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The map label for this gene is msrA [H]

Identifier: 74316865

GI number: 74316865

Start: 896416

End: 896949

Strand: Direct

Name: msrA [H]

Synonym: Tbd_0847

Alternate gene names: 74316865

Gene position: 896416-896949 (Clockwise)

Preceding gene: 74316864

Following gene: 74316867

Centisome position: 30.81

GC content: 62.55

Gene sequence:

>534_bases
ATGGCGCATGAAATCGCAACGCTGGCGGGCGGCTGCTTCTGGTGCATCGAGACCGTCTTCAATCGCCTGCAAGGCGTCGA
ATCCGCCGTCTCGGGCTACATGGGCGGGCATACCGAAACGCCCAGCTACGAAGCCGTCTGCAACGGCGACACCGGCCACG
CTGAAGTCGTACAGATCACGTTCGACCCCGACGTGATTTCCTATCGCGACCTGCTCGATGTCTTCTTCACGATCCACGAC
CCGACCCAGCTCAACCGGCAAGGCAACGACGTCGGCACGCAATACCGCTCGGCGATCTTCTGGCATACGCCCGCGCAGAA
GGCCGAAGCCGAAGCTGCAATCGCGGCCCTCGACGCATCGAAACAATACGGCTCGCCCGTCGTCACCGAAGTCGCCGAGG
CGACGACGTTCTACCCCGCCGAGACCTATCACCAGCGCTACTACGAGGCCAACCCGCGGCAGCCGTATTGCCAGTATGTC
GTCGCACCCAAGGTCGCGAAGGCCGAGCAGAAATTCGCGGACCGGCTCAAATAG

Upstream 100 bases:

>100_bases
TGATGACGCGCGCCTCGTTCAAGGATTCGGTGCCCGTCGCCTGAGTCGCATGGCCGCGCCGTTCGCGGACGGCGCGAATT
CCACTTCGCGGGAGTCGATC

Downstream 100 bases:

>100_bases
CTCACTCGCCGAGCGAGCCCCACTCCTTGAACTGGCGTTCCATATCCTTTTCCTCGGCCTCGATCGAGTCCGGTCCGGCG
TCGGGACATTCGGTCGGCGC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MAHEIATLAGGCFWCIETVFNRLQGVESAVSGYMGGHTETPSYEAVCNGDTGHAEVVQITFDPDVISYRDLLDVFFTIHD
PTQLNRQGNDVGTQYRSAIFWHTPAQKAEAEAAIAALDASKQYGSPVVTEVAEATTFYPAETYHQRYYEANPRQPYCQYV
VAPKVAKAEQKFADRLK

Sequences:

>Translated_177_residues
MAHEIATLAGGCFWCIETVFNRLQGVESAVSGYMGGHTETPSYEAVCNGDTGHAEVVQITFDPDVISYRDLLDVFFTIHD
PTQLNRQGNDVGTQYRSAIFWHTPAQKAEAEAAIAALDASKQYGSPVVTEVAEATTFYPAETYHQRYYEANPRQPYCQYV
VAPKVAKAEQKFADRLK
>Mature_176_residues
AHEIATLAGGCFWCIETVFNRLQGVESAVSGYMGGHTETPSYEAVCNGDTGHAEVVQITFDPDVISYRDLLDVFFTIHDP
TQLNRQGNDVGTQYRSAIFWHTPAQKAEAEAAIAALDASKQYGSPVVTEVAEATTFYPAETYHQRYYEANPRQPYCQYVV
APKVAKAEQKFADRLK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=44.6540880503145, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=44.6540880503145, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=46.0176991150442, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=52.6315789473684, Blast_Score=154, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=33.7931034482759, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=39.5061728395062, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664627, Length=166, Percent_Identity=34.3373493975904, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45553131, Length=161, Percent_Identity=34.1614906832298, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24664631, Length=166, Percent_Identity=33.7349397590361, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19650; Mature: 19519

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHEIATLAGGCFWCIETVFNRLQGVESAVSGYMGGHTETPSYEAVCNGDTGHAEVVQIT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEEEEE
FDPDVISYRDLLDVFFTIHDPTQLNRQGNDVGTQYRSAIFWHTPAQKAEAEAAIAALDAS
ECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHCH
KQYGSPVVTEVAEATTFYPAETYHQRYYEANPRQPYCQYVVAPKVAKAEQKFADRLK
HHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AHEIATLAGGCFWCIETVFNRLQGVESAVSGYMGGHTETPSYEAVCNGDTGHAEVVQIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEEEEE
FDPDVISYRDLLDVFFTIHDPTQLNRQGNDVGTQYRSAIFWHTPAQKAEAEAAIAALDAS
ECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHCH
KQYGSPVVTEVAEATTFYPAETYHQRYYEANPRQPYCQYVVAPKVAKAEQKFADRLK
HHHCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]