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The map label for this gene is hpt [H]

Identifier: 74316795

GI number: 74316795

Start: 821606

End: 822163

Strand: Direct

Name: hpt [H]

Synonym: Tbd_0777

Alternate gene names: 74316795

Gene position: 821606-822163 (Clockwise)

Preceding gene: 74316789

Following gene: 74316796

Centisome position: 28.24

GC content: 68.28

Gene sequence:

>558_bases
ATGACACCGCACGAAGCGCAGCAGTTGCTCCACGATGCCGAGTGCGTCGCGACCGCCGAGCGCGTGCAGGCCGCGCTCGA
TCGCCTGGCTGGCGAAATCGGCGAGGCGCTCTCCAGCGAAATGCCGCTCGTGCTCGCGGTGATGGGGGGAGCGGTCGTGT
TTGCCGGGCAGCTGCTTACGCGTCTCGCTTTTCCGCTCGAATTCGACTACCTGCACGTCACCCGCTACCGCGGCAAGACC
CGCGGCGGCGAGATCGAGTGGCGCGTGCTCCCCGGCAAGAGCGTCGCCGGCCGCGCCGTGCTCGTGCTCGACGACATCCT
CGACGAAGGCGAGACGCTCGCGGCGGTGCGCGCCAAGCTCCTGGAAATGGGCGCGGCACGCGTCTGGTCGGCGGTGCTGA
CCGACAAGGCCAACGGCCTCGTCAAACCCGTGCGGGCGGACTTCGTCGGACTCGAAGTCCCCGACCGCTACGTCTTTGGT
TGCGGCATGGACGCCTACGGACTGTGGCGCAACCTGCCAGCGATTTACGCTTTGAGCCCCGACGCCGCGTCGGGATAA

Upstream 100 bases:

>100_bases
GGAAATCGGCATCGCGCAAGCTTACTCGACCCGAGCGCGCGCTGGAAACATCGGCGGCGACGGCTTAGACTGCCGACTTT
CGCCGATTTCACCGCCGCTC

Downstream 100 bases:

>100_bases
GGAAAACTACATGTTGGGAATCATCGGCGGCACTGGGTTGACCCAGCTCGCCAACCTCAAGATCACGCATCGCCGCGTCG
CGCGCACGCCCTACGGCGAG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MTPHEAQQLLHDAECVATAERVQAALDRLAGEIGEALSSEMPLVLAVMGGAVVFAGQLLTRLAFPLEFDYLHVTRYRGKT
RGGEIEWRVLPGKSVAGRAVLVLDDILDEGETLAAVRAKLLEMGAARVWSAVLTDKANGLVKPVRADFVGLEVPDRYVFG
CGMDAYGLWRNLPAIYALSPDAASG

Sequences:

>Translated_185_residues
MTPHEAQQLLHDAECVATAERVQAALDRLAGEIGEALSSEMPLVLAVMGGAVVFAGQLLTRLAFPLEFDYLHVTRYRGKT
RGGEIEWRVLPGKSVAGRAVLVLDDILDEGETLAAVRAKLLEMGAARVWSAVLTDKANGLVKPVRADFVGLEVPDRYVFG
CGMDAYGLWRNLPAIYALSPDAASG
>Mature_184_residues
TPHEAQQLLHDAECVATAERVQAALDRLAGEIGEALSSEMPLVLAVMGGAVVFAGQLLTRLAFPLEFDYLHVTRYRGKTR
GGEIEWRVLPGKSVAGRAVLVLDDILDEGETLAAVRAKLLEMGAARVWSAVLTDKANGLVKPVRADFVGLEVPDRYVFGC
GMDAYGLWRNLPAIYALSPDAASG

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=26.6272189349112, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510817, Length=167, Percent_Identity=31.7365269461078, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19877; Mature: 19746

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPHEAQQLLHDAECVATAERVQAALDRLAGEIGEALSSEMPLVLAVMGGAVVFAGQLLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
RLAFPLEFDYLHVTRYRGKTRGGEIEWRVLPGKSVAGRAVLVLDDILDEGETLAAVRAKL
HHHCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCHHHHHHHHHH
LEMGAARVWSAVLTDKANGLVKPVRADFVGLEVPDRYVFGCGMDAYGLWRNLPAIYALSP
HHHHHHHHHHHHHHHCCCCCCCCHHHCEECCCCCCCEEEECCCCHHHHHHCCCEEEEECC
DAASG
CCCCC
>Mature Secondary Structure 
TPHEAQQLLHDAECVATAERVQAALDRLAGEIGEALSSEMPLVLAVMGGAVVFAGQLLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
RLAFPLEFDYLHVTRYRGKTRGGEIEWRVLPGKSVAGRAVLVLDDILDEGETLAAVRAKL
HHHCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCHHHHHHHHHH
LEMGAARVWSAVLTDKANGLVKPVRADFVGLEVPDRYVFGCGMDAYGLWRNLPAIYALSP
HHHHHHHHHHHHHHHCCCCCCCCHHHCEECCCCCCCEEEECCCCHHHHHHCCCEEEEECC
DAASG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1465108; 11337471 [H]