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The map label for this gene is fppS [H]

Identifier: 74316898

GI number: 74316898

Start: 930350

End: 931240

Strand: Reverse

Name: fppS [H]

Synonym: Tbd_0880

Alternate gene names: 74316898

Gene position: 931240-930350 (Counterclockwise)

Preceding gene: 74316899

Following gene: 74316897

Centisome position: 32.0

GC content: 69.7

Gene sequence:

>891_bases
GTGATGAGTGATTTTTCCGCCTGGACACAGGCATGCCAGGCGCGTATCGAACACGTGCTGGCCGAGCGGCTGCCGCCGTC
CGACATTGCACCGAAGCGGCTGCACGAGGCCATGCGCTACGCGGTGCTGGGCGGCGGAAAACGCGTGCGTCCGCTGCTGG
CGTTCGCCGCCGGCGACGTCACGGGCGCCGCCGTCGAACAGGTGCAGCACGCGGCGGCCGCGGTCGAATTGATTCACGCC
TATTCGCTCGTTCACGACGACATGCCGGCGATGGACGACGACGCGCTGCGCCGCGGCAAGCCCACCGTCCATGTCGAGTT
CGACGAGCCGACCGCGCTGCTCGTGGGCGACGCGCTGCAGAGCCTCGCCTTCGACATCCTGGCGAGCCCCGGACTGGCGC
AGGCCGCTTCGACGCAACTCGCGATGGTGCAGCTGCTGGCCCGGGCGTCCGGCTCGCGCGGCATGGCCGGCGGCCAGGCG
ATCGACCTCGCGAACGTCGGCAAGTCTCTCGACCTCACCGAACTCGAATTCATGCACATCCACAAGACGGGCGCCCTGAT
CCGCGCGTCGGTCCTGCTCGGCGCCGAGTGCGGCACGCTGTCGGAGCCTGCGCGCACGGCGCTCGACCATTACGCGAAAT
GCATCGGCCTCGCCTTCCAGGTCGTCGACGATGTGCTCGACGCCGAGGCGTCGACCGCGACGCTCGGCAAAACCGCGGGC
AAGGACGCGGCGAACAACAAGCCGACCTACGTCAGTCTGCTCGGCGTCCAACGCGCCCGCGAACGGGCCCTGGAATTGCG
CGCCGACGCCTGCGCCGCGCTCGATCCGCTCGGTCCGTCCGCGCGACGCCTGCGCGAGCTGGCGGATTTCGTCGTCGAGC
GGACGTTCTGA

Upstream 100 bases:

>100_bases
GCCGAACTGTTGCAGTACTGCCGCCAGCAGCTGGCCGACGCCGAGCAGCAGGTCCGGATTCTCGAAAACGGAACGCTTCA
GCCTTTCAATCCCCAAGACA

Downstream 100 bases:

>100_bases
CATGCCGGCGTCGCTGCTCGACACGATAGAAAGCCCGGCCGATCTGCGCGCCCTGCCCGCCGCCGAGCTGCCCGGGCTCG
CCGCGGAAGTGCGCGCCTTC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MMSDFSAWTQACQARIEHVLAERLPPSDIAPKRLHEAMRYAVLGGGKRVRPLLAFAAGDVTGAAVEQVQHAAAAVELIHA
YSLVHDDMPAMDDDALRRGKPTVHVEFDEPTALLVGDALQSLAFDILASPGLAQAASTQLAMVQLLARASGSRGMAGGQA
IDLANVGKSLDLTELEFMHIHKTGALIRASVLLGAECGTLSEPARTALDHYAKCIGLAFQVVDDVLDAEASTATLGKTAG
KDAANNKPTYVSLLGVQRARERALELRADACAALDPLGPSARRLRELADFVVERTF

Sequences:

>Translated_296_residues
MMSDFSAWTQACQARIEHVLAERLPPSDIAPKRLHEAMRYAVLGGGKRVRPLLAFAAGDVTGAAVEQVQHAAAAVELIHA
YSLVHDDMPAMDDDALRRGKPTVHVEFDEPTALLVGDALQSLAFDILASPGLAQAASTQLAMVQLLARASGSRGMAGGQA
IDLANVGKSLDLTELEFMHIHKTGALIRASVLLGAECGTLSEPARTALDHYAKCIGLAFQVVDDVLDAEASTATLGKTAG
KDAANNKPTYVSLLGVQRARERALELRADACAALDPLGPSARRLRELADFVVERTF
>Mature_296_residues
MMSDFSAWTQACQARIEHVLAERLPPSDIAPKRLHEAMRYAVLGGGKRVRPLLAFAAGDVTGAAVEQVQHAAAAVELIHA
YSLVHDDMPAMDDDALRRGKPTVHVEFDEPTALLVGDALQSLAFDILASPGLAQAASTQLAMVQLLARASGSRGMAGGQA
IDLANVGKSLDLTELEFMHIHKTGALIRASVLLGAECGTLSEPARTALDHYAKCIGLAFQVVDDVLDAEASTATLGKTAG
KDAANNKPTYVSLLGVQRARERALELRADACAALDPLGPSARRLRELADFVVERTF

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=31.5555555555556, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786623, Length=297, Percent_Identity=46.8013468013468, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1789578, Length=212, Percent_Identity=33.0188679245283, Blast_Score=107, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24651612, Length=270, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31382; Mature: 31382

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSDFSAWTQACQARIEHVLAERLPPSDIAPKRLHEAMRYAVLGGGKRVRPLLAFAAGDV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCH
TGAAVEQVQHAAAAVELIHAYSLVHDDMPAMDDDALRRGKPTVHVEFDEPTALLVGDALQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHH
SLAFDILASPGLAQAASTQLAMVQLLARASGSRGMAGGQAIDLANVGKSLDLTELEFMHI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHCCCCCCCHHHHHHHH
HKTGALIRASVLLGAECGTLSEPARTALDHYAKCIGLAFQVVDDVLDAEASTATLGKTAG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
KDAANNKPTYVSLLGVQRARERALELRADACAALDPLGPSARRLRELADFVVERTF
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMSDFSAWTQACQARIEHVLAERLPPSDIAPKRLHEAMRYAVLGGGKRVRPLLAFAAGDV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCH
TGAAVEQVQHAAAAVELIHAYSLVHDDMPAMDDDALRRGKPTVHVEFDEPTALLVGDALQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHH
SLAFDILASPGLAQAASTQLAMVQLLARASGSRGMAGGQAIDLANVGKSLDLTELEFMHI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHCCCCCCCHHHHHHHH
HKTGALIRASVLLGAECGTLSEPARTALDHYAKCIGLAFQVVDDVLDAEASTATLGKTAG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
KDAANNKPTYVSLLGVQRARERALELRADACAALDPLGPSARRLRELADFVVERTF
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]