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The map label for this gene is aroA

Identifier: 74316972

GI number: 74316972

Start: 1016479

End: 1017765

Strand: Direct

Name: aroA

Synonym: Tbd_0954

Alternate gene names: 74316972

Gene position: 1016479-1017765 (Clockwise)

Preceding gene: 74316971

Following gene: 74316973

Centisome position: 34.93

GC content: 68.92

Gene sequence:

>1287_bases
ATGGAATTTCTCGATTTGCCCGGACGCAGCCGGGCCAGCGGCACCGTGCGCTTGCCGGGTTCGAAAAGCATTTCCAACCG
CGTACTGCTGCTCGCCGCGCTGGCCGAGGGCGTGACCGACGTTTACGACGTGCTCGATTCGGACGACACGCGCTACATGC
TGGCGGCGCTGCAGGCGCTCGGTGTCGGCGTCGAGGATCGCGGCGACAACCACTGGCGGGTCACCGGCGTCGCCGGGGCG
TTTCCGGCGCGCCAGGCCGAGCTCTTCCTCGGTAACGCCGGCACCGCGTTCCGGCCGCTGACGGCCGTGCTCGCGCTGTC
GGGCGGCGACTACGTCCTCGACGGCGTCGCACGCATGCACGAGCGCCCGATCGGTGACCTCGTCGACGCGTTGCGCCAGT
TGGGTGGGCGGATCGATTATCGCGGCACGCTCGGCTTCCCACCGCTGCATGTCCATCCCCCGCAGGCCGGGGCGGACGTG
GCCCACATCCGCGGAAACGTCTCGAGCCAGTTTCTGACCGGCCTTCTCATGGCCTTGCCGCTCAGGCGGCTTCGCACACG
CGTCGAGGTCGTCGGCGAGCTGATCTCCAAGCCCTACATCGAAATCACGCTCGCGATGCTGCGCCGCTTCGGCGTCGAGG
TGGCGCGCGACGGCTGGCAGGCCTTTTCGGTCGCCGCGGACGCCTGCTATCGCAGTCCGCGCGAAATCTACGTCGAGGGC
GACGCCTCGTCGGCATCGTACTTTTTGGCCGCTGGCGCGATCGGCGGCGGTCCGGTCCGCGTCGAGGGCGTGGGGCGCGA
CAGCGTCCAGGGTGACGTCGGTTTCGCCGACGCACTGGCTGCGATGGGCGCGCGGATCGCGATGGGACCGAACTGGATCG
AAGCCTGCGCGCCAGCGCAGGGGCGTCTCAAGGCGATCGACCTCGATTGCAACGCGATCCCAGACGCCGCGATGACGCTC
GCCGTCGCGGCCTTGTTCGCCGACGGCACGACGACGCTGCGAAACATCGCAAGCTGGCGCGTCAAGGAGACCGACCGCAT
CGCGGCGATGGCGACCGAACTGCGCAAGGTCGGCGCGACGGTCGAGGAGGGTGACGACTTCCTGCGCGTCACGCCGCCGG
AAACCCTGCGCGCGGGCGCCGTTATCGACACCTACGACGACCATCGCATGGCGATGTGCCTGTCGCTCGTGTCGCTCGGC
GGTGTCGCCGTCCGCATCAACGACCCGGGCTGCGTCGCCAAGACCTTCCCCGGTTACTTCAACGCCTTTGCGGAGATCGC
GCGATGA

Upstream 100 bases:

>100_bases
TGAGCACCGCCGTCGCGGCCGCAGACGGCACCGCGCTGCTCGAGATTTTTTCGCGTGCGCGGGATGCCCGCGCGGGCTGG
ATCGACACTCAGGACCTGTA

Downstream 100 bases:

>100_bases
GACCGTCCGATTCCTTGGCCCCGGTCCTGACCGTCGACGGCCCCTCGGCCTCGGGCAAGGGCACGGTCGCCGAACGCGTC
GCGGCCGCGCTTGGCTTCCA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MEFLDLPGRSRASGTVRLPGSKSISNRVLLLAALAEGVTDVYDVLDSDDTRYMLAALQALGVGVEDRGDNHWRVTGVAGA
FPARQAELFLGNAGTAFRPLTAVLALSGGDYVLDGVARMHERPIGDLVDALRQLGGRIDYRGTLGFPPLHVHPPQAGADV
AHIRGNVSSQFLTGLLMALPLRRLRTRVEVVGELISKPYIEITLAMLRRFGVEVARDGWQAFSVAADACYRSPREIYVEG
DASSASYFLAAGAIGGGPVRVEGVGRDSVQGDVGFADALAAMGARIAMGPNWIEACAPAQGRLKAIDLDCNAIPDAAMTL
AVAALFADGTTTLRNIASWRVKETDRIAAMATELRKVGATVEEGDDFLRVTPPETLRAGAVIDTYDDHRMAMCLSLVSLG
GVAVRINDPGCVAKTFPGYFNAFAEIAR

Sequences:

>Translated_428_residues
MEFLDLPGRSRASGTVRLPGSKSISNRVLLLAALAEGVTDVYDVLDSDDTRYMLAALQALGVGVEDRGDNHWRVTGVAGA
FPARQAELFLGNAGTAFRPLTAVLALSGGDYVLDGVARMHERPIGDLVDALRQLGGRIDYRGTLGFPPLHVHPPQAGADV
AHIRGNVSSQFLTGLLMALPLRRLRTRVEVVGELISKPYIEITLAMLRRFGVEVARDGWQAFSVAADACYRSPREIYVEG
DASSASYFLAAGAIGGGPVRVEGVGRDSVQGDVGFADALAAMGARIAMGPNWIEACAPAQGRLKAIDLDCNAIPDAAMTL
AVAALFADGTTTLRNIASWRVKETDRIAAMATELRKVGATVEEGDDFLRVTPPETLRAGAVIDTYDDHRMAMCLSLVSLG
GVAVRINDPGCVAKTFPGYFNAFAEIAR
>Mature_428_residues
MEFLDLPGRSRASGTVRLPGSKSISNRVLLLAALAEGVTDVYDVLDSDDTRYMLAALQALGVGVEDRGDNHWRVTGVAGA
FPARQAELFLGNAGTAFRPLTAVLALSGGDYVLDGVARMHERPIGDLVDALRQLGGRIDYRGTLGFPPLHVHPPQAGADV
AHIRGNVSSQFLTGLLMALPLRRLRTRVEVVGELISKPYIEITLAMLRRFGVEVARDGWQAFSVAADACYRSPREIYVEG
DASSASYFLAAGAIGGGPVRVEGVGRDSVQGDVGFADALAAMGARIAMGPNWIEACAPAQGRLKAIDLDCNAIPDAAMTL
AVAALFADGTTTLRNIASWRVKETDRIAAMATELRKVGATVEEGDDFLRVTPPETLRAGAVIDTYDDHRMAMCLSLVSLG
GVAVRINDPGCVAKTFPGYFNAFAEIAR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=430, Percent_Identity=56.7441860465116, Blast_Score=430, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6320332, Length=464, Percent_Identity=37.0689655172414, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_THIDA (Q3SK83)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314712.1
- HSSP:   P0A6D3
- ProteinModelPortal:   Q3SK83
- SMR:   Q3SK83
- STRING:   Q3SK83
- GeneID:   3672746
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0954
- NMPDR:   fig|292415.3.peg.544
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   GADIEWG
- PhylomeDB:   Q3SK83
- BioCyc:   TDEN292415:TBD_0954-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 45483; Mature: 45483

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLDLPGRSRASGTVRLPGSKSISNRVLLLAALAEGVTDVYDVLDSDDTRYMLAALQAL
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GVGVEDRGDNHWRVTGVAGAFPARQAELFLGNAGTAFRPLTAVLALSGGDYVLDGVARMH
CCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHEECCCCHHHHHHHHHH
ERPIGDLVDALRQLGGRIDYRGTLGFPPLHVHPPQAGADVAHIRGNVSSQFLTGLLMALP
CCCHHHHHHHHHHHCCCEEECCCCCCCCCEECCCCCCCCHHHHCCCCHHHHHHHHHHHHH
LRRLRTRVEVVGELISKPYIEITLAMLRRFGVEVARDGWQAFSVAADACYRSPREIYVEG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCEEEEEC
DASSASYFLAAGAIGGGPVRVEGVGRDSVQGDVGFADALAAMGARIAMGPNWIEACAPAQ
CCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCEEECCCCHHHHCCCCC
GRLKAIDLDCNAIPDAAMTLAVAALFADGTTTLRNIASWRVKETDRIAAMATELRKVGAT
CCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
VEEGDDFLRVTPPETLRAGAVIDTYDDHRMAMCLSLVSLGGVAVRINDPGCVAKTFPGYF
HHCCCCEEEECCCHHHHCCCEEECCCCHHHHHHHHHHHHCCEEEEECCCCCEECCCCHHH
NAFAEIAR
HHHHHHCC
>Mature Secondary Structure
MEFLDLPGRSRASGTVRLPGSKSISNRVLLLAALAEGVTDVYDVLDSDDTRYMLAALQAL
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GVGVEDRGDNHWRVTGVAGAFPARQAELFLGNAGTAFRPLTAVLALSGGDYVLDGVARMH
CCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHEECCCCHHHHHHHHHH
ERPIGDLVDALRQLGGRIDYRGTLGFPPLHVHPPQAGADVAHIRGNVSSQFLTGLLMALP
CCCHHHHHHHHHHHCCCEEECCCCCCCCCEECCCCCCCCHHHHCCCCHHHHHHHHHHHHH
LRRLRTRVEVVGELISKPYIEITLAMLRRFGVEVARDGWQAFSVAADACYRSPREIYVEG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCEEEEEC
DASSASYFLAAGAIGGGPVRVEGVGRDSVQGDVGFADALAAMGARIAMGPNWIEACAPAQ
CCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCEEECCCCHHHHCCCCC
GRLKAIDLDCNAIPDAAMTLAVAALFADGTTTLRNIASWRVKETDRIAAMATELRKVGAT
CCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
VEEGDDFLRVTPPETLRAGAVIDTYDDHRMAMCLSLVSLGGVAVRINDPGCVAKTFPGYF
HHCCCCEEEECCCHHHHCCCEEECCCCHHHHHHHHHHHHCCEEEEECCCCCEECCCCHHH
NAFAEIAR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA