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The map label for this gene is icd [H]

Identifier: 74316872

GI number: 74316872

Start: 903000

End: 904241

Strand: Direct

Name: icd [H]

Synonym: Tbd_0854

Alternate gene names: 74316872

Gene position: 903000-904241 (Clockwise)

Preceding gene: 74316867

Following gene: 74316874

Centisome position: 31.03

GC content: 63.37

Gene sequence:

>1242_bases
ATGACTTATCAGCACATCCAGATCCCCGCTGCCGGCCAGAAGATCACGGTCAACGCCGACAACACCCTCAACGTGCCCGA
CACGCCGATCATTCCCTTCATCGAAGGCGACGGCACGGGCGTCGACATCACGCCTGCGATGAAGAAGGTCGTCGACGCGG
CGGTCGCCAAGGCCTACGGCGGCCGGCGCCAGATCGCCTGGATGGAGGTCTTTGCCGGCGAGAAAGCCGTCAAGGTCTAC
GGCGGCGACCAGTGGTTGCCCGAAGAAACCGTTTCCGCCGTCAGGGACTACGTGATTTCGATCAAGGGCCCGCTGACGAC
GCCGACGTCGGGCGGCATCCGTTCGCTCAACGTCGCGTTGCGCCAGATCCTCGATCTCTACGTCTGCCTGCGCCCAGTGC
GCTACTTCGCGGGCGTGCCCAGCCCGGTGAAGGCGCCCGAGAAGGTCGACATGGTTATCTTCCGCGAGAACACCGAAGAC
ATTTACGCCGGCGTCGAATGGGAAGCCAACTCCGACGAGGCGAAGCGCGTCATCAAGTACCTGCAGCGGCAGATGGGCGT
GAAGAAGATCCGCTTCCCCGCCACCTCGGCGATCGGCATCAAGCCCGTCTCGATCGAGGGTTCGGAACGGCTGATCAGAA
AAGCGATCCAGTACGCGATCGACAACAAGCGCCGCTCGGTGACCCTCGTGCACAAGGGCAACATCATGAAGTTCACCGAA
GGCGGTTTCAAGAAGTGGGGCTACGAACTCGCCGCGCGTGAGTTCGGCGCCAAGCTGATCGGCGAAGGCCCGTGGATGGA
ATTGCCGAACGGAATCGTGATCAAGGACGTGATTGCCGACGCCTTCCTGCAACAGATCCTGCTGCGCCCCGACGAGTACG
ACGTGATCGCGACGCTGAACCTCAACGGCGACTACATCTCCGACGCGCTGGCGGCGGAAGTCGGCGGCATCGGCATCGCG
CCGGGCGCGAACCTCTCGGACACCGTCGCGATGTTCGAAGCCACGCACGGCACCGCGCCGAAGTACGCCGGCAAGGACTA
CGTCAACCCCGGTTCGCTGATCCTGTCGGCCGAGATGATGCTGCGCCACCTCGGCTGGATCGAAGCCGCCGACCTCATCG
TCGCGAGCATGGAAAAGGCGATCGCGGCGAAGGCCGTCACCTACGACTTCGCGCGACTCATGGAAGGCGCGACCGAAGTC
AAGTGCTCGCAGTTCGCCGAGGCGATGGTCGCGAAGATGTGA

Upstream 100 bases:

>100_bases
ATCAATCGCGCCACGCTGGAAAAACGAACGTCGGAAAAGACGCCATTTTAACGTTAGCCACGCGCCGCCCCGCCTCTAAT
TCACCCAGCATTTACTCGCC

Downstream 100 bases:

>100_bases
GTGACGCTGTCCTGCGGACGAAAAAAACCCCCGTCGAGGCGGGGGCGGTAGCAAAAGAAAACTCCGCTGTGGCGGGGCCG
TATCAAAAGAAAACCCCGCC

Product: isocitrate dehydrogenase (NADP)

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTYQHIQIPAAGQKITVNADNTLNVPDTPIIPFIEGDGTGVDITPAMKKVVDAAVAKAYGGRRQIAWMEVFAGEKAVKVY
GGDQWLPEETVSAVRDYVISIKGPLTTPTSGGIRSLNVALRQILDLYVCLRPVRYFAGVPSPVKAPEKVDMVIFRENTED
IYAGVEWEANSDEAKRVIKYLQRQMGVKKIRFPATSAIGIKPVSIEGSERLIRKAIQYAIDNKRRSVTLVHKGNIMKFTE
GGFKKWGYELAAREFGAKLIGEGPWMELPNGIVIKDVIADAFLQQILLRPDEYDVIATLNLNGDYISDALAAEVGGIGIA
PGANLSDTVAMFEATHGTAPKYAGKDYVNPGSLILSAEMMLRHLGWIEAADLIVASMEKAIAAKAVTYDFARLMEGATEV
KCSQFAEAMVAKM

Sequences:

>Translated_413_residues
MTYQHIQIPAAGQKITVNADNTLNVPDTPIIPFIEGDGTGVDITPAMKKVVDAAVAKAYGGRRQIAWMEVFAGEKAVKVY
GGDQWLPEETVSAVRDYVISIKGPLTTPTSGGIRSLNVALRQILDLYVCLRPVRYFAGVPSPVKAPEKVDMVIFRENTED
IYAGVEWEANSDEAKRVIKYLQRQMGVKKIRFPATSAIGIKPVSIEGSERLIRKAIQYAIDNKRRSVTLVHKGNIMKFTE
GGFKKWGYELAAREFGAKLIGEGPWMELPNGIVIKDVIADAFLQQILLRPDEYDVIATLNLNGDYISDALAAEVGGIGIA
PGANLSDTVAMFEATHGTAPKYAGKDYVNPGSLILSAEMMLRHLGWIEAADLIVASMEKAIAAKAVTYDFARLMEGATEV
KCSQFAEAMVAKM
>Mature_412_residues
TYQHIQIPAAGQKITVNADNTLNVPDTPIIPFIEGDGTGVDITPAMKKVVDAAVAKAYGGRRQIAWMEVFAGEKAVKVYG
GDQWLPEETVSAVRDYVISIKGPLTTPTSGGIRSLNVALRQILDLYVCLRPVRYFAGVPSPVKAPEKVDMVIFRENTEDI
YAGVEWEANSDEAKRVIKYLQRQMGVKKIRFPATSAIGIKPVSIEGSERLIRKAIQYAIDNKRRSVTLVHKGNIMKFTEG
GFKKWGYELAAREFGAKLIGEGPWMELPNGIVIKDVIADAFLQQILLRPDEYDVIATLNLNGDYISDALAAEVGGIGIAP
GANLSDTVAMFEATHGTAPKYAGKDYVNPGSLILSAEMMLRHLGWIEAADLIVASMEKAIAAKAVTYDFARLMEGATEVK
CSQFAEAMVAKM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=385, Percent_Identity=33.2467532467532, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI28178816, Length=387, Percent_Identity=27.906976744186, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI28178821, Length=347, Percent_Identity=28.8184438040346, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4758582, Length=358, Percent_Identity=29.0502793296089, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI28178838, Length=358, Percent_Identity=29.0502793296089, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI28178819, Length=176, Percent_Identity=34.0909090909091, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787381, Length=411, Percent_Identity=70.0729927007299, Blast_Score=602, Evalue=1e-174,
Organism=Escherichia coli, GI1788101, Length=370, Percent_Identity=28.9189189189189, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081683, Length=395, Percent_Identity=26.5822784810127, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=388, Percent_Identity=33.2474226804124, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=300, Percent_Identity=32.3333333333333, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17505779, Length=290, Percent_Identity=31.7241379310345, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=376, Percent_Identity=26.5957446808511, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=386, Percent_Identity=30.5699481865285, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322097, Length=358, Percent_Identity=29.3296089385475, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324291, Length=366, Percent_Identity=29.5081967213115, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24643268, Length=387, Percent_Identity=34.1085271317829, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643270, Length=387, Percent_Identity=34.1085271317829, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24661184, Length=386, Percent_Identity=31.8652849740933, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161078637, Length=298, Percent_Identity=29.1946308724832, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161078635, Length=298, Percent_Identity=29.1946308724832, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161078633, Length=298, Percent_Identity=29.1946308724832, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24650122, Length=298, Percent_Identity=29.1946308724832, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161078639, Length=298, Percent_Identity=29.1946308724832, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI20130355, Length=393, Percent_Identity=24.4274809160305, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281362242, Length=320, Percent_Identity=28.125, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24648872, Length=320, Percent_Identity=28.125, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45044; Mature: 44912

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQHIQIPAAGQKITVNADNTLNVPDTPIIPFIEGDGTGVDITPAMKKVVDAAVAKAYG
CCCEEEECCCCCCEEEEECCCEECCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHCC
GRRQIAWMEVFAGEKAVKVYGGDQWLPEETVSAVRDYVISIKGPLTTPTSGGIRSLNVAL
CCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
RQILDLYVCLRPVRYFAGVPSPVKAPEKVDMVIFRENTEDIYAGVEWEANSDEAKRVIKY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEECEEECCCCHHHHHHHHH
LQRQMGVKKIRFPATSAIGIKPVSIEGSERLIRKAIQYAIDNKRRSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GGFKKWGYELAAREFGAKLIGEGPWMELPNGIVIKDVIADAFLQQILLRPDEYDVIATLN
CCHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEEE
LNGDYISDALAAEVGGIGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSLILSAEMM
CCCCHHHHHHHHHHCCEECCCCCCCHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHH
LRHLGWIEAADLIVASMEKAIAAKAVTYDFARLMEGATEVKCSQFAEAMVAKM
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYQHIQIPAAGQKITVNADNTLNVPDTPIIPFIEGDGTGVDITPAMKKVVDAAVAKAYG
CCEEEECCCCCCEEEEECCCEECCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHCC
GRRQIAWMEVFAGEKAVKVYGGDQWLPEETVSAVRDYVISIKGPLTTPTSGGIRSLNVAL
CCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
RQILDLYVCLRPVRYFAGVPSPVKAPEKVDMVIFRENTEDIYAGVEWEANSDEAKRVIKY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEECEEECCCCHHHHHHHHH
LQRQMGVKKIRFPATSAIGIKPVSIEGSERLIRKAIQYAIDNKRRSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GGFKKWGYELAAREFGAKLIGEGPWMELPNGIVIKDVIADAFLQQILLRPDEYDVIATLN
CCHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEEE
LNGDYISDALAAEVGGIGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSLILSAEMM
CCCCHHHHHHHHHHCCEECCCCCCCHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHH
LRHLGWIEAADLIVASMEKAIAAKAVTYDFARLMEGATEVKCSQFAEAMVAKM
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]