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The map label for this gene is nadC [H]

Identifier: 74316832

GI number: 74316832

Start: 854877

End: 855722

Strand: Reverse

Name: nadC [H]

Synonym: Tbd_0814

Alternate gene names: 74316832

Gene position: 855722-854877 (Counterclockwise)

Preceding gene: 74316836

Following gene: 74316831

Centisome position: 29.41

GC content: 69.15

Gene sequence:

>846_bases
ATGTCCGAATTGCTCGCTTCAGCTGTCGAAACCGATGTTGCGCGTGCCCTGGCCGAGGACGTCGGCAGCGGCGACCTGAC
TGCGCGGCTCATCCCCGCGGCGCAGACCGGCACGGCGCGGCTCATCACGCGCGAGGCCGCCGTGATCGCGGGGCGGCCGT
GGTTCGACGCCTGTTTCAAGGCGCTCGACCTTGCTTGCAGCATAGACTGGCAGGTCAAGGAGGGGGACGGGGTCGCGGCC
GGCACCGCGCTGGTCGAGATTCGCGGCAACGCGCGCGCCCTGCTCACCGCCGAGCGACCTGCGCTCAATTTTCTGCAGAC
GCTCTCGGGCGTGGCGACCGTGACCCGCGCCTACGTCGACGCCGTGCGCGGCACCGGCGCGGCCATCGTCGACACGCGCA
AGACCCTGCCCGGCCTGCGACTGGCGCAGAAGTACGCGGTGCGCACCGGCGGCGGGCAGAACCAGCGGATCGGGCTCTAC
GACGGCATCCTGATCAAGGAGAACCATATCCTCGCGGCGGGTGGCATCAAGGCCGTGCTCGACGCGGCGTTCCGGCTTGC
CGAAGACCAGGTCAGCGTGCAGATCGAAGTGGAAACTTTGGACGAACTCCAGCAGGCGCTGGACGCGCAGGCGCCGTCGA
TCCTGCTCGACAACTTCGAACTCGCCGCGATGCGGCGAGCGGTGGAGCTGACCGCGGGGCGCGCACTGCTCGAAGCCTCG
GGCAACATCACACTCGCGAACGTGCGCGCCGTGGCCGAAACCGGCGTCGACCGCATCTCGATCGGGAGCCTCACCAAGCA
CGTGCGCGCCATCGATCTGTCGATGCGCGCGCTCGCCCGTGCTTGA

Upstream 100 bases:

>100_bases
TGATTCCTGCGCAAACTGGCTCTAGGGTATATTTCGATGCCACCCAAATAGGGGCGTCTGCGCCGATTTCAACCCGCTGT
GTCCTAAATAGAGGCCCGCC

Downstream 100 bases:

>100_bases
GGTCGTTCGCGCGCGTTACCGCGATCCGGTCCACGCCGCCGCGCTGATCGCGTTGCTCGACGGCTATTCGCGCGACCCGG
CCGGCGGCGGCAAGCCGCTG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSELLASAVETDVARALAEDVGSGDLTARLIPAAQTGTARLITREAAVIAGRPWFDACFKALDLACSIDWQVKEGDGVAA
GTALVEIRGNARALLTAERPALNFLQTLSGVATVTRAYVDAVRGTGAAIVDTRKTLPGLRLAQKYAVRTGGGQNQRIGLY
DGILIKENHILAAGGIKAVLDAAFRLAEDQVSVQIEVETLDELQQALDAQAPSILLDNFELAAMRRAVELTAGRALLEAS
GNITLANVRAVAETGVDRISIGSLTKHVRAIDLSMRALARA

Sequences:

>Translated_281_residues
MSELLASAVETDVARALAEDVGSGDLTARLIPAAQTGTARLITREAAVIAGRPWFDACFKALDLACSIDWQVKEGDGVAA
GTALVEIRGNARALLTAERPALNFLQTLSGVATVTRAYVDAVRGTGAAIVDTRKTLPGLRLAQKYAVRTGGGQNQRIGLY
DGILIKENHILAAGGIKAVLDAAFRLAEDQVSVQIEVETLDELQQALDAQAPSILLDNFELAAMRRAVELTAGRALLEAS
GNITLANVRAVAETGVDRISIGSLTKHVRAIDLSMRALARA
>Mature_280_residues
SELLASAVETDVARALAEDVGSGDLTARLIPAAQTGTARLITREAAVIAGRPWFDACFKALDLACSIDWQVKEGDGVAAG
TALVEIRGNARALLTAERPALNFLQTLSGVATVTRAYVDAVRGTGAAIVDTRKTLPGLRLAQKYAVRTGGGQNQRIGLYD
GILIKENHILAAGGIKAVLDAAFRLAEDQVSVQIEVETLDELQQALDAQAPSILLDNFELAAMRRAVELTAGRALLEASG
NITLANVRAVAETGVDRISIGSLTKHVRAIDLSMRALARA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=258, Percent_Identity=37.2093023255814, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=51.8382352941177, Blast_Score=239, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6321162, Length=283, Percent_Identity=30.7420494699647, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29577; Mature: 29446

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELLASAVETDVARALAEDVGSGDLTARLIPAAQTGTARLITREAAVIAGRPWFDACFK
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEHHHEEECCCHHHHHHH
ALDLACSIDWQVKEGDGVAAGTALVEIRGNARALLTAERPALNFLQTLSGVATVTRAYVD
HHHHHEECEEEEECCCCEEECEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
AVRGTGAAIVDTRKTLPGLRLAQKYAVRTGGGQNQRIGLYDGILIKENHILAAGGIKAVL
HHCCCCCEEEECHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEEECCCEEEECCHHHHH
DAAFRLAEDQVSVQIEVETLDELQQALDAQAPSILLDNFELAAMRRAVELTAGRALLEAS
HHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCHHEEECC
GNITLANVRAVAETGVDRISIGSLTKHVRAIDLSMRALARA
CCEEEEEEHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SELLASAVETDVARALAEDVGSGDLTARLIPAAQTGTARLITREAAVIAGRPWFDACFK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEHHHEEECCCHHHHHHH
ALDLACSIDWQVKEGDGVAAGTALVEIRGNARALLTAERPALNFLQTLSGVATVTRAYVD
HHHHHEECEEEEECCCCEEECEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
AVRGTGAAIVDTRKTLPGLRLAQKYAVRTGGGQNQRIGLYDGILIKENHILAAGGIKAVL
HHCCCCCEEEECHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEEECCCEEEECCHHHHH
DAAFRLAEDQVSVQIEVETLDELQQALDAQAPSILLDNFELAAMRRAVELTAGRALLEAS
HHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCHHEEECC
GNITLANVRAVAETGVDRISIGSLTKHVRAIDLSMRALARA
CCEEEEEEHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]