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The map label for this gene is obgE

Identifier: 74316884

GI number: 74316884

Start: 915795

End: 916847

Strand: Direct

Name: obgE

Synonym: Tbd_0866

Alternate gene names: 74316884

Gene position: 915795-916847 (Clockwise)

Preceding gene: 74316883

Following gene: 74316895

Centisome position: 31.47

GC content: 65.91

Gene sequence:

>1053_bases
ATGAAATTCATCGACGAAGCAAAGATTACGGTTCTGGCCGGCAAGGGCGGGGACGGCAGCGCTTCGTTTCGGCGCGAGAA
GTACATCCCGAAGGGGGGACCCGACGGCGGCGACGGCGGCCGCGGCGGCAGCGTCTACGCAGTCGCCGACCGCAATGTCA
ACACGCTCGTGGAATTTCGCTATACGCGCATCTTCAAGGCGCAGAAGGGCGAGAACGGCCGCGGTGCGCAATGCTACGGC
AAGGCCGGCGACGACCTCACGATCCGCGTTCCGGTCGGCACGGTGTTCAGCGACGTCAACAGCGGCGAAGTCGTCGCCGA
TCTCGCCGAGGACGGCGAGACCGTGTGTCTGGCGAAAGGTGGCAAGGGCGGATTGGGCAATATCCATTTCAAATCGAGCA
CCAATCGCGCACCGCGCCAGCACACACTCGGCGAACCGGGAGAGGAATGGGAGCTCGCGCTCGAGTTGAAGGTGCTGGCC
GACGTGGGTCTGCTCGGCATGCCGAACGCGGGCAAGTCGACGTTCATACGCGCCGTCTCGGCGGCCCGGCCCAAGGTGGC
GGACTATCCGTTCACGACGCTGGCGCCGAATCTGGGCGTCGTGCGCGTCGACAGTGAACGCAGCTTCGTCATCGCCGACA
TCCCCGGGCTGATCGAGGGGGCGGCGGAGGGCGCGGGCCTTGGCCACCAGTTCCTCCGCCATTTGCAGCGCACGCGCCTG
CTGCTGCATCTGGTCGACATTTCGCCGCGCTGGGAAGCCGGCGATCCCGTGCACGAGGCGCGCGCGATCGTCGAGGAACT
GCGCAAGTACGACCAGGCGCTCTACGAGAAGCCGCGCTGGCTCGTCCTCAATAAACTCGACATGGTCGATGAAGGCGAGC
GCGAAGCGGTCGTCGCGAAATTCGTCGAGGATTATGGCTGGAATGGGCCGGTTTTTGCGATCTCGGCGCTCGACGGCAGC
GGTTGCAGCGCGCTGACCTACGCCGTGATGGACTACCTCGGGATGCTTGCGCCGCGGCACGAGGCCGAAGACCCGGCCCC
GCCCGCCAGCTGA

Upstream 100 bases:

>100_bases
ATCGAGCCGCTCGCGGCCTGATCGCGCTTGAACTGAAGCGCCTCCCGCGAAAAAAGCCCTGTCCGCCGGATAGGGCTTTT
TTGTTTATGGACACACTCCC

Downstream 100 bases:

>100_bases
CTCCGGCTGGCGGCGGGTGCACCGCCTTCAGGACGTCGCGGGTTCGTCGGGTGCGCGCTTCCAGTCGTTTTCCAGCAGTT
CGACCCGGTGCTTCGCCCAC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKFIDEAKITVLAGKGGDGSASFRREKYIPKGGPDGGDGGRGGSVYAVADRNVNTLVEFRYTRIFKAQKGENGRGAQCYG
KAGDDLTIRVPVGTVFSDVNSGEVVADLAEDGETVCLAKGGKGGLGNIHFKSSTNRAPRQHTLGEPGEEWELALELKVLA
DVGLLGMPNAGKSTFIRAVSAARPKVADYPFTTLAPNLGVVRVDSERSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTRL
LLHLVDISPRWEAGDPVHEARAIVEELRKYDQALYEKPRWLVLNKLDMVDEGEREAVVAKFVEDYGWNGPVFAISALDGS
GCSALTYAVMDYLGMLAPRHEAEDPAPPAS

Sequences:

>Translated_350_residues
MKFIDEAKITVLAGKGGDGSASFRREKYIPKGGPDGGDGGRGGSVYAVADRNVNTLVEFRYTRIFKAQKGENGRGAQCYG
KAGDDLTIRVPVGTVFSDVNSGEVVADLAEDGETVCLAKGGKGGLGNIHFKSSTNRAPRQHTLGEPGEEWELALELKVLA
DVGLLGMPNAGKSTFIRAVSAARPKVADYPFTTLAPNLGVVRVDSERSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTRL
LLHLVDISPRWEAGDPVHEARAIVEELRKYDQALYEKPRWLVLNKLDMVDEGEREAVVAKFVEDYGWNGPVFAISALDGS
GCSALTYAVMDYLGMLAPRHEAEDPAPPAS
>Mature_350_residues
MKFIDEAKITVLAGKGGDGSASFRREKYIPKGGPDGGDGGRGGSVYAVADRNVNTLVEFRYTRIFKAQKGENGRGAQCYG
KAGDDLTIRVPVGTVFSDVNSGEVVADLAEDGETVCLAKGGKGGLGNIHFKSSTNRAPRQHTLGEPGEEWELALELKVLA
DVGLLGMPNAGKSTFIRAVSAARPKVADYPFTTLAPNLGVVRVDSERSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTRL
LLHLVDISPRWEAGDPVHEARAIVEELRKYDQALYEKPRWLVLNKLDMVDEGEREAVVAKFVEDYGWNGPVFAISALDGS
GCSALTYAVMDYLGMLAPRHEAEDPAPPAS

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=325, Percent_Identity=41.8461538461538, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI111955139, Length=278, Percent_Identity=37.7697841726619, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI111955063, Length=133, Percent_Identity=41.3533834586466, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=31.8518518518519, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789574, Length=348, Percent_Identity=58.6206896551724, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1787454, Length=100, Percent_Identity=38, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=323, Percent_Identity=39.0092879256966, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17552324, Length=325, Percent_Identity=29.8461538461538, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=33.0935251798561, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321962, Length=190, Percent_Identity=38.9473684210526, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319281, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585318, Length=300, Percent_Identity=41.3333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129375, Length=329, Percent_Identity=39.8176291793313, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24640873, Length=133, Percent_Identity=33.8345864661654, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640877, Length=133, Percent_Identity=33.8345864661654, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640875, Length=133, Percent_Identity=33.8345864661654, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_THIDA (Q3SKG2)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314624.1
- HSSP:   Q5SJ29
- ProteinModelPortal:   Q3SKG2
- STRING:   Q3SKG2
- GeneID:   3671631
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0866
- NMPDR:   fig|292415.3.peg.294
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   Q3SKG2
- ProtClustDB:   PRK12299
- BioCyc:   TDEN292415:TBD_0866-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37576; Mature: 37576

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDEAKITVLAGKGGDGSASFRREKYIPKGGPDGGDGGRGGSVYAVADRNVNTLVEFR
CCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
YTRIFKAQKGENGRGAQCYGKAGDDLTIRVPVGTVFSDVNSGEVVADLAEDGETVCLAKG
HHHHEECCCCCCCCCCEEECCCCCCEEEEEECHHHHHCCCCCCEEEEHHCCCCEEEEEEC
GKGGLGNIHFKSSTNRAPRQHTLGEPGEEWELALELKVLADVGLLGMPNAGKSTFIRAVS
CCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHH
AARPKVADYPFTTLAPNLGVVRVDSERSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTRL
HCCCCCCCCCCHHHCCCCCEEEECCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHH
LLHLVDISPRWEAGDPVHEARAIVEELRKYDQALYEKPRWLVLNKLDMVDEGEREAVVAK
HHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
FVEDYGWNGPVFAISALDGSGCSALTYAVMDYLGMLAPRHEAEDPAPPAS
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFIDEAKITVLAGKGGDGSASFRREKYIPKGGPDGGDGGRGGSVYAVADRNVNTLVEFR
CCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
YTRIFKAQKGENGRGAQCYGKAGDDLTIRVPVGTVFSDVNSGEVVADLAEDGETVCLAKG
HHHHEECCCCCCCCCCEEECCCCCCEEEEEECHHHHHCCCCCCEEEEHHCCCCEEEEEEC
GKGGLGNIHFKSSTNRAPRQHTLGEPGEEWELALELKVLADVGLLGMPNAGKSTFIRAVS
CCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHH
AARPKVADYPFTTLAPNLGVVRVDSERSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTRL
HCCCCCCCCCCHHHCCCCCEEEECCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHH
LLHLVDISPRWEAGDPVHEARAIVEELRKYDQALYEKPRWLVLNKLDMVDEGEREAVVAK
HHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
FVEDYGWNGPVFAISALDGSGCSALTYAVMDYLGMLAPRHEAEDPAPPAS
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA