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The map label for this gene is gyrA [H]

Identifier: 74316966

GI number: 74316966

Start: 1008562

End: 1011111

Strand: Direct

Name: gyrA [H]

Synonym: Tbd_0948

Alternate gene names: 74316966

Gene position: 1008562-1011111 (Clockwise)

Preceding gene: 74316960

Following gene: 74316967

Centisome position: 34.66

GC content: 63.88

Gene sequence:

>2550_bases
ATGGAACAGTTTGCCAAGGAAACCCTCCCGGTCAGTCTCGAGGAGGAGATGCGGCGTTCATACCTCGATTATGCGATGAG
CGTGATCGTCGGCCGTGCACTCCCCGACGTGCGCGACGGGCTCAAGCCCGTGCACCGTCGTGTGCTGTACGCGATGAACG
AGCTTGGCAACGACTGGAACAAGGCTTACAAGAAGTCGGCGCGCGTCGTCGGCGACGTCATCGGTAAATACCACCCGCAC
GGCGACACGGCCGTCTACGACACCATGGTCCGCATGGCGCAGGACTTCTCGCTGCGCTACCCGCTGATCGACGGCCAGGG
CAACTTCGGCTCGGTCGACGGCGACAACGCCGCGGCGATGCGTTACACCGAAGTGCGCATGGCGCGGATCGCGCACGAGT
TGCTGGCCGACCTCGACAAGGAAACAGTCGACTTCGGCCCCAACTACGACGGCTCCGAGCAGGAGCCGCTCGTGCTGCCG
ACCAAGATTCCGAATCTGCTGATCAACGGTTCGTCGGGCATCGCGGTCGGCATGGCGACGAACATCCCGCCGCACAATCT
CACCGACATCTGCAACGCCCTGTTCGCGCTGCTCGACGCCCCCGCGACCGACATCGAGTCGCTGATCAGCATCGTCCAGG
CGCCCGACTTTCCGACCGCCGGCATCATCTACGGCCTTTCCGGCGTGCGCGACGGCTACCGTACCGGTCGCGGCCGCGTC
GTCATGCGTGCGACCTGCCACGTCGAGGACCTCGACAAGAGCGGCGGCAAGCAGGCGATCATCATCGACGAGCTGCCCTA
TCAGGTGAACAAGGCCAATCTGCTGATCCGGATCGGCGAACTCGTGCGCGACAAGCAGATCGACGGCATCGCCGACCTGC
GCGACGAGTCCGACAAGTCGGGCATGCGCGTCTACATCGAACTCAAGCGCGGCGAGAACGCCGACGTGGTCCTGAACAAT
CTGTACAAGCAGACACAGATGCAGGACACCTTCGGCATGAACATGGTCGCGCTGATCGACGGGCAGCCGCGGCTCCTGAA
CCTCAAGGAGATGCTCGACGCCTTCCTGCGCCACCGCCGTGAAGTCGTCACCCGGCGCACCGTCTTCGATCTCAGGAAGG
CACGCGAGCGCGGCCACATCCTCGAGGGCCTGGCGGTCGCGCTCGCCAACGTCGACGAGATCGTCGAGTTGATCAAGTCG
TCGGAAACGCCTGCGATCGCGAAGGAACGCCTGCTCGGCCGCGCGTGGAAGTCGGCGATGGTCGAGGAGATGCTCGCGCG
CATCGACCCCGAATATTCGCGGCCGGTGAACATGGGGCCGGAATTCGGCCTGCACGCCGATGGCTATCACCTCTCGGAAA
TCCAGGCGCAGCGCATCCTCGAAATGCAGTTGCAGCGCCTGACCAACCTCGAGTCGGACAAGATCCTCGCCGAGTACAAG
GAAATCATGGCGAAGATCGCCGACCTGCTCGACATTCTGGCGAATCCGGCGCGCATCACCCAGATCATCCGCGAGGAACT
GACCCAGGTCCGCGACCAGTTCGGCGATGGGCGGCGCTCGACCATCGTCGAGAACGCGCAGGACATGTCGATGGAAGACC
TGATCAAGCCCGAGGAGATGGTCGTCACGCTGTCACACGGCGGCTACATGAAGTCGCAGCCGCTGGATGATTACCGAGCA
CAGAAGCGCGGCGGCCGCGGCAAGCAGGCGGCGGGGACCAAGGACGAGGACTTCATCGAGAAGATGTTCGTCGCCAACAC
CCACGACTACATCCTCTGCTTCTCCAACCGCGGGCGGCTGTACTGGCTCAAGGTCTACAACGTGCCACAGGGCGGACGCG
CCGCCCGCGGCAAGCCGATCGTCAACCTGCTACCGCTCGAGGACGGCGAGAAGATCAGCGCGCTCTTGCCGGTCAAGACC
TTCGACGACGAGCACTACGTGTTCATGGCGACCGCCAACGGCATCGTCAAGAAGACGCCGCTTTCCGAATTCTCGCGCCC
GCGCACGGCCGGCATCATCGCGGTCGGCCTCGACGACGGCGATGTGCTGTGCGGTGCGTCGATCACCGACGGTCGTCACG
ACGTGATGCTGTTCTCCGATTCCGGCAAGGCCGTGCGCTTCGACGAGAACGACGTGCGCCCGATGGGCCGTGCCGCGCGC
GGCGTGATCGGCATGAAGCTCGCCAAGGGCGCCAAGCTGATCTCGTTGCTCGTGGCTGAAGACGAGAACGACTTCGTGCT
CACGGCGACCGAAAACGGCTACGGCAAGCGGACGCCGATCGCGGAATACACGCGTCACGCGCGGGCCACGCAAGGCATGA
TCGCGATCCAGACCAGCGAGCGCAACGGCAAGGTCGTCGCGGCCAACCTCGTCAAGGCGGACGACGAAATCATGCTGATC
ACGACCGGCGGCGTGCTGATCCGCACGCGCGTCAAGGAGATCCGCGCGATGAGCCGGGCGACCCAGGGCGTCACGCTGAT
CAATCTGGACAAGGGCGAAAAGCTCATCAGCCTGGAAAAAGTAGCCGAGACCGACAACGAAGAGGAATGA

Upstream 100 bases:

>100_bases
TGGCCGCATTCTCACTGTTTGCCTGCCGTTTGGCAAAGGCGGGCGGGGCAGGCGGCCATGCTAAAATCGCCCTCTTTGAA
GCTTGGGTATAAAGCCGGTT

Downstream 100 bases:

>100_bases
GAGGGTAACCGCATGACCATTTACAACTTCAGCGCCGGCCCGGCCGTGCTTCCCAAGGATGTGCTGCAGCAGGTGCAAGC
CGAGCTCGTCGACTGGCACG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 849; Mature: 849

Protein sequence:

>849_residues
MEQFAKETLPVSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKAYKKSARVVGDVIGKYHPH
GDTAVYDTMVRMAQDFSLRYPLIDGQGNFGSVDGDNAAAMRYTEVRMARIAHELLADLDKETVDFGPNYDGSEQEPLVLP
TKIPNLLINGSSGIAVGMATNIPPHNLTDICNALFALLDAPATDIESLISIVQAPDFPTAGIIYGLSGVRDGYRTGRGRV
VMRATCHVEDLDKSGGKQAIIIDELPYQVNKANLLIRIGELVRDKQIDGIADLRDESDKSGMRVYIELKRGENADVVLNN
LYKQTQMQDTFGMNMVALIDGQPRLLNLKEMLDAFLRHRREVVTRRTVFDLRKARERGHILEGLAVALANVDEIVELIKS
SETPAIAKERLLGRAWKSAMVEEMLARIDPEYSRPVNMGPEFGLHADGYHLSEIQAQRILEMQLQRLTNLESDKILAEYK
EIMAKIADLLDILANPARITQIIREELTQVRDQFGDGRRSTIVENAQDMSMEDLIKPEEMVVTLSHGGYMKSQPLDDYRA
QKRGGRGKQAAGTKDEDFIEKMFVANTHDYILCFSNRGRLYWLKVYNVPQGGRAARGKPIVNLLPLEDGEKISALLPVKT
FDDEHYVFMATANGIVKKTPLSEFSRPRTAGIIAVGLDDGDVLCGASITDGRHDVMLFSDSGKAVRFDENDVRPMGRAAR
GVIGMKLAKGAKLISLLVAEDENDFVLTATENGYGKRTPIAEYTRHARATQGMIAIQTSERNGKVVAANLVKADDEIMLI
TTGGVLIRTRVKEIRAMSRATQGVTLINLDKGEKLISLEKVAETDNEEE

Sequences:

>Translated_849_residues
MEQFAKETLPVSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKAYKKSARVVGDVIGKYHPH
GDTAVYDTMVRMAQDFSLRYPLIDGQGNFGSVDGDNAAAMRYTEVRMARIAHELLADLDKETVDFGPNYDGSEQEPLVLP
TKIPNLLINGSSGIAVGMATNIPPHNLTDICNALFALLDAPATDIESLISIVQAPDFPTAGIIYGLSGVRDGYRTGRGRV
VMRATCHVEDLDKSGGKQAIIIDELPYQVNKANLLIRIGELVRDKQIDGIADLRDESDKSGMRVYIELKRGENADVVLNN
LYKQTQMQDTFGMNMVALIDGQPRLLNLKEMLDAFLRHRREVVTRRTVFDLRKARERGHILEGLAVALANVDEIVELIKS
SETPAIAKERLLGRAWKSAMVEEMLARIDPEYSRPVNMGPEFGLHADGYHLSEIQAQRILEMQLQRLTNLESDKILAEYK
EIMAKIADLLDILANPARITQIIREELTQVRDQFGDGRRSTIVENAQDMSMEDLIKPEEMVVTLSHGGYMKSQPLDDYRA
QKRGGRGKQAAGTKDEDFIEKMFVANTHDYILCFSNRGRLYWLKVYNVPQGGRAARGKPIVNLLPLEDGEKISALLPVKT
FDDEHYVFMATANGIVKKTPLSEFSRPRTAGIIAVGLDDGDVLCGASITDGRHDVMLFSDSGKAVRFDENDVRPMGRAAR
GVIGMKLAKGAKLISLLVAEDENDFVLTATENGYGKRTPIAEYTRHARATQGMIAIQTSERNGKVVAANLVKADDEIMLI
TTGGVLIRTRVKEIRAMSRATQGVTLINLDKGEKLISLEKVAETDNEEE
>Mature_849_residues
MEQFAKETLPVSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKAYKKSARVVGDVIGKYHPH
GDTAVYDTMVRMAQDFSLRYPLIDGQGNFGSVDGDNAAAMRYTEVRMARIAHELLADLDKETVDFGPNYDGSEQEPLVLP
TKIPNLLINGSSGIAVGMATNIPPHNLTDICNALFALLDAPATDIESLISIVQAPDFPTAGIIYGLSGVRDGYRTGRGRV
VMRATCHVEDLDKSGGKQAIIIDELPYQVNKANLLIRIGELVRDKQIDGIADLRDESDKSGMRVYIELKRGENADVVLNN
LYKQTQMQDTFGMNMVALIDGQPRLLNLKEMLDAFLRHRREVVTRRTVFDLRKARERGHILEGLAVALANVDEIVELIKS
SETPAIAKERLLGRAWKSAMVEEMLARIDPEYSRPVNMGPEFGLHADGYHLSEIQAQRILEMQLQRLTNLESDKILAEYK
EIMAKIADLLDILANPARITQIIREELTQVRDQFGDGRRSTIVENAQDMSMEDLIKPEEMVVTLSHGGYMKSQPLDDYRA
QKRGGRGKQAAGTKDEDFIEKMFVANTHDYILCFSNRGRLYWLKVYNVPQGGRAARGKPIVNLLPLEDGEKISALLPVKT
FDDEHYVFMATANGIVKKTPLSEFSRPRTAGIIAVGLDDGDVLCGASITDGRHDVMLFSDSGKAVRFDENDVRPMGRAAR
GVIGMKLAKGAKLISLLVAEDENDFVLTATENGYGKRTPIAEYTRHARATQGMIAIQTSERNGKVVAANLVKADDEIMLI
TTGGVLIRTRVKEIRAMSRATQGVTLINLDKGEKLISLEKVAETDNEEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=176, Percent_Identity=31.8181818181818, Blast_Score=76, Evalue=2e-13,
Organism=Homo sapiens, GI19913408, Length=176, Percent_Identity=32.3863636363636, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1788562, Length=849, Percent_Identity=60.7773851590106, Blast_Score=1053, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=744, Percent_Identity=35.4838709677419, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI212645845, Length=539, Percent_Identity=23.0055658627087, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=31.0344827586207, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=402, Percent_Identity=24.3781094527363, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136538, Length=411, Percent_Identity=24.330900243309, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94418; Mature: 94418

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQFAKETLPVSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
KAYKKSARVVGDVIGKYHPHGDTAVYDTMVRMAQDFSLRYPLIDGQGNFGSVDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEECCEECCCCCCCCCCCCCCHHH
RYTEVRMARIAHELLADLDKETVDFGPNYDGSEQEPLVLPTKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC
NIPPHNLTDICNALFALLDAPATDIESLISIVQAPDFPTAGIIYGLSGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHCCHHHCCHHHCCCCCE
VMRATCHVEDLDKSGGKQAIIIDELPYQVNKANLLIRIGELVRDKQIDGIADLRDESDKS
EEEEEECHHHHHCCCCCEEEEEECCCCEECCCCEEEEEHHHHHHCCCCCHHHHCCCCCCC
GMRVYIELKRGENADVVLNNLYKQTQMQDTFGMNMVALIDGQPRLLNLKEMLDAFLRHRR
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHH
EVVTRRTVFDLRKARERGHILEGLAVALANVDEIVELIKSSETPAIAKERLLGRAWKSAM
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VEEMLARIDPEYSRPVNMGPEFGLHADGYHLSEIQAQRILEMQLQRLTNLESDKILAEYK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EIMAKIADLLDILANPARITQIIREELTQVRDQFGDGRRSTIVENAQDMSMEDLIKPEEM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHCCCHHHCCCCCCE
VVTLSHGGYMKSQPLDDYRAQKRGGRGKQAAGTKDEDFIEKMFVANTHDYILCFSNRGRL
EEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCE
YWLKVYNVPQGGRAARGKPIVNLLPLEDGEKISALLPVKTFDDEHYVFMATANGIVKKTP
EEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEECEEECCCCCEEEEEECCCCEECCC
LSEFSRPRTAGIIAVGLDDGDVLCGASITDGRHDVMLFSDSGKAVRFDENDVRPMGRAAR
HHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHH
GVIGMKLAKGAKLISLLVAEDENDFVLTATENGYGKRTPIAEYTRHARATQGMIAIQTSE
HHHHHHHHCCHHEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECC
RNGKVVAANLVKADDEIMLITTGGVLIRTRVKEIRAMSRATQGVTLINLDKGEKLISLEK
CCCCEEEEEEEECCCCEEEEEECCEEEHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHH
VAETDNEEE
HHCCCCCCC
>Mature Secondary Structure
MEQFAKETLPVSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
KAYKKSARVVGDVIGKYHPHGDTAVYDTMVRMAQDFSLRYPLIDGQGNFGSVDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEECCEECCCCCCCCCCCCCCHHH
RYTEVRMARIAHELLADLDKETVDFGPNYDGSEQEPLVLPTKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC
NIPPHNLTDICNALFALLDAPATDIESLISIVQAPDFPTAGIIYGLSGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHCCHHHCCHHHCCCCCE
VMRATCHVEDLDKSGGKQAIIIDELPYQVNKANLLIRIGELVRDKQIDGIADLRDESDKS
EEEEEECHHHHHCCCCCEEEEEECCCCEECCCCEEEEEHHHHHHCCCCCHHHHCCCCCCC
GMRVYIELKRGENADVVLNNLYKQTQMQDTFGMNMVALIDGQPRLLNLKEMLDAFLRHRR
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHH
EVVTRRTVFDLRKARERGHILEGLAVALANVDEIVELIKSSETPAIAKERLLGRAWKSAM
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VEEMLARIDPEYSRPVNMGPEFGLHADGYHLSEIQAQRILEMQLQRLTNLESDKILAEYK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EIMAKIADLLDILANPARITQIIREELTQVRDQFGDGRRSTIVENAQDMSMEDLIKPEEM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHCCCHHHCCCCCCE
VVTLSHGGYMKSQPLDDYRAQKRGGRGKQAAGTKDEDFIEKMFVANTHDYILCFSNRGRL
EEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCE
YWLKVYNVPQGGRAARGKPIVNLLPLEDGEKISALLPVKTFDDEHYVFMATANGIVKKTP
EEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEECEEECCCCCEEEEEECCCCEECCC
LSEFSRPRTAGIIAVGLDDGDVLCGASITDGRHDVMLFSDSGKAVRFDENDVRPMGRAAR
HHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHH
GVIGMKLAKGAKLISLLVAEDENDFVLTATENGYGKRTPIAEYTRHARATQGMIAIQTSE
HHHHHHHHCCHHEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECC
RNGKVVAANLVKADDEIMLITTGGVLIRTRVKEIRAMSRATQGVTLINLDKGEKLISLEK
CCCCEEEEEEEECCCCEEEEEECCEEEHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHH
VAETDNEEE
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]