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The map label for this gene is gltP [H]

Identifier: 74316664

GI number: 74316664

Start: 686331

End: 687641

Strand: Reverse

Name: gltP [H]

Synonym: Tbd_0646

Alternate gene names: 74316664

Gene position: 687641-686331 (Counterclockwise)

Preceding gene: 74316666

Following gene: 74316663

Centisome position: 23.63

GC content: 68.19

Gene sequence:

>1311_bases
ATGATCCCGAACCCGACCTCCACGCTCACCCGACGCATCGTGATCGCCATGCTGGCGGGCATCGCGCTGGGCAGCACGCT
GAATCAGTTCGGCCCGCCGGCCTGGGCGCAGCTCTATCTGCTCGACGGCATACTCGGCGTCGTCGGCGCGCTCTTCGTCG
CTGCGCTCAAGATGATGGTCGTTCCGCTCGTCTTCGTGTCGCTGGTCGTCGGCGTCACGGCGCTGTCCGACCTGCGCACG
CTCGGTCGCGTCGGCGCCAAGGCGCTGACGCTCTACCTCGTGACCACGGCGCTCGCGGTAACGATCGCGCTCGCGCTCGC
CGCAGCAGTCGCGCCGGGCGGCGGATTCAACGCCGGCAGGACCGATGCGAGCTTCAGCGGCAAGCCGGCGCCGCCGCTGA
CCGAAATGCTGATCGGCCTCGTGCCGACCAACCCGATCGCCGCGATGGCCGAAGGCAACATGCTGCAGATCATCGTCTTC
GCGCTGCTGTTCGGCGTCGCGGTGACGATGTCGGGCGCACGCGGCACGCATGTGCTCAAGCTCTTCAACGATCTCGACGC
CGTGATCATGCACATGGTCGAGTGGATCATGCGGCTCGCGCCCTACGGCGTCTTCGCGCTGATCACGCGCACGTTCGCGA
CGCAGGGGCTCGACGTTCTGTTGCCGCTGGCGTCCTATTTCCTCACGCTGACGGCCGCGCTCGCGATCCAGCTGTTCGTG
AGCTACCCGCTGCTGCTGCGCCTGCTCGCCTCGCTCAACCCGATCACCTTTCTGAAGAAGATGCGCGACCCGGCGGCGTT
CGCCTTCTCGACCGCGAGTTCCGGCGCGACGATCCCGGTCACGCTGCGCACGGTCGAATACAAGATGGGCGTGCCGAACA
GCATCGGTGCGTTCACGGTGCCGCTCGGCGCGACGATCAACATGGACGGCACGGCGATGATGCAGGGCGTCGCGACCGTC
TTCATCGCCAACGTCTACGGCGTAGACCTCGCGTTCGGCGACTACCTGCTGGTCGTGCTGACGGCGACGCTCGCCTCGGT
CGGCACCGCGGCGATTCCCGCGGTCGGCCTCGTCACGCTGGCGATGGTGCTCGGCCAGGTCGGGCTGCCGGTCGAGGGCA
TCGCGCTCATCCTCGGCGTCGACCGCCTGCTCGACATGATGCGCACGACCGTCAACGTCACGGGCGACTGCGCGGTGAGC
TGCATCGTCGCGCAGAGCGAGCGCACGCTCGACCGTGCAATATTCGACGACCCGGCCGCGGGTTCGGTCACCGCCGCGAC
CCGCCGTCCCTCTCCTTCCGCCCCCGCCTGA

Upstream 100 bases:

>100_bases
GGGGGTGAGCCTCGGCCAGGAGGGCCAGCGGTTGCCGCGCGCCCTGCGAGGCGGCCGCCGCGCCGCTGATACAATTCCAG
GGCCCGACTCTAGGCGCGCC

Downstream 100 bases:

>100_bases
ACATGCTTTATTCGCTGATCCGCCCCGCCCTCTTTTCGCTCGACGCCGAAGACGCCCACGGCCTGACGCTCACCGGCCTC
GACGTGGCACAGCGCCTCGG

Product: Na+/H+ - glutamate/aspartate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MIPNPTSTLTRRIVIAMLAGIALGSTLNQFGPPAWAQLYLLDGILGVVGALFVAALKMMVVPLVFVSLVVGVTALSDLRT
LGRVGAKALTLYLVTTALAVTIALALAAAVAPGGGFNAGRTDASFSGKPAPPLTEMLIGLVPTNPIAAMAEGNMLQIIVF
ALLFGVAVTMSGARGTHVLKLFNDLDAVIMHMVEWIMRLAPYGVFALITRTFATQGLDVLLPLASYFLTLTAALAIQLFV
SYPLLLRLLASLNPITFLKKMRDPAAFAFSTASSGATIPVTLRTVEYKMGVPNSIGAFTVPLGATINMDGTAMMQGVATV
FIANVYGVDLAFGDYLLVVLTATLASVGTAAIPAVGLVTLAMVLGQVGLPVEGIALILGVDRLLDMMRTTVNVTGDCAVS
CIVAQSERTLDRAIFDDPAAGSVTAATRRPSPSAPA

Sequences:

>Translated_436_residues
MIPNPTSTLTRRIVIAMLAGIALGSTLNQFGPPAWAQLYLLDGILGVVGALFVAALKMMVVPLVFVSLVVGVTALSDLRT
LGRVGAKALTLYLVTTALAVTIALALAAAVAPGGGFNAGRTDASFSGKPAPPLTEMLIGLVPTNPIAAMAEGNMLQIIVF
ALLFGVAVTMSGARGTHVLKLFNDLDAVIMHMVEWIMRLAPYGVFALITRTFATQGLDVLLPLASYFLTLTAALAIQLFV
SYPLLLRLLASLNPITFLKKMRDPAAFAFSTASSGATIPVTLRTVEYKMGVPNSIGAFTVPLGATINMDGTAMMQGVATV
FIANVYGVDLAFGDYLLVVLTATLASVGTAAIPAVGLVTLAMVLGQVGLPVEGIALILGVDRLLDMMRTTVNVTGDCAVS
CIVAQSERTLDRAIFDDPAAGSVTAATRRPSPSAPA
>Mature_436_residues
MIPNPTSTLTRRIVIAMLAGIALGSTLNQFGPPAWAQLYLLDGILGVVGALFVAALKMMVVPLVFVSLVVGVTALSDLRT
LGRVGAKALTLYLVTTALAVTIALALAAAVAPGGGFNAGRTDASFSGKPAPPLTEMLIGLVPTNPIAAMAEGNMLQIIVF
ALLFGVAVTMSGARGTHVLKLFNDLDAVIMHMVEWIMRLAPYGVFALITRTFATQGLDVLLPLASYFLTLTAALAIQLFV
SYPLLLRLLASLNPITFLKKMRDPAAFAFSTASSGATIPVTLRTVEYKMGVPNSIGAFTVPLGATINMDGTAMMQGVATV
FIANVYGVDLAFGDYLLVVLTATLASVGTAAIPAVGLVTLAMVLGQVGLPVEGIALILGVDRLLDMMRTTVNVTGDCAVS
CIVAQSERTLDRAIFDDPAAGSVTAATRRPSPSAPA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=422, Percent_Identity=33.175355450237, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI21314632, Length=390, Percent_Identity=33.5897435897436, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI169790839, Length=416, Percent_Identity=32.6923076923077, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI5032093, Length=371, Percent_Identity=36.9272237196765, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI66773030, Length=400, Percent_Identity=32.75, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI223468566, Length=255, Percent_Identity=40.7843137254902, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI223468564, Length=246, Percent_Identity=41.0569105691057, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4827012, Length=296, Percent_Identity=38.1756756756757, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI194239697, Length=430, Percent_Identity=30, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI262359914, Length=346, Percent_Identity=28.9017341040462, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI301601644, Length=142, Percent_Identity=40.8450704225352, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI1790514, Length=426, Percent_Identity=35.9154929577465, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789947, Length=426, Percent_Identity=30.2816901408451, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1788024, Length=393, Percent_Identity=29.0076335877863, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789473, Length=382, Percent_Identity=29.5811518324607, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=430, Percent_Identity=34.1860465116279, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71983099, Length=430, Percent_Identity=34.1860465116279, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17537407, Length=436, Percent_Identity=35.0917431192661, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193206505, Length=435, Percent_Identity=32.8735632183908, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=31.858407079646, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI193206654, Length=439, Percent_Identity=30.5239179954442, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17541374, Length=414, Percent_Identity=30.6763285024155, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24583025, Length=385, Percent_Identity=31.4285714285714, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17137668, Length=385, Percent_Identity=31.4285714285714, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24583023, Length=385, Percent_Identity=31.4285714285714, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI281360483, Length=297, Percent_Identity=34.6801346801347, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137666, Length=297, Percent_Identity=34.6801346801347, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360481, Length=297, Percent_Identity=34.6801346801347, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45191; Mature: 45191

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCEEECCCCCCCCCCC
>Mature Secondary Structure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CCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]