTCGCGCTTCCTGATCCTGGACTTCGG
CAACATTCCGGGCGTGGAAGTCTGGCAGATCGGCAACGAGGGCGGCTTCCTCGCCGCACCCGTGAACCTCACCGCGATCA
ACGACAACACGCTGCTGATGGGCCTGGCCGAGCGTGCGGACGTGATCGTCGATTTCACCAACGTTCCGCCTGGCCATTAC
GTGCTCGGCAACGTCGGGCCGGACGAGCCTTTTCCGGGTCTGGAAGACGAATTCGACGCCGCCGACCCCGACACGACCGG
GCAAATCATGCAGTTCCGCGTCGCGCCGGCGGCGAGGCCCGATCCGAGCACGCCGCCCGCGTTCCTGCAGTTGCCGGCGA
TCACGCCGCTGCCGCCCGAAACCGTCACCCGCCCGTTGGCGTTGCTCGAGGAGATGTCGGCGGCCTTCGAGGACGCGCCG
GTCGAGGCGCTGCTTGGCACCGTGGCCTTCGACGGCAATGGCACGGGCGTGTGCACCGGGCGCCTGTGGATGGAGCCGGT
CAGCGAAAACCCGGAAACGGGCGCCACCGAGGTTTGGGAAATCTACAACGCCACCGGCGACGCCCACCCGATCCACATCC
ACGAGGTCGCGTTCGAAGTCGTCAATCGGCAGGATATCGTCGTGGACGAGGCCGAGGGCAGGGTCGCGCTTGCTCCCGGT
TCCGAGCCTGCGCCGCCCGCAGCCTGGGAGACAGGCTTCAAGGACACCGTCATCGCTTATCCCGGGCACGTCACGCGCGT
GCGGGCGCGGTTCAACACGCCCGGCCAGTTCACCTGGCACTGTCACATCCTCGAGCACGAGGACAACGAGATGATGCGGC
CGTTTCGCGTCGGTCCGGTTCGGCCTGGTCAGCCCGGTTAG

Upstream 100 bases:

>100_bases
GACGGCCGGGGCTCGCCCCTTGGCAGACCCCCCCAAGCCGACCTAAGAATAGATTTACACAATAAAAATCGGCCTGACGG
CGACGACTGGCCCGTGCTGA

Downstream 100 bases:

>100_bases
GAAGGTCGGGGAGGCGAGACCCGCTTCGCGCATTTGGCCTACCCGATCCCGGTCCACGTCGCGCAATCACGCATCACCTG
TTTCCGGCTTTCAGCCGAAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MLGGVAAEGFARFIRSAKGGKRMVTRRAFLKYTASTVLTWFAFDRFGIRKAIADIPGGSLDPRGVPKFETPLLIPPVMPR
AAKIARAGKNVDYYEISMKPLHQQILPVGLPATPVWGYGAVTSASKKGLLLHNAPSLTIEAKWDTPVRVKWINDLKDAAG
NFVPHLLPVDPTLHWANPPGGATGRDTRPTFTETPGPYDGPVPIVTHVHGAAGVGDESDGYAEAWYLPAAGGIPPGFATE
GSWYGFFADKAAAKFGVTWGPGYAVFQYPNKNRASTIWYHDHTLGMTRLNVYAGPAGFYIIRGGPAGDDTVIDSRTGTPA
ILPGPAPREHDKFPPNKSYREIPMAIQDRSFNADGSLFYPDTRTFFDGVAGPFVPESDLSPIWNPEFFGNMMTVNGNTWP
FQTVEQARYRFRFLNGCQSRFLILDFGNIPGVEVWQIGNEGGFLAAPVNLTAINDNTLLMGLAERADVIVDFTNVPPGHY
VLGNVGPDEPFPGLEDEFDAADPDTTGQIMQFRVAPAARPDPSTPPAFLQLPAITPLPPETVTRPLALLEEMSAAFEDAP
VEALLGTVAFDGNGTGVCTGRLWMEPVSENPETGATEVWEIYNATGDAHPIHIHEVAFEVVNRQDIVVDEAEGRVALAPG
SEPAPPAAWETGFKDTVIAYPGHVTRVRARFNTPGQFTWHCHILEHEDNEMMRPFRVGPVRPGQPG

Sequences:

>Translated_706_residues
MLGGVAAEGFARFIRSAKGGKRMVTRRAFLKYTASTVLTWFAFDRFGIRKAIADIPGGSLDPRGVPKFETPLLIPPVMPR
AAKIARAGKNVDYYEISMKPLHQQILPVGLPATPVWGYGAVTSASKKGLLLHNAPSLTIEAKWDTPVRVKWINDLKDAAG
NFVPHLLPVDPTLHWANPPGGATGRDTRPTFTETPGPYDGPVPIVTHVHGAAGVGDESDGYAEAWYLPAAGGIPPGFATE
GSWYGFFADKAAAKFGVTWGPGYAVFQYPNKNRASTIWYHDHTLGMTRLNVYAGPAGFYIIRGGPAGDDTVIDSRTGTPA
ILPGPAPREHDKFPPNKSYREIPMAIQDRSFNADGSLFYPDTRTFFDGVAGPFVPESDLSPIWNPEFFGNMMTVNGNTWP
FQTVEQARYRFRFLNGCQSRFLILDFGNIPGVEVWQIGNEGGFLAAPVNLTAINDNTLLMGLAERADVIVDFTNVPPGHY
VLGNVGPDEPFPGLEDEFDAADPDTTGQIMQFRVAPAARPDPSTPPAFLQLPAITPLPPETVTRPLALLEEMSAAFEDAP
VEALLGTVAFDGNGTGVCTGRLWMEPVSENPETGATEVWEIYNATGDAHPIHIHEVAFEVVNRQDIVVDEAEGRVALAPG
SEPAPPAAWETGFKDTVIAYPGHVTRVRARFNTPGQFTWHCHILEHEDNEMMRPFRVGPVRPGQPG
>Mature_706_residues
MLGGVAAEGFARFIRSAKGGKRMVTRRAFLKYTASTVLTWFAFDRFGIRKAIADIPGGSLDPRGVPKFETPLLIPPVMPR
AAKIARAGKNVDYYEISMKPLHQQILPVGLPATPVWGYGAVTSASKKGLLLHNAPSLTIEAKWDTPVRVKWINDLKDAAG
NFVPHLLPVDPTLHWANPPGGATGRDTRPTFTETPGPYDGPVPIVTHVHGAAGVGDESDGYAEAWYLPAAGGIPPGFATE
GSWYGFFADKAAAKFGVTWGPGYAVFQYPNKNRASTIWYHDHTLGMTRLNVYAGPAGFYIIRGGPAGDDTVIDSRTGTPA
ILPGPAPREHDKFPPNKSYREIPMAIQDRSFNADGSLFYPDTRTFFDGVAGPFVPESDLSPIWNPEFFGNMMTVNGNTWP
FQTVEQARYRFRFLNGCQSRFLILDFGNIPGVEVWQIGNEGGFLAAPVNLTAINDNTLLMGLAERADVIVDFTNVPPGHY
VLGNVGPDEPFPGLEDEFDAADPDTTGQIMQFRVAPAARPDPSTPPAFLQLPAITPLPPETVTRPLALLEEMSAAFEDAP
VEALLGTVAFDGNGTGVCTGRLWMEPVSENPETGATEVWEIYNATGDAHPIHIHEVAFEVVNRQDIVVDEAEGRVALAPG
SEPAPPAAWETGFKDTVIAYPGHVTRVRARFNTPGQFTWHCHILEHEDNEMMRPFRVGPVRPGQPG

Specific function: Involved in brown pigmentation during sporogenesis [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To S.antibioticus phenoxazinone synthase (phsA) [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=452, Percent_Identity=25.2212389380531, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 76682; Mature: 76682

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGGVAAEGFARFIRSAKGGKRMVTRRAFLKYTASTVLTWFAFDRFGIRKAIADIPGGSL
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPRGVPKFETPLLIPPVMPRAAKIARAGKNVDYYEISMKPLHQQILPVGLPATPVWGYGA
CCCCCCCCCCCEECCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCC
VTSASKKGLLLHNAPSLTIEAKWDTPVRVKWINDLKDAAGNFVPHLLPVDPTLHWANPPG
CCCCCCCCEEEECCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCCEEECCCEEEECCCCC
GATGRDTRPTFTETPGPYDGPVPIVTHVHGAAGVGDESDGYAEAWYLPAAGGIPPGFATE
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
GSWYGFFADKAAAKFGVTWGPGYAVFQYPNKNRASTIWYHDHTLGMTRLNVYAGPAGFYI
CCEEEEECCCHHHHCCCEECCCEEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCEEE
IRGGPAGDDTVIDSRTGTPAILPGPAPREHDKFPPNKSYREIPMAIQDRSFNADGSLFYP
EECCCCCCCCEEECCCCCCEEECCCCCCCCCCCCCCCCHHHCCEEEECCCCCCCCCEECC
DTRTFFDGVAGPFVPESDLSPIWNPEFFGNMMTVNGNTWPFQTVEQARYRFRFLNGCQSR
CCHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCE
FLILDFGNIPGVEVWQIGNEGGFLAAPVNLTAINDNTLLMGLAERADVIVDFTNVPPGHY
EEEEECCCCCCEEEEEECCCCCEEEECEEEEEECCCEEEEEECCCCCEEEEECCCCCCCE
VLGNVGPDEPFPGLEDEFDAADPDTTGQIMQFRVAPAARPDPSTPPAFLQLPAITPLPPE
EECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCHH
TVTRPLALLEEMSAAFEDAPVEALLGTVAFDGNGTGVCTGRLWMEPVSENPETGATEVWE
HHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCHHHHH
IYNATGDAHPIHIHEVAFEVVNRQDIVVDEAEGRVALAPGSEPAPPAAWETGFKDTVIAY
HHCCCCCCCCEEHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCHHHCCCCCEEEEC
PGHVTRVRARFNTPGQFTWHCHILEHEDNEMMRPFRVGPVRPGQPG
CCCEEEEEEECCCCCCEEEEEEEEEECCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MLGGVAAEGFARFIRSAKGGKRMVTRRAFLKYTASTVLTWFAFDRFGIRKAIADIPGGSL
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPRGVPKFETPLLIPPVMPRAAKIARAGKNVDYYEISMKPLHQQILPVGLPATPVWGYGA
CCCCCCCCCCCEECCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCC
VTSASKKGLLLHNAPSLTIEAKWDTPVRVKWINDLKDAAGNFVPHLLPVDPTLHWANPPG
CCCCCCCCEEEECCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCCEEECCCEEEECCCCC
GATGRDTRPTFTETPGPYDGPVPIVTHVHGAAGVGDESDGYAEAWYLPAAGGIPPGFATE
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
GSWYGFFADKAAAKFGVTWGPGYAVFQYPNKNRASTIWYHDHTLGMTRLNVYAGPAGFYI
CCEEEEECCCHHHHCCCEECCCEEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCEEE
IRGGPAGDDTVIDSRTGTPAILPGPAPREHDKFPPNKSYREIPMAIQDRSFNADGSLFYP
EECCCCCCCCEEECCCCCCEEECCCCCCCCCCCCCCCCHHHCCEEEECCCCCCCCCEECC
DTRTFFDGVAGPFVPESDLSPIWNPEFFGNMMTVNGNTWPFQTVEQARYRFRFLNGCQSR
CCHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCE
FLILDFGNIPGVEVWQIGNEGGFLAAPVNLTAINDNTLLMGLAERADVIVDFTNVPPGHY
EEEEECCCCCCEEEEEECCCCCEEEECEEEEEECCCEEEEEECCCCCEEEEECCCCCCCE
VLGNVGPDEPFPGLEDEFDAADPDTTGQIMQFRVAPAARPDPSTPPAFLQLPAITPLPPE
EECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCHH
TVTRPLALLEEMSAAFEDAPVEALLGTVAFDGNGTGVCTGRLWMEPVSENPETGATEVWE
HHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCHHHHH
IYNATGDAHPIHIHEVAFEVVNRQDIVVDEAEGRVALAPGSEPAPPAAWETGFKDTVIAY
HHCCCCCCCCEEHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCHHHCCCCCEEEEC
PGHVTRVRARFNTPGQFTWHCHILEHEDNEMMRPFRVGPVRPGQPG
CCCEEEEEEECCCCCCEEEEEEEEEECCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969499; 9455482; 9384377; 2821284; 3135411 [H]