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The map label for this gene is hisC1

Identifier: 74316970

GI number: 74316970

Start: 1014462

End: 1015616

Strand: Direct

Name: hisC1

Synonym: Tbd_0952

Alternate gene names: 74316970

Gene position: 1014462-1015616 (Clockwise)

Preceding gene: 74316969

Following gene: 74316971

Centisome position: 34.86

GC content: 68.74

Gene sequence:

>1155_bases
ATGAGCGGCTGCGATTCGATCTGCGCTGCAACCGCGCCGCCCCACGTGCGCGCGATCGCTCCGTATCAGCCCGGCAAGCC
GATTTCCGAGCTTGCACGCGAACTGGGCCTGGCCGAAGCCGATATCGTCAAGCTCGCTTCGAACGAAAATCCGCTCGGTC
CGAGCCCGTTCGCGCTTGCCGCGGCCCAGGACGCGCTCCTGGACATGGCCTTGTATCCGGACGGTGCGGGCTACGCGCTG
AAGGCGAAGCTCTCGGCCAGGCTCGGCGTCGACGCGGCGCAGATCGTGCTCGGCAATGGTTCCAACGACGTGCTCGACAT
GGTCGCGCGCGCCTATCTCGCGCCGGGGACCTCGGCCGTCTATGCGCAGTACGCGTTCGCGGTCTACCCGATCGCCACGC
ATACGGTCGGTGCCCACGGGATCGCGGTCGCGGCGCGGGACTTCGGCCACGACCTCGAACGCATGCGCGCCGCGATCCGT
GACGACACCCGGGTGGTGTGGATCGCGAATCCCAACAACCCGACCGGCACTTTCCTGCCGTGGAACGAGATCGAGGCCTT
CCTCGAGACCGTGCCGCCCCGCGTGCTGGTCGTCCTCGACGAGGCCTACGGCGAATACCTCGCGCCCGCGTCGCGCTGCG
ACACGGCGGCCTGGGTGGTGCGTTTCCCCAATCTCTTGATCAGCCGCACCTTTTCCAAGGCCTACGGTCTGGCCGGGCTA
CGGGTCGGCTACGGGATCGGGCACGCCGACGTCGTCGACCTGCTGAACCGGGTCCGCCATCCGTTCAACGTCAACGCCTC
GGCGCTCGCCGCGGCGGAGGCCGCGCTCGACGACGACGCCTTTCTCGCGCGAAGCTATGCGCTCAACGCGGCGGGCATGC
AGCAACTCTTAGGCGGGCTCGCGGCCCTGGACATCGAGACCGTCCCGTCGAAGGGCAATTTCGTCCTCGCGCGGGTCGGC
GATGCGGCGCGCATCAACACCGAGCTACTCAAGCGCGGCGTGATCGTACGACCGGTCGCAGCCTACGGGCTGCCCGAATT
CCTGCGCGTGTCTGTCGGTCTTGCCGGCCAGAATGCGCGCTTTCTCGACGCCCTGGGCGAGGTTCTCGCGGCGGCGCCCG
GCCGGCACCCCGACAGCCGGAAAGCCCTGCCGTGA

Upstream 100 bases:

>100_bases
AAGGTCACCGCAAGGACGCACGGCTCGCCGCGGCGCTCGCCGAAATCGATTCGCGGGCGGCCTTCCTCAAGATCCTCGGC
TCCTACCCTGCGGCGTCGGC

Downstream 100 bases:

>100_bases
TCGTCGAGCGCCTCGCAGTCATTGGCGTCGGCCTGATCGGTGGATCGTTTGCGCTCGCCCTGAAGCAGGCCGGCGCGGTT
GGCGAGGTGGTCGGTGTCGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSGCDSICAATAPPHVRAIAPYQPGKPISELARELGLAEADIVKLASNENPLGPSPFALAAAQDALLDMALYPDGAGYAL
KAKLSARLGVDAAQIVLGNGSNDVLDMVARAYLAPGTSAVYAQYAFAVYPIATHTVGAHGIAVAARDFGHDLERMRAAIR
DDTRVVWIANPNNPTGTFLPWNEIEAFLETVPPRVLVVLDEAYGEYLAPASRCDTAAWVVRFPNLLISRTFSKAYGLAGL
RVGYGIGHADVVDLLNRVRHPFNVNASALAAAEAALDDDAFLARSYALNAAGMQQLLGGLAALDIETVPSKGNFVLARVG
DAARINTELLKRGVIVRPVAAYGLPEFLRVSVGLAGQNARFLDALGEVLAAAPGRHPDSRKALP

Sequences:

>Translated_384_residues
MSGCDSICAATAPPHVRAIAPYQPGKPISELARELGLAEADIVKLASNENPLGPSPFALAAAQDALLDMALYPDGAGYAL
KAKLSARLGVDAAQIVLGNGSNDVLDMVARAYLAPGTSAVYAQYAFAVYPIATHTVGAHGIAVAARDFGHDLERMRAAIR
DDTRVVWIANPNNPTGTFLPWNEIEAFLETVPPRVLVVLDEAYGEYLAPASRCDTAAWVVRFPNLLISRTFSKAYGLAGL
RVGYGIGHADVVDLLNRVRHPFNVNASALAAAEAALDDDAFLARSYALNAAGMQQLLGGLAALDIETVPSKGNFVLARVG
DAARINTELLKRGVIVRPVAAYGLPEFLRVSVGLAGQNARFLDALGEVLAAAPGRHPDSRKALP
>Mature_383_residues
SGCDSICAATAPPHVRAIAPYQPGKPISELARELGLAEADIVKLASNENPLGPSPFALAAAQDALLDMALYPDGAGYALK
AKLSARLGVDAAQIVLGNGSNDVLDMVARAYLAPGTSAVYAQYAFAVYPIATHTVGAHGIAVAARDFGHDLERMRAAIRD
DTRVVWIANPNNPTGTFLPWNEIEAFLETVPPRVLVVLDEAYGEYLAPASRCDTAAWVVRFPNLLISRTFSKAYGLAGLR
VGYGIGHADVVDLLNRVRHPFNVNASALAAAEAALDDDAFLARSYALNAAGMQQLLGGLAALDIETVPSKGNFVLARVGD
AARINTELLKRGVIVRPVAAYGLPEFLRVSVGLAGQNARFLDALGEVLAAAPGRHPDSRKALP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=360, Percent_Identity=29.1666666666667, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=360, Percent_Identity=28.0555555555556, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_THIDA (Q3SK85)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314710.1
- ProteinModelPortal:   Q3SK85
- SMR:   Q3SK85
- STRING:   Q3SK85
- GeneID:   3672744
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0952
- NMPDR:   fig|292415.3.peg.542
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   KLIYIAN
- ProtClustDB:   PRK02731
- BioCyc:   TDEN292415:TBD_0952-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40438; Mature: 40306

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGCDSICAATAPPHVRAIAPYQPGKPISELARELGLAEADIVKLASNENPLGPSPFALA
CCCCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCHHHH
AAQDALLDMALYPDGAGYALKAKLSARLGVDAAQIVLGNGSNDVLDMVARAYLAPGTSAV
HHHHHHHHHEECCCCCCEEEEEEHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHH
YAQYAFAVYPIATHTVGAHGIAVAARDFGHDLERMRAAIRDDTRVVWIANPNNPTGTFLP
HHHHHHHEEEHHHHCCCCCHHEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
WNEIEAFLETVPPRVLVVLDEAYGEYLAPASRCDTAAWVVRFPNLLISRTFSKAYGLAGL
HHHHHHHHHHCCCEEEEEEEHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RVGYGIGHADVVDLLNRVRHPFNVNASALAAAEAALDDDAFLARSYALNAAGMQQLLGGL
HHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHH
AALDIETVPSKGNFVLARVGDAARINTELLKRGVIVRPVAAYGLPEFLRVSVGLAGQNAR
HHEEEEECCCCCCEEEEECCCCHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHCCCCCCCH
FLDALGEVLAAAPGRHPDSRKALP
HHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SGCDSICAATAPPHVRAIAPYQPGKPISELARELGLAEADIVKLASNENPLGPSPFALA
CCCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCHHHH
AAQDALLDMALYPDGAGYALKAKLSARLGVDAAQIVLGNGSNDVLDMVARAYLAPGTSAV
HHHHHHHHHEECCCCCCEEEEEEHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHH
YAQYAFAVYPIATHTVGAHGIAVAARDFGHDLERMRAAIRDDTRVVWIANPNNPTGTFLP
HHHHHHHEEEHHHHCCCCCHHEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
WNEIEAFLETVPPRVLVVLDEAYGEYLAPASRCDTAAWVVRFPNLLISRTFSKAYGLAGL
HHHHHHHHHHCCCEEEEEEEHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RVGYGIGHADVVDLLNRVRHPFNVNASALAAAEAALDDDAFLARSYALNAAGMQQLLGGL
HHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHH
AALDIETVPSKGNFVLARVGDAARINTELLKRGVIVRPVAAYGLPEFLRVSVGLAGQNAR
HHEEEEECCCCCCEEEEECCCCHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHCCCCCCCH
FLDALGEVLAAAPGRHPDSRKALP
HHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA