Click here to switch to the map view.

The map label for this gene is cyaA [H]

Identifier: 74317001

GI number: 74317001

Start: 1046077

End: 1048290

Strand: Direct

Name: cyaA [H]

Synonym: Tbd_0983

Alternate gene names: 74317001

Gene position: 1046077-1048290 (Clockwise)

Preceding gene: 74317000

Following gene: 74317002

Centisome position: 35.95

GC content: 69.29

Gene sequence:

>2214_bases
GTGACGCGGGTCTCGTCGAGGCTGCTTCAGGCGGGGCTGTCGGCGCTGTTCGTGCTGCTGATCGCGGCGCACGTCGGCGG
CGCGCTCCATTTCGATCCGATCGAGCGCGTCGAGGCTTGGCTTTACGACGCGTGGCTCAAGCGCACCGCGCCGACCGGGG
CGGACGATCGCATCGCGATTCTCGACATCGACGAGGCGAGCCTGAAGAGCGTGGGCCGCTGGCCATGGAGCCGGGACACG
ATGACCGCGCTGGTCGAGCGCCTGTTCGACCATTACGGCGTCGCAGCGGTCGGCTTCGACGTCGTCTTCGCCGAAGCCGA
CCGCAGTTCCGGGCTCGATACCTTGAAGGCGCTCTCGCAGGGCGAGCTCGCAGGCGAGCGCGCGTTCGCTGCGGCGCTGC
AGAAGATCGCGCCGCGCCTCGACTACGACGCGCGGTTTGCCGAGGCGCTCGCGGAGCGGCCGGTGTCGCTCGGCTATTAC
TTCGTCCCCGAGGGATACCGTGCGACGCGCACCGGTACGTTGCCCCCGTGGTCCCTGCCGCCCGAGGTGTTCGGCGCGCT
GAAGCCGGGCAGGCCGGCGGCCGGGTATGGCGCCAATCTCGCGCCCTTCCAGGACGCGGCACAGGGTGCGGGCTTCTTCA
ACATGCTCGCCGACGACGACGGCACGGCCCGGCAGATGTCGCTCGTTCTCCCTTACGGCGAGGGCTATTACCTTGCGCTC
TCGGCGTCGACCCTGCGCATCGCGTTCGGGGGCGACGCCGCGAGCGCCGGGGTCGAGCAAAGCGAACTGCTCGGGCGCAA
CTACCTCGCGCCGTGGCTCGAGGTCGGCGGCATTCGCGTGCCGCTCGGCGCCGACGGCACCGTGCACGTGCCCTACCGGG
CGGGCTCGCCGTTTCCCTACATCTCGGCGGCCGACGTGCTGGCTGGCAAAGCGCCGGTCGGGCAACTCGAGAATCGCATC
GTGCTCGTCGGCTCGACCGCGCCGGGGCTCGCCGATCTGCGCGTCACCCCGTTCTCCAGCACCTTTCCGGGCGTGGAGAT
CCACGCCCACCTGATCGCGGGCATGCTCGACGGCACGACGCGGGTGACGCCGCCGTGGGCGCGCGACGCGAGGCTGGCGG
CGGTATTGCTGCTGGGCGCCGTGCTGATCGTGGTGCTGCTGCGCTTCGGCCCGGCGCTCGGCCTCGCCGCGACGCTCGCG
TTGCTCGGCCTTCTGCTCGCCGCCTACGGCGCCGCGTGGGCGCGCTTCCAGGTGGTGCCGATGGCGGCGCCGATGCTCGC
GGTGGCGGGGCTGTATGCGCTCAACACCGCGTACGGCCTTTTCGCCGCGACGCGCAGCAAGCGCCAGATCACGCGGCTCT
TCGGCCAATACGTGCCACCCGAACTCGCCGCCGAGATGAGCCGCGATCCCGCGCACTACACGATGGAAGGGCAGTCGCGC
GACATGAGCGTCCTGTTCTCCGACATTCGCGGCTTCACCAATTTTTCCGAAAAGCTGAGCCCGACCGAGCTTTCCGAGGT
GCTCAACGCCTATCTTTCGACGATGACGCGCATCGTGCAGCAGCATCAGGGCACGATCGACAAGTACATCGGCGACGCCA
TCATGGCGTTCTGGAATGCGCCGGTCGATCTCGCGGACCATGCCGCGCGCGCGGTCCGCACAGCGCTCGAGATGCAGGCG
GCGCTGCCGCAGCTCAACGACGAGTTCGCCGCGCGCGGCTGGCCGGCGGTGAAGATCGGCGTCGGCGTCAACACCGGGCG
CATGAGCGTGGGCAACATGGGCTCGGAATTCCGCATGGCCTACACCGTGATGGGGGACGCGGTGAACCTCGGATCGCGCC
TCGAGGGCATCACCAAGCAGTACGGCGTCGGCATCCTCGTCACCCAGTCGACGGTCGACGCCGACCCGGTTCACGCCTAC
ATGAAGGTCGACGAAGTCCGCGTCAAGGGCAAGGAGACGCCGGTCGCGATCTATGAGCCGCTCGGGGCAAAAGACCGCCT
CGCCGACGACGTGCGCAGCGCCGCCGCCGCCTTCGACGCCGCCTTCGCCGCGTATCAGAAGCAGGACTGGGACGCTGCCG
AGACGGCCCTGCGCGCGCTTGACGCGAAGTCGCCGCGCGCGTTGTACGATGTCTATCTTGAGCGCATCGCGCAGTTCCGC
GCCGCGCCTCCGCCGCAAGGCTGGGACGGCGTCTACGTCTACACAACGAAATAA

Upstream 100 bases:

>100_bases
CGCACCCGGCCGACCGGCTGGCGGCGTTGGGCGAGGCGGTCGATGGCCGCCTCGACGCCGTGCAGGGCAAGACGCTCGCC
GACCGCTTCTACCGCATCAA

Downstream 100 bases:

>100_bases
CGATGAAACTCACCGTATTGGGCTGCAGCGGCGGGATCGGCAGCGGCCGCCACACGACCGGCCTGCTCGTCGACGACGAC
ATCCTGATCGACGCCGGCAC

Product: adenylyl cyclase class-3/4/guanylyl cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 737; Mature: 736

Protein sequence:

>737_residues
MTRVSSRLLQAGLSALFVLLIAAHVGGALHFDPIERVEAWLYDAWLKRTAPTGADDRIAILDIDEASLKSVGRWPWSRDT
MTALVERLFDHYGVAAVGFDVVFAEADRSSGLDTLKALSQGELAGERAFAAALQKIAPRLDYDARFAEALAERPVSLGYY
FVPEGYRATRTGTLPPWSLPPEVFGALKPGRPAAGYGANLAPFQDAAQGAGFFNMLADDDGTARQMSLVLPYGEGYYLAL
SASTLRIAFGGDAASAGVEQSELLGRNYLAPWLEVGGIRVPLGADGTVHVPYRAGSPFPYISAADVLAGKAPVGQLENRI
VLVGSTAPGLADLRVTPFSSTFPGVEIHAHLIAGMLDGTTRVTPPWARDARLAAVLLLGAVLIVVLLRFGPALGLAATLA
LLGLLLAAYGAAWARFQVVPMAAPMLAVAGLYALNTAYGLFAATRSKRQITRLFGQYVPPELAAEMSRDPAHYTMEGQSR
DMSVLFSDIRGFTNFSEKLSPTELSEVLNAYLSTMTRIVQQHQGTIDKYIGDAIMAFWNAPVDLADHAARAVRTALEMQA
ALPQLNDEFAARGWPAVKIGVGVNTGRMSVGNMGSEFRMAYTVMGDAVNLGSRLEGITKQYGVGILVTQSTVDADPVHAY
MKVDEVRVKGKETPVAIYEPLGAKDRLADDVRSAAAAFDAAFAAYQKQDWDAAETALRALDAKSPRALYDVYLERIAQFR
AAPPPQGWDGVYVYTTK

Sequences:

>Translated_737_residues
MTRVSSRLLQAGLSALFVLLIAAHVGGALHFDPIERVEAWLYDAWLKRTAPTGADDRIAILDIDEASLKSVGRWPWSRDT
MTALVERLFDHYGVAAVGFDVVFAEADRSSGLDTLKALSQGELAGERAFAAALQKIAPRLDYDARFAEALAERPVSLGYY
FVPEGYRATRTGTLPPWSLPPEVFGALKPGRPAAGYGANLAPFQDAAQGAGFFNMLADDDGTARQMSLVLPYGEGYYLAL
SASTLRIAFGGDAASAGVEQSELLGRNYLAPWLEVGGIRVPLGADGTVHVPYRAGSPFPYISAADVLAGKAPVGQLENRI
VLVGSTAPGLADLRVTPFSSTFPGVEIHAHLIAGMLDGTTRVTPPWARDARLAAVLLLGAVLIVVLLRFGPALGLAATLA
LLGLLLAAYGAAWARFQVVPMAAPMLAVAGLYALNTAYGLFAATRSKRQITRLFGQYVPPELAAEMSRDPAHYTMEGQSR
DMSVLFSDIRGFTNFSEKLSPTELSEVLNAYLSTMTRIVQQHQGTIDKYIGDAIMAFWNAPVDLADHAARAVRTALEMQA
ALPQLNDEFAARGWPAVKIGVGVNTGRMSVGNMGSEFRMAYTVMGDAVNLGSRLEGITKQYGVGILVTQSTVDADPVHAY
MKVDEVRVKGKETPVAIYEPLGAKDRLADDVRSAAAAFDAAFAAYQKQDWDAAETALRALDAKSPRALYDVYLERIAQFR
AAPPPQGWDGVYVYTTK
>Mature_736_residues
TRVSSRLLQAGLSALFVLLIAAHVGGALHFDPIERVEAWLYDAWLKRTAPTGADDRIAILDIDEASLKSVGRWPWSRDTM
TALVERLFDHYGVAAVGFDVVFAEADRSSGLDTLKALSQGELAGERAFAAALQKIAPRLDYDARFAEALAERPVSLGYYF
VPEGYRATRTGTLPPWSLPPEVFGALKPGRPAAGYGANLAPFQDAAQGAGFFNMLADDDGTARQMSLVLPYGEGYYLALS
ASTLRIAFGGDAASAGVEQSELLGRNYLAPWLEVGGIRVPLGADGTVHVPYRAGSPFPYISAADVLAGKAPVGQLENRIV
LVGSTAPGLADLRVTPFSSTFPGVEIHAHLIAGMLDGTTRVTPPWARDARLAAVLLLGAVLIVVLLRFGPALGLAATLAL
LGLLLAAYGAAWARFQVVPMAAPMLAVAGLYALNTAYGLFAATRSKRQITRLFGQYVPPELAAEMSRDPAHYTMEGQSRD
MSVLFSDIRGFTNFSEKLSPTELSEVLNAYLSTMTRIVQQHQGTIDKYIGDAIMAFWNAPVDLADHAARAVRTALEMQAA
LPQLNDEFAARGWPAVKIGVGVNTGRMSVGNMGSEFRMAYTVMGDAVNLGSRLEGITKQYGVGILVTQSTVDADPVHAYM
KVDEVRVKGKETPVAIYEPLGAKDRLADDVRSAAAAFDAAFAAYQKQDWDAAETALRALDAKSPRALYDVYLERIAQFRA
APPPQGWDGVYVYTTK

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI115387102, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=3e-12,
Organism=Homo sapiens, GI24497587, Length=161, Percent_Identity=31.055900621118, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484477, Length=208, Percent_Identity=30.2884615384615, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI62484298, Length=208, Percent_Identity=30.2884615384615, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116008008, Length=208, Percent_Identity=30.2884615384615, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366320, Length=347, Percent_Identity=23.9193083573487, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161084260, Length=347, Percent_Identity=23.9193083573487, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078020, Length=210, Percent_Identity=25.2380952380952, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI85725044, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 79099; Mature: 78968

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVSSRLLQAGLSALFVLLIAAHVGGALHFDPIERVEAWLYDAWLKRTAPTGADDRIAI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LDIDEASLKSVGRWPWSRDTMTALVERLFDHYGVAAVGFDVVFAEADRSSGLDTLKALSQ
EECCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHEEEEEECCCCCCHHHHHHHHH
GELAGERAFAAALQKIAPRLDYDARFAEALAERPVSLGYYFVPEGYRATRTGTLPPWSLP
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCCCCCCCCCCC
PEVFGALKPGRPAAGYGANLAPFQDAAQGAGFFNMLADDDGTARQMSLVLPYGEGYYLAL
HHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCEEEEE
SASTLRIAFGGDAASAGVEQSELLGRNYLAPWLEVGGIRVPLGADGTVHVPYRAGSPFPY
ECCEEEEEECCCHHHCCCCHHHHHCCCCCCHHHHHCCEEEECCCCCEEEEEECCCCCCCC
ISAADVLAGKAPVGQLENRIVLVGSTAPGLADLRVTPFSSTFPGVEIHAHLIAGMLDGTT
CCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCC
RVTPPWARDARLAAVLLLGAVLIVVLLRFGPALGLAATLALLGLLLAAYGAAWARFQVVP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEH
MAAPMLAVAGLYALNTAYGLFAATRSKRQITRLFGQYVPPELAAEMSRDPAHYTMEGQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCCC
DMSVLFSDIRGFTNFSEKLSPTELSEVLNAYLSTMTRIVQQHQGTIDKYIGDAIMAFWNA
HHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
PVDLADHAARAVRTALEMQAALPQLNDEFAARGWPAVKIGVGVNTGRMSVGNMGSEFRMA
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEE
YTVMGDAVNLGSRLEGITKQYGVGILVTQSTVDADPVHAYMKVDEVRVKGKETPVAIYEP
EEECCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHEECCCCCCEEEECC
LGAKDRLADDVRSAAAAFDAAFAAYQKQDWDAAETALRALDAKSPRALYDVYLERIAQFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
AAPPPQGWDGVYVYTTK
CCCCCCCCCCEEEEECC
>Mature Secondary Structure 
TRVSSRLLQAGLSALFVLLIAAHVGGALHFDPIERVEAWLYDAWLKRTAPTGADDRIAI
CHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LDIDEASLKSVGRWPWSRDTMTALVERLFDHYGVAAVGFDVVFAEADRSSGLDTLKALSQ
EECCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHEEEEEECCCCCCHHHHHHHHH
GELAGERAFAAALQKIAPRLDYDARFAEALAERPVSLGYYFVPEGYRATRTGTLPPWSLP
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCCCCCCCCCCC
PEVFGALKPGRPAAGYGANLAPFQDAAQGAGFFNMLADDDGTARQMSLVLPYGEGYYLAL
HHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCEEEEE
SASTLRIAFGGDAASAGVEQSELLGRNYLAPWLEVGGIRVPLGADGTVHVPYRAGSPFPY
ECCEEEEEECCCHHHCCCCHHHHHCCCCCCHHHHHCCEEEECCCCCEEEEEECCCCCCCC
ISAADVLAGKAPVGQLENRIVLVGSTAPGLADLRVTPFSSTFPGVEIHAHLIAGMLDGTT
CCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCC
RVTPPWARDARLAAVLLLGAVLIVVLLRFGPALGLAATLALLGLLLAAYGAAWARFQVVP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEH
MAAPMLAVAGLYALNTAYGLFAATRSKRQITRLFGQYVPPELAAEMSRDPAHYTMEGQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCCC
DMSVLFSDIRGFTNFSEKLSPTELSEVLNAYLSTMTRIVQQHQGTIDKYIGDAIMAFWNA
HHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
PVDLADHAARAVRTALEMQAALPQLNDEFAARGWPAVKIGVGVNTGRMSVGNMGSEFRMA
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEE
YTVMGDAVNLGSRLEGITKQYGVGILVTQSTVDADPVHAYMKVDEVRVKGKETPVAIYEP
EEECCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHEECCCCCCEEEECC
LGAKDRLADDVRSAAAAFDAAFAAYQKQDWDAAETALRALDAKSPRALYDVYLERIAQFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
AAPPPQGWDGVYVYTTK
CCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]